Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
Submit an article Journal homepage
2,975
Views
23
CrossRef citations to date
0
Altmetric
Research Paper

Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds

Ahmed K. Faraga RI Translational Research Team, Division of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Republic of KoreaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-4420-3451View further author information
ORCID Icon,
Ahmed H. E. Hassanb Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptORCID Iconhttps://orcid.org/0000-0002-1048-6281View further author information
ORCID Icon,
Byung Sun Ahnc Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea;d Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul, Republic of KoreaView further author information
,
Ki Duk Parkd Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul, Republic of Korea;e Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaView further author information
&
Eun Joo Rohc Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea;d Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul, Republic of KoreaCorrespondence[email protected]
View further author information
Pages 311-324 | Received 13 Sep 2019, Accepted 25 Nov 2019, Published online: 06 Dec 2019

Citations (23)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Ahmed H. E. Hassan, Waleed A. Bayoumi, Selwan M. El-Sayed, Trong-Nhat Phan, Yeon Ju Kim, Chae Hyeon Lee, Soo Bin Cho, Taegeun Oh, Gyeongpyo Ham, Kazem Mahmoud, Joo Hwan No & Yong Sup Lee. (2023) Rational repurposing, synthesis, in vitro and in silico studies of chromone-peptidyl hybrids as potential agents against Leishmania donovani. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
Read now
Ahmed H. E. Hassan, Yeon Il Oh, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Md. Maqusood Alam, Sang-Eun Park, Kyung-Sook Chung, Kyung-Tae Lee & Yong Sup Lee. (2023) Design, synthesis, and study of novel phenethyl-based antitumor phospholipids downregulating p38 mitogen-activated protein kinase. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
Read now
Ahmed H. E. Hassan, Hyeon Jeong Kim, Min Sung Gee, Jong-Hyun Park, Hye Rim Jeon, Cheol Jung Lee, Yeonwoo Choi, Suyeon Moon, Danbi Lee, Jong Kil Lee, Ki Duk Park & Yong Sup Lee. (2022) Positional scanning of natural product hispidol’s ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 768-780.
Read now
Ahmed H. E. Hassan, Trong-Nhat Phan, Seolmin Yoon, Cheol Jung Lee, Hye Rim Jeon, Seung-Hwan Kim, Joo Hwan No & Yong Sup Lee. (2021) Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1922-1930.
Read now

Articles from other publishers (19)

Bilal O. Alkubaisi, Raya Aljobowry, Salma M. Ali, Sara Sultan, Seyed-Omar Zaraei, Anil Ravi, Taleb H. Al-Tel & Mohammed I. El-Gamal. (2023) The latest perspectives of small molecules FMS kinase inhibitors. European Journal of Medicinal Chemistry 261, pages 115796.
Crossref
Ahmed H.E. Hassan, Mohammad Maqusood Alam, Trong-Nhat Phan, Kyung-Hwa Baek, Hyeryon Lee, Soo Bin Cho, Chae Hyeon Lee, Yeon Ju Kim, Joo Hwan No & Yong Sup Lee. (2023) Repurposing of conformationally-restricted cyclopentane-based AKT–inhibitors leads to discovery of potential and more selective antileishmanial agents than miltefosine. Bioorganic Chemistry 141, pages 106890.
Crossref
Ahmed H.E. Hassan, Cai Yi Wang, Hyo Jong Lee, Su Jin Jung, Yeon Ju Kim, Soo Bin Cho, Chae Hyeon Lee, Gyeongpyo Ham, Taegeun Oh, Sang Kook Lee & Yong Sup Lee. (2023) Scaffold hopping of N-benzyl-3,4,5-trimethoxyaniline: 5,6,7-Trimethoxyflavan derivatives as novel potential anticancer agents modulating hippo signaling pathway. European Journal of Medicinal Chemistry 256, pages 115421.
Crossref
Akshun Vyas, Bhaskar Sahu, Shelly Pathania, Nilay Kumar Nandi, Gaurav Chauhan, Vivek Asati & Bhupinder Kumar. (2022) An insight on medicinal attributes of pyrimidine scaffold: An updated review. Journal of Heterocyclic Chemistry 60:7, pages 1081-1121.
Crossref
Ahmed H.E. Hassan, Hye Jin Kim, Su Jin Jung, Seo-Yun Jang, Selwan M. El-Sayed, Kyung-Tae Lee & Yong Sup Lee. (2023) Design, synthesis, and evaluation of new anti-inflammatory natural products amide derivatives endowed with anti-blood cancer activity towards development of potential multifunctional agents against hematological cancers. European Journal of Medicinal Chemistry, pages 115566.
Crossref
Ahmed H. E. Hassan, Hyeon Jeong Kim, Keontae Park, Yeonwoo Choi, Suyeon Moon, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Min Sung Gee, Danbi Lee, Jong-Hyun Park, Jong Kil Lee, Jong Hoon Ryu, Ki Duk Park & Yong Sup Lee. (2023) Synthesis and Biological Evaluation of O6-Aminoalkyl-Hispidol Analogs as Multifunctional Monoamine Oxidase-B Inhibitors towards Management of Neurodegenerative Diseases. Antioxidants 12:5, pages 1033.
Crossref
Kanika Gulia, Ahmed H. E. Hassan, Justin R. Lenhard & Abdelbasset A. Farahat. (2023) Escaping ESKAPE resistance: in vitro and in silico studies of multifunctional carbamimidoyl-tethered indoles against antibiotic-resistant bacteria . Royal Society Open Science 10:4.
Crossref
Ahmed H.E. Hassan, Kazem Mahmoud, Trong-Nhat Phan, Moataz A. Shaldam, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Waleed A. Bayoumi, Selwan M. El-Sayed, Yeonwoo Choi, Suyeon Moon, Joo Hwan No & Yong Sup Lee. (2023) Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies. European Journal of Medicinal Chemistry 250, pages 115211.
Crossref
Ahmed Karam Farag, Byung Sun Ahn, Je Sik Yoo, Reham Karam & Eun Joo Roh. (2022) Design, synthesis, and biological evaluation of pseudo-bicyclic pyrimidine-based compounds as potential EGFR inhibitors. Bioorganic Chemistry 126, pages 105918.
Crossref
Mohamed A. Abdelgawad, Fatma E.A. Mohamed, Phoebe F. Lamie, Syed N.A. Bukhari, Mohammad M. Al-Sanea, Arafa Musa, Mohammed Elmowafy, A.A. Nayl, Ahmed Karam Farag, Sameeha M. Ali, Mohamed E. Shaker, Hany A. Omar, Mohammed K. Abdelhameid & Manal M. Kandeel. (2022) Design, synthesis, and biological evaluation of novel pyrido-dipyrimidines as dual topoisomerase II/FLT3 inhibitors in leukemia cells. Bioorganic Chemistry 122, pages 105752.
Crossref
Milan Sencanski, Vladimir Perovic, Jelena Milicevic, Tamara Todorovic, Radivoje Prodanovic, Veljko Veljkovic, Slobodan Paessler & Sanja Glisic. (2022) Identification of SARS‐CoV‐2 Papain‐like Protease (PLpro) Inhibitors Using Combined Computational Approach**. ChemistryOpen 11:2.
Crossref
Jeelan Basha N & Naganna M. Goudgaon. (2021) A comprehensive review on pyrimidine analogs-versatile scaffold with medicinal and biological potential. Journal of Molecular Structure 1246, pages 131168.
Crossref
Richard Kwamla Amewu, Patrick Opare Sakyi, Dorcas Osei-Safo & Ivan Addae-Mensah. (2021) Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets. Molecules 26:23, pages 7134.
Crossref
Beata Donarska, Marta Świtalska, Wojciech Płaziński, Joanna Wietrzyk & Krzysztof Z. Łączkowski. (2021) Effect of the dichloro-substitution on antiproliferative activity of phthalimide-thiazole derivatives. Rational design, synthesis, elastase, caspase 3/7, and EGFR tyrosine kinase activity and molecular modeling study. Bioorganic Chemistry 110, pages 104819.
Crossref
Parinee Kittimongkolsuk, Mariana Roxo, Hanmei Li, Siriporn Chuchawankul, Michael Wink & Tewin Tencomnao. (2021) Extracts of the Tiger Milk Mushroom (Lignosus rhinocerus) Enhance Stress Resistance and Extend Lifespan in Caenorhabditis elegans via the DAF-16/FoxO Signaling Pathway. Pharmaceuticals 14:2, pages 93.
Crossref
Ruoyao ZouHaoya XuFeifei LiShengke WangLiancheng Zhu. (2021) Increased Expression of UBE2T Predicting Poor Survival of Epithelial Ovarian Cancer: Based on Comprehensive Analysis of UBE2s , Clinical Samples, and the GEO Database . DNA and Cell Biology 40:1, pages 36-60.
Crossref
Wenjing Liu, Guangcheng Wang, Zhiyun Peng & Yongjun Li. (2020) Design, Synthesis and Biological Evaluation of Novel 4-(4-Methoxynaphthalen-1-yl)-5-arylpyrimidin-2-amines as Tubulin Polymerization Inhibitors. Chemical and Pharmaceutical Bulletin 68:12, pages 1184-1192.
Crossref
Ahmed Karam Farag, Ahmed H.E. Hassan, Kyung-Sook Chung, Jeong-Hun Lee, Hyo-Sun Gil, Kyung-Tae Lee & Eun Joo Roh. (2020) Diarylurea derivatives comprising 2,4-diarylpyrimidines: Discovery of novel potential anticancer agents via combined failed-ligands repurposing and molecular hybridization approaches. Bioorganic Chemistry 103, pages 104121.
Crossref
Ahmed H.E. Hassan, Kyung-Tae Lee & Yong Sup Lee. (2020) Flavone-based arylamides as potential anticancers: Design, synthesis and in vitro cell-based/cell-free evaluations. European Journal of Medicinal Chemistry 187, pages 111965.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.