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Nucleosides, Nucleotides & Nucleic Acids Volume 35, 2016 - Issue 10-12: Proceedings of the 16th International Symposium on Purine and Pyrimidine Metabolism in Man (PP15)
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Mitochondrial purine and pyrimidine metabolism and beyond

Liya WangDepartment of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, SwedenCorrespondence[email protected]
Pages 578-594 | Received 29 Sep 2015, Accepted 17 Nov 2015, Published online: 01 Dec 2016

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Crossref
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