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Natural Product Research
Formerly Natural Product Letters
Volume 24, 2010 - Issue 3
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Original Articles

Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleucine) in C57BL/KsJ-db/db mice

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Pages 258-265 | Received 24 Jun 2008, Accepted 20 Feb 2009, Published online: 05 Feb 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Chenglin Zhang, Jie Ma, Zhixiang Li, Yunlong Liang, Qingyang Xu, Xixian Xie & Ning Chen. (2018) A strategy for L-isoleucine dioxygenase screening and 4-hydroxyisoleucine production by resting cells. Bioengineered 9:1, pages 72-79.
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Feng Gao, Wen Du, Mohammad Ishraq Zafar, Raja Adeel Shafqat, Liumeng Jian, Qin Cai & Furong Lu. (2015) 4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression. Drug Design, Development and Therapy 9, pages 5727-5736.
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Articles from other publishers (39)

Jiwon Kim, Woojeong Noh, Ahrim Kim, Yoomin Choi & Young-Sik Kim. (2023) The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Molecular Sciences 24:18, pages 13999.
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Pushpa Ruwali, Niharika Pandey, Khusboo Jindal & Rahul Vikram Singh. (2022) Fenugreek (Trigonella foenum-graecum): Nutraceutical values, phytochemical, ethnomedicinal and pharmacological overview. South African Journal of Botany 151, pages 423-431.
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Shima Nematollahi, Gholam Reza Pishdad, Mehrnoosh Zakerkish, Foroogh Namjoyan, Kambiz Ahmadi Angali & Fatemeh Borazjani. (2022) The effect of berberine and fenugreek seed co-supplementation on inflammatory factor, lipid and glycemic profile in patients with type 2 diabetes mellitus: a double-blind controlled randomized clinical trial. Diabetology & Metabolic Syndrome 14:1.
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Pragati Singh, Sharmeen Ishteyaque, Ramanand Prajapati, Karan Singh Yadav, Rupali Singh, Akhilesh Kumar, Sharad Sharma, Tadigoppula Narender & Madhav Nilakanth Mugale. (2022) Assessment of antidiabetic effect of 4-HIL in type 2 diabetic and healthy Sprague Dawley rats. Human & Experimental Toxicology 41, pages 096032712110618.
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Sunita Singh, D.P. Maurya, Ambreen Shoaib, Alka Tripathi & Dhananjay Singh. (2021) Phytochemical analysis and antidiabetic efficacy of Morus rubra. Journal of the Indian Chemical Society 98:10, pages 100170.
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Jiali Yang, Yunhui Ran, Yonghui Yang, Shuyi Song, Yahong Wu, Yuanming Qi, Yanfeng Gao & Guodong Li. (2021) 4-Hydroxyisoleucine Alleviates Macrophage-Related Chronic Inflammation and Metabolic Syndrome in Mice Fed a High-Fat Diet. Frontiers in Pharmacology 11.
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Uma Maheshwari Srinivasa & Madeneni Madhava Naidu. 2021. 141 184 .
Heena Tabassum & Iffat Zareen Ahmad. 2021. Fenugreek. Fenugreek 447 480 .
Jianhong An, Wenli Zhang, Xiaoran Jing, Yao Nie & Yan Xu. (2020) Reconstitution of TCA cycle involving l-isoleucine dioxygenase for hydroxylation of l-isoleucine in Escherichia coli using CRISPR-Cas9. 3 Biotech 10:4.
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Geetika Wadhwa, Kowthavarapu Venkata Krishna, Rajeev Taliyan, Neeraj Tandon, Satyapal Singh Yadav, Chandrakant Katiyar & Sunil Kumar Dubey. (2020) Pre-clinical pharmacokinetic and pharmacodynamic modelling study of 4-hydroxyisoleucine using validated ultra-performance liquid chromatography-tandem mass spectrometry. RSC Advances 10:10, pages 5525-5532.
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Shahid AkbarShahid Akbar. 2020. Handbook of 200 Medicinal Plants. Handbook of 200 Medicinal Plants 1851 1871 .
Genet Alem Geberemeskel, Yared Godefa Debebe & Nigisty Abraha Nguse. (2019) Antidiabetic Effect of Fenugreek Seed Powder Solution ( Trigonella foenum-graecum L .) on Hyperlipidemia in Diabetic Patients . Journal of Diabetes Research 2019, pages 1-8.
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Raheela Rashid, Hajra Ahmad, Zaheer Ahmed, Farhat Rashid & Nauman Khalid. (2019) Clinical investigation to modulate the effect of fenugreek polysaccharides on type-2 diabetes. Bioactive Carbohydrates and Dietary Fibre 19, pages 100194.
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Seetur R. Pradeep & Krishnapura Srinivasan. 2019. Bioactive Food as Dietary Interventions for Diabetes. Bioactive Food as Dietary Interventions for Diabetes 407 424 .
Solomon Habtemariam. 2019. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases 579 637 .
D Y Sun, X T Cheng, D K Gao, P P Xu, Q Q Guo, Z L Zhu, M L Zhu, X Y Wang, H M Qin & F P Lu. (2018) Properties, biosynthesis, and catalytic mechanisms of hydroxy-amino-acids. IOP Conference Series: Earth and Environmental Science 188, pages 012084.
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Aminu Mohammed & Md. Shahidul Islam. (2018) Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus. Frontiers in Pharmacology 9.
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Jie Ma, Zhixiang Li, Lei Zhao, Qingyang Xu, Chenlin Zhang, Xixian Xie & Chen Ning. 2018. Advances in Applied Biotechnology. Advances in Applied Biotechnology 183 190 .
Anaguiven Avalos-Soriano, Ricardo De la Cruz-Cordero, Jorge Rosado & Teresa Garcia-Gasca. (2016) 4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity. Molecules 21:11, pages 1596.
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Feng Shi, Huimin Fang, Tengfei Niu & Zhengke Lu. (2016) Overexpression of ppc and lysC to improve the production of 4-hydroxyisoleucine and its precursor l-isoleucine in recombinant Corynebacterium glutamicum ssp. lactofermentum. Enzyme and Microbial Technology 87-88, pages 79-85.
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Sarra Khlifi, Houda Ben Jemaa, Halima Ben Hmad, Hajer Abaza, Inchirah Karmous, Abdelmajid Abid, Anis Benzarti, Jalila Elati & Abdallah Aouidet. (2016) Antioxidant, Antidiabetic and Antihyperlipidemic Effects of Trigonella foenum-graecum Seeds. International Journal of Pharmacology 12:4, pages 394-400.
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Sudeep Gautam, Nayab Ishrat, Pragya Yadav, Rohit Singh, Tadigoppula Narender & Arvind K. Srivastava. (2016) 4-Hydroxyisoleucine attenuates the inflammation-mediated insulin resistance by the activation of AMPK and suppression of SOCS-3 coimmunoprecipitation with both the IR-β subunit as well as IRS-1. Molecular and Cellular Biochemistry 414:1-2, pages 95-104.
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Arezou Rezaei, Azad Farzadfard, Atefe Amirahmadi, Maasoomeh Alemi & Mitra Khademi. (2015) Diabetes mellitus and its management with medicinal plants: A perspective based on Iranian research. Journal of Ethnopharmacology 175, pages 567-616.
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Kyeong Soo Lee, Eun Kyung Lee, Shin Yeon Kim, Tae Hwan Kim & Hyun Pyo Kim. (2015) Effect of a Mixed Extract of Fenugreek Seeds and Lespedeza cuneata on Testosterone Deficiency Syndrome. Korean Journal of Food Science and Technology 47:4, pages 492-498.
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Feng Shi, Tengfei Niu & Huimin Fang. (2015) 4-Hydroxyisoleucine production of recombinant Corynebacterium glutamicum ssp. lactofermentum under optimal corn steep liquor limitation. Applied Microbiology and Biotechnology 99:9, pages 3851-3863.
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Scott Fuller & Jacqueline M Stephens. (2015) Diosgenin, 4-Hydroxyisoleucine, and Fiber from Fenugreek: Mechanisms of Actions and Potential Effects on Metabolic Syndrome. Advances in Nutrition 6:2, pages 189-197.
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Vinod D. Rangari, Prachi Shukla & Sachin L. Badole. 2015. Glucose Intake and Utilization in Pre-Diabetes and Diabetes. Glucose Intake and Utilization in Pre-Diabetes and Diabetes 191 198 .
Nithya Neelakantan, Madanagopal Narayanan, Russell J de Souza & Rob M van Dam. (2014) Effect of fenugreek (Trigonella foenum-graecumL.) intake on glycemia: a meta-analysis of clinical trials. Nutrition Journal 13:1.
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P Shukla & V.D. Rangari. (2014) PHYTOCHEMISTRY, MODE OF ACTION AND PHARMACOLOGICAL APPLICATIONS OF 4-HYDROXYISOLEUCINE FROM TRIGONELLA FOENUM GRAECUM. INDIAN DRUGS 51:11, pages 5-16.
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Syed Ibrahim Rizvi & Neetu Mishra. 2013. Metabolic Syndrome and Neurological Disorders. Metabolic Syndrome and Neurological Disorders 261 274 .
Upma Chaturvedi, Atul Shrivastava, Smriti Bhadauria, Jitendra K. Saxena & Gitika Bhatia. (2013) A Mechanism-based Pharmacological Evaluation of Efficacy of Trigonella foenum graecum (Fenugreek) Seeds in Regulation of Dyslipidemia and Oxidative Stress in Hyperlipidemic Rats. Journal of Cardiovascular Pharmacology 61:6, pages 505-512.
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Syed Ibrahim Rizvi & Neetu Mishra. (2013) Traditional Indian Medicines Used for the Management of Diabetes Mellitus. Journal of Diabetes Research 2013, pages 1-11.
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Natasha Jaiswal, Chandan K. Maurya, K. Venkateswarlu, P. Sukanya, Arvind K. Srivastava, Tadigoppula Narender & Akhilesh K. Tamrakar. (2012) 4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway. European Journal of Nutrition 51:7, pages 893-898.
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Sachin Arora, Subhash L. Bodhank, V. Mohan & Prasad A. Thakurd. (2012) Renoprotective Effects of Reconstructed Composition of Trigonella foenum-graecum L. Seeds in Animal Model of Diabetic Nephropathy with and without Renal Ischemia Reperfusion in Rats. International Journal of Pharmacology 8:5, pages 321-332.
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Kaïss Aouadi, Erwann Jeanneau, Moncef Msaddek & Jean-Pierre Praly. (2012) 1,3-Dipolar cycloaddition of a chiral nitrone to (E)-1,4-dichloro-2-butene: a new efficient synthesis of (2S,3S,4R)-4-hydroxyisoleucine. Tetrahedron Letters 53:23, pages 2817-2821.
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Mohammed R. Haeri, Hamidreza Khalatbari Limaki, Christopher J. Branford White & Kenneth N. White. (2012) Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats. Phytomedicine 19:7, pages 571-574.
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T. K. LimT. K. Lim. 2012. Edible Medicinal And Non-Medicinal Plants. Edible Medicinal And Non-Medicinal Plants 906 924 .
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