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Journal of Toxicology and Environmental Health, Part A
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Volume 74, 2011 - Issue 12
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Original Articles

Hepatotoxicity and Nephrotoxicity Produced by 4-Hydroxy-2-Nonenal (4-HNE) Following 4-Week Oral Administration to Sprague-Dawley Rats

Se Chan Kang Department of Natural Product Resources, Semyung University, Jecheon, South Korea
,
Hyun-Woo Kim Department of Natural Product Resources, Semyung University, Jecheon, South Korea
,
Kyu Bong Kim Department of Pharmaceutical Engineering, Inje University, 607 Obang-dong, Gimhae, Gyeongnam, 621-749, South Korea
,
Seung Jun Kwack National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, Seoul, Korea
,
Il Young Ahn Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
,
Jung Yun Bae Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
,
Seoung Kwang Lim Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
&
Byung Mu Lee Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, South KoreaCorrespondence[email protected]
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Pages 779-789 | Received 27 Oct 2010, Accepted 01 Dec 2010, Published online: 02 May 2011

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Dong Hyun Kim, Seung Jun Kwack, Kyung Sik Yoon, Jin Shil Choi & Byung-Mu Lee. (2015) 4-Hydroxynonenal: A Superior Oxidative Biomarker Compared to Malondialdehyde and Carbonyl Content Induced by Carbon Tetrachloride in Rats. Journal of Toxicology and Environmental Health, Part A 78:16, pages 1051-1062.
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Seung Jun Kwack, Seon-Gil Do, Young Woo Kim, Yeon-Joo Kim, Hyo-Min Gwak, Hyun Jong Park, Taehyun Roh, Min Kyung Shin, Seong Kwang Lim, Hyung Sik Kim & Byung-Mu Lee. (2014) The No-Observed-Adverse-Effect Level (NOAEL) of Baby Aloe Powder (BAP) for Nutraceutical Application Based Upon Toxicological Evaluation. Journal of Toxicology and Environmental Health, Part A 77:22-24, pages 1319-1331.
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Articles from other publishers (10)

Yi-ni Cao, Shan-shan Yue, An-yi Wang, Lu Xu, Yi-tong Hu, Xue Qiao, Tung-Ying Wu, Min Ye, Yang-Chang Wu & Rong Qi. (2022) Antrodia cinnamomea and its compound dehydroeburicoic acid attenuate nonalcoholic fatty liver disease by upregulating ALDH2 activity. Journal of Ethnopharmacology 292, pages 115146.
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Julia Keller, Sylvie Chevolleau, Maria-Helena Noguer-Meireles, Estelle Pujos-Guillot, Mylène Delosière, Céline Chantelauze, Charlotte Joly, Florence Blas-y-Estrada, Isabelle Jouanin, Denys Durand, Fabrice Pierre, Laurent Debrauwer, Vassilia Theodorou & Françoise Guéraud. (2020) Heme-Iron-Induced Production of 4-Hydroxynonenal in Intestinal Lumen May Have Extra-Intestinal Consequences through Protein-Adduct Formation. Antioxidants 9:12, pages 1293.
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Xuxia Zhou, Zhiwen Zhang, Xiaoying Liu, Di Wu, Yuting Ding, Guoliang Li & Yongning Wu. (2020) Typical reactive carbonyl compounds in food products: Formation, influence on food quality, and detection methods. Comprehensive Reviews in Food Science and Food Safety 19:2, pages 503-529.
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Jeroen F.J. Bogie, Mansour Haidar, Gijs Kooij & Jerome J.A. Hendriks. (2020) Fatty acid metabolism in the progression and resolution of CNS disorders. Advanced Drug Delivery Reviews 159, pages 198-213.
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A. Saari Csallany, I. Han, D. W. Shoeman, C. Chen & Jieyao Yuan. (2015) 4-Hydroxynonenal (HNE), a Toxic Aldehyde in French Fries from Fast Food Restaurants. Journal of the American Oil Chemists' Society 92:10, pages 1413-1419.
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Rudolf Schaur, Werner Siems, Nikolaus Bresgen & Peter Eckl. (2015) 4-Hydroxy-nonenal—A Bioactive Lipid Peroxidation Product. Biomolecules 5:4, pages 2247-2337.
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Julia Keller, Maryse Baradat, Isabelle Jouanin, Laurent Debrauwer & Françoise Guéraud. (2015) “Twin peaks”: Searching for 4-hydroxynonenal urinary metabolites after oral administration in rats. Redox Biology 4, pages 136-148.
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Umesh Chand Singh Yadav. 2015. Free Radicals in Human Health and Disease. Free Radicals in Human Health and Disease 119 129 .
Bharat Aggarwal & David HeberDavid Heber & Bharat Aggarwal. 2014. Immunonutrition. Immunonutrition 19 38 .
Umesh C. S. Yadav & Kota V. Ramana. (2013) Regulation of NF-B-Induced Inflammatory Signaling by Lipid Peroxidation-Derived Aldehydes. Oxidative Medicine and Cellular Longevity 2013, pages 1-11.
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