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Original Research

Active matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: a pilot study

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Pages 777-784 | Received 13 Oct 2020, Accepted 27 Nov 2020, Published online: 07 Jan 2021

References

  • Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7–30.
  • Karam SD, Raben D. Radioimmunotherapy for the treatment of head and neck cancer. Lancet Oncol. 2019;20(8):e404–e416.
  • Schuurhuis JM, Stokman MA, Witjes MJH, et al. Patients with advanced periodontal disease before intensity-modulated radiation therapy are prone to develop bone healing problems: a 2-year prospective follow-up study. Support Care Cancer. 2018;26(4):1133–1142.
  • Irie MS, Mendes EM, Borges JS, et al. Periodontal therapy for patients before and after radiotherapy: A review of the literature and topics of interest for clinicians. Med Oral Patol Oral Cir Bucal. 2018;23(5):e524–e530.
  • Sroussi HY, Epstein JB, Bensadoun RJ, et al., Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med. 2017;6(12):2918–2931.
  • Marques MA, Dib LL. Periodontal changes in patients undergoing radiotherapy. J Periodontol. 2004;75(9):1178–1187.
  • Ammajan RR, Joseph R, Rajeev R, et al. Assessment of periodontal changes in patients undergoing radiotherapy for head and neck malignancy: a hospital-based study. J Cancer Res Ther. 2013;9(4):630–637.
  • Ferreira MC, Dias-Pereira AC, Branco-de-Almeida LS, et al. Impact of periodontal disease on quality of life: a systematic review. J Periodontal Res. 2017;52(4):651–665.
  • Sorsa T, Gursoy UK, Nwhator S, et al., Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases. Periodontol 2000. 2016;70(1):142–163.
  • Ghallab NA. Diagnostic potential and future directions of biomarkers in gingival crevicular fluid and saliva of periodontal diseases: review of the current evidence. Arch Oral Biol. 2018;87:115–124.
  • Sorsa T, Tjäderhane L, Konttinen YT, et al. Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann Med. 2006;38(5):306–321.
  • Lee W, Aitken S, Sodek J, et al. Evidence of a direct relationship between neutrophil collagenase activity and periodontal tissue destruction in vivo: role of active enzyme in human periodontitis. J Periodontal Res. 1995;30(1):23–33.
  • Romanelli R, Mancini S, Laschinger C, et al. Activation of neutrophil collagenase in periodontitis. Infect Immun. 1999;67(5):2319–2326.
  • Pärnänen P, Sorsa T, Tervahartiala T, et al. Isolation, characterization and regulation of moonlighting proteases from Candida glabrata cell wall. Microb Pathog. 2020;149(104547). DOI:10.1016/j.micpath.2020.104547
  • Scheller J, Chalaris A, Schmidt-Arras D, et al. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta. 2011;1813(5):878–888.
  • Pan W, Wang Q, Chen Q. The cytokine network involved in the host immune response to periodontitis. Int J Oral Sci. 2019;11(3):30.
  • Harmer D, Falank C, Reagan MR. Interleukin-6 interweaves the bone marrow microenvironment, bone loss, and multiple myeloma. Front Endocrinol (Lausanne). 2019;9:788.
  • Miller PD Jr. A classification of marginal tissue recession. Int J Periodontics Restorative Dent. 1985;5(2):8–13.
  • Silness J, Loe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand. 1964;22:121–135.
  • Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol. 2018;89(Suppl 1):S159–S172.
  • Sorsa T, Alassiri S, Grigoriadis A, et al. Active MMP-8 (aMMP-8) as a grading and staging biomarker in the periodontitis classification. Diagnostics (Basel). 2020;10(2):61.
  • Bakdash JZ, Marusich LR. Repeated measures correlation. Front Psychol. 2017;8:456.
  • Thirkettle S, Decock J, Arnold H, et al. Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells. J Biol Chem. 2013;288(3):16282–16294.
  • Al-Majid A, Alassiri S, Rathnayake N, et al. Matrix metalloproteinase-8 as an inflammatory and prevention biomarker in periodontal and peri-implant diseases. Int J Dent. 2018;2018:7891323.
  • Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017;3:17038.
  • Alassiri S, Parnanen P, Rathnayake N, et al. The ability of quantitative, specific, and sensitive point-of-care/chair-side oral fluid immunotests for aMMP-8 to detect periodontal and peri-implant diseases. Dis Markers. 2018;2018:1306396.
  • Grigoriadis A, Sorsa T, Räisänen I, et al. Prediabetes/diabetes can be screened at the dental office by a low-cost and fast chair-side/point-of-care aMMP-8 immunotest. Diagnostics (Basel). 2019;9(4):151.
  • Chaparro A, Realini O, Hernández M, et al. Early pregnancy levels of gingival crevicular fluid matrix metalloproteinases-8 and −9 are associated with the severity of periodontitis and the development of gestational diabetes mellitus. J Periodontol. 2020. DOI:10.1002/JPER.19-0743.
  • Räisänen IT, Umeizudike A, Pärnänen P, et al. Periodontal disease and targeted prevention using aMMP-8 point-of-care oral fluid analytics in the COVID-19 era. Med Hypotheses. 2020;144:110276.