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The Journal of Maternal-Fetal & Neonatal Medicine Volume 32, 2019 - Issue 12
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Original Article

In vivo evidence of inflammasome activation during spontaneous labor at term

Bogdan PanaitescuPerinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, USA; ;Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; Correspondence[email protected]
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Roberto RomeroPerinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, USA; ;Department of Obstetrics & Gynecology, University of Michigan, Ann Arbor, MI, USA; ;Department of Epidemiology & Biostatistics, Michigan State University, East Lansing, MI, USA; ;Center for Molecular Medicine & Genetics, Wayne State University, Detroit, MI, USA; Correspondence[email protected]
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Nardhy Gomez-LopezPerinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, USA; ;Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; ;Department of Immunology, Microbiology & Biochemistry, Wayne State University School of Medicine, Detroit, MI, USA; View further author information
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Yi XuPerinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, USA; ;Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; View further author information
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Yaozhu LengPerinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, USA; ;Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; View further author information
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Eli MaymonPerinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, USA; ;Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; ;Department of Obstetrics and Gynecology, Soroka University Medical Center, School of Medicine, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel; View further author information
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Percy PacoraPerinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, USA; ;Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; View further author information
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Offer ErezPerinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, USA; ;Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; ;Department of Obstetrics and Gynecology, Soroka University Medical Center, School of Medicine, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel; View further author information
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Lami YeoPerinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, USA; ;Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; View further author information
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Sonia S. HassanPerinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, USA; ;Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; ;Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USAView further author information
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Chaur-Dong HsuDepartment of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; View further author information
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Pages 1978-1991 | Received 13 Nov 2017, Accepted 27 Dec 2017, Published online: 17 Jan 2018

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José Morales-Roselló, Gabriela Loscalzo, Gemma Perez, Alicia Soriano Payá, Vaidilė Jakaitė & Alfredo Perales-Marín. (2022) Association of first trimester fetal heart rate and nuchal translucency with preterm birth. The Journal of Maternal-Fetal & Neonatal Medicine 35:25, pages 5572-5579.
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Shu-Yue Yu & Xue-Lian Li. (2021) Pyroptosis and inflammasomes in obstetrical and gynecological diseases. Gynecological Endocrinology 37:5, pages 385-391.
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Nardhy Gomez-Lopez, Roberto Romero, Bogdan Panaitescu, Derek Miller, Chengrui Zou, Dereje W. Gudicha, Adi L. Tarca, Robert Para, Percy Pacora, Sonia S. Hassan & Chaur-Dong Hsu. (2021) Gasdermin D: in vivo evidence of pyroptosis in spontaneous labor at term. The Journal of Maternal-Fetal & Neonatal Medicine 34:4, pages 569-579.
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Robert Para, Roberto Romero, Derek Miller, Bogdan Panaitescu, Aneesha Varrey, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Chaur-Dong Hsu & Nardhy Gomez-Lopez. (2020) Human β-defensin-3 participates in intra-amniotic host defense in women with labor at term, spontaneous preterm labor and intact membranes, and preterm prelabor rupture of membranes. The Journal of Maternal-Fetal & Neonatal Medicine 33:24, pages 4117-4132.
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Articles from other publishers (18)

Jose Galaz, Kenichiro Motomura, Roberto Romero, Zhenjie Liu, Valeria Garcia-Flores, Li Tao, Yi Xu, Bogdan Done, Marcia Arenas-Hernandez, Tomi Kanninen, Marcelo Farias-Jofre, Derek Miller, Adi L. Tarca & Nardhy Gomez-Lopez. (2023) A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B. Translational Research 259, pages 46-61.
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Gaurav Bhatti, Roberto Romero, Nardhy Gomez-Lopez, Tinnakorn Chaiworapongsa, Nandor Gabor Than, Kevin R. Theis, Jose Galaz, Francesca Gotsch, Roger Pique-Regi, Stanley M. Berry, Mahendra Kavdia & Adi L. Tarca. (2023) The amniotic fluid proteome changes with term labor and informs biomarker discovery in maternal plasma. Scientific Reports 13:1.
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Emilia Nunzi, Letizia Mezzasoma, Ilaria Bellezza, Teresa Zelante, Pierluigi Orvietani, Giuliana Coata, Irene Giardina, Krizia Sagini, Giorgia Manni, Alessandro Di Michele, Marco Gargaro, Vincenzo N. Talesa, Gian Carlo Di Renzo, Francesca Fallarino & Rita Romani. (2023) Microbiota-Associated HAF-EVs Regulate Monocytes by Triggering or Inhibiting Inflammasome Activation. International Journal of Molecular Sciences 24:3, pages 2527.
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Anya L. Arthurs, Melanie D. Smith, Mhyles D. Hintural, James Breen, Dylan McCullough, Francesca I. Thornton, Shalem Y. Leemaqz, Gustaaf A. Dekker, Tanja Jankovic-Karasoulos & Claire T. Roberts. (2022) Placental Inflammasome mRNA Levels Differ by Mode of Delivery and Fetal Sex. Frontiers in Immunology 13.
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Tina Šket, Taja Železnik Ramuta, Marjanca Starčič Erjavec & Mateja Erdani Kreft. (2021) The Role of Innate Immune System in the Human Amniotic Membrane and Human Amniotic Fluid in Protection Against Intra-Amniotic Infections and Inflammation. Frontiers in Immunology 12.
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Sayani Banerjee, Zheping Huang, Zhengke Wang, Akitoshi Nakashima, Shigeru Saito, Surendra Sharma & Shibin Cheng. (2021) Etiological Value of Sterile Inflammation in Preeclampsia: Is It a Non-Infectious Pregnancy Complication?. Frontiers in Cellular and Infection Microbiology 11.
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Jean Gabriel Souza, Nancy Starobinas & Olga Celia Martinez Ibañez. (2021) Unknown/enigmatic functions of extracellular ASC. Immunology 163:4, pages 377-388.
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Roberto Romero, Percy Pacora, Juan Pedro Kusanovic, Eunjung Jung, Bogdan Panaitescu, Eli Maymon, Offer Erez, Susan Berman, David R. Bryant, Nardhy Gomez-Lopez, Kevin R. Theis, Gaurav Bhatti, Chong Jai Kim, Bo Hyun Yoon, Sonia S. Hassan, Chaur-Dong Hsu, Lami Yeo, Ramiro Diaz-Primera, Julio Marin-Concha, Kia Lannaman, Ali Alhousseini, Hunter Gomez-Roberts, Aneesha Varrey, Angel Garcia-Sanchez & Maria Teresa Gervasi. (2021) Clinical chorioamnionitis at term X: microbiology, clinical signs, placental pathology, and neonatal bacteremia – implications for clinical care. Journal of Perinatal Medicine 49:3, pages 275-298.
Crossref
Nardhy Gomez-Lopez & Roberto Romero. 2021. Reproductive Immunology. Reproductive Immunology 207 237 .
Padma Murthi & Gayathri Rajaraman. (2020) Inflammasomes in the Pathophysiology of Maternal Obesity: Potential Therapeutic Targets to Reduce Long-Term Adverse Health Outcomes in the Mother and Offspring. Current Vascular Pharmacology 19:2, pages 165-175.
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Marilyne Lavergne, Corinne Belville, Héléna Choltus, Christelle Gross, Régine Minet-Quinard, Denis Gallot, Vincent Sapin & Loïc Blanchon. (2020) Human Amnion Epithelial Cells (AECs) Respond to the FSL-1 Lipopeptide by Engaging the NLRP7 Inflammasome. Frontiers in Immunology 11.
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Kevin R. Theis, Roberto Romero, Kenichiro Motomura, Jose Galaz, Andrew D. Winters, Percy Pacora, Derek Miller, Rebecca Slutsky, Violetta Florova, Dustyn Levenson, Robert Para, Aneesha Varrey, Marian Kacerovsky, Chaur-Dong Hsu & Nardhy Gomez-Lopez. (2020) Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes. Journal of Perinatal Medicine 48:2, pages 115-131.
Crossref
Padma Murthi, Anita A. Pinar, Evdokia Dimitriadis & Chrishan S. Samuel. (2020) Inflammasomes—A Molecular Link for Altered Immunoregulation and Inflammation Mediated Vascular Dysfunction in Preeclampsia. International Journal of Molecular Sciences 21:4, pages 1406.
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Juan Pablo de Rivero Vaccari. (2020) The Inflammasome in Reproductive Biology: A Promising Target for Novel Therapies. Frontiers in Endocrinology 11.
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Nardhy Gomez-Lopez, Roberto Romero, George Schwenkel, Valeria Garcia-Flores, Bogdan Panaitescu, Aneesha Varrey, Fatime Ayoub, Sonia S. Hassan & Mark Phillippe. (2020) Cell-Free Fetal DNA Increases Prior to Labor at Term and in a Subset of Preterm Births. Reproductive Sciences 27:1, pages 218-232.
Crossref
Nardhy Gomez-Lopez, Kenichiro Motomura, Derek Miller, Valeria Garcia-Flores, Jose Galaz & Roberto Romero. (2019) Inflammasomes: Their Role in Normal and Complicated Pregnancies. The Journal of Immunology 203:11, pages 2757-2769.
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Silvana Pereyra, Claudio Sosa, Bernardo Bertoni & Rossana Sapiro. (2019) Transcriptomic analysis of fetal membranes reveals pathways involved in preterm birth. BMC Medical Genomics 12:1.
Crossref
Kyung Joon Oh, Roberto Romero, Jee Yoon Park, JoonHo Lee, Agustin Conde-Agudelo, Joon-Seok Hong & Bo Hyun Yoon. (2019) Evidence that antibiotic administration is effective in the treatment of a subset of patients with intra-amniotic infection/inflammation presenting with cervical insufficiency. American Journal of Obstetrics and Gynecology 221:2, pages 140.e1-140.e18.
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