7,165
Views
104
CrossRef citations to date
0
Altmetric
Research Paper

Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro

, , , & ORCID Icon
Pages 1539-1544 | Received 17 May 2020, Accepted 18 Jul 2020, Published online: 04 Aug 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Jang Hoon Kim, Yea-In Park, Mok Hur, Woo Tae Park, Youn-Ho Moon, Yun-Chan Huh, Tae IL Kim, Min Hye Kang, Jong Seong Kang, Chong Woon Cho & Junsoo Park. (2023) Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
Read now
Sreus A. G. Naidu, Yamini B. Tripathi, Priya Shree, Roger A. Clemens & A. Satyanarayan Naidu. (2023) Phytonutrient Inhibitors of SARS-CoV-2/NSP5-Encoded Main Protease (Mpro) Autocleavage Enzyme Critical for COVID-19 Pathogenesis. Journal of Dietary Supplements 20:2, pages 284-311.
Read now
Abdullah Khalid Omer, Sonia Khorshidi, Negar Mortazavi & Heshu Sulaiman Rahman. (2022) A Review on the Antiviral Activity of Functional Foods Against COVID-19 and Viral Respiratory Tract Infections. International Journal of General Medicine 15, pages 4817-4835.
Read now
Jiajie Zhu, Haiyan Zhang, Qinghong Lin, Jingting Lyu, Lu Lu, Hanxi Chen, Xuning Zhang, Yanjun Zhang & Keda Chen. (2022) Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory Compounds. Drug Design, Development and Therapy 16, pages 1067-1082.
Read now
Xinyi Yang, Sihao Zheng, Xiaotong Wang, Jing Wang, Syed Basit Ali shah, Yu Wang, Ranran Gao & Zhichao Xu. (2022) Advances in pharmacology, biosynthesis, and metabolic engineering of Scutellaria-specialized metabolites. Critical Reviews in Biotechnology 0:0, pages 1-17.
Read now
Vaishali Chandel, Garima Tripathi, Seema A. Nayar, Brijesh Rathi, Abhijeet Kumar & Dhruv Kumar. (2022) In silico identification and validation of triarylchromones as potential inhibitor against main protease of severe acute respiratory syndrome coronavirus 2. Journal of Biomolecular Structure and Dynamics 40:19, pages 8850-8865.
Read now

Articles from other publishers (97)

Zahra Alipour, Somayeh Zarezadeh & Ali Akbar Ghotbi-Ravandi. (2023) The Potential of Anti-coronavirus Plant Secondary Metabolites in COVID-19 Drug Discovery as an Alternative to Repurposed Drugs: A Review. Planta Medica.
Crossref
Xin Li & Yongcheng Song. (2023) Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review. European Journal of Medicinal Chemistry 260, pages 115772.
Crossref
Gyaltsen Dakpa, K. J. Senthil Kumar, Jochem Nelen, Horacio Pérez-Sánchez & Sheng-Yang Wang. (2023) Antcin-B, a phytosterol-like compound from Taiwanofungus camphoratus inhibits SARS-CoV-2 3-chymotrypsin-like protease (3CLPro) activity in silico and in vitro. Scientific Reports 13:1.
Crossref
Biswanath Dinda, Manikarna Dinda, Subhajit Dinda & Utpal Chandra De. (2023) An overview of anti-SARS-CoV-2 and anti-inflammatory potential of baicalein and its metabolite baicalin: Insights into molecular mechanisms. European Journal of Medicinal Chemistry 258, pages 115629.
Crossref
Jee Hyun Yi, Eunbi Cho, Soowon Lee, Kyoung Ja Kwon, Seungheon Lee, Juyong Lee, Changyeol Lee, Chan Young Shin, Dong Hyun Kim & Sang Hee Shim. (2023) Aβ dissociation by pectolinarin may counteract against Aβ-induced synaptic dysfunction and memory impairment. Biochemical Pharmacology 216, pages 115792.
Crossref
Robert Konkel, Aleksandra Milewska, Nguyen Dan Thuc Do, Emilia Barreto Duran, Artur Szczepanski, Jacek Plewka, Ewa Wieczerzak, Sofia Iliakopoulou, Triantafyllos Kaloudis, Dirk Jochmans, Johan Neyts, Krzysztof Pyrc & Hanna Mazur-Marzec. (2023) Anti-SARS-CoV-2 activity of cyanopeptolins produced by Nostoc edaphicum CCNP1411. Antiviral Research, pages 105731.
Crossref
Samar Sami Alkafaas, Abanoub Mosaad Abdallah, Aya Misbah Hussien, Heba Bedair, Mahmoud Abdo, Soumya Ghosh, Sara Samy Elkafas, Wilgince Apollon, Morteza Saki, Samah A. Loutfy, Helen Onyeaka & Mohamed Hessien. (2023) A study on the effect of natural products against the transmission of B.1.1.529 Omicron. Virology Journal 20:1.
Crossref
Mohammed Abdalla Hussein, Rita M. Borik, Mohamed S. Nafie, Heba M. Abo-Salem, Sylvia A. Boshra & Zahraa N. Mohamed. (2023) Structure Activity Relationship and Molecular Docking of Some Quinazolines Bearing Sulfamerazine Moiety as New 3CLpro, cPLA2, sPLA2 Inhibitors. Molecules 28:16, pages 6052.
Crossref
Zhonglei Wang & Liyan Yang. (2023) The Therapeutic Potential of Natural Dietary Flavonoids against SARS-CoV-2 Infection. Nutrients 15:15, pages 3443.
Crossref
Shremayi Chatterjee, Nibedita Pyne & Santanu Paul. (2023) In silico screening of flavonoids unearthed Apigenin and Epigallocatechin Gallate, possessing antiviral potentiality against Delta and Omicron variants of SARS-CoV-2. The Nucleus.
Crossref
Larissa Toigo, Emilly Isabelli dos Santos Teodoro, Ana Carolina Guidi, Naiara Cássia Gancedo, Marcus Vinícius Petruco, Eduardo Borges Melo, Fernanda Stumpf Tonin, Fernando Fernandez-Llimos, Danielly Chierrito, João Carlos Palazzo de Mello, Daniela Cristina de Medeiros Araújo & Andréia Cristina Conegero Sanches. (2023) Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies. DARU Journal of Pharmaceutical Sciences 31:1, pages 51-68.
Crossref
Jhansi Nathan, Rabiathul Shameera & Arunkumar Ramachandran. (2023) Impact of nutraceuticals on immunomodulation against viral infections—A review during COVID‐19 pandemic in Indian scenario. Journal of Biochemical and Molecular Toxicology 37:5.
Crossref
Kanpong Boonthaworn, Kowit Hengphasatporn, Yasuteru Shigeta, Warinthorn Chavasiri, Thanyada Rungrotmongkol & Puey Ounjai. (2023) In silico screening of chalcones and flavonoids as potential inhibitors against yellow head virus 3C-like protease. PeerJ 11, pages e15086.
Crossref
Duoning Wang & Yi Li. (2023) Pharmacological effects of baicalin in lung diseases. Frontiers in Pharmacology 14.
Crossref
Vitor Martins de Freitas Amorim, Robson Francisco de Souza, Cristiane Rodrigues Guzzo & Anacleto Silva de Souza. (2023) Molecular Dynamics Simulations Suggest SARS-CoV-2 3CLpro Mutations in Beta and Omicron Variants Do Not Alter Binding Affinities for Cleavage Sites of Non-Structural Proteins. COVID 3:4, pages 622-636.
Crossref
Mohamed R. Elamin, Tarek A. Yousef & Amin O. Elzupir. (2023) Insight into Tyrosine-Containing Pharmaceuticals as Potential Inhibitors of SARS-CoV-2 3CLpro and NSP16: Structural Analysis, Docking Studies, Molecular Dynamics Simulations, and Density Functional Theory Investigations. Chemistry 5:2, pages 762-777.
Crossref
Deborah Giordano, Angelo Facchiano & Virginia Carbone. (2023) Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview. Molecules 28:6, pages 2470.
Crossref
Marcelina Chmiel & Monika Stompor-Gorący. (2023) Promising Role of the Scutellaria baicalensis Root Hydroxyflavone–Baicalein in the Prevention and Treatment of Human Diseases. International Journal of Molecular Sciences 24:5, pages 4732.
Crossref
Mattia Mori, Deborah Quaglio, Andrea Calcaterra, Francesca Ghirga, Leonardo Sorrentino, Silvia Cammarone, Matteo Fracella, Alessandra D’Auria, Federica Frasca, Elena Criscuolo, Nicola Clementi, Nicasio Mancini, Bruno Botta, Guido Antonelli, Alessandra Pierangeli & Carolina Scagnolari. (2023) Natural Flavonoid Derivatives Have Pan-Coronavirus Antiviral Activity. Microorganisms 11:2, pages 314.
Crossref
Divya Sharma, Mit Joshi, Subbu Apparsundaram, Ramesh K. Goyal, Bhoomika Patel & Mahaveer Dhobi. (2023) Solanum nigrum L. in COVID-19 and post-COVID complications: a propitious candidate. Molecular and Cellular Biochemistry.
Crossref
Ting Hu, Li Li & Qin Ma. (2023) Research Progress of Immunomodulation on Anti-COVID-19 and the Effective Components from Traditional Chinese Medicine. The American Journal of Chinese Medicine 51:06, pages 1337-1360.
Crossref
Caio Felipe de Araujo Ribas Cheohen, Maria Eduarda Alves Esteves, Thamirys Silva da Fonseca, Carla Monteiro Leal, Fernanda de Lemos Fernandes Assis, Mariana Freire Campos, Raianne Soares Rebelo, Diego Allonso, Gilda Guimarães Leitão, Manuela Leal da Silva & Suzana Guimarães Leitão. (2023) In silico screening of phenylethanoid glycosides, a class of pharmacologically active compounds as natural inhibitors of SARS-CoV-2 proteases. Computational and Structural Biotechnology Journal 21, pages 1461-1472.
Crossref
Kunal Bhattacharya, Ripunjoy Bordoloi, Nongmaithem Randhoni Chanu, Ramen Kalita, Bhargab Jyoti Sahariah & Atanu Bhattacharjee. (2022) In silico discovery of 3 novel quercetin derivatives against papain-like protease, spike protein, and 3C-like protease of SARS-CoV-2. Journal of Genetic Engineering and Biotechnology 20:1.
Crossref
Jang Hoon Kim, Yea-In Park, Mok Hur, Woo Tae Park, Youn-Ho Moon, Sung Cheol Koo, Her Yun-Chan, Ik Soo Lee & Junsoo Park. (2022) The inhibitory activity of methoxyl flavonoids derived from Inula britannica flowers on SARS-CoV-2 3CLpro. International Journal of Biological Macromolecules 222, pages 2098-2104.
Crossref
Mehdi Valipour. (2022) Recruitment of chalcone's potential in drug discovery of a nti‐SARS‐CoV ‐2 agents . Phytotherapy Research 36:12, pages 4477-4490.
Crossref
Srividhya Venkataraman. (2022) Plant Molecular Pharming and Plant-Derived Compounds towards Generation of Vaccines and Therapeutics against Coronaviruses. Vaccines 10:11, pages 1805.
Crossref
Jehoshaphat Oppong Mensah, Gilbert Boadu Ampomah, Edward Ntim Gasu, Abigail Kusiwaa Adomako, Elliott Sarpong Menkah & Lawrence Sheringham Borquaye. (2022) Allosteric Modulation of the Main Protease (MPro) of SARS-CoV-2 by Casticin—Insights from Molecular Dynamics Simulations. Chemistry Africa 5:5, pages 1305-1320.
Crossref
Jurica Novak & Vladimir A. Potemkin. (2022) A new glimpse on the active site of SARS-CoV-2 3CLpro, coupled with drug repurposing study. Molecular Diversity 26:5, pages 2631-2645.
Crossref
Varruchi Sharma, Nirmala Sehrawat, Ajay Sharma, Mukesh Yadav, Pawan Verma & Anil K. Sharma. (2021) Multifaceted antiviral therapeutic potential of dietary flavonoids: Emerging trends and future perspectives. Biotechnology and Applied Biochemistry 69:5, pages 2028-2045.
Crossref
Piyush Kashyap, Mamta Thakur, Nidhi Singh, Deep Shikha, Shiv Kumar, Poonam Baniwal, Yogender Singh Yadav, Minaxi Sharma, Kandi Sridhar & Baskaran Stephen Inbaraj. (2022) In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease. Molecules 27:19, pages 6374.
Crossref
Sarah Mousavi, Shima Zare, Mahmoud Mirzaei & Awat Feizi. (2022) Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies. Canadian Journal of Infectious Diseases and Medical Microbiology 2022, pages 1-70.
Crossref
Juliana Helena Castro e Silva, Jéssica Teles Souza, Clarissa Schitine, Aníbal de Freitas Santos Júnior, Eduardo Muniz Santana Bastos & Silvia Lima Costa. (2022) Pharmacological Potential of Flavonoids against Neurotropic Viruses. Pharmaceuticals 15:9, pages 1149.
Crossref
Moua Yang. (2022) Redox stress in COVID-19: Implications for hematologic disorders. Best Practice & Research Clinical Haematology 35:3, pages 101373.
Crossref
Gabriela León-Gutiérrez, James Edward Elste, Carlos Cabello-Gutiérrez, Cesar Millán-Pacheco, Mario H. Martínez-Gómez, Rafael Mejía-Alvarez, Vaibhav Tiwari & Armando Mejía. (2022) A potent virucidal activity of functionalized TiO2 nanoparticles adsorbed with flavonoids against SARS-CoV-2. Applied Microbiology and Biotechnology 106:18, pages 5987-6002.
Crossref
Douglas B. Kell & Etheresia Pretorius. (2022) The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications. Biochemical Journal 479:16, pages 1653-1708.
Crossref
Yerlan M. Suleimen, Rani A. Jose, Gulnur K. Mamytbekova, Raigul N. Suleimen, Margarita Y. Ishmuratova, Wim Dehaen, Bshra A. Alsfouk, Eslam B. Elkaeed, Ibrahim H. Eissa & Ahmed M. Metwaly. (2022) Isolation and In Silico Inhibitory Potential against SARS-CoV-2 RNA Polymerase of the Rare Kaempferol 3-O-(6″-O-acetyl)-Glucoside from Calligonum tetrapterum. Plants 11:15, pages 2072.
Crossref
S. V. Pechinskii, A. G. Kuregyan & E. T. Oganesyan. (2022) Chemoenzyme Synthesis of Flavonoid Esters. Russian Journal of General Chemistry 92:8, pages 1401-1407.
Crossref
B. Uma Reddy, Nanda Kishore Routhu & Anuj Kumar. (2022) Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2. Microbial Pathogenesis 168, pages 105512.
Crossref
Chao-Hui Feng, Chiko Otani & Yuichi Ogawa. (2022) Innovatively identifying naringin and hesperidin by using terahertz spectroscopy and evaluating flavonoids extracts from waste orange peels by coupling with multivariate analysis. Food Control 137, pages 108897.
Crossref
Seri Jo, Luca Signorile, Suwon Kim, Mi-Sun Kim, Oscar Huertas, Raúl Insa, Núria Reig & Dong Hae Shin. (2022) A Study of Drug Repurposing to Identify SARS-CoV-2 Main Protease (3CLpro) Inhibitors. International Journal of Molecular Sciences 23:12, pages 6468.
Crossref
Jingwen Feng, Dongyang Li, Jin Zhang, Xiushan Yin & Jian Li. (2022) Crystal structure of SARS-CoV 3C-like protease with baicalein. Biochemical and Biophysical Research Communications 611, pages 190-194.
Crossref
Seri Jo, Hwa Young Kim, Dong Hae Shin & Mi-Sun Kim. (2022) Dimerization Tendency of 3CLpros of Human Coronaviruses Based on the X-ray Crystal Structure of the Catalytic Domain of SARS-CoV-2 3CLpro. International Journal of Molecular Sciences 23:9, pages 5268.
Crossref
Federico Iacovelli, Gaetana Costanza, Alice Romeo, Terenzio Cosio, Caterina Lanna, Antonino Bagnulo, Umberto Di Maio, Alice Sbardella, Roberta Gaziano, Sandro Grelli, Ettore Squillaci, Alessandro Miani, Prisco Piscitelli, Luca Bianchi, Mattia Falconi & Elena Campione. (2022) Interaction of Pelargonium sidoides Compounds with Lactoferrin and SARS-CoV-2: Insights from Molecular Simulations. International Journal of Environmental Research and Public Health 19:9, pages 5254.
Crossref
Yi Wang, Sui Fang, Yan Wu, Xi Cheng, Lei-ke Zhang, Xu-rui Shen, Shuang-qu Li, Jian-rong Xu, Wei-juan Shang, Zhao-bing Gao & Bing-qing Xia. (2021) Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates. Acta Pharmacologica Sinica 43:4, pages 781-787.
Crossref
Alaa Ibrahim, Maha Nasr & Ibrahim M. El-Sherbiny. (2022) Baicalin as an emerging magical nutraceutical molecule: Emphasis on pharmacological properties and advances in pharmaceutical delivery. Journal of Drug Delivery Science and Technology 70, pages 103269.
Crossref
Scott Legare, Fabian Heide, Ben A. Bailey-Elkin & Jörg Stetefeld. (2022) Improved SARS-CoV-2 main protease high-throughput screening assay using a 5-carboxyfluorescein substrate. Journal of Biological Chemistry 298:4, pages 101739.
Crossref
Bin Wang, Yan Ding, Penghui Zhao, Wei Li, Ming Li, Jingbo Zhu & Shuhong Ye. (2022) Systems pharmacology-based drug discovery and active mechanism of natural products for coronavirus pneumonia (COVID-19): An example using flavonoids. Computers in Biology and Medicine 143, pages 105241.
Crossref
Lennie KY Cheung & Rickey Y Yada. (2022) Predicting global diet-disease relationships at the atomic level: a COVID-19 case study. Current Opinion in Food Science 44, pages 100804.
Crossref
Li-chuan Zhang, Hui-lin Zhao, Jin Liu, Lei He, Ri-lei Yu & Cong-min Kang. (2022) Design of SARS-CoV-2 Mpro, PLpro dual-target inhibitors based on deep reinforcement learning and virtual screening. Future Medicinal Chemistry 14:6, pages 393-405.
Crossref
Junsoo Park, Rackhyun Park, Minsu Jang, Yea-In Park & Yeonjeong Park. (2022) Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants. Journal of Microbiology 60:3, pages 347-354.
Crossref
Mahmoud A. A. Ibrahim, Alaa H. M. Abdelrahman, Laila A. Jaragh-Alhadad, Mohamed A. M. Atia, Othman R. Alzahrani, Muhammad Naeem Ahmed, Moustafa Sherief Moustafa, Mahmoud E. S. Soliman, Ahmed M. Shawky, Paul W. Paré, Mohamed-Elamir F. Hegazy & Peter A. Sidhom. (2022) Exploring Toxins for Hunting SARS-CoV-2 Main Protease Inhibitors: Molecular Docking, Molecular Dynamics, Pharmacokinetic Properties, and Reactome Study. Pharmaceuticals 15:2, pages 153.
Crossref
Muhammad Umar Ijaz, Shama Mustafa, Riffat Batool, Huma Naz, Hussain Ahmed & Haseeb Anwar. (2022) Ameliorative effect of herbacetin against cyclophosphamide-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction. Human & Experimental Toxicology 41, pages 096032712211321.
Crossref
Chiara Vidoni, Andréa Fuzimoto, Alessandra Ferraresi & Ciro Isidoro. (2022) Targeting autophagy with natural products to prevent SARS-CoV-2 infection. Journal of Traditional and Complementary Medicine 12:1, pages 55-68.
Crossref
Atsushi Hijikata, Clara Shionyu‐Mitsuyama, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Takatsugu Hirokawa, Shogo Nakajima, Koichi Watashi & Tsuyoshi Shirai. (2021) Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐2. FEBS Open Bio 12:1, pages 285-294.
Crossref
Jiří Patočka, Zdeňka Navrátilová, Kamil Kuča, Patrik Olekšák & Uday Kumar Killi. (2021) CAN BAICALEIN BECOME A NEW DRUG FOR COVID-19?. Military Medical Science Letters 90:4, pages 198-207.
Crossref
Rajeev K. Singla, Xuefei He, Hitesh Chopra, Christos Tsagkaris, Li Shen, Mohammad Amjad Kamal & Bairong Shen. (2021) Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources. Frontiers in Pharmacology 12.
Crossref
Charles Arvind Sethuraman Vairavan, Devarani Rameshnathan, Nagaraja Suryadevara & Gnanendra Shanmugam. (2021) Global Pandemic as a Result of Severe Acute Respiratory Syndrome Coronavirus 2 Outbreak: A Biomedical Perspective. Journal of Pure and Applied Microbiology 15:4, pages 1759-1780.
Crossref
Pawan K. Agrawal, Chandan Agrawal & Gerald Blunden. (2021) Naringenin as a Possible Candidate Against SARS-CoV-2 Infection and in the Pathogenesis of COVID-19. Natural Product Communications 16:12, pages 1934578X2110667.
Crossref
Yan Ling Ng, Cyrill Kafi Salim & Justin Jang Hann Chu. (2021) Drug repurposing for COVID-19: Approaches, challenges and promising candidates. Pharmacology & Therapeutics 228, pages 107930.
Crossref
Yoji Kato, Akari Higashiyama, Emi Takaoka, Miyu Nishikawa & Shinichi Ikushiro. (2021) Food phytochemicals, epigallocatechin gallate and myricetin, covalently bind to the active site of the coronavirus main protease in vitro. Advances in Redox Research 3, pages 100021.
Crossref
Qi Liao, Ziyu Chen, Yanlin Tao, Beibei Zhang, Xiaojun Wu, Li Yang, Qingzhong Wang & Zhengtao Wang. (2021) An integrated method for optimized identification of effective natural inhibitors against SARS-CoV-2 3CLpro. Scientific Reports 11:1.
Crossref
Dinesh K. Patel. (2021) Biological Importance, Therapeutic Benefit and Analytical Aspects of Bioactive Flavonoid Pectolinarin in the Nature. Drug Metabolism Letters 14:2, pages 117-125.
Crossref
Nikola Gligorijevic, Mirjana Radomirovic, Olgica Nedic, Marija Stojadinovic, Urmila Khulal, Dragana Stanic-Vucinic & Tanja Cirkovic Velickovic. (2021) Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention. International Journal of Molecular Sciences 22:22, pages 12385.
Crossref
Chingju Lin, Fuu-Jen Tsai, Yuan-Man Hsu, Tsung-Jung Ho, Guo-Kai Wang, Yu-Jen Chiu, Hai-Anh Ha & Jai-Sing Yang. (2021) Study of Baicalin toward COVID-19 Treatment: In silico Target Analysis and in vitro Inhibitory Effects on SARS-CoV-2 Proteases. Biomedicine Hub 6:3, pages 122-137.
Crossref
Priyanka Saha, Subhankar Bose, Amit Kumar Srivastava, Anis Ahmad Chaudhary, Rajiv Lall & Sahdeo Prasad. (2021) Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions. Molecules 26:22, pages 6783.
Crossref
Erica Españo, Jiyeon Kim, Kiho Lee & Jeong-Ki Kim. (2021) Phytochemicals for the treatment of COVID-19. Journal of Microbiology 59:11, pages 959-977.
Crossref
James H. Zothantluanga, Neelutpal Gogoi, Anshul Shakya, Dipak Chetia & H. Lalthanzara. (2021) Computational guided identification of potential leads from Acacia pennata (L.) Willd. as inhibitors for cellular entry and viral replication of SARS-CoV-2. Future Journal of Pharmaceutical Sciences 7:1.
Crossref
Xiaohan Wei, Zhejun Zhao, Rongheng Zhong & Xiaomei Tan. (2021) A comprehensive review of herbacetin: From chemistry to pharmacological activities. Journal of Ethnopharmacology 279, pages 114356.
Crossref
Carla Monteiro Leal, Suzana Guimarães Leitão, Romain Sausset, Simony C. Mendonça, Pedro H. A. Nascimento, Caio Felipe de Araujo R. Cheohen, Maria Eduarda A. Esteves, Manuela Leal da Silva, Tayssa Santos Gondim, Maria Eduarda S. Monteiro, Amanda Resende Tucci, Natália Fintelman-Rodrigues, Marilda M. Siqueira, Milene Dias Miranda, Fernanda N. Costa, Rosineide C. Simas & Gilda Guimarães Leitão. (2021) Flavonoids from Siparuna cristata as Potential Inhibitors of SARS-CoV-2 Replication. Revista Brasileira de Farmacognosia 31:5, pages 658-666.
Crossref
Bruno Rizzuti, Laura Ceballos-Laita, David Ortega-Alarcon, Ana Jimenez-Alesanco, Sonia Vega, Fedora Grande, Filomena Conforti, Olga Abian & Adrian Velazquez-Campoy. (2021) Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural Compounds. Pharmaceuticals 14:9, pages 892.
Crossref
Jiansong Fang, Qihui Wu, Fei Ye, Chuipu Cai, Lvjie Xu, Yong Gu, Qi Wang, Ai-lin Liu, Wenjie Tan & Guan-hua Du. (2021) Network-Based Identification and Experimental Validation of Drug Candidates Toward SARS-CoV-2 via Targeting Virus–Host Interactome. Frontiers in Genetics 12.
Crossref
Bao-Hong Li, Zhong-Yuan Li, Miao-Miao Liu, Jing-Zhen Tian & Qing-Hua Cui. (2021) Progress in Traditional Chinese Medicine Against Respiratory Viruses: A Review. Frontiers in Pharmacology 12.
Crossref
Wei-Chung Chiou, Hsu-Feng Lu, Nung-Yu Hsu, Tein-Yao Chang, Yuan-Fan Chin, Ping-Cheng Liu, Jir-Mehng Lo, Yeh B Wu, Jinn-Moon Yang & Cheng Huang. (2021) Ugonin J Acts as a SARS-CoV-2 3C-like Protease Inhibitor and Exhibits Anti-inflammatory Properties. Frontiers in Pharmacology 12.
Crossref
Naiara Naiana Dejani, Hatem A. Elshabrawy, Carlos da Silva Maia Bezerra Filho & Damião Pergentino de Sousa. (2021) Anticoronavirus and Immunomodulatory Phenolic Compounds: Opportunities and Pharmacotherapeutic Perspectives. Biomolecules 11:8, pages 1254.
Crossref
Kunwei Li, Yiyu Liang, Ao Cheng, Qi Wang, Ying Li, Haocheng Wei, Changzheng Zhou & Xinhuan Wan. (2021) Antiviral Properties of Baicalin: a Concise Review. Revista Brasileira de Farmacognosia 31:4, pages 408-419.
Crossref
Monika Kowalczyk, Aleksandra Golonko, Renata Świsłocka, Monika Kalinowska, Monika Parcheta, Artur Swiergiel & Włodzimierz Lewandowski. (2021) Drug Design Strategies for the Treatment of Viral Disease. Plant Phenolic Compounds and Their Derivatives. Frontiers in Pharmacology 12.
Crossref
Gabriel Jiménez-Avalos, A. Paula Vargas-Ruiz, Nicolás E. Delgado-Pease, Gustavo E. Olivos-Ramirez, Patricia Sheen, Manolo Fernández-Díaz, Miguel Quiliano, Mirko Zimic, Andres Agurto-Arteaga, Ricardo Antiparra, Manuel Ardiles-Reyes, Katherine Calderon, Yudith Cauna-Orocollo, Maria de Grecia Cauti-Mendoza, Naer Chipana-Flores, Ricardo Choque-Guevara, Xiomara Chunga-Girón, Manuel Criollo-Orozco, Lewis De La Cruz, Elmer Delgado-Ccancce, Christian Elugo-Guevara, Manolo Fernández-Sanchez, Luis Guevara-Sarmiento, Kristel Gutiérrez, Oscar Heredia-Almeyda, Edison Huaccachi-Gonzalez, Pedro Huerta-Roque, Eliana Icochea, Gisela Isasi-Rivas, Romina A. Juscamaita-Bartra, Abraham Licla-Inca, Angela Montalvan, Ricardo Montesinos-Millan, Dennis Núñez-Fernández, Adiana Ochoa-Ortiz, Erika Páucar-Montoro, Kathy Pauyac, Jose L. Perez-Martinez, Norma Perez-M, Astrid Poma-Acevedo, Stefany Quiñones-Garcia, Ingrid Ramirez-Ortiz, Daniel Ramos-Sono, Angela A. Rios-Angulo, Dora Rios-Matos, Aldo Rojas-Neyra, Yomara K. Romero, Mario I. Salguedo-Bohorquez, Yacory Sernaque-Aguilar, Luis F. Soto, Luis Tataje-Lavanda, Julio Ticona, Katherine Vallejos-Sánchez, Doris Villanueva-Pérez & Freddy Ygnacio-Aguirre. (2021) Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 MPRO. Scientific Reports 11:1.
Crossref
Mahmoud A. A. Ibrahim, Alaa H. M. Abdelrahman, Mohamed A. M. Atia, Tarik A. Mohamed, Mahmoud F. Moustafa, Abdulrahim R. Hakami, Shaden A. M. Khalifa, Fahad A. Alhumaydhi, Faris Alrumaihi, Syed Hani Abidi, Khaled S. Allemailem, Thomas Efferth, Mahmoud E. Soliman, Paul W. Paré, Hesham R. El-Seedi & Mohamed-Elamir F. Hegazy. (2021) Blue Biotechnology: Computational Screening of Sarcophyton Cembranoid Diterpenes for SARS-CoV-2 Main Protease Inhibition. Marine Drugs 19:7, pages 391.
Crossref
Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon & Andrea Zaliani. (2021) Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen. ACS Pharmacology & Translational Science 4:3, pages 1096-1110.
Crossref
Patrícia I. C. Godinho, Raquel G. Soengas & Vera L. M. Silva. (2021) Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral Agents. Pharmaceuticals 14:6, pages 546.
Crossref
Mahmoud A.A. Ibrahim, Eslam A.R. Mohamed, Alaa H.M. Abdelrahman, Khaled S. Allemailem, Mahmoud F. Moustafa, Ahmed M. Shawky, Ali Mahzari, Abdulrahim Refdan Hakami, Khlood A.A. Abdeljawaad & Mohamed A.M. Atia. (2021) Rutin and flavone analogs as prospective SARS-CoV-2 main protease inhibitors: In silico drug discovery study. Journal of Molecular Graphics and Modelling 105, pages 107904.
Crossref
V. A. Shiryaev & Yu. N. Klimochkin. (2021) Main Chemotypes of SARS-CoV-2 Reproduction Inhibitors. Russian Journal of Organic Chemistry 57:5, pages 730-767.
Crossref
Ruixuan Wang, Preyesh Stephen, Yi Tao, Wenfa Zhang & Sheng-Xiang Lin. (2021) Human endeavor for anti-SARS-CoV-2 pharmacotherapy: A major strategy to fight the pandemic. Biomedicine & Pharmacotherapy 137, pages 111232.
Crossref
Keivan Zandi, Katie Musall, Adrian Oo, Dongdong Cao, Bo Liang, Pouya Hassandarvish, Shuiyun Lan, Ryan L. Slack, Karen A. Kirby, Leda Bassit, Franck Amblard, Baek Kim, Sazaly AbuBakar, Stefan G. Sarafianos & Raymond F. Schinazi. (2021) Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase. Microorganisms 9:5, pages 893.
Crossref
Mahmoud A. A. Ibrahim, Alaa H. M. Abdelrahman, Tarik A. Mohamed, Mohamed A. M. Atia, Montaser A. M. Al-Hammady, Khlood A. A. Abdeljawaad, Eman M. Elkady, Mahmoud F. Moustafa, Faris Alrumaihi, Khaled S. Allemailem, Hesham R. El-Seedi, Paul W. Paré, Thomas Efferth & Mohamed-Elamir F. Hegazy. (2021) In Silico Mining of Terpenes from Red-Sea Invertebrates for SARS-CoV-2 Main Protease (Mpro) Inhibitors. Molecules 26:7, pages 2082.
Crossref
Seri Jo, Suwon Kim, Jahyun Yoo, Mi-Sun Kim & Dong Hae Shin. (2021) A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2. Microorganisms 9:4, pages 756.
Crossref
Pooi Ling Mok, Avin Ee-Hwan Koh, Aisha Farhana, Abdullah Alsrhani, Mohammad Khursheed Alam & Subbiah Suresh Kumar. (2021) Computational drug screening against the SARS-CoV-2 Saudi Arabia isolates through a multiple-sequence alignment approach. Saudi Journal of Biological Sciences 28:4, pages 2502-2509.
Crossref
Manisha Ray, Mukund Namdev Sable, Saurav Sarkar & Vinaykumar Hallur. (2021) Essential interpretations of bioinformatics in COVID-19 pandemic. Meta Gene 27, pages 100844.
Crossref
Isabella Romeo, Francesco Mesiti, Antonio Lupia & Stefano Alcaro. (2021) Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets. Molecules 26:3, pages 632.
Crossref
Anna Lucia Fedullo, Antonio Schiattarella, Maddalena Morlando, Anna Raguzzini, Elisabetta Toti, Pasquale De Franciscis & Ilaria Peluso. (2021) Mediterranean Diet for the Prevention of Gestational Diabetes in the Covid-19 Era: Implications of Il-6 In Diabesity. International Journal of Molecular Sciences 22:3, pages 1213.
Crossref
Taizhen Liang, Jiayin Qiu, Xiaoge Niu, Qinhai Ma, Chenliang Zhou, Pei Chen, Qiao Zhang, Meiyun Chen, Zifeng Yang, Shuwen Liu & Lin Li. (2021) 3-Hydroxyphthalic Anhydride-Modified Chicken Ovalbumin as a Potential Candidate Inhibits SARS-CoV-2 Infection by Disrupting the Interaction of Spike Protein With Host ACE2 Receptor. Frontiers in Pharmacology 11.
Crossref
Atsushi Hijikata, Clara Shionyu, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko KanayaTsuyoshi Shirai. (2021) Current status of structure-based drug repurposing against COVID-19 by targeting SARS-CoV-2 proteins. Biophysics and Physicobiology 18:0, pages 226-240.
Crossref
Tobias Goris, Álvaro Pérez‐Valero, Igor Martínez, Dong Yi, Luis Fernández‐Calleja, David San León, Uwe T. Bornscheuer, Patricia Magadán‐Corpas, Felipe Lombó & Juan Nogales. (2020) Repositioning microbial biotechnology against COVID‐19: the case of microbial production of flavonoids. Microbial Biotechnology 14:1, pages 94-110.
Crossref
Fangfang Yan & Feng Gao. (2021) An overview of potential inhibitors targeting non-structural proteins 3 (PLpro and Mac1) and 5 (3CLpro/Mpro) of SARS-CoV-2. Computational and Structural Biotechnology Journal 19, pages 4868-4883.
Crossref
Max Bueckert, Rishi Gupta, Aditi Gupta, Mohit Garg & Asit Mazumder. (2020) Infectivity of SARS-CoV-2 and Other Coronaviruses on Dry Surfaces: Potential for Indirect Transmission. Materials 13:22, pages 5211.
Crossref
Leticia Matilla-Cuenca, Carmen Gil, Sergio Cuesta, Beatriz Rapún-Araiz, Miglė Žiemytė, Alex Mira, Iñigo Lasa & Jaione Valle. (2020) Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids. Scientific Reports 10:1.
Crossref
Rami A. Al-Horani & Srabani Kar. (2020) Potential Anti-SARS-CoV-2 Therapeutics That Target the Post-Entry Stages of the Viral Life Cycle: A Comprehensive Review. Viruses 12:10, pages 1092.
Crossref