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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds

Ahmed K. Faraga RI Translational Research Team, Division of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Republic of KoreaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-4420-3451View further author information
ORCID Icon,
Ahmed H. E. Hassanb Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptORCID Iconhttps://orcid.org/0000-0002-1048-6281View further author information
ORCID Icon,
Byung Sun Ahnc Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea;d Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul, Republic of KoreaView further author information
,
Ki Duk Parkd Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul, Republic of Korea;e Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaView further author information
&
Eun Joo Rohc Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea;d Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul, Republic of KoreaCorrespondence[email protected]
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Pages 311-324 | Received 13 Sep 2019, Accepted 25 Nov 2019, Published online: 06 Dec 2019

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Ahmed H. E. Hassan, Waleed A. Bayoumi, Selwan M. El-Sayed, Trong-Nhat Phan, Yeon Ju Kim, Chae Hyeon Lee, Soo Bin Cho, Taegeun Oh, Gyeongpyo Ham, Kazem Mahmoud, Joo Hwan No & Yong Sup Lee. (2023) Rational repurposing, synthesis, in vitro and in silico studies of chromone-peptidyl hybrids as potential agents against Leishmania donovani. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Ahmed H. E. Hassan, Yeon Il Oh, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Md. Maqusood Alam, Sang-Eun Park, Kyung-Sook Chung, Kyung-Tae Lee & Yong Sup Lee. (2023) Design, synthesis, and study of novel phenethyl-based antitumor phospholipids downregulating p38 mitogen-activated protein kinase. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Ahmed H. E. Hassan, Hyeon Jeong Kim, Min Sung Gee, Jong-Hyun Park, Hye Rim Jeon, Cheol Jung Lee, Yeonwoo Choi, Suyeon Moon, Danbi Lee, Jong Kil Lee, Ki Duk Park & Yong Sup Lee. (2022) Positional scanning of natural product hispidol’s ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 768-780.
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Ahmed H. E. Hassan, Trong-Nhat Phan, Seolmin Yoon, Cheol Jung Lee, Hye Rim Jeon, Seung-Hwan Kim, Joo Hwan No & Yong Sup Lee. (2021) Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1922-1930.
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