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Research Paper

The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors

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Pages 1011-1020 | Received 06 Mar 2020, Accepted 01 Apr 2020, Published online: 16 Apr 2020

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Read on this site (8)

Anastasija Balašova, Aleksandrs Pustenko, Alessio Nocentini, Daniela Vullo, Claudiu T. Supuran & Raivis Žalubovskis. (2023) Aryl derivatives of 3H-1,2-benzoxaphosphepine 2-oxides as inhibitors of cancer-related carbonic anhydrase isoforms IX and XII. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Shaik Mahammad Ghouse, Kavyaraj Bahatam, Andrea Angeli, Gaurav Pawar, Krishna Kartheek Chinchilli, Venkata Madhavi Yaddanapudi, Arifuddin Mohammed, Claudiu T. Supuran & Srinivas Nanduri. (2023) Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XII. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Jekaterīna Ivanova, Morteza Abdoli, Alessio Nocentini, Raivis Žalubovskis & Claudiu T. Supuran. (2023) Derivatives of 4-methyl-1,2,3-benzoxathiazine 2,2-dioxide as selective inhibitors of human carbonic anhydrases IX and XII over the cytosolic isoforms I and II. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Aleksandrs Pustenko, Anastasija Balašova, Alessio Nocentini, Claudiu T. Supuran & Raivis Žalubovskis. (2023) 3H-1,2-Benzoxaphosphepine 2-oxides as selective inhibitors of carbonic anhydrase IX and XII. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 216-224.
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Jekaterina Ivanova, Morteza Abdoli, Alessio Nocentini, Raivis Žalubovskis & Claudiu T. Supuran. (2023) 1,2,3-Benzoxathiazine-2,2-dioxides – effective inhibitors of human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 225-238.
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Satyajit Khatua & Srabani Taraphder. (2023) In the footsteps of an inhibitor unbinding from the active site of human carbonic anhydrase II. Journal of Biomolecular Structure and Dynamics 41:8, pages 3187-3204.
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Morteza Abdoli, Simone Giovannuzzi, Claudiu T. Supuran & Raivis Žalubovskis. (2022) 4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1568-1576.
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Alessandro Bonardi, Alessio Nocentini, Sameh Mohamed Osman, Fatmah Ali Alasmary, Tahani Mazyad Almutairi, Dalal Saied Abdullah, Paola Gratteri & Claudiu T. Supuran. (2021) Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with aromatic sulphonamides and clinically licenced drugs – a joint docking/molecular dynamics study. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 469-479.
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Articles from other publishers (18)

Satyajit Khatua & Srabani Taraphder. (2023) Dynamics of an inhibitor at and away from an out-of-active site binding location in human carbonic anhydrase II. Chemical Physics Impact 7, pages 100329.
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Shaik Mahammad Ghouse, Kareena Sinha, Alessandro Bonardi, Gaurav Pawar, Satyaveni Malasala, Srikanth Danaboina, Arifuddin Mohammed, Venkata M. Yaddanapudi, Claudiu T. Supuran & Srinivas Nanduri. (2023) 6‐Aminocoumarin oxime‐ether/sulfonamides as selective hCA IX and XII inhibitors: Synthesis, evaluation, and molecular dynamics studies. Archiv der Pharmazie.
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Alessio Nocentini, Alessandro Bonardi, Carla Bazzicalupi, Vincenzo Alterio, Davide Esposito, Simona Maria Monti, Michael Smietana, Giuseppina De Simone, Claudiu T. Supuran, Paola Gratteri & Jean-Yves Winum. (2023) 6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography . Journal of Medicinal Chemistry 66:12, pages 8118-8129.
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Maria Giulia Davighi, Camilla Matassini, Andrea Goti, Marta Ferraroni, Andrea Angeli, Claudiu T. Supuran & Francesca Cardona. (2023) Mono- and three-tailed sugar and iminosugar decorated benzenesulfonamide carbonic anhydrase inhibitors. Organic & Biomolecular Chemistry 21:21, pages 4491-4503.
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Morteza Abdoli, Alessandro Bonardi, Niccolò Paoletti, Ashok Aspatwar, Seppo Parkkila, Paola Gratteri, Claudiu T. Supuran & Raivis Žalubovskis. (2023) Inhibition Studies on Human and Mycobacterial Carbonic Anhydrases with N-((4-Sulfamoylphenyl)carbamothioyl) Amides. Molecules 28:10, pages 4020.
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Morteza Abdoli, Viviana De Luca, Clemente Capasso, Claudiu T Supuran & Raivis Žalubovskis. (2023) Investigation of carbonic anhydrase inhibitory potency of ( Z/E )-alkyl N ‘-benzyl- N -(arylsulfonyl)-carbamimidothioates . Future Medicinal Chemistry 15:7, pages 615-627.
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Morteza Abdoli, Viviana De Luca, Clemente Capasso, Claudiu T. Supuran & Raivis Žalubovskis. (2023) Inhibition Studies on Carbonic Anhydrase Isoforms I, II, IX, and XII with a Series of Sulfaguanidines. ChemMedChem 18:6.
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Mahmoud A. Ragab, Wagdy M. Eldehna, Alessio Nocentini, Alessandro Bonardi, Hazem E. Okda, Bahaa Elgendy, Tarek S. Ibrahim, Mohammad M. Abd-Alhaseeb, Paola Gratteri, Claudiu T. Supuran, Ahmed A. Al-Karmalawy & Mohamed Elagawany. (2023) 4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments. European Journal of Medicinal Chemistry 250, pages 115180.
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M. İhsan Han, Miyase Gözde Gündüz, Gökçe Alçı, Simone Giovannuzzi, Dönay Yuvalı, Claudiu T. Supuran & Şengül Dilem Doğan. (2023) Sulfonamides linked to sulfonate esters via hydrazone functionality: synthesis, human carbonic anhydrase inhibitory activities, and molecular modeling studies . New Journal of Chemistry 47:9, pages 4267-4276.
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Morteza Abdoli, Viviana De Luca, Clemente Capasso, Claudiu T. Supuran & Raivis Žalubovskis. (2022) Benzenesulfonamides Incorporating Hydantoin Moieties Effectively Inhibit Eukaryoticand Human Carbonic Anhydrases. International Journal of Molecular Sciences 23:22, pages 14115.
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Melisa E. Gantner, Denis N. Prada Gori, Manuel A. Llanos, Alan Talevi, Andrea Angeli, Daniela Vullo, Claudiu T. Supuran & Luciana Gavernet. (2022) Identification of New Carbonic Anhydrase VII Inhibitors by Structure-Based Virtual Screening. Journal of Chemical Information and Modeling 62:19, pages 4760-4770.
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E. V. Kulchavenya, S. Yu. Shevchenko & D. P. Kholtobin. (2022) Recurrent cystitis in women: principles of rational therapy. Meditsinskiy sovet = Medical Council:5, pages 128-134.
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Davide Sbravati, Alessandro Bonardi, Silvia Bua, Andrea Angeli, Marta Ferraroni, Alessio Nocentini, Alessandro Casnati, Paola Gratteri, Francesco Sansone & Claudiu T. Supuran. (2021) Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition. Chemistry – A European Journal 28:6.
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Rajiv Kumar, Amit Kumar, Sita Ram, Andrea Angeli, Alessandro Bonardi, Alessio Nocentini, Paola Gratteri, Claudiu T. Supuran & Pawan K. Sharma. (2021) Novel benzenesulfonamide‐bearing pyrazoles and 1,2,4‐thiadiazoles as selective carbonic anhydrase inhibitors. Archiv der Pharmazie 355:1.
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Assem H. Eldeeb, Mahmoud F. Abo-Ashour, Andrea Angeli, Alessandro Bonardi, Deena S. Lasheen, Eman Z. Elrazaz, Alessio Nocentini, Paola Gratteri, Hatem A. Abdel-Aziz & Claudiu T. Supuran. (2021) Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies. European Journal of Medicinal Chemistry 221, pages 113486.
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Mostafa M. Elbadawi, Wagdy M. Eldehna, Alessio Nocentini, Mahmoud F. Abo-Ashour, Eslam B. Elkaeed, Mohamed A. Abdelgawad, Khalid S. Alharbi, Hatem A. Abdel-Aziz, Claudiu T. Supuran, Paola Gratteri & Mohammad M. Al-Sanea. (2021) Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities. European Journal of Medicinal Chemistry 218, pages 113360.
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Mehtap Tugrak, Halise Inci Gul, Yeliz Demir, Serkan Levent & Ilhami Gulcin. (2020) Synthesis and in vitro carbonic anhydrases and acetylcholinesterase inhibitory activities of novel imidazolinone‐based benzenesulfonamides. Archiv der Pharmazie 354:4.
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Alessandro Bonardi, Alessio Nocentini, Silvia Bua, Jacob Combs, Carrie Lomelino, Jacob Andring, Laura Lucarini, Silvia Sgambellone, Emanuela Masini, Robert McKenna, Paola Gratteri & Claudiu T. Supuran. (2020) Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action. Journal of Medicinal Chemistry 63:13, pages 7422-7444.
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