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Journal of Toxicology and Environmental Health, Part A
Current Issues
Volume 71, 2008 - Issue 17: Integrated Disinfection By-Products Mixtures Research: Toxicology and Chemical Evaluation of Alternative Disinfection Treatment Scenarios
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Original Articles

Integrated Disinfection By-Products Mixtures Research: Assessment of Developmental Toxicity in Sprague-Dawley Rats Exposed to Concentrates of Water Disinfected by Chlorination and Ozonation/Postchlorination

Michael G. Narotsky Reproductive Toxicology Division, Correspondence[email protected]
,
Deborah S. Best Reproductive Toxicology Division,
,
Ellen H. Rogers Reproductive Toxicology Division,
,
Anthony McDonald Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
Yusupha M. Sey Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
&
Jane Ellen Simmons Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Pages 1216-1221 | Published online: 17 Jul 2008

Citations (22)

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Read on this site (7)

Chris S. Elcombe, Neil P. Evans & Michelle Bellingham. (2022) Critical review and analysis of literature on low dose exposure to chemical mixtures in mammalian in vivo systems. Critical Reviews in Toxicology 52:3, pages 221-238.
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Armindo Melo, Cláudia Ferreira, Isabel M.P.L.V.O. Ferreira & Catarina Mansilha. (2019) Acute and chronic toxicity assessment of haloacetic acids using Daphnia magna. Journal of Toxicology and Environmental Health, Part A 82:18, pages 977-989.
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Ezdihar Hassoun, Jacquelyn Cearfoss, Sukamto Mamada, Noor Al-Hassan, Michael Brown, Kevin Heimberger & Ming-Cheh Liu. (2014) The Effects of Mixtures of Dichloroacetate and Trichloroacetate on Induction of Oxidative Stress in Livers of Mice After Subchronic Exposure. Journal of Toxicology and Environmental Health, Part A 77:6, pages 313-323.
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Glenn Rice, LindaK. Teuschler, ThomasF. Speth, SusanD. Richardson, RichardJ. Miltner, KathleenM. Schenck, Chris Gennings, E. Sidney Hunter$suffix/text()$suffix/text(), MichaelG. Narotsky & Jane Ellen Simmons. (2008) Integrated Disinfection By-Products Research: Assessing Reproductive and Developmental Risks Posed by Complex Disinfection By-Product Mixtures. Journal of Toxicology and Environmental Health, Part A 71:17, pages 1222-1234.
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LarryD. Claxton, Rex Pegram, KathleenM. Schenck, Jane Ellen Simmons & SarahH. Warren. (2008) Integrated Disinfection By-Products Research: Salmonella Mutagenicity of Water Concentrates Disinfected by Chlorination and Ozonation/Postchlorination. Journal of Toxicology and Environmental Health, Part A 71:17, pages 1187-1194.
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SusanD. Richardson, AlfredD. Thruston$suffix/text()$suffix/text(), StuartW. Krasner, HowardS. Weinberg, RichardJ. Miltner, KathleenM. Schenck, MichaelG. Narotsky, A. Bruce McKague & Jane Ellen Simmons. (2008) Integrated Disinfection By-Products Mixtures Research: Comprehensive Characterization of Water Concentrates Prepared from Chlorinated and Ozonated/Postchlorinated Drinking Water. Journal of Toxicology and Environmental Health, Part A 71:17, pages 1165-1186.
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Jane Ellen Simmons, SusanD. Richardson, LindaK. Teuschler, RichardJ. Miltner, ThomasF. Speth, KathleenM. Schenck, E. Sidney Hunter$suffix/text()$suffix/text() & Glenn Rice. (2008) Research Issues Underlying the Four-Lab Study: Integrated Disinfection By-Products Mixtures Research. Journal of Toxicology and Environmental Health, Part A 71:17, pages 1125-1132.
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Articles from other publishers (15)

Li‐Tang Qin, Min Liu, Xin Zhang, Ling‐Yun Mo, Hong‐Hu Zeng & Yan‐Peng Liang. (2021) Concentration Addition, Independent Action, and Quantitative Structure–Activity Relationships for Chemical Mixture Toxicities of the Disinfection By products of Haloacetic Acids on the Green Alga Raphidocelis subcapitata . Environmental Toxicology and Chemistry 40:5, pages 1431-1442.
Crossref
R.S.H. Yang. 2018. Comprehensive Toxicology. Comprehensive Toxicology 489 518 .
Jane Ellen Simmons, Ingvar Eide, Glenn Rice & Paul Feder. 2018. Chemical Mixtures and Combined Chemical and Nonchemical Stressors. Chemical Mixtures and Combined Chemical and Nonchemical Stressors 335 366 .
Shahid Parvez, Glenn E. Rice, Linda K. Teuschler, Jane Ellen Simmons, Thomas F. Speth, Susan D. Richardson, Richard J. Miltner, E. Sidney HunterIIIIII, Jonathan G. Pressman, Lillian F. Strader, Gary R. Klinefelter, Jerome M. Goldman & Michael G. Narotsky. (2017) Method to assess component contribution to toxicity of complex mixtures: Assessment of puberty acquisition in rats exposed to disinfection byproducts. Journal of Environmental Sciences 58, pages 311-321.
Crossref
Cristina M. Villanueva, Sylvaine Cordier, Laia Font-Ribera, Lucas A. Salas & Patrick Levallois. (2015) Overview of Disinfection By-products and Associated Health Effects. Current Environmental Health Reports 2:1, pages 107-115.
Crossref
Bonnie A. Lyon, Rebecca Y. Milsk, Anthony B. DeAngelo, Jane Ellen Simmons, Mary P. Moyer & Howard S. Weinberg. (2014) Integrated Chemical and Toxicological Investigation of UV-Chlorine/Chloramine Drinking Water Treatment. Environmental Science & Technology 48:12, pages 6743-6753.
Crossref
Ezdihar A. Hassoun, Jacquelyn Cearfoss, Brian Musser, Sarah Krispinsky, Noor Al‐Hassan & Ming‐Cheh Liu. (2013) The Induction of Phagocytic Activation by Mixtures of the Water Chlorination By‐Products, Dichloroacetate‐ and Trichloroacetate, in Mice after Subchronic Exposure. Journal of Biochemical and Molecular Toxicology 27:4, pages 237-242.
Crossref
Robert Y. S. Cheng & Wan‐yee Tang. 2012. Toxicology and Epigenetics. Toxicology and Epigenetics 5 24 .
Michael G. Narotsky, Jonathan G. Pressman, Richard J. Miltner, Thomas F. Speth, Linda K. Teuschler, Glenn E. Rice, Susan D. Richardson, Deborah S. Best, Anthony McDonald, E. Sidney HunterIIIIII & Jane Ellen Simmons. (2012) Developmental Toxicity Evaluations of Whole Mixtures of Disinfection By‐products using Concentrated Drinking Water in Rats: Gestational and Lactational Effects of Sulfate and Sodium. Birth Defects Research Part B: Developmental and Reproductive Toxicology 95:3, pages 202-212.
Crossref
Eileen A. MurphyGloria B. Post, Brian T. BuckleyRobert L. Lippincott & Mark G. Robson. (2012) Future Challenges to Protecting Public Health from Drinking-Water Contaminants. Annual Review of Public Health 33:1, pages 209-224.
Crossref
Cheryl A. Dingus, Linda K. Teuschler, Glenn E. Rice, Jane Ellen Simmons & Michael G. Narotsky. (2011) Prospective Power Calculations for the Four Lab Study of A Multigenerational Reproductive/Developmental Toxicity Rodent Bioassay Using A Complex Mixture of Disinfection By-Products in the Low-Response Region. International Journal of Environmental Research and Public Health 8:10, pages 4082-4101.
Crossref
Michael G. Narotsky, Deborah S. Best, Anthony McDonald, Elizabeth A. Godin, E. Sidney HunterIIIIII & Jane Ellen Simmons. (2011) Pregnancy loss and eye malformations in offspring of F344 rats following gestational exposure to mixtures of regulated trihalomethanes and haloacetic acids. Reproductive Toxicology 31:1, pages 59-65.
Crossref
Jane Ellen Simmons & Linda K. Teuschler. 2010. Principles and Practice of Mixtures Toxicology. Principles and Practice of Mixtures Toxicology 401 419 .
C. G. Daughton. 2010. Contaminants of Emerging Concern in the Environment: Ecological and Human Health Considerations. Contaminants of Emerging Concern in the Environment: Ecological and Human Health Considerations 9 68 .
R.S.H. Yang. 2010. Comprehensive Toxicology. Comprehensive Toxicology 179 202 .

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