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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Brief Report

Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation

Paolo Guglielmia Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-5452-8869View further author information
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Giulia Rotondia Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, ItalyView further author information
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Daniela Seccia Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, ItalyORCID Iconhttps://orcid.org/0000-0001-8115-026XView further author information
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Andrea Angelib Neurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino, Italy;c Centre of Advanced Research in Bionanoconjugates and Biopolymers Department, “Petru Poni” Institute of Macromolecular Chemistry, Iasi, RomaniaORCID Iconhttps://orcid.org/0000-0002-1470-7192View further author information
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Paola Chimentia Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, ItalyView further author information
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Alessio Nocentinib Neurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino, Italy;d Neurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR University of Florence, Sesto FiorentinoItalyORCID Iconhttps://orcid.org/0000-0003-3342-702XView further author information
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Alessandro Bonardib Neurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino, Italy;d Neurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR University of Florence, Sesto FiorentinoItalyView further author information
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Paola Gratterib Neurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino, Italy;d Neurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR University of Florence, Sesto FiorentinoItalyView further author information
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Simone Carradorie Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, Chieti, ItalyCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-8698-9440View further author information
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Claudiu T. Supuranb Neurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino, ItalyCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-4262-0323View further author information
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Pages 1891-1905 | Received 24 Aug 2020, Accepted 18 Sep 2020, Published online: 02 Oct 2020

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Claudiu T. Supuran, Alessio Nocentini, Elena Yakubova, Nikolay Savchuk, Stanislav Kalinin & Mikhail Krasavin. (2021) Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida®) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoforms. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1056-1060.
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Articles from other publishers (11)

Janis Leitans, Andris Kazaks, Janis Bogans, Claudiu T. Supuran, Inara Akopjana, Jekaterina Ivanova, Raivis Zalubovskis & Kaspars Tars. (2023) Structural Basis of Saccharin Derivative Inhibition of Carbonic Anhydrase IX. ChemMedChem 18:22.
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Muhammed Trawally, Kübra Demir-Yazıcı, Serap İpek Dingiş-Birgül, Kerem Kaya, Atilla Akdemir & Özlen Güzel-Akdemir. (2023) Dithiocarbamates and dithiocarbonates containing 6-nitrosaccharin scaffold: Synthesis, antimycobacterial activity and in silico target prediction using ensemble docking-based reverse virtual screening. Journal of Molecular Structure 1277, pages 134818.
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Amit Kumar, Kiran Siwach, Claudiu T. Supuran & Pawan K. Sharma. (2022) A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors. Bioorganic Chemistry 126, pages 105920.
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Krishna K. Chinchilli, Venkata N. Royyala, Pavitra S. Thacker, Andrea Angeli, Srikanth Danaboina, Priti Singh, Srinivas Nanduri, Claudiu T. Supuran & Mohammed Arifuddin. (2022) Design, synthesis, SAR, and biological evaluation of saccharin‐based hybrids as carbonic anhydrase inhibitors. Archiv der Pharmazie 355:8.
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Virginia Pontecorvi, Mattia Mori, Francesca Picarazzi, Susi Zara, Simone Carradori, Amelia Cataldi, Andrea Angeli, Emanuela Berrino, Paola Chimenti, Alessia Ciogli, Daniela Secci, Paolo Guglielmi & Claudiu T. Supuran. (2022) Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies. International Journal of Molecular Sciences 23:14, pages 7950.
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Wuqiang Wen, Hongxuan Cao, Yixiang Xu, Yanliang Ren, Li Rao, Xubo Shao, Han Chen, Lixia Wu, Jiaqi Liu, Chen Su, Chao Peng, Yunyuan Huang & Jian Wan. (2022) N -Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction . Journal of Medicinal Chemistry 65:13, pages 9126-9143.
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Luís M. T. Frija, André L. Fernandes, Bruno Guerreiro & M. Lurdes S. Cristiano. 2022. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles 625 648 .
Sevgi Kansız, Arda Tolan, Mohammad Azam, Necmi Dege, Mahboob Alam, Yusuf Sert, Saud I. Al-Resayes & Hasan İçbudak. (2022) Acesulfame based Co(II) complex: Synthesis, structural investigations, solvatochromism, Hirshfeld surface analysis and molecular docking studies. Polyhedron 218, pages 115762.
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Min Wang, Xia Meng, Changqun Cai, Lingyun Wang & Hang Gong. (2022) Synthesis of benzisothiazoles by a three-component reaction using elemental sulfur and ammonium as heteroatom components under transition metal-free conditions. Green Synthesis and Catalysis 3:2, pages 168-174.
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Marialucia Gallorini, Anna C. Berardi, Alessia Ricci, Cristina Antonetti Lamorgese Passeri, Susi Zara, Francesco Oliva, Amelia Cataldi, Fabrizio Carta & Simone Carradori. (2021) Dual Acting Carbon Monoxide Releasing Molecules and Carbonic Anhydrase Inhibitors Differentially Modulate Inflammation in Human Tenocytes. Biomedicines 9:2, pages 141.
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Andrea Angeli, Fabrizio Carta, Alessio Nocentini, Jean-Yves Winum, Raivis Zalubovskis, Atilla Akdemir, Valentina Onnis, Wagdy M. Eldehna, Clemente Capasso, Giuseppina De Simone, Simona Maria Monti, Simone Carradori, William A. Donald, Shoukat Dedhar & Claudiu T. Supuran. (2020) Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment. Metabolites 10:10, pages 412.
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