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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 33, 2018 - Issue 1
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Short Communication

Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors

Minhang XinDepartment of Medicinal Chemistry, School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, P.R. ChinaView further author information
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Weiming DuanDepartment of Medicinal Chemistry, School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, P.R. ChinaView further author information
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Yifan FengDepartment of Medicinal Chemistry, School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, P.R. ChinaView further author information
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Yuan-Yuan HeiDepartment of Medicinal Chemistry, School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, P.R. ChinaView further author information
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Hao ZhangDepartment of Medicinal Chemistry, School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, P.R. ChinaView further author information
,
Ying ShenDepartment of Medicinal Chemistry, School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, P.R. ChinaView further author information
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Hong-Yi ZhaoDepartment of Medicinal Chemistry, School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, P.R. ChinaView further author information
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Shuai MaoDepartment of Medicinal Chemistry, School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, P.R. ChinaView further author information
&
San-Qi ZhangDepartment of Medicinal Chemistry, School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, P.R. ChinaCorrespondence[email protected]
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Pages 651-656 | Received 05 Jan 2018, Accepted 20 Feb 2018, Published online: 14 Mar 2018

Citations (7)

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Read on this site (1)

Yifan Feng, Xiaochuan Cu & Minhang Xin. (2019) PI3Kδ inhibitors for the treatment of cancer: a patent review (2015-present). Expert Opinion on Therapeutic Patents 29:12, pages 925-941.
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Articles from other publishers (6)

Mengyan Ma, Yifan Feng, San-Qi Zhang, Weiming Duan, Li Gao, Bo Yuan & Minhang Xin. (2023) Design, synthesis and biological evaluation of novel selective PI3Kδ inhibitors containing pyridopyrimidine scaffold. Future Medicinal Chemistry.
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Minhang Xin, Hui-Yan Wang, Hao Zhang, Ying Shen & San-Qi Zhang. (2020) Synthesis and biological activity of new 2,4,6-trisubstituted triazines as potential phosphoinositide 3-kinase inhibitors. Journal of Chemical Research 44:7-8, pages 393-402.
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Fatma M. Elmenier, Deena S. Lasheen & Khaled A.M. Abouzid. (2019) Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer. European Journal of Medicinal Chemistry 183, pages 111718.
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Yifan Feng, Weiming Duan, Shu Fan, Hao Zhang, San-Qi Zhang & Minhang Xin. (2019) Synthesis and biological evaluation of 4-(piperid-3-yl)amino substituted 6-pyridylquinazolines as potent PI3Kδ inhibitors. Bioorganic & Medicinal Chemistry 27:19, pages 115035.
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Yuan-Yuan Hei, San-Qi Zhang, Yifan Feng, Jin Wang, Weiming Duan, Hao Zhang, Shuai Mao, Haopeng Sun & Minhang Xin. (2019) Alkylsulfonamide-containing quinazoline derivatives as potent and orally bioavailable PI3Ks inhibitors. Bioorganic & Medicinal Chemistry 27:20, pages 114930.
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Matthew W. D. Perry, Raolat Abdulai, Mickael Mogemark, Jens Petersen, Matthew J. Thomas, Barbara Valastro & Annika Westin Eriksson. (2018) Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases. Journal of Medicinal Chemistry 62:10, pages 4783-4814.
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