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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson’s disease

Serena Vittorioa Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Viale Palatucci, Messina, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6092-5011View further author information
ORCID Icon,
Ilenia Adornatoa Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Viale Palatucci, Messina, ItalyView further author information
,
Rosaria Gittoa Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Viale Palatucci, Messina, ItalyORCID Iconhttps://orcid.org/0000-0003-0002-2253View further author information
ORCID Icon,
Samuel Peña-Díazb Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Spain;c Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, SpainView further author information
,
Salvador Venturab Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Spain;c Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Spain;d ICREA, Passeig Lluis Companys 23, Barcelona, SpainView further author information
&
Laura De Lucaa Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Viale Palatucci, Messina, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0614-5713View further author information
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Pages 1727-1735 | Received 07 Jul 2020, Accepted 21 Aug 2020, Published online: 14 Sep 2020

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Gabriel F. Martins & N. Galamba. (2023) Protein aggregation-inhibition: a therapeutic route from Parkinson’s disease to sickle cell anemia. Critical Reviews in Biochemistry and Molecular Biology 58:1, pages 50-80.
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Articles from other publishers (16)

Niharika Amireddy, Vandana Dulam, Shweta Kaul, Rajeswari Pakkiri & Shasi V. Kalivendi. (2023) The mitochondrial uncoupling effects of nitazoxanide enhances cellular autophagy and promotes the clearance of α-synuclein: Potential role of AMPK-JNK pathway. Cellular Signalling 109, pages 110769.
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Yassir Boulaamane, Kailash Jangid, Mohammed Reda Britel & Amal Maurady. (2023) Probing the molecular mechanisms of α-synuclein inhibitors unveils promising natural candidates through machine-learning QSAR, pharmacophore modeling, and molecular dynamics simulations. Molecular Diversity.
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Tulika Srivastava, Divya Tyagi, Siraj Fatima, Malur Thirumalesh Vishnu Sathyan, Ritu Raj, Aniket Sharma, Minal Chaturvedi, Meetali Sinha, Sonia Kumari Shishodia, Dinesh Kumar, Sandeep K. Sharma, Jata Shankar, Aruna Satish & Smriti Priya. (2023) A natural small molecule‐mediated inhibition of alpha‐synuclein aggregation leads to neuroprotection in Caenorhabditis elegans . Journal of Neurochemistry.
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Rita Rosado-Ramos, Gonçalo M. Poças, Daniela Marques, Alexandre Foito, David M. Sevillano, Mafalda Lopes-da-Silva, Luís G. Gonçalves, Regina Menezes, Marcel Ottens, Derek Stewart, Alain Ibáñez de Opakua, Markus Zweckstetter, Miguel C. Seabra, César S. Mendes, Tiago Fleming Outeiro, Pedro M. Domingos & Cláudia N. Santos. (2023) Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage. Nature Communications 14:1.
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Jinjian Hu, Yufen Zhao & Yanmei Li. (2023) Rationally designed amyloid inhibitors based on amyloid-related structural studies. Chinese Chemical Letters 34:2, pages 107623.
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Poonkuzhali Kaliyaperumal, Seenivasagan Renganathan, Karthika Arumugam & Bukola Rhoda Aremu. (2023) Engineered graphene quantum dot nanocomposite triggers α-synuclein defibrillation: Therapeutics against Parkinson's disease. Nanomedicine: Nanotechnology, Biology and Medicine 47, pages 102608.
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Virginia Gao, Juan A. Briano, Lauren E. Komer & Jacqueline Burré. (2023) Functional and Pathological Effects of α-Synuclein on Synaptic SNARE Complexes. Journal of Molecular Biology 435:1, pages 167714.
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Bilqis Abiola Lawal, Yusuf Oloruntoyin Ayipo, Abisola Oyindamola Adekunle, Mohammed Otuofu Amali, Umar Muhammad Badeggi, Waleed A. Alananzeh & Mohd Nizam Mordi. (2023) Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies. Journal of Ethnopharmacology 300, pages 115753.
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Laura De Luca, Serena Vittorio, Samuel Peña-Díaz, Giovanna Pitasi, Marc Fornt-Suñé, Federica Bucolo, Salvador Ventura & Rosaria Gitto. (2022) Ligand-Based Discovery of a Small Molecule as Inhibitor of α-Synuclein Amyloid Formation. International Journal of Molecular Sciences 23:23, pages 14844.
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Feiling Xie. (2022) Network Pharmacology and Molecular Docking Analysis on Mechanisms of Isobavachalcone in Parkinson’s Disease. Frontiers in Sustainable Development 2:6, pages 1-9.
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Soha Parsafar, Farhang Aliakbari, Sepideh Sadat Seyedfatemi, Zahra Najarzadeh, Hamdam Hourfar, Hassan Bardania, Mohsen Farhadpour, Mehdi Mohammadi & Dina Morshedi. (2022) Insights into the inhibitory mechanism of skullcapflavone II against α-synuclein aggregation and its mediated cytotoxicity. International Journal of Biological Macromolecules 209, pages 426-440.
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Rosaria Gitto, Serena Vittorio, Federica Bucolo, Samuel Peña-Díaz, Rosalba Siracusa, Salvatore Cuzzocrea, Salvador Ventura, Rosanna Di Paola & Laura De Luca. (2022) Discovery of Neuroprotective Agents Based on a 5-(4-Pyridinyl)-1,2,4-triazole Scaffold. ACS Chemical Neuroscience 13:5, pages 581-586.
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Soham Maity, Kazuma Shimanaka, Laken N. Rivet, Malikah O'Dell, Anisa M. Rashid, Nurhanis B.M. Isa, Rachel S. Kepczynski, Ulf Dettmer, Babak Borhan & Jessica S. Fortin. (2022) In vitro characterization of urea derivatives to inhibit alpha-synuclein early-stage aggregation. Journal of Molecular Structure 1249, pages 131569.
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Pankuri Gupta & Abha Sharma. 2022. N-Heterocycles. N-Heterocycles 355 393 .
Mehdi Sahihi, Fatma Gaci & Isabelle Navizet. (2021) Identification of new alpha-synuclein fibrillogenesis inhibitor using in silico structure-based virtual screening. Journal of Molecular Graphics and Modelling 108, pages 108010.
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K Poonkuzhali, Srini R & Jeevaratnam K. (2022) Design, Synthesis and Chemically Engineered Graphene Quantum Dot Applications: Contrast Agent for Mr Imaging and Targeted Therapeutics on Parkinson's Treatment. SSRN Electronic Journal.
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