Fenugreek (Trigonella foenum-graecum L. Leguminosae): An Evidence-Based Systematic Review by the Natural Standard Research Collaboration

REFERENCES

• Parvizpur A, Ahmadiani A, Kamalinejad M. Spinal serotonergic system is partially involved in antinociception induced by Trigonella foenum-graecum (TFG) leaf extract. J Ethnopharmacol 2004; 95(1)13–17
   PubMed Web of Science ®Google Scholar
• Devasena T, Menon VP. Enhancement of circulatory antioxidants by fenugreek during 1,2-dimethylhydrazine-induced rat colon carcinogenesis. J Biochem Mol Biol Biophys 2002; 6(4)289–292
   PubMedGoogle Scholar
• Kaviarasan S, Vijayalakshmi K, Anuradha CV. Polyphenol-rich extract of fenugreek seeds protect erythrocytes from oxidative damage. Plant Foods Hum Nutr 2004; 59(4)143–147
   PubMed Web of Science ®Google Scholar
• Fugh-Berman A. “Bust enhancing” herbal products. Obstet Gynecol 2003; 101(6)1345–1349
   PubMed Web of Science ®Google Scholar
• Sur P, Das M, Gomes A, Vedasiromoni JR, Sahu NP, Banerjee S, Sharma RM, Ganguly DK. Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent. Phytother Res 2001; 15(3)257–259
   PubMed Web of Science ®Google Scholar
• Vats V, Yadav SP, Biswas NR, Grover JK. Anti-cataract activity of Pterocarpus marsupium bark and Trigonella foenum-graecum seeds extract in alloxan diabetic rats. J Ethnopharmacol 2004; 93(2–3)289–294
   PubMed Web of Science ®Google Scholar
• Devasena T, Menon VP. Fenugreek affects the activity of beta-glucuronidase and mucinase in the colon. Phytother Res 2003; 17(9)1088–1091
   PubMed Web of Science ®Google Scholar
• Raju J, Patlolla JM, Swamy MV, Rao CV. Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Cancer Epidemiol Biomarkers Prev 2004; 13(8)1392–1398
   PubMed Web of Science ®Google Scholar
• Damanik R, Wahlqvist ML, Wattanapenpaiboon N. The use of a putative lactagogue plant on breast milk production in Simalungun, North Sumatra, Indonesia. Asia Pac J Clin Nutr 2004; 13(Suppl)Sl–18
   Google Scholar
• Gabay MP. Galactogogues: medications that induce lactation. J Hum Lact 2002; 18(3)274–279
   PubMedGoogle Scholar
• Pandian RS, Anuradha CV, Viswanathan P. Gastroprotective effect of fenugreek seeds (Trigonella foenum graecum) on experimental gastric ulcer in rats. J Ethnopharmacol 2002; 81(3)393–397
   PubMed Web of Science ®Google Scholar
• Tahiliani P, Kar A. Mitigation of thyroxine-induced hyperglycaemia by two plant extracts. Phytother Res 2003; 17(3)294–296
   PubMed Web of Science ®Google Scholar
• Bin-Hafeez B, Haque R, Parvez S, Pandey S, Sayeed I, Raisuddin S. Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice. Int Imminopharmacol 2003; 3(2)257–265
   PubMed Web of Science ®Google Scholar
• Harve G, Kamath V. Larvicidal activity of plant extracts used alone and in combination with known synthetic larvicidal agents against Aedes aegypti. Indian J Exp Biol 2004; 42(12)1216–1219
   PubMedGoogle Scholar
• Broca C, Breil V, Cruciani-Guglielmacci C, Manteghetti M, Rouault C, Derouet M, Rizkalla S, Pau B, Petit P, Ribes G, Ktorza A, Gross R, Reach G, Taouis M. Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat. Am J Physiol Endocrinol Metab 2004; 287(3)E463–E471
   PubMed Web of Science ®Google Scholar
• Thakran S, Siddiqui MR, Baquer NZ. Trigonella foenum graecum seed powder protects against histopathological abnormalities in tissues of diabetic rats. Mol Cell Biochem 2004; 266(1–2)151–159
   PubMed Web of Science ®Google Scholar
• Hibasami H, Moteki H, Ishikawa K, Katsuzaki H, Imai K, Yoshioka K, Ishii Y, Komiya T. Protodioscin isolated from fenugreek (Trigonella foenumgraecum L.) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III. Int J Mol Med 2003; ll(l)23–26
   Google Scholar
• Kaviarasan S, Ramamurty N, Gunasekaran P, Varalakshmi E, Anuradha CV. Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells. Alcohol Alcohol 2006; 41(3)267–273
   PubMed Web of Science ®Google Scholar
• Randhir R, Lin YT, Shetty K. Phenolics, their antioxidant and antimicrobial activity in dark germinated fenugreek sprouts in response to peptide and phytochemical elicitors. Asia Pac J Clin Nutr 2004; 13(3)295–307
   PubMed Web of Science ®Google Scholar
• Thirunavukkarasu V, Anuradha CV, Viswanathan P. Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity. Phytother Res 2003; 17(7)737–743
   PubMed Web of Science ®Google Scholar
• Zia T, Hasnain SN, Hasan SK. Evaluation of the oral hypoglycaemic effect of Trigonella foenum graecum L. (methi) in normal mice. J Ethnopharmacol 2001; 75(2–3)191–195
   PubMed Web of Science ®Google Scholar
• Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenumgraecum). Ann Allergy Asthma Immunol 1997; 78(3)297–300
   PubMed Web of Science ®Google Scholar
• Israel D, Youngkin EQ. Herbal therapies for perimenopausal and menopausal complaints. Pharmacotherapy 1997; 17(5)970–984
   PubMed Web of Science ®Google Scholar
• Basch E, Ulbricht C, Kuo G, Szapary P, Smith M. Therapeutic applications of fenugreek. Altern Med Rev 2003; 8(l)20–27
   PubMedGoogle Scholar
• Sharma RD, Sarkar A, Hazra DK, et al. Toxicological evaluation of fenugreek seeds: A long term feeding experiment in diabetic patients. Phytother Res 1996; 10(6)519–520
   Web of Science ®Google Scholar
• Sharma RD, Sarkar DK, Hazra B, et al. Hypolipidaemic effect of fenugreek seeds: A chronic study in non-insulin dependent diabetic patients. Phytother Res 1996; 10: 332–334
   Web of Science ®Google Scholar
• Raghuram TC, Sharma RD, Sivakumar B, et al. Effect of fenugreek seeds on intravenous glucose disposition in non-insulin dependent diabetic patients. Phytotherapy Research 1994; 8(2)83–86
   Web of Science ®Google Scholar
• Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rose.) and fenugreek (Trigonella foenum graecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 1997; 56(5)379–384
   PubMed Web of Science ®Google Scholar
• Sharma RD, Raghuram TC. Hypoglycaemic effect of fenugreek seeds in non-insulin dependent diabetic subjects. Nutr Res 1990; 10: 731–739
   Web of Science ®Google Scholar
• Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutrit 1990; 44(4)301–306
   PubMed Web of Science ®Google Scholar
• Opdyke DL. Fenugreek absolute. Food Cosmet Toxicol 1978; 16(Suppl 1)755–756
   Google Scholar
• Muralidhara, Narasimhamurthy K, Viswanatha S, Ramesh BS. Acute and subchronic toxicity assessment of debitterized fenugreek powder in the mouse and rat. Food Chem Toxicol 1999; 37(8)831–838
   PubMed Web of Science ®Google Scholar
• Rao PU, Sesikeran B, Rao PS, et al. Short term nutritional and safety evaluation of fenugreek. Nutr Res 1996; 16(9)1495–1505
   Web of Science ®Google Scholar
• Flammang AM, Cifone MA, Erexson GL, Stankowski LF, Jr. Genotoxicity testing of a fenugreek extract. Food Chem Toxicol 2004; 42(11)1769–1775
   PubMed Web of Science ®Google Scholar
• Ohnuma N, Yamaguchi E, Kawakami Y. Anaphylaxis to curry powder. Allergy 1998; 53(4)452–454
   PubMed Web of Science ®Google Scholar
• Madar Z, Abel R, Samish S, Arad J. Glucose-lowering effect of fenugreek in non-insulin dependent diabetics. Eur J Clin Nutr 1988; 42(l)51–54
   PubMedGoogle Scholar
• Mishkinsky J, Joseph B, Sulman FG. Hypoglycemic effect of trigonelline. Lancet 12–16-1967; 2(7529)1311–1312
   PubMed Web of Science ®Google Scholar
• Sharma RD, Sarkar A, Hazra DK, et al. Use of fenugreek seed powder in the management of non-insulin dependent diabetes mellitus. Nutrit Res 1996; 16(8)1331–1339
   Web of Science ®Google Scholar
• Sharma RD. Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects. Nutr Res 1986; 6: 1353–1364
   Web of Science ®Google Scholar
• Abdel-Barry JA, Abdel-Hassan IA, Jawad AM, al Hakiem MH. Hypoglycaemic effect of aqueous extract of the leaves of Trigonella foenum-graecum in healthy volunteers. East Mediterr Health J 2000; 6(l)83–88
   PubMedGoogle Scholar
• Panda S, Tahiliani P, Kar A. Inhibition of triiodothyronine production by fenugreek seed extract in mice and rats. Pharmacol Res 1999; 40(5)405–409
   PubMed Web of Science ®Google Scholar
• Sharma RD. An evaluation of hypocholesterolemic factor of fenugreek seeds (T. foenum graecuni) in rats. Nutrit Rep Internat 1986; 33: 669–677
   Google Scholar
• Al Khaldi SF, Martin SA, Prakash L. Fermentation of fenugreek fiber, psyllium husk, and wheat bran by Bacteroides ovatus V975. Curr Microbiol 1999; 39(4)231–232
   PubMed Web of Science ®Google Scholar
• Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 7-l-2000; 57(13)1221–1227
   PubMed Web of Science ®Google Scholar
• Abebe W. Herbal medication: potential for adverse interactions with analgesic drugs. J Clin Pharm Ther 2002; 27(6)391–401
   PubMed Web of Science ®Google Scholar
• Lambert JP, Cormier A. Potential interaction between warfarin and boldo-fenu-greek. Pharmacotherapy 2001; 21(4)509–512
   PubMed Web of Science ®Google Scholar
• Takruri HR, Humeid MA. Nitrate levels in edible wild herbs and vegetables common in Jordan. Nutr Health 1988; 6(2)89–98
   PubMedGoogle Scholar
• Sewell AC, Mosandl A, Bohles H. False diagnosis of maple syrup urine disease owing to ingestion of herbal tea. N Engl J Med 9–2-1999; 341(10)769
   PubMed Web of Science ®Google Scholar
• Abdo MS, al Kafawi AA. Experimental studies on the effect of Trigonella foenum-graecum. Planta Med 1969; 17(1)14–18
   PubMed Web of Science ®Google Scholar
• Farnsworth NR, Bingel AS, Cordell GA, Crane FA, Fong HH. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975; 64(4)535–598
   PubMed Web of Science ®Google Scholar
• Tiran D. The use of fenugreek for breast feeding women. Complement Ther Nurs Midwifery 2003; 9(3)155–156
   PubMedGoogle Scholar
• Parvizpur A, Ahmadiani A, Kamalinejad M. Probable role of spinal purino-ceptors in the analgesic effect of Trigonella foenum (TFG) leaves extract. J Ethno-pharmacol 3–8-2006; 104(l-2)108–112
   PubMed Web of Science ®Google Scholar
• Ajabnoor MA, Tilmisany AK. Effect of Trigonella foenum graecum on blood glucose levels in normal and alloxan-diabetic mice. J Ethnopharm 1988; 22: 45–49
   PubMed Web of Science ®Google Scholar
• Amin R, Abdul-Ghani AS, Suleiman MS. Effect of Trigonella feonum graecum on intestinal absorption. Proc. of the 47th Annual Meeting of the American Diabetes Association (Indianapolis U.S.A.). Diabetes 1987; 36(Supp l)211a
   Google Scholar
• Kochhar A, Nagi M. Effect of supplementation of traditional medicinal plants on blood glucose in non-insulin-dependent diabetics: a pilot study. J Med Food 2005; 8(4)545–549
   PubMed Web of Science ®Google Scholar
• Sauvaire Y, Petit P, Broca C, Manteghetti M, Baissac Y, Fernandez-Alvarez J, Gross R, Roye M, Leconte A, Gomis R, Ribes G. 4-Hydroxyisoleucine: A novel amino acid potentiator of insulin secretion. Diabetes 1998; 47(2)206–210
   PubMed Web of Science ®Google Scholar
• Vijayakumar MV, Singh S, Chhipa RR, Bhat MK. The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. Br J Pharmacol 2005; 146(l)41–48
   PubMedGoogle Scholar
• Stark A, Madar Z. The effect of an ethanol extract derived from fenugreek (Trigonella foenum-graecum) on bile acid absorption and cholesterol levels in rats. Br J Nutr 1993; 69(l)277–287
   PubMedGoogle Scholar
• Petit P, Sauvaire Y, Ponsin G, Manteghetti M, Fave A, Ribes G. Effects of a fenugreek seed extract on feeding behaviour in the rat: Metabolic-endocrine correlates. Pharmacol Biochem Behav 1993; 45(2)369–374
   PubMed Web of Science ®Google Scholar
• Al-Habori M, Al-Aghbari AM, Al-Mamary M. Effects of fenugreek seeds and its extracts on plasma lipid profile: a study on rabbits. Phytother Res 1998; 12(8)572–575
   Web of Science ®Google Scholar
• Al-Habori M, Raman A. Antidiabetic and hypocholesterolaemic effects of fenugreek. Phytother Res 1998; 12(4)233–242
   Web of Science ®Google Scholar
• Valette G, Sauvaire Y, Baccou JC, Ribes G. Hypocholesterolaemic effect of fenugreek seeds in dogs. Atherosclerosis 1984; 50(1)105–111
   PubMed Web of Science ®Google Scholar
• Sauvaire Y, Ribes G, Baccou JC, Loubatieres-Mariani MM. Implication of steroid saponins and sapogenins in the hypocholesterolemic effect of fenugreek. Lipids 1991; 26(3)191–197
   PubMed Web of Science ®Google Scholar
• Varshney IP, Sharma SC. Saponins and sapogenins: Part XXXII. Studies on Trigonella foenum-graecum Linn. Seeds. J Indian Chem Soc 1966; 43(8)564–567
   Google Scholar
• Yoshikawa M, Murakami T, Komatsu H, Murakami N, Yamahara J, Matsuda H. Medicinal foodstuffs. IV. Fenugreek seed. (1): structures of trigoneosides la, Ib, Ila, lib, Hla, and Illb, new furostanol saponins from the seeds of Indian Trigonella foenum-graecum L. Chem Pharm Bull (Tokyo) 1997; 45(l)81–87
   PubMedGoogle Scholar
• Venkatesan N, Devaraj SN, Devaraj H. Increased binding of LDL and VLDL to apo B,E receptors of hepatic plasma membrane of rats treated with Fibernat. Eur J Nutr 2003; 42(5)262–271
   PubMed Web of Science ®Google Scholar
• Shishodia S, Aggarwal BB. Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression. Oncogene 3–9-2006; 25(10)1463–1473
   PubMed Web of Science ®Google Scholar
• Ruby BC, Gaskill SE, Slivka D, Harger SG. The addition of fenugreek extract (Trigonella foenum-graecum) to glucose feeding increases muscle glycogen resynthe-sis after exercise. Amino Acids 2005; 28(l)71–76
   PubMedGoogle Scholar
• Vats V, Yadav SP, Grover JK. Effect of T. foenumgraecum on glycogen content of tissues and the key enzymes of carbohydrate metabolism. J Ethnopharmacol 2003; 85(2-3)237–242
   PubMed Web of Science ®Google Scholar
• Yadav SK, Sehgal S. Effect of domestic processing and cooking methods on total, HC1 extractable iron and in vitro availability of iron in bathua and fenugreek leaves. Nutr Health 2003; 17(l)61–63
   PubMedGoogle Scholar
• Bartley GB, Hilty MD, Andreson BD, Clairmont AC, Maschke SP. “Maple-syrup” urine odor due to fenugreek ingestion. N Engl J Med 8–20-1981; 305(8)467
   PubMed Web of Science ®Google Scholar
• Topaloglu AK, Zeller WP, Andersen BD, et al. Maternal fenugreek ingestion simulating maple syrup urine odor in the infant. Ann Med Sci 1996; 5(l)41–42
   Google Scholar
• Singh UP, Singh DP, Maurya S, Maheshwari R, Singh M, Dubey RS, Singh RB. Investigation on the phenolics of some spices having pharmacotherapeuthic properties. J Herb Pharmacother 2004; 4(4)27–42
   PubMedGoogle Scholar
• Hooda S, Jood S. Physicochemical, rheological, andorganoleptic characteristics of wheat-fenugreek supplemented blends. Nahrung 2003; 47(4)265–268
   PubMedGoogle Scholar
• Ribes G, Sauvaire Y, Baccou JC, Valette G, Chenon D, Trimble ER, Loubatieres-Mariani MM. Effects of fenugreek seeds on endocrine pancreatic secretions in dogs. Ann Nutr Metab 1984; 28(l)37–43
   PubMedGoogle Scholar
• Ribes G, Sauvaire Y, Da Costa C, Baccou JC, Loubatieres-Mariani MM. Antidiabetic effects of subfractions from fenugreek seeds in diabetic dogs. Proc Soc Exp Biol Med 1986; 182(2)159–166
   PubMed Web of Science ®Google Scholar
• Sidhu GS, Oakenfull DG. A mechanism for the hypocholesterolaemic activity of saponins. Br J Nutr 1986; 55(3)643–649
   PubMed Web of Science ®Google Scholar
• Zhao HQ, Qu Y, Wang XY, Lu XY, Zhang XH, Hattori M. [Determination of trigonelline by HPLC and study on its pharmacokinetics]. Yao Xue Xue Bao 2003; 38(4)279–282
   PubMedGoogle Scholar
• Hooda S, Jood S. Nutritional evaluation of wheat-fenugreek blends for product making. Plant Foods Hum Nutr 2004; 59(4)149–154
   PubMed Web of Science ®Google Scholar
• Negi PS, Roy SK. Changes in beta-carotene and ascorbic acid content of fresh amaranth and fenugreek leaves during storage by low cost technique. Plant Foods Hum Nutr 2003; 58(3)225–230
   PubMed Web of Science ®Google Scholar
• Srinivasan K. Plant foods in the management of diabetes mellitus: Spices as beneficial antidiabetic food adjuncts. Int J Food Sci Nutr 2005; 56(6)399–414
   PubMed Web of Science ®Google Scholar
• Gupta A, Gupta R, Lai B. Effect of Trigonellafoenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: A double blind placebo controlled study. J Assoc Physicians India 2001; 49: 1057–1061
   PubMedGoogle Scholar
• Neeraja A, Pajyalakshmi P. Hypoglycemic effect of processed fenugreek seeds in humans. J Food Sci Technol 1996; 33(5)427–430
   Web of Science ®Google Scholar
• Sharma RD, Raghuram TC, Dayasagar Rao V. Hypolipidaemic effect of fenugreek seeds. Phytother Res 1991; 3(5)145–147, A clinical study
   Google Scholar
• Sowmya P, Rajyalakshmi P. Hypocholesterolemic effect of germinated fenugreek seeds in human subjects. Plant Foods Hum Nutr 1999; 53(4)359–365
   PubMed Web of Science ®Google Scholar