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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

Discovery of novel ATAD2 bromodomain inhibitors that trigger apoptosis and autophagy in breast cells by structure-based virtual screening

Dahong Yaoa Guangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen, China;b Shenzhen Key Laboratory of Novel Natural Health Care Products, Innovation Platform for Natural small molecule Drugs, Engineering Laboratory of Shenzhen Natural small molecule Innovative Drugs, Shenzhen University Health Science Center, Shenzhen, ChinaView further author information
,
Jin Zhangc State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu, ChinaView further author information
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Jinhui Wangd Shenzhen Honghui Bio-Pharmaceutical Co. Ltd., Shenzhen, ChinaView further author information
,
Dabo Pane Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P. R. ChinaCorrespondence[email protected]
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&
Zhendan Hea Guangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen, China;b Shenzhen Key Laboratory of Novel Natural Health Care Products, Innovation Platform for Natural small molecule Drugs, Engineering Laboratory of Shenzhen Natural small molecule Innovative Drugs, Shenzhen University Health Science Center, Shenzhen, ChinaCorrespondence[email protected]
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Pages 713-725 | Received 23 Jan 2020, Accepted 03 Mar 2020, Published online: 16 Mar 2020

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Dahong Yao, Jieshu You, Xuetao Yang, Jin Zhang & Xiaojun Yao. (2023) Fragment-based design, synthesis and biological evaluation of theophylline derivatives as ATAD2 inhibitors in BT-549 cells. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Lokesh Ravi, Ajith Kumar K, Shree Kumari G R, Harsha S, Jabin B. Sam Raj, Likitha R, Prawin Chinnaiyan, David Jonnes K C, Megha J K, Dhanush Sudhakara, Musaib Shafi Dar, Yashaswini D M & Sathvik G. (2023) Stearyl palmitate a multi-target inhibitor against breast cancer: in-silico, in-vitro & in-vivo approach. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-18.
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Aditi Nayak, Sugandh Kumar, Shivaram Prasad Singh, Asima Bhattacharyya, Anshuman Dixit & Anasuya Roychowdhury. (2022) Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain. Journal of Biomolecular Structure and Dynamics 40:12, pages 5606-5622.
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Articles from other publishers (12)

Bharath Kumar Gajjela & Ming-Ming Zhou. (2023) Bromodomain inhibitors and therapeutic applications. Current Opinion in Chemical Biology 75, pages 102323.
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Praveen Guruvaiah, Suresh Chava, Chiao-Wang Sun, Nirupama Singh, Courtney A. Penn & Romi Gupta. (2023) ATAD2 is a driver and a therapeutic target in ovarian cancer that functions by upregulating CENPE. Cell Death & Disease 14:7.
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Qun Liu, Heshu Liu, Xuying Huang, Xiaona Fan, Zeru Xiao, Rui Yan, Jiannan Yao, Guanyu An, Yang Ge, Jinwei Miao & Jian Liu. (2022) A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer. Cancer Gene Therapy 30:1, pages 192-208.
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Madhuri Dutta, Debasish Mohapatra, Amlan Priyadarshee Mohapatra, Shantibhusan Senapati & Anasuya Roychowdhury. (2022) ATAD2 suppression enhances the combinatorial effect of gemcitabine and radiation in pancreatic cancer cells. Biochemical and Biophysical Research Communications 635, pages 179-186.
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Can Wang, Yue Yin, Zhenxing Sun, Yiru Wang, Fei Li, Yan Wang, Zexue Zhang & Xiuwei Chen. (2022) ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration. Disease Markers 2022, pages 1-12.
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Haicheng Liu, Qianghai Wen, Sheng Yan, Weikun Zeng, Yuhua Zou, Quanliang Liu, Guoxi Zhang, Junrong Zou & Xiaofeng Zou. (2022) Tumor-Promoting ATAD2 and Its Preclinical Challenges. Biomolecules 12:8, pages 1040.
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Madhuri Dutta, Biswajit Das, Debasish Mohapatra, Padmanava Behera, Shantibhusan Senapati & Anasuya Roychowdhury. (2022) MicroRNA-217 modulates pancreatic cancer progression via targeting ATAD2. Life Sciences 301, pages 120592.
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Nanda Kumar Yellapu, Thuc Ly, Mihaela E. Sardiu, Dong Pei, Danny R. Welch, Jeffery A. Thompson & Devin C. Koestler. (2022) Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer. BMC Cancer 22:1.
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Jon J. Winter-Holt, Catherine Bardelle, Elisabetta Chiarparin, Ian L. Dale, Paul R. J. Davey, Nichola L. Davies, Christopher Denz, Shaun M. Fillery, Carine M. Guérot, Fujin Han, Samantha J. Hughes, Meghana Kulkarni, Zhaoqun Liu, Alexander Milbradt, Thomas A. Moss, Huijun Niu, Joe Patel, Alfred A. Rabow, Marianne Schimpl, Junjie Shi, Dongqing Sun, Dejian Yang & Sylvie Guichard. (2022) Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models. Journal of Medicinal Chemistry 65:4, pages 3306-3331.
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Samuel P. Boyson, Cong Gao, Kathleen Quinn, Joseph Boyd, Hana Paculova, Seth Frietze & Karen C. Glass. (2021) Functional Roles of Bromodomain Proteins in Cancer. Cancers 13:14, pages 3606.
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Aditi Nayak, Madhuri Dutta & Anasuya Roychowdhury. (2021) Emerging oncogene ATAD2: Signaling cascades and therapeutic initiatives. Life Sciences 276, pages 119322.
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Wenhui Hu, Lincheng Zhang, Yutong Dong, Zhansong Tian, Yueqi Chen & Shiwu Dong. (2020) Tumour dormancy in inflammatory microenvironment: A promising therapeutic strategy for cancer-related bone metastasis. Cellular and Molecular Life Sciences 77:24, pages 5149-5169.
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