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Original Articles

Physiological Modeling of Age-Specific Changes in the Pharmacokinetics of Organic Chemicals in Children

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Pages 417-433 | Published online: 07 Jan 2011

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Read on this site (27)

Thomas Gastellu, Bruno Le Bizec & Gilles Rivière. (2023) Characterisation of the risk associated with chronic lifetime exposure to mixture of chemical hazards: case study of trace elements. Food Additives & Contaminants: Part A 40:8, pages 951-970.
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Linjing Deng, Hui Liu & Qihong Deng. (2021) Physiologically-based pharmacokinetic modeling of benzo(a)pyrene and the metabolite in humans of different ages. International Journal of Environmental Health Research 31:2, pages 202-214.
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Honesty Tohon, Andy Nong, Marjory Moreau, Mathieu Valcke & Sami Haddad. (2018) Reverse dosimetry modeling of toluene exposure concentrations based on biomonitoring levels from the Canadian health measures survey. Journal of Toxicology and Environmental Health, Part A 81:20, pages 1066-1082.
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Susan P. Felter, George P. Daston, Susan Y. Euling, Aldert H. Piersma & Melissa S. Tassinari. (2015) Assessment of health risks resulting from early-life exposures: Are current chemical toxicity testing protocols and risk assessment methods adequate?. Critical Reviews in Toxicology 45:3, pages 219-244.
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Sieto Bosgra, Jan van Eijkeren, Peter Bos, Marco Zeilmaker & Wout Slob. (2012) An improved model to predict physiologically based model parameters and their inter-individual variability from anthropometry. Critical Reviews in Toxicology 42:9, pages 751-767.
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ChadM. Thompson, DouglasO. Johns, Babasaheb Sonawane, HughA. Barton, Dale Hattis, Robert Tardif & Kannan Krishnan. (2009) Database for Physiologically Based Pharmacokinetic (PBPK) Modeling: Physiological Data for Healthy and Health-Impaired Elderly. Journal of Toxicology and Environmental Health, Part B 12:1, pages 1-24.
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Andrea N Edginton, Frank-Peter Theil, Walter Schmitt & Stefan Willmann. (2008) Whole body physiologically-based pharmacokinetic models: their use in clinical drug development. Expert Opinion on Drug Metabolism & Toxicology 4:9, pages 1143-1152.
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ChadM. Thompson, Babasaheb Sonawane, HughA. Barton, RobertS. DeWoskin, JohnC. Lipscomb, Paul Schlosser, WeihsuehA. Chiu & Kannan Krishnan. (2008) Approaches for Applications of Physiologically Based Pharmacokinetic Models in Risk Assessment. Journal of Toxicology and Environmental Health, Part B 11:7, pages 519-547.
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Michael Firestone, Babasaheb Sonawane, Stanley Barone, AndrewG. Salmon, JosephP. Brown, Dale Hattis & Tracey Woodruff . (2007) Potential New Approaches for Children's Inhalation Risk Assessment. Journal of Toxicology and Environmental Health, Part A 71:3, pages 208-217.
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MaryJaneK. Selgrade, CharlesG. Plopper, M. Ian Gilmour, RoryB. Conolly & BrendaS. P. Foos. (2007) Assessing The Health Effects and Risks Associated with Children's Inhalation Exposures—Asthma and Allergy. Journal of Toxicology and Environmental Health, Part A 71:3, pages 196-207.
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Katherine Walker, Dale Hattis, Abel Russ, Bob Sonawane & Gary Ginsberg. (2007) Approaches to Acrylamide Physiologically Based Toxicokinetic Modeling for Exploring Child–adult Dosimetry Differences. Journal of Toxicology and Environmental Health, Part A 70:24, pages 2033-2055.
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DeirdreA. Mahle, JefferyM. Gearhart, ClaudeC. Grigsby, DavidR. Mattie, HughA. Barton, JohnC. Lipscomb & RobertS. Cook. (2007) Age-Dependent Partition Coefficients for a Mixture of Volatile Organic Solvents in Sprague-Dawley Rats and Humans. Journal of Toxicology and Environmental Health, Part A 70:20, pages 1745-1751.
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Ahmad Mirfazaelian & JeffreyW. Fisher. (2007) Organ Growth Functions in Maturing Male Sprague-Dawley Rats Based on a Collective Database. Journal of Toxicology and Environmental Health, Part A 70:12, pages 1052-1063.
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RichardH. Luecke, BruceA. Pearce, WalterD. Wosilait, William Slikker$suffix/text()$suffix/text() & JohnF. Young. (2007) Postnatal Growth Considerations for PBPK Modeling. Journal of Toxicology and Environmental Health, Part A 70:12, pages 1027-1037.
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Ivan Nestorov. (2007) Whole-body physiologically based pharmacokinetic models. Expert Opinion on Drug Metabolism & Toxicology 3:2, pages 235-249.
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Ahmad Mirfazaelian, Kyu-Bong Kim, Sookwang Lee, HyoJ. Kim, JamesV. Bruckner & JeffreyW. Fisher. (2007) Organ Growth Functions in Maturing Male Sprague-Dawley Rats. Journal of Toxicology and Environmental Health, Part A 70:5, pages 429-438.
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MichaelG. Tyshenko, Jamie Benidickson, MichelleC. Turner, Lorraine Craig, Vic Armstrong, John Harrison & Daniel Krewski. (2007) Regulatory and Nonregulatory Strategies for Improving Children's Environmental Health in Canada. Journal of Toxicology and Environmental Health, Part B 10:1-2, pages 143-156.
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Sami Haddad, Ginette-Charest Tardif & Robert Tardif. (2006) Development of Physiologically Based Toxicokinetic Models for Improving the Human Indoor Exposure Assessment to Water Contaminants: Trichloroethylene and Trihalomethanes. Journal of Toxicology and Environmental Health, Part A 69:23, pages 2095-2136.
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JudyS. LaKind, RobertL. Brent, MichaelL. Dourson, Sam Kacew, Gideon Koren, Babasaheb Sonawane, AnitaJ. Tarzian & Kathleen Uhl. (2005) Human Milk Biomonitoring Data: Interpretation and Risk Assessment Issues. Journal of Toxicology and Environmental Health, Part A 68:20, pages 1713-1769.
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HughA. Barton. (2005) Computational Pharmacokinetics During Developmental Windows of Susceptibility. Journal of Toxicology and Environmental Health, Part A 68:11-12, pages 889-900.
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Kannan Krishnan, Gunnar Johanson . (2005) Physiologically-Based Pharmacokinetic and Toxicokinetic Models in Cancer Risk Assessment. Journal of Environmental Science and Health, Part C 23:1, pages 31-53.
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Gary L. Ginsberg, Brenda Perkovich Foos & Michael P. Firestone. (2005) Review and Analysis of Inhalation Dosimetry Methods for Application to Children’s Risk Assessment. Journal of Toxicology and Environmental Health, Part A 68:8, pages 573-615.
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Gary Ginsberg, Dale Hattis, Abel Russ & Babasaheb Sonawane. (2004) Physiologically Based Pharmacokinetic (PBPK) Modeling of Caffeine and Theophylline in Neonates and Adults: Implications for Assessing Children's Risks from Environmental Agents. Journal of Toxicology and Environmental Health, Part A 67:4, pages 297-329.
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Kannan Krishnan. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 47 55 .
. 2010. Mixture Toxicity. Mixture Toxicity 229 269 .
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Crossref
Charles Timchalk. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 1409 1433 .
R.A. Corley. 2010. Comprehensive Toxicology. Comprehensive Toxicology 27 58 .
Frederique Fenneteau, Patrick Poulin & Fahima Nekka. (2010) Physiologically Based Predictions of the Impact of Inhibition of Intestinal and Hepatic Metabolism on Human Pharmacokinetics of CYP3A Substrates. Journal of Pharmaceutical Sciences 99:1, pages 486-514.
Crossref
Marc-André VernerPierre AyotteGina MuckleMichel Charbonneau & Sami Haddad. (2009) A Physiologically Based Pharmacokinetic Model for the Assessment of Infant Exposure to Persistent Organic Pollutants in Epidemiologic Studies. Environmental Health Perspectives 117:3, pages 481-487.
Crossref
F. Bouzom & B. Walther. (2008) Pharmacokinetic predictions in children by using the physiologically based pharmacokinetic modelling. Fundamental & Clinical Pharmacology 22:6, pages 579-587.
Crossref
Marc-André Verner, Michel Charbonneau, Lizbeth López-Carrillo & Sami Haddad. (2008) Physiologically Based Pharmacokinetic Modeling of Persistent OrganicPollutants for Lifetime Exposure Assessment: A New Tool in Breast CancerEpidemiologic Studies. Environmental Health Perspectives 116:7, pages 886-892.
Crossref
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Charles Timchalk, Ahmed A. Kousba & Torka S. Poet. (2007) An Age-Dependent Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat. Toxicological Sciences 98:2, pages 348-365.
Crossref
Weihsueh A. Chiu, Hugh A. Barton, Robert S. DeWoskin, Paul Schlosser, Chad M. Thompson, Babasaheb Sonawane, John C. Lipscomb & Kannan Krishnan. (2007) Evaluation of physiologically based pharmacokinetic models for use in risk assessment. Journal of Applied Toxicology 27:3, pages 218-237.
Crossref
A. Nong, D.G. McCarver, R.N. Hines & K. Krishnan. (2006) Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: A case study with toluene. Toxicology and Applied Pharmacology 214:1, pages 78-87.
Crossref
C. Timchalk, T.S. Poet & A.A. Kousba. (2006) Age-dependent pharmacokinetic and pharmacodynamic response in preweanling rats following oral exposure to the organophosphorus insecticide chlorpyrifos. Toxicology 220:1, pages 13-25.
Crossref
Charles Timchalk. 2006. Toxicology of Organophosphate & Carbamate Compounds. Toxicology of Organophosphate & Carbamate Compounds 103 125 .
Trevor N. Johnson, Geoffrey T. Tucker, M. Stuart Tanner & Amin Rostami-Hodjegan. (2005) Changes in liver volume from birth to adulthood: A meta-analysis. Liver Transplantation 11:12, pages 1481-1493.
Crossref
Trevor N. Johnson. (2005) Modelling approaches to dose estimation in children. British Journal of Clinical Pharmacology 59:6, pages 663-669.
Crossref
Sven Bjorkman. (2005) Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs. British Journal of Clinical Pharmacology 59:6, pages 691-704.
Crossref
Klaus Abraham, Hans Mielke, Wilhelm Huisinga & Ursula Gundert-Remy. (2004) Elevated internal exposure of children in simulated acute inhalation of volatile organic compounds: effects of concentration and duration. Archives of Toxicology 79:2, pages 63-73.
Crossref
P. Gentry, Lynne Haber, Tracy McDonald, Qiyu Zhao, Tammie Covington, Patricia Nance, Harvey Clewell III, John Lipscomb & Hugh Barton. (2004) Data for Physiologically Based Pharmacokinetic Modeling in Neonatal Animals: Physiological Parameters in Mice and Sprague-Dawley Rats. Journal of Children's Health 2:3-4, pages 363-411.
Crossref
Gary Ginsberg, Dale Hattis & Babasaheb Sonawane. (2004) Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants. Toxicology and Applied Pharmacology 198:2, pages 164-183.
Crossref
Gary Ginsberg, Dale Hattis, Richard Miller & Babasaheb Sonawane. (2004) Pediatric Pharmacokinetic Data: Implications for Environmental Risk Assessment for Children. Pediatrics 113:Supplement_3, pages 973-983.
Crossref
David E. Leahy. (2004) Drug discovery information integration: virtual humans for pharmacokinetics. Drug Discovery Today: BIOSILICO 2:2, pages 78-84.
Crossref
. (2003) Literature Watch. Pediatric Endosurgery & Innovative Techniques 7:3, pages 345-351.
Crossref

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