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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 11
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Short Communication

Gypensapogenin H from hydrolyzate of total Gynostemma pentaphyllum saponins induces apoptosis in human breast carcinoma cells

Xiaoshu ZhangSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China; ;Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang, People’s Republic of China; View further author information
,
Guohui ShiSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China; ;Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang, People’s Republic of China; View further author information
,
Xiaojun WuKey Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang, People’s Republic of China; ;Shenyang Pharmaceutical University, Shenyang, People’s Republic of ChinaView further author information
&
Yuqing ZhaoSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China; ;Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang, People’s Republic of China; Correspondence[email protected]
View further author information
Pages 1642-1646 | Received 25 Apr 2018, Accepted 11 Sep 2018, Published online: 23 Nov 2018

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Wei-Ye Cui, Yulian Jin, Hui Liu, Ma-Li Zu, Xin-Fang Zhai, Ce Yang, Yu-Long Gu, Yong Cheng & Xiang-Lan Piao. (2021) Dammarane-type saponins from Gynostemma pentaphyllum and their cytotoxicities. Natural Product Research 35:22, pages 4433-4441.
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Articles from other publishers (15)

Xuan Sun, Li Xu, Huijiao Yan, Peng Li, Hidayat Hussain, Jiguo Liu, Jinjie Zhang & Daijie Wang. (2023) Isolation and purification of high polar glycosides from aerial parts of Gynostemma pentaphyllum (Thunb.) Makino by linear gradient counter‐current chromatography coupled with inner‐recycling mode . Journal of Separation Science.
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Irma Podolak, Karolina Grabowska, Danuta Sobolewska, Dagmara Wróbel-Biedrawa, Justyna Makowska-Wąs & Agnieszka Galanty. (2022) Saponins as cytotoxic agents: an update (2010–2021). Part II—Triterpene saponins. Phytochemistry Reviews 22:1, pages 113-167.
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冠平 吕. (2023) Analysis of the Efficacy of Gynostemias pentaphyllum in the Treatment of Acute Lung Injury Based on Network Pharmacology. Hans Journal of Biomedicine 13:01, pages 20-34.
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Jinping Liu, Cuizhu Wang, Qianyun Wang, Wannan Zhang, Zhuoqiao Li, Shanmei He, Junzhe Wu & Peng Cao. 2023. Privileged Scaffolds in Drug Discovery. Privileged Scaffolds in Drug Discovery 613 671 .
Hongyan Tan, Meng Zhang, Lei Xu, Xiaoshu Zhang & Yuqing Zhao. (2022) Gypensapogenin H suppresses tumor growth and cell migration in triple-negative breast cancer by regulating PI3K/AKT/NF-κB/MMP-9 signaling pathway. Bioorganic Chemistry 126, pages 105913.
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Hongyan Tan, Minjie Li, Linlin Han, Yuqing Zhao & Xiaoshu Zhang. (2022) Gypensapogenin I Suppresses Cell Proliferation in Triple-Negative Breast Cancer Via Triggering the Closure of AKT/GSK3β/β-Catenin and Notch-1 Signaling Pathways. Journal of Agricultural and Food Chemistry 70:17, pages 5438-5449.
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Ruo Wang. (2022) Current perspectives on naturally occurring saponins as anticancer agents. Archiv der Pharmazie 355:5, pages 2100469.
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Martina Veit-Acosta & Walter Filgueira de Azevedo Junior. (2022) Computational Prediction of Binding Affinity for CDK2-ligand Complexes. A Protein Target for Cancer Drug Discovery. Current Medicinal Chemistry 29:14, pages 2438-2455.
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Ding Huang, Ruhong Ming, Shiqiang Xu, Shaochang Yao, Liangbo Li, Rongshao Huang & Yong Tan. (2022) Genome-Wide Identification of R2R3-MYB Transcription Factors: Discovery of a “Dual-Function” Regulator of Gypenoside and Flavonol Biosynthesis in Gynostemma pentaphyllum. Frontiers in Plant Science 12.
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Hongyan Tan, Meng Zhang, Xiaojun Wu, Jiaqi Cheng, Mufan Xu, Yuqing Zhao & Xiaoshu Zhang. (2021) New anti-proliferative triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins induces cell cycle arrest and apoptosis in human breast cancer cells. Phytochemistry Letters 46, pages 166-171.
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Jun Wang, Cheng-Bo Wang, Xian-Hua Meng, Wei-Feng Wang, Tian Chai, Mahdi Moridi Farimani & Jun-Li Yang. (2021) Cytotoxic dammarane triterpenoids from the hydrolyzate of Gynostemma pentaphyllum. Phytochemistry Letters 46, pages 136-142.
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Chao Su, Nan Li, Ruru Ren, Yingli Wang, Xiaojuan Su, Fangfang Lu, Rong Zong, Lingling Yang & Xueqin Ma. (2021) Progress in the Medicinal Value, Bioactive Compounds, and Pharmacological Activities of Gynostemma pentaphyllum. Molecules 26:20, pages 6249.
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Gerburg Keilhoff, Christina Ludwig, Josephine Pinkernelle & Benjamin Lucas. (2021) Effects of Gynostemma pentaphyllum on spinal cord motor neurons and microglial cells in vitro. Acta Histochemica 123:6, pages 151759.
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Olga Babich, Stanislav Sukhikh, Alexander Prosekov, Lyudmila Asyakina & Svetlana Ivanova. (2020) Medicinal Plants to Strengthen Immunity during a Pandemic. Pharmaceuticals 13:10, pages 313.
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Kaijun Li, Chao Ma, Haoyu Li, Sooranna Dev, JianFeng He & Xiaosheng Qu. (2020) Medicinal Value and Potential Therapeutic Mechanisms of Gynostemma pentaphyllum (Thunb.) Makino and Its Derivatives: An Overview. Current Topics in Medicinal Chemistry 19:31, pages 2855-2867.
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