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Review Article

Multitargeting approaches involving carbonic anhydrase inhibitors: hybrid drugs against a variety of disorders

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Pages 1702-1714 | Received 25 May 2021, Accepted 14 Jun 2021, Published online: 30 Jul 2021

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Andrea Angeli, Marta Ferraroni, Alessandro Bonardi, Claudiu T. Supuran & Alessio Nocentini. (2023) Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Ashok Aspatwar, Alessandro Bonardi, Heidi Aisala, Ksenia Zueva, Craig R Primmer, Jaakko Lumme, Seppo Parkkila & Claudiu T. Supuran. (2023) Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Andrea Angeli & Claudiu T. Supuran. (2023) Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Morteza Abdoli, Alessandro Bonardi, Claudiu T. Supuran & Raivis Žalubovskis. (2023) Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Claudiu T Supuran. (2023) Targeting carbonic anhydrases for the management of hypoxic metastatic tumors. Expert Opinion on Therapeutic Patents 0:0, pages 1-20.
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Haytham O. Tawfik, Amany Belal, Mohammed A. S. Abourehab, Andrea Angeli, Alessandro Bonardi, Claudiu T. Supuran & Mervat H. El-Hamamsy. (2022) Dependence on linkers’ flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2765-2785.
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Mateusz Kciuk, Adrianna Gielecińska, Somdutt Mujwar, Mariusz Mojzych, Beata Marciniak, Rafał Drozda & Renata Kontek. (2022) Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1278-1298.
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Mehmet Onyılmaz, Murat Koca, Alessandro Bonardi, Mustafa Degirmenci & Claudiu T. Supuran. (2022) Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 743-748.
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Simone Giovannuzzi, Viviana De Luca, Alessio Nocentini, Clemente Capasso & Claudiu T. Supuran. (2022) Coumarins inhibit η-class carbonic anhydrase from Plasmodium falciparum. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 680-685.
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Wagdy M. Eldehna, Mohammed S. Taghour, Tarfah Al-Warhi, Alessio Nocentini, Mostafa M. Elbadawi, Hazem A. Mahdy, Mohamed A. Abdelrahman, Ohoud J. Alotaibi, Nada Aljaeed, Diaaeldin M. Elimam, Kamyar Afarinkia, Hatem A. Abdel-Aziz & Claudiu T. Supuran. (2022) Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 531-541.
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Simone Giovannuzzi, Chad S. Hewitt, Alessio Nocentini, Clemente Capasso, Daniel P. Flaherty & Claudiu T. Supuran. (2022) Coumarins effectively inhibit bacterial α-carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 333-338.
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Alma Fuentes-Aguilar, Penélope Merino-Montiel, Sara Montiel-Smith, Socorro Meza-Reyes, José Luis Vega-Báez, Adrián Puerta, Miguel X. Fernandes, José M. Padrón, Andrea Petreni, Alessio Nocentini, Claudiu T. Supuran, Óscar López & José G. Fernández-Bolaños. (2022) 2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 168-177.
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Alane Beatriz Vermelho, Giseli Capaci Rodrigues, Alessio Nocentini, Felipe R. P. Mansoldo & Claudiu T. Supuran. (2022) Discovery of novel drugs for Chagas disease: is carbonic anhydrase a target for antiprotozoal drugs?. Expert Opinion on Drug Discovery 17:10, pages 1147-1158.
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Claudiu T. Supuran. (2021) Carbonic anhydrase inhibitors: an update on experimental agents for the treatment and imaging of hypoxic tumors. Expert Opinion on Investigational Drugs 30:12, pages 1197-1208.
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Toni C. Denner, Niels Heise, Julian Zacharias, Oliver Kraft, Sophie Hoenke & René Csuk. (2023) Small Structural Differences Govern the Carbonic Anhydrase II Inhibition Activity of Cytotoxic Triterpene Acetazolamide Conjugates. Molecules 28:3, pages 1009.
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Laura De Luca, Andrea Angeli, Federico Ricci, Claudiu T. Supuran & Rosaria Gitto. (2022) Structure‐guided identification of a selective sulfonamide‐based inhibitor targeting the human carbonic anhydrase VA isoform. Archiv der Pharmazie 356:1.
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Francesca Mancuso, Andrea Angeli, Viviana De Luca, Federica Bucolo, Laura De Luca, Clemente Capasso, Claudiu T. Supuran & Rosaria Gitto. (2022) Synthesis and biological evaluation of sulfonamide‐based compounds as inhibitors of carbonic anhydrase from Vibrio cholerae . Archiv der Pharmazie 355:10, pages 2200070.
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Virginia Pontecorvi, Mattia Mori, Francesca Picarazzi, Susi Zara, Simone Carradori, Amelia Cataldi, Andrea Angeli, Emanuela Berrino, Paola Chimenti, Alessia Ciogli, Daniela Secci, Paolo Guglielmi & Claudiu T. Supuran. (2022) Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies. International Journal of Molecular Sciences 23:14, pages 7950.
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Giulia Arrighi, Adrián Puerta, Andrea Petrini, Francisco J. Hicke, Alessio Nocentini, Miguel X. Fernandes, José M. Padrón, Claudiu T. Supuran, José G. Fernández-Bolaños & Óscar López. (2022) Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations. International Journal of Molecular Sciences 23:14, pages 7685.
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Javier Quero, José Carlos Royo, Beatrice Fodor, María Concepción Gimeno, Jesús Osada, María Jesús Rodríguez-Yoldi & Elena Cerrada. (2022) Sulfonamide-Derived Dithiocarbamate Gold(I) Complexes Induce the Apoptosis of Colon Cancer Cells by the Activation of Caspase 3 and Redox Imbalance. Biomedicines 10:6, pages 1437.
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Erden Banoglu, Taner Ercanlı, Tuğçe Gür Maz, Daniela Vullo, Alessandro Bonardi, Paola Gratteri & Claudiu T. Supuran. (2022) A Series of Thiadiazolyl‐Benzenesulfonamides Incorporating an Aromatic Tail as Isoform‐Selective, Potent Carbonic Anhydrase II/XII Inhibitors. ChemMedChem 17:10.
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Chiraz Ismail, Alessio Nocentini, Claudiu T. Supuran, Jean‐Yves Winum & Rafik Gharbi. (2021) 1,5‐Benzodiazepines as a platform for the design of carbonic anhydrase inhibitors. Archiv der Pharmazie 355:3, pages 2100405.
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