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Journal Of Herbal Pharmacotherapy Volume 7, 2008 - Issue 3-4
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NATURAL STANDARD REVIEW

Fenugreek (Trigonella foenum-graecum L. Leguminosae): An Evidence-Based Systematic Review by the Natural Standard Research Collaboration

Catherine Ulbricht Massachusetts General Hospital
, PharmD,
Ethan Basch Memorial Sloan-Kettering Cancer Center
, MD, MPhil,
Dilys Burke Natural Standard Research Collaboration
, BA,
Lisa Cheung University of Rhode Island
, PharmD,
Edzard Ernst University of Exeter
, MD,
Nicole Giese Natural Standard Research Collaboration
, MS,
Ivo Foppa University of South Carolina
, MD, ScD,
Paul Hammerness Harvard Medical School
, MD,
Sadaf Hashmi Natural Standard Research Collaboration
, MD, MPH,
Grace Kuo Baylor College of Medicine
, PharmD,
Michelle Miranda University of Rhode Island
, PharmD,
Siddhartha Mukherjee Harvard Medical School
, MD,
Michael Smith Canadian College of Natu-ropathic Medicine
, MRPharmS, ND,
David Sollars New England School of Acupuncture
, MAc, HMC,
Shaina Tanguay-Colucci Natural Standard Research Collaboration
, BS,
Nazhiyath Vijayan University of California, Davis
, MD &
Wendy Weissner Natural Standard Research Collaboration
, BA show all
Pages 143-177 | Published online: 13 Jul 2009

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S. N. Sankhwar, Pawan Kumar, Manashi Bagchi, Mehul Rungta & Debasis Bagchi. (2023) Safety and Efficacy of Furosap®, a Patented Trigonella foenum-graecum Seed Extract, in Boosting Testosterone Level, Reproductive Health and Mood Alleviation in Male Volunteers. Journal of the American Nutrition Association 42:1, pages 27-35.
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Pallavi Deshpande, Vishwaraman Mohan, Dilip Ingavale, Jyoti Mane, Mukul Pore & Prasad Thakurdesai, PhD. (2017) Preclinical Safety Assessment of Furostanol Glycoside-Based Standardized Fenugreek Seed Extract in Laboratory Rats. Journal of Dietary Supplements 14:5, pages 521-541.
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Narsingh Verma, Kauser Usman, Naresh Patel, Arvind Jain, Sudhir Dhakre, Anand Swaroop, Manashi Bagchi, Pawan Kumar, Harry G. Preuss & Debasis Bagchi. (2016) A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes. Food & Nutrition Research 60:1.
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Amit D. Kandhare, Subhash L. Bodhankar, V. Mohan & Prasad A. Thakurdesai. (2015) Pharmacokinetics, tissue distribution and excretion study of a furostanol glycoside-based standardized fenugreek seed extract in rats. Renal Failure 37:7, pages 1208-1218.
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Erica Rosalle. (2015) Milking the Information: Resources on Herbal Lactation Aids. Journal of Consumer Health on the Internet 19:2, pages 93-99.
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Asmaa S. Zaky, Mohamed Kandeil, Mohamed Abdel-Gabbar, Eman M. Fahmy, Mazen M. Almehmadi, Tarek M. Ali & Osama M. Ahmed. (2022) The Antidiabetic Effects and Modes of Action of the Balanites aegyptiaca Fruit and Seed Aqueous Extracts in NA/STZ-Induced Diabetic Rats. Pharmaceutics 14:2, pages 263.
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Mohammed H. Alqarni, Prawez Alam, Abulaziz M. Al Kharji, Mohammad Ayman A. Salkini & Maged S. Abdel-Kader. (2020) Effect of Environmental Conditions on the Biomarker Trigonelline in Trigonella foenum-graecum L. seeds Using Validated HPTLC Method. Current Pharmaceutical Analysis 16:6, pages 698-704.
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Zi‐Li Kong, Kui Che, Jian‐Xia Hu, Ying Chen, Yun‐Yang Wang, Xiang Wang, Wen‐Shan Lü, Yan‐Gang Wang & Jing‐Wei Chi. (2020) Orientin Protects Podocytes from High Glucose Induced Apoptosis through Mitophagy. Chemistry & Biodiversity 17:3.
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Arezoo Moini Jazani, Hamidreza Nasimi Doost Azgomi, Alireza Nasimi Doost Azgomi & Ramin Nasimi Doost Azgomi. (2019) A comprehensive review of clinical studies with herbal medicine on polycystic ovary syndrome (PCOS). DARU Journal of Pharmaceutical Sciences 27:2, pages 863-877.
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Ahmed I. Foudah, Prawez Alam, Mohammed H. Alqarni, Mohammad Ayman A. Salkini & Maged S. Abdel-Kader. (2019) Development of a Reversed-Phase High-Performance Thin-Layer Chromatography Method for the Simultaneous Determination of Trigonelline and Diosgenin Biomarkers in Trigonella foenum-graecum L. Seeds Grown in Variable Environment . JPC - Journal of Planar Chromatography - Modern TLC 32:5, pages 379-384.
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Yolanda Muñoz Balbontín, Derek Stewart, Ashalatha Shetty, Catherine A. Fitton & James S. McLay. (2019) Herbal Medicinal Product Use During Pregnancy and the Postnatal Period. Obstetrics & Gynecology 133:5, pages 920-932.
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Ahmed I. Foudah, Prawez Alam, Abdulaziz I. Al Furaih, Mohammad Ayman A. Salkini & Maged S. Abdel-Kader. (2019) Assessment of environmental quantitative variation of diosgenin in fenugreek seeds via high-performance thin-layer chromatography method . JPC - Journal of Planar Chromatography - Modern TLC 32:2, pages 89-93.
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Amit D. Kandhare, Prasad A. Thakurdesai, Pralhad Wangikar & Subhash L. Bodhankar. (2019) A systematic literature review of fenugreek seed toxicity by using ToxRTool: evidence from preclinical and clinical studies. Heliyon 5:4, pages e01536.
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Daniel L. Krinsky, Stefanie P. Ferreri, Brian Hemstreet, Anne L. Hume, Gail D. Newton, Carol J. Rollins & Karen J. TietzeCydney E. McQueen & Katherine Kelly Orr. 2017. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 19th Edition. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 19th Edition.
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F. Yousef Nasab, M. R. Hajinezhad, H. Hashemi & Abdolhossein Miri. (2017) Comparative study of antidiabetic activity of two herbal extracts in alloxan-induced diabetic rats. Oriental Pharmacy and Experimental Medicine 17:3, pages 291-295.
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Kalyan C. Nagulapalli Venkata, Anand Swaroop, Debasis Bagchi & Anupam Bishayee. (2017) A small plant with big benefits: Fenugreek ( Trigonella foenum-graecum Linn.) for disease prevention and health promotion . Molecular Nutrition & Food Research 61:6, pages 1600950.
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Keith W. Singletary. (2017) Fenugreek. Nutrition Today 52:2, pages 93-111.
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Masood-ur-Rahman, Younis Mohammad, Khalid Majid Fazili, Khursheed Ahmad Bhat & Tabassum Ara. (2017) Synthesis and biological evaluation of novel 3- O -tethered triazoles of diosgenin as potent antiproliferative agents. Steroids 118, pages 1-8.
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Tariq Ahmad Dar, Moin Uddin, M. Masroor A. Khan, Akbar Ali & Lalit Varshney. (2016) Modulation of alkaloid content, growth and productivity of Trigonella foenum-graecum L. using irradiated sodium alginate in combination with soil applied phosphorus. Journal of Applied Research on Medicinal and Aromatic Plants 3:4, pages 200-210.
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Tin Sim, H. Hattingh, Jillian Sherriff & Lisa Tee. (2015) The Use, Perceived Effectiveness and Safety of Herbal Galactagogues During Breastfeeding: A Qualitative Study. International Journal of Environmental Research and Public Health 12:9, pages 11050-11071.
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Amit D. Kandhare, Subhash L. Bodhankar, V. Mohan & Prasad A. Thakurdesai. (2015) Acute and repeated doses (28 days) oral toxicity study of glycosides based standardized fenugreek seed extract in laboratory mice. Regulatory Toxicology and Pharmacology 72:2, pages 323-334.
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Tariq Ahmad Dar, Moin Uddin, M. Masroor A. Khan, Akbar Ali, Suhail Rasool Mir & Lalit Varshney. (2015) Effect of Co-60 gamma irradiated chitosan and phosphorus fertilizer on growth, yield and trigonelline content of Trigonella foenum-graecum L.. Journal of Radiation Research and Applied Sciences 8:3, pages 446-458.
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Cydney E. McQueen & Katherine Kelly Orr. 2015. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 18th Edition. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 18th Edition.
Nithya Neelakantan, Madanagopal Narayanan, Russell J de Souza & Rob M van Dam. (2014) Effect of fenugreek (Trigonella foenum-graecumL.) intake on glycemia: a meta-analysis of clinical trials. Nutrition Journal 13:1.
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Tin Fei Sim, H Laetitia Hattingh, Jillian Sherriff & Lisa B G Tee. (2014) Perspectives and attitudes of breastfeeding women using herbal galactagogues during breastfeeding: a qualitative study. BMC Complementary and Alternative Medicine 14:1.
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Hari Cheryl Sachs, Daniel A. C. Frattarelli, Jeffrey L. Galinkin, Thomas P. Green, Timothy Johnson, Kathleen Neville, Ian M. Paul & John Van den Anker. (2013) The Transfer of Drugs and Therapeutics Into Human Breast Milk: An Update on Selected Topics. Pediatrics 132:3, pages e796-e809.
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Hemant Kamble, Amit D. Kandhare, Subhash Bodhankar, Viswanathan Mohan & Prasad Thakurdesai. (2013) Effect of low molecular weight galactomannans from fenugreek seeds on animal models of diabetes mellitus. Biomedicine & Aging Pathology 3:3, pages 145-151.
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Paul Posadzki, Leala Watson & Edzard Ernst. (2013) Herb-drug interactions: an overview of systematic reviews. British Journal of Clinical Pharmacology 75:3, pages 603-618.
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Paul Posadzki, Leala K Watson & Edzard Ernst. (2013) Adverse effects of herbal medicines: an overview of systematic reviews. Clinical Medicine 13:1, pages 7-12.
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Nasser M Al-Daghri, Majed S Alokail, Khalid M Alkharfy, Abdul Khader Mohammed, Sherif H Abd-Alrahman, Sobhy M Yakout, Osama E Amer & Soundararajan Krishnaswamy. (2012) Fenugreek extract as an inducer of cellular death via autophagy in human T lymphoma Jurkat cells. BMC Complementary and Alternative Medicine 12:1.
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Sachin Arora, Subhash L. Bodhank, V. Mohan & Prasad A. Thakurd. (2012) Renoprotective Effects of Reconstructed Composition of Trigonella foenum-graecum L. Seeds in Animal Model of Diabetic Nephropathy with and without Renal Ischemia Reperfusion in Rats. International Journal of Pharmacology 8:5, pages 321-332.
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Khaled Hamden, Bassem Jaouadi, Tahia Salami, Serge Carreau, Samir Bejar & Abdelfattah Elfeki. (2010) Modulatory effect of fenugreek saponins on the activities of intestinal and hepatic disaccharidase and glycogen and liver function of diabetic rats. Biotechnology and Bioprocess Engineering 15:5, pages 745-753.
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Khaled Hamden, Bassem Jaouadi, Serge Carreau, Samir Bejar & Abdelfattah Elfeki. (2010) Inhibitory effect of fenugreek galactomannan on digestive enzymes related to diabetes, hyperlipidemia, and liver-kidney dysfunctions. Biotechnology and Bioprocess Engineering 15:3, pages 407-413.
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