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Expert Review of Proteomics Volume 17, 2020 - Issue 10
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Original Research

Active matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: a pilot study

Mutlu Keskina Oral and Dental Health Department, Altınbaş University, İstanbul, TurkeyView further author information
,
Hanna Lähteenmäkib Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki University Hospital, Helsinki, FinlandView further author information
,
Nilminie Rathnayakeb Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki University Hospital, Helsinki, FinlandView further author information
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Ismo T. Räisänenb Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki University Hospital, Helsinki, FinlandCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5821-5299View further author information
ORCID Icon,
Taina Tervahartialab Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki University Hospital, Helsinki, FinlandView further author information
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Pirjo Pärnänenb Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki University Hospital, Helsinki, FinlandView further author information
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Ahmet Murat Şenışıkc Radiotherapy Department, Altınbaş University, İstanbul, TurkeyView further author information
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Didem Karaçetind Radiation Oncology Department, Başakşehir Çam and Sakura City Hospital, İstanbul, TurkeyView further author information
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Ayben Yentek Balkanayd Radiation Oncology Department, Başakşehir Çam and Sakura City Hospital, İstanbul, TurkeyView further author information
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Pia Heikkiläb Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki University Hospital, Helsinki, FinlandView further author information
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Jaana Hagströme Department of Oral Pathology and Radiology, University of Turku, Turku, Finland;f Department of Pathology HUSLAB, Helsinki University Hospital, Helsinki, Finland;g Research Programs Unit, Translational Cancer Medicine, University of Helsinki, Helsinki, FinlandView further author information
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Jaana Rautavab Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki University Hospital, Helsinki, Finland;e Department of Oral Pathology and Radiology, University of Turku, Turku, Finland;h Department of Pathology, HUSLAB & University of Helsinki, Helsinki, FinlandView further author information
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Caj Haglundg Research Programs Unit, Translational Cancer Medicine, University of Helsinki, Helsinki, Finland;i Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandView further author information
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Ulvi Kahraman Gursoyj Department of Periodontology, Institute of Dentistry, University of Turku, Turku, FinlandView further author information
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Angelika Silbereisenk Section of Periodontology and Dental Prevention, Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, SwedenView further author information
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Nagihan Bostancik Section of Periodontology and Dental Prevention, Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, SwedenView further author information
&
Timo Sorsab Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki University Hospital, Helsinki, Finland;k Section of Periodontology and Dental Prevention, Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, SwedenView further author information
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Pages 777-784 | Received 13 Oct 2020, Accepted 27 Nov 2020, Published online: 07 Jan 2021

Citations (19)

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Read on this site (2)

Hanna Lähteenmäki, Tommi Pätilä, Pirjo Pärnänen, Ismo Räisänen, Taina Tervahartiala, Shipra Gupta & Timo Sorsa. (2023) aMMP-8 point-of-care - diagnostic methods and treatment modalities in periodontitis and peri-implantitis. Expert Opinion on Therapeutic Targets 27:7, pages 627-637.
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Timo Sorsa, Vaibhav Sahni, Nurcan Buduneli, Shipra Gupta, Ismo T. Räisänen, Lorne M. Golub, Hsi-Ming Lee, Tommi Pätilä, Nagihan Bostanci, Jukka Meurman, Pirjo Pärnänen, Solomon O. Nwhator, Mohita Singla & Krishan Gauba. (2021) Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic. Expert Review of Proteomics 18:8, pages 707-717.
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Articles from other publishers (17)

Ella Brandt, Mutlu Keskin, Taina Tervahartiala, Mustafa Yılmaz, İlknur Harmankaya, Didem Karaçetin, Turgut İpek, Ulvi Kahraman Gürsoy, Jaana Rautava, Shipra Gupta, Jaana Hagström, Ismo T. Räisänen & Timo Sorsa. (2023) Radiotherapy Increases aMMP-8-Levels and Neutrophil/Lymphocyte Ratio Rapidly in Head and Neck Cancer Patients: A Pilot Study. Cancer Control 30, pages 107327482311636.
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Haiqiong Yue, Yudong Liu & Libin Zhou. (2023) Jaw Osteomyelitis of Impacted Tooth After Radiotherapy: A Report of a Case. Journal of Craniofacial Surgery 34:8, pages e810-e812.
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Ismo T. Räisänen, Nur Rahman Ahmad Seno Aji, Dimitra Sakellari, Andreas Grigoriadis, Iina Rantala, Tommi Pätilä, Pia Heikkilä, Shipra Gupta & Timo Sorsa. (2023) Active Matrix Metalloproteinase-8 (aMMP-8) Versus Total MMP-8 in Periodontal and Peri-Implant Disease Point-of-Care Diagnostics. Biomedicines 11:11, pages 2885.
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Haiqiong Yue, Jun Zeng, Yudong Liu & Libin Zhou. (2023) Jaw osteomyelitis of impacted tooth after radiotherapy: A report of a case. International Journal of Surgery Case Reports, pages 108378.
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Essi Kallio, Tero Puolakkainen, Taina Tervahartiala, Johanna Snäll, Emilia Marttila, Timo Sorsa & Johanna Uittamo. (2023) Applicability of an active matrix metalloproteinase-8 point-of-care test in an oral and maxillofacial surgery clinic: a pilot study. Odontology.
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Mutlu Keskin, Juulia Rintamarttunen, Emre Gülçiçek, Ismo T. Räisänen, Shipra Gupta, Taina Tervahartiala, Tommi Pätilä & Timo Sorsa. (2023) A Comparative Analysis of Treatment-Related Changes in the Diagnostic Biomarker Active Metalloproteinase-8 Levels in Patients with Periodontitis. Diagnostics 13:5, pages 903.
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Mutlu Keskin, Emma Suomi, İlknur Harmankaya, Didem Karaçetin, Timo Sorsa & Ulvi Kahraman Gürsoy. (2023) Oral Cavity Beta-Defensin Levels Are Regulated Differently during Radiotherapy in Head and Neck Cancer Patients. Applied Sciences 13:4, pages 2056.
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Shipra Gupta, Ritin Mohindra, Mohita Singla, Sagar Khera, Amit Kumar, Nilminie Rathnayake, Timo Sorsa, Andreas Pfützner, Ismo T. Räisänen, Roop K. Soni, Poonam Kanta, Akanksha Jain, Krishan Gauba, Kapil Goyal, Mini P. Singh, Arnab Ghosh, Kamal Kajal, Varun Mahajan, Vikas Suri & Ashish Bhalla. (2022) Validation of a noninvasive aMMP‐8 point‐of‐care diagnostic methodology in COVID‐19 patients with periodontal disease. Clinical and Experimental Dental Research 8:4, pages 988-1001.
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Andreas Grigoriadis, Ismo T. Räisänen, Pirjo Pärnänen, Taina Tervahartiala, Timo Sorsa & Dimitra Sakellari. (2022) Is There a Link between COVID-19 and Periodontal Disease? A Narrative Review. European Journal of Dentistry 16:03, pages 514-520.
Crossref
Timo Sorsa, Solomon Olusegun Nwhator, Dimitra Sakellari, Andreas Grigoriadis, Kehinde Adesola Umeizudike, Ella Brandt, Mutlu Keskin, Taina Tervahartiala, Pirjo Pärnänen, Shipra Gupta, Ritin Mohindra, Nagihan Bostanci, Nurcan Buduneli & Ismo Tapani Räisänen. (2022) aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases. Frontiers in Oral Health 3.
Crossref
Rajesh V. Lalla, Nathaniel S. Treister, Thomas P. Sollecito, Brian L. Schmidt, Lauren L. Patton, Erika S. Helgeson, Alexander Lin, Cynthia Rybczyk, Robert Dowsett, Upendra Hegde, Timothy S. Boyd, Thomas G. Duplinsky & Michael T. Brennan. (2022) Radiation therapy for head and neck cancer leads to gingival recession associated with dental caries. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 133:5, pages 539-546.
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Hanna Lähteenmäki, Taina Tervahartiala, Ismo T. Räisänen, Pirjo Pärnänen, Matti Mauramo, Shipra Gupta, Victoria Sampson, Nilminie Rathnayake, Anna‐Maria Heikkinen, Saeed Alassiri, Dirk‐Rolf Gieselmann, Roland Frankenberger & Timo Sorsa. (2022) Active MMP‐8 point‐of‐care (PoC)/chairside enzyme‐test as an adjunctive tool for early and real‐time diagnosis of peri‐implantitis. Clinical and Experimental Dental Research 8:2, pages 485-496.
Crossref
Shipra Gupta, Ritin Mohindra, Mohita Singla, Sagar Khera, Vaibhav Sahni, Poonam Kanta, Roop Kishor Soni, Amit Kumar, Krishan Gauba, Kapil Goyal, Mini P. Singh, Arnab Ghosh, Kamal Kajal, Varun Mahajan, Ashish Bhalla, Timo Sorsa & Ismo Räisänen. (2021) The clinical association between Periodontitis and COVID-19. Clinical Oral Investigations 26:2, pages 1361-1374.
Crossref
Kehinde Umeizudike, Ismo Räisänen, Shipra Gupta, Solomon Nwhator, Andreas Grigoriadis, Dimitra Sakellari & Timo Sorsa. (2021) Active matrix metalloproteinase‐8: A potential biomarker of oral systemic link. Clinical and Experimental Dental Research 8:1, pages 359-365.
Crossref
Timo Sorsa, Andreas Grigoriadis, Dimitra Sakellari, Shipra Gupta, Vaibhav Sahni, Taina Tervahartiala & Ismo T. Räisänen. (2021) On the accuracy, sensitivity, and grading of mouthrinse active matrix metalloproteinase‐8 (aMMP‐8) point‐of‐care testing (POCT). Journal of Clinical Periodontology 48:11, pages 1495-1498.
Crossref
Nur Balci, Şivge Kurgan, Ali Çekici, Tülin Çakır & Muhittin A. Serdar. (2021) Free amino acid composition of saliva in patients with healthy periodontium and periodontitis. Clinical Oral Investigations 25:6, pages 4175-4183.
Crossref
Ismo T. Räisänen, Hanna Lähteenmäki, Shipra Gupta, Andreas Grigoriadis, Vaibhav Sahni, Juho Suojanen, Hanna Seppänen, Taina Tervahartiala, Dimitra Sakellari & Timo Sorsa. (2021) An aMMP-8 Point-of-Care and Questionnaire Based Real-Time Diagnostic Toolkit for Medical Practitioners. Diagnostics 11:4, pages 711.
Crossref

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