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Original Articles

Sodium Fluoride Promotes Apoptosis by Generation of Reactive Oxygen Species in Human Lymphocytes

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Pages 1269-1280 | Received 29 Mar 2014, Accepted 23 May 2014, Published online: 30 Sep 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Giovana Wagner Branda Drummond, Wilton Mitsunari Takeshita, Glaucia Monteiro de Castro, Jean Nunes dos Santos, Patricia Ramos Cury, Ana Claudia Muniz Renno & Daniel Araki Ribeiro. (2023) Could fluoride be considered a genotoxic chemical agent in vivo? A systematic review with meta-analysis. International Journal of Environmental Health Research 0:0, pages 1-14.
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Lucila Álvarez-Barrera, Juan J. Rodríguez-Mercado, Michel López-Chaparro & Mario A. Altamirano-Lozano. (2017) Genotoxicity of Casiopeina III-Ea in mouse bone marrow cells. Drug and Chemical Toxicology 40:3, pages 333-338.
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Ankit Verma, Daoud Ali & Anumesh K. Pathak. (2017) Fluoride induces DNA damage and cytotoxicity in human hepatocellular carcinoma cells. Toxicological & Environmental Chemistry 99:1, pages 148-159.
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Qi Xiong, Qin Ru, Lin Chen, Kai Yue, Xiang Tian, Baomiao Ma, Lu Liu, Rihui Wu, Congyue Xu, Mingshan Pi & Chaoying Li. (2015) Combined Effects of Fine Particulate Matter and Lipopolysaccharide on Apoptotic Responses in NR8383 Macrophages. Journal of Toxicology and Environmental Health, Part A 78:7, pages 443-452.
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Articles from other publishers (28)

Entsar R. Abd-Allah & Heba Ali Abd El-Rahman. (2023) Ameliorative effects of nano Moringa on fluoride-induced testicular damage via down regulation of the StAR gene and altered steroid hormones. Reproductive Biology 23:1, pages 100724.
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Priyanka Sharma, Pawan Kumar Verma, Shilpa Sood, Maninder Singh & Deepika Verma. (2022) Impact of Chronic Sodium Fluoride Toxicity on Antioxidant Capacity, Biochemical Parameters, and Histomorphology in Cardiac, Hepatic, and Renal Tissues of Wistar Rats. Biological Trace Element Research 201:1, pages 229-241.
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Hao Ju, Siyuan Chen, Yajie Xue, Xiaodong Zhang & Yongxia Wang. (2021) The role of Nrf2 pathway in alleviating fluorine-induced apoptosis by different selenium sources in the chicken duodenum and jejunum. Ecotoxicology and Environmental Safety 224, pages 112708.
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Apoorva H. Nagendra, Bipasha Bose & Sudheer Shenoy P. (2021) Recent advances in cellular effects of fluoride: an update on its signalling pathway and targeted therapeutic approaches. Molecular Biology Reports 48:7, pages 5661-5673.
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Sedat Çetin, Ayşe Usta & Veysel Yüksek. (2020) The Effect of Lycopene on DNA Damage and Repair in Fluoride-Treated NRK-52E Cell Line. Biological Trace Element Research 199:5, pages 1979-1985.
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Valentin P. Volobaev, Ekaterina S. Lytkina, Ekaterina A. Schetnikova, Evgenia D. Vdovina, Ekaterina E. Mikheeva, Elena B. Gurevich, Elena P. Mishchenko & Alexey V. Larionov. (2021) The frequency of chromosomal aberrations in individuals chronically in contact with excess dosages of fluorides. Ecological genetics 19:1, pages 59-66.
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Didong Lou, Yan Luo, Jing Liu, Dan Zheng, Rongrong Ma, Fangping Chen, Yanni Yu & Zhizhong Guan. (2020) Refinement Impairments of Verbal-Performance Intelligent Quotient in Children Exposed to Fluoride Produced by Coal Burning. Biological Trace Element Research 199:2, pages 482-489.
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Nikhil Maheshwari, Neha Qasim, Ruhi Anjum & Riaz Mahmood. (2021) Fluoride enhances generation of reactive oxygen and nitrogen species, oxidizes hemoglobin, lowers antioxidant power and inhibits transmembrane electron transport in isolated human red blood cells. Ecotoxicology and Environmental Safety 208, pages 111611.
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V. P. Volobaev, E. S. Serdyukova, E. E. Kalyuzhnaya, E. A. Schetnikova, A. D. Korotkova, A. A. Naik, S. N. Bach, A. Y. Prosekov & A. V. Larionov. (2020) Investigation of the genotoxic effects of fluoride on a bone tissue model. Toxicological Research 36:4, pages 337-342.
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Е.Э. E. Калюжная, А.Ю. Yu. Просеков & Валентин Павлович Волобаев. (2020) Genotoxic properties of fluorines (review). Hygiene and sanitation 99:3, pages 253-258.
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E. E. Kalyuzhnaya, A. Yu. Prosekov & Valentin P. Volobaev. (2020) GENOTOXIC PROPERTIES OF FLUORINES (REVIEW). Hygiene and sanitation 99:3, pages 253-258.
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Nichole R. Johnston & Scott A. Strobel. (2020) Principles of fluoride toxicity and the cellular response: a review. Archives of Toxicology 94:4, pages 1051-1069.
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Adnan KİRMİT, Mehmet İrfan YEŞİLNACAR, Metin ÇALIŞIR, İbrahim BAYHAN & Hakim ÇELİK. (2020) Oxidative stress, DNA damage and apoptosis levels in those who use borderline high level fluoride content drinking waterSınırda Yüksek Düzeyde Florid İçeren İçme Suyu Kullananlarda Oksidatif Stres, DNA Hasarı ve Apoptoz Düzeyleri. Journal of Contemporary Medicine 10:1, pages 45-50.
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Chen Liang, Yan Gao, Yuyang He, Yongli Han, Ram Kumar Manthari, Chiranjeevi Tikka, Chenkai Chen, Jundong Wang & Jianhai Zhang. (2020) Fluoride induced mitochondrial impairment and PINK1-mediated mitophagy in Leydig cells of mice: In vivo and in vitro studies. Environmental Pollution 256, pages 113438.
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Mohammad Mahdi Eftekharian, Alireza Komaki, Vahid Kholghi Oskooie, Amir Namvar, Mohammad Taheri & Soudeh Ghafouri-Fard. (2019) Assessment of Apoptosis Pathway in Peripheral Blood of Autistic Patients. Journal of Molecular Neuroscience 69:4, pages 588-596.
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Xiaobo Xu, Wen Chen, Mei Yang, Xian-Jun Liu, Fenglin Wang, Ru-Qin Yu & Jian-Hui Jiang. (2019) Mitochondrial-targeted near-infrared fluorescence probe for selective detection of fluoride ions in living cells. Talanta 204, pages 655-662.
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Mónica I. Jiménez-Córdova, Carmen González-Horta, Julio C. Ayllón-Vergara, Laura Arreola-Mendoza, Guadalupe Aguilar-Madrid, Efraín E. Villareal-Vega, Ángel Barrera-Hernández, Olivier C. Barbier & Luz M. Del Razo. (2019) Evaluation of vascular and kidney injury biomarkers in Mexican children exposed to inorganic fluoride. Environmental Research 169, pages 220-228.
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Pingjing Wen, Xiaomin Wei, Guiqiang Liang, Yanfei Wang, Yiping Yang, Lilin Qin, Weiyi Pang, Guangqiu Qin, Hai Li, Yueming Jiang & Qijun Wu. (2018) Long-term exposure to low level of fluoride induces apoptosis via p53 pathway in lymphocytes of aluminum smelter workers. Environmental Science and Pollution Research 26:3, pages 2671-2680.
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Qi Xiong, Qin Ru, Xiang Tian, Mei Zhou, Lin Chen, Yi Li & Chaoying Li. (2018) Krill oil protects PC12 cells against methamphetamine-induced neurotoxicity by inhibiting apoptotic response and oxidative stress. Nutrition Research 58, pages 84-94.
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Magdalena Kimsa-Dudek, Agnieszka Synowiec-Wojtarowicz, Małgorzata Derewniuk, Stanisław Gawron, Monika Paul-Samojedny, Celina Kruszniewska-Rajs & Katarzyna Pawłowska-Góral. (2018) Impact of fluoride and a static magnetic field on the gene expression that is associated with the antioxidant defense system of human fibroblasts. Chemico-Biological Interactions 287, pages 13-19.
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Luqing Liu, Xiuli Chang, Yubin Zhang, Chunhua Wu, Rui Li, Liming Tang & Zhijun Zhou. (2018) Fluorochloridone induces primary cultured Sertoli cells apoptosis: Involvement of ROS and intracellular calcium ions-mediated ERK1/2 activation. Toxicology in Vitro 47, pages 228-237.
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Hongrui Guo, Ping Kuang, Qin Luo, Hengmin Cui, Huidan Deng, Huan Liu, Yujiao Lu, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang & Ling Zhao. (2017) Effects of sodium fluoride on blood cellular and humoral immunity in mice. Oncotarget 8:49, pages 85504-85515.
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Daniel Araki Ribeiro, Veronica Quispe Yujra, Victor Hugo Pereira da Silva, Samuel Rangel Claudio, Debora Estadella, Milena de Barros Viana & Celina Tizuko Fujiyama Oshima. (2017) Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review. Environmental Science and Pollution Research 24:18, pages 15254-15259.
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F.D. Campos-Pereira, L. Lopes-Aguiar, F.L. Renosto, G.A.S. Nogueira, E.F.D. Costa, R. Barbieri Pulz, E.C.M. Silva-Zacarin, C.A. Oliveira, A.A. Pigoso & G.D.C. Severi-Aguiar. (2017) Genotoxic effect and rat hepatocyte death occurred after oxidative stress induction and antioxidant gene downregulation caused by long term fluoride exposure. Chemico-Biological Interactions 264, pages 25-33.
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Huidan Deng, Ping Kuang, Hengmin Cui, Lian Chen, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang & Ling Zhao. (2016) Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice. Oncotarget 7:42, pages 67880-67900.
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Jie Wu, Ming Cheng, Qiufang Liu, Jinghua Yang, Shengwen Wu, Xiaobo Lu, Cuihong Jin, Honglin Ma & Yuan Cai. (2015) Protective Role of tert-Butylhydroquinone Against Sodium Fluoride-Induced Oxidative Stress and Apoptosis in PC12 Cells. Cellular and Molecular Neurobiology 35:7, pages 1017-1025.
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