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Part one: Introduction

Ozone: An overview of its toxicity in man and animals

Pages 181-204 | Published online: 20 Oct 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (29)

Jens J. Thiele, Frank Dreher & Lester Packer. (2002) Antioxidant defense systems in skin. Journal of Toxicology: Cutaneous and Ocular Toxicology 21:1-2, pages 119-160.
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Claudia Dorado-Martínez, Cristina Paredes-carbajal, Dieter Mascher, Gabino Borgonio-Pérez & Selva Rivas-arancibia. (2001) Effects of Different Ozone Doses on Memory, Motor Activity and Lipid Peroxidation Levels, in Rats. International Journal of Neuroscience 108:3-4, pages 149-161.
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Monique Saintot, Nadine Bernard, Cécile Astre, Mariette Gerber & Inserm-crlc. (1999) Ozone Exposure and Blood Antioxidants: A Study in a Periurban Area in Southern France. Archives of Environmental Health: An International Journal 54:1, pages 34-39.
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B. J. Finlayson-Pitts T. T. H. Pham C. C. Lai S. N. Johnson L. L. Lucio-Gough J. Mestas D. Iwig. (1998) THERMAL DECOMPOSITION OF PHOSPHOLIPID SECONDARY OZONIDES: IMPLICATIONS FOR THE TOXICITY OF INHALED OZONE. Inhalation Toxicology 10:8, pages 813-830.
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Corinne G. Wong, Mojgan Bonakdar, Michael T. Kleinman, Judith Chow & Deepak K. Bhalla. (1994) Elevation of Stress-Inducible Heat Shock Protein 70 in the Rat Lung After Exposure to Ozone and Particle-Containing Atmospheres. Inhalation Toxicology 6:5, pages 501-514.
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Richard B. Schlesinger, Hassan A. N. El-fawal, Judith T. Zelikoff, John E. Gorczynski, Timothy Mcgovern, Christine E. Nadziejko & Lung Chi Chen. (1994) Pulmonary Effects of Repeated Episodic Exposures to Nitric Acid Vapor Alone and in Combination with Ozone. Inhalation Toxicology 6:1, pages 21-41.
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Nancy B. Beck, Jane Q. Koenig, Daniel L. Luchtel, Leonard C. Altman, Mack T. Orsborn & John S. Kenney. (1994) Ozone Can Increase the Expression of Intercellular Adhesion Molecule-1 and the Synthesis of Cytokines by Human Nasal Epithelial Cells. Inhalation Toxicology 6:4, pages 345-357.
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B. J. Finlayson-pitts, W. J. Mautz, C. C. Lai, C. Bufalino, K. Messer, J. Mestas, H. Koch & L. Lucio. (1994) Are Changes in Breathing Pattern on Exposure to Ozone Related to Changes in Pulmonary Surfactant?. Inhalation Toxicology 6:3, pages 267-287.
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Nicole C. Paquette, Clarke G. Tankersley, Liu-Yi Zhang & Steven R. Kleeberger. (1994) Repeated Subacute Ozone Exposure of Inbred Mice: Airway Inflammation and Ventilation. Experimental Lung Research 20:6, pages 579-594.
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Kenneth Donaldson, Geraldine M. Brown, David M. Brown, Joan Slight, William Maclaren & John M. G. Davis. (1993) Characteristics of Bronchoalveolar Leukocytes from the Lungs of Rats Inhaling 0.2–0.8 ppm OF Ozone. Inhalation Toxicology 5:1, pages 149-164.
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Craig E. Smith, Hillel S. Koren, Delores G. Graham & David A. Johnson. (1993) Mast Cell Tryptase is Increased in the Nasal and Bronchoalveolar Lavage Fluids of Humans after Ozone Exposure. Inhalation Toxicology 5:1, pages 117-127.
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Matthew Ian Gilmour, Patricia Park, Donald Doerfler & Maryjane K. Selgrade. (1993) Factors that Influence the Suppression of Pulmonary Antibacterial Defenses in Mice Exposed to Ozone. Experimental Lung Research 19:3, pages 299-314.
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Donata Mayer & Detlev Branscheid. (1992) Exposure of human lung fibroblasts to ozone: Cell mortality and hyaluronan metabolism. Journal of Toxicology and Environmental Health 35:4, pages 235-246.
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Matthew I. Gilmour & George J. Jakab. (1991) Modulation of Immune Function in Mice Exposed to 0.8 PPM Ozone. Inhalation Toxicology 3:3, pages 293-308.
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Richard B. Schlesinger, Patricia A. Weideman & Judith T. Zelikoff. (1991) Effects of Repeated Exposures to Ozone and Nitrogen Dioxide on Respiratory Tract Prostanoids. Inhalation Toxicology 3:1, pages 27-36.
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Matthew I. Gilmour, Robert R. Hmieleski, Elizabeth A. Stafford & George J. Jakab. (1991) Suppression and Recovery of the Alveolar Macrophage Phagocytic System during Continuous Exposure to 0.5 ppm Ozone. Experimental Lung Research 17:3, pages 547-558.
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RichardB. Schlesinger, KevinE. Driscoll, AlbertF. Gunnison & JudithT. Zelikoff. (1990) Pulmonary arachidonic acid metabolism following acute exposures to ozone and nitrogen dioxide. Journal of Toxicology and Environmental Health 31:4, pages 275-290.
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J.J. Steinberg, JanetL. Gleeson & Dan Gil. (1990) The Pathobiology of Ozone-Induced Damage. Archives of Environmental Health: An International Journal 45:2, pages 80-87.
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ClaudiaR. Turner, StevenR. Kleeberger & ErnstW. Spannhake. (1989) Preexposure to ozone blocks the antigen‐induced late asthmatic response of the canine peripheral airways. Journal of Toxicology and Environmental Health 28:3, pages 363-371.
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StevenR. Kleeberger, John Kolbe, Claudia Turner & ErnstW. Spannhake. (1989) Exposure to 1 ppm ozone attenuates the immediate antigenic response of canine peripheral airways. Journal of Toxicology and Environmental Health 28:3, pages 349-362.
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David B. Warheit. (1989) Interspecies Comparisons of Lung Responses to Inhaled Particles and Gases. Critical Reviews in Toxicology 20:1, pages 1-29.
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Amis Richters. (1988) Effects of nitrogen dioxide and ozone on blood‐borne cancer cell colonization of the lungs. Journal of Toxicology and Environmental Health 25:3, pages 383-390.
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I. M. C. M. Rietjens, J. A. M. A. Dormans, P. J. A. Rombout & L. van Bree. (1988) Qualitative and quantitative changes in cytochrome p‐450‐dependent xenobiotic metabolism in pulmonary microsomes and isolated clara cell populations derived from ozone‐exposed rats. Journal of Toxicology and Environmental Health 24:4, pages 515-531.
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C.S. Stevens. (1987) Ozone Episodes and Related Vehicle Pollutant Emission Ratios in the Greater Johannesburg Area. South African Geographical Journal 69:2, pages 107-118.
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I. M. C. M. Rietjens, C. A. M. van Tilburg, T. M. M. Coenen, G. M. Alink & A. W. T. Konings. (1987) Influence of polyunsaturated fatty acid supplementation and membrane fluidity on ozone and nitrogen dioxide sensitivity of rat alveolar macrophages. Journal of Toxicology and Environmental Health 21:1-2, pages 45-56.
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KevinE. Driscoll, ThomasA. Vollmuth & RichardB. Schlesinger. (1987) Acute and subchronic ozone inhalation in the rabbit: Response of alveolar macrophages. Journal of Toxicology and Environmental Health 21:1-2, pages 27-43.
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RichardB. Schlesinger & KevinE. Driscoll. (1987) Mucociuary clearance from the lungs of rabbits following single and intermittent exposures to ozone. Journal of Toxicology and Environmental Health 20:1-2, pages 125-134.
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PhilipA. Bromberg. (1984) Introduction. Journal of Toxicology and Environmental Health 13:2-3, pages 295-299.
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Siegfried Schulz, Ulrich Häussler, Robert Mandic, Johannes T. Heverhagen, Andreas Neubauer, Anja A. Dünne, Jochen A. Werner, Eberhard Weihe & Michael Bette. (2008) Treatment with ozone/oxygen‐pneumoperitoneum results in complete remission of rabbit squamous cell carcinomas. International Journal of Cancer 122:10, pages 2360-2367.
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Brian J. Millar & Nicholas Hodson. (2007) Assessment of the safety of two ozone delivery devices. Journal of Dentistry 35:3, pages 195-200.
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Reinhard A. Hirt, Katerina Vondrakova, Abigail Guija de Arespacochaga, Andrea Gütl & René van den Hoven. (2007) Effects of cadmium chloride inhalation on airflow limitation to histamine, carbachol and adenosine 5′-monophosphate assessed by barometric whole body plethysmography in healthy dogs. The Veterinary Journal 173:1, pages 62-72.
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Rebecca Z. Sokol, Peter Kraft, Ian M. Fowler, Rizvan Mamet, Elizabeth Kim & Kiros T. Berhane. (2006) Exposure to Environmental Ozone Alters Semen Quality. Environmental Health Perspectives 114:3, pages 360-365.
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William J. Mautz & Michael R. Dohm. (2004) Respiratory and behavioral effects of ozone on a lizard and a frog. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 139:3, pages 371-377.
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