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Original Articles

The mutagenicities of seven coumarin derivatives and a furan derivative (nimbolide) isolated from three medicinal plants

Pages 521-530 | Received 13 Jun 1983, Accepted 19 Sep 1983, Published online: 20 Oct 2009

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Vinod Vijayan, Pramod Kumar Tiwari & Ghansham Pundilikji Meshram. (2013) Inhibitory effects of neem seed oil and its extract on various direct acting and activation-dependant mutagens-induced bacterial mutagenesis. Pharmaceutical Biology 51:12, pages 1525-1530.
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Ifeoma C. Ezenyi, Jersley D. Chirawurah, Nekpen Erhunse, Prakhar Agrawal, Dinkar Sahal & John O. Igoli. (2023) Marmesin isolated from Celtis durandii Engl. root bioactive fraction inhibits β-hematin formation and contributes to antiplasmodial activity. Journal of Ethnopharmacology 317, pages 116804.
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Emmanuel Kofi Kumatia, Felix Kwame Zoiku, Alex Asase & Nguyen Huu Tung. (2023) Anti-malarial activity of the alkaloid, heptaphylline, and the furanocoumarin, imperatorin, from Clausena anisata against human Plasmodium falciparum malaria parasites: ex vivo trophozoitocidal, schizonticidal and gametocytocidal approach. Malaria Journal 22:1.
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Siddavaram Nagini, Ramesh Nivetha, Manikandan Palrasu & Rajakishore Mishra. (2021) Nimbolide, a Neem Limonoid, Is a Promising Candidate for the Anticancer Drug Arsenal. Journal of Medicinal Chemistry 64:7, pages 3560-3577.
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Figueroa-Valverde Lauro, Rosas-Nexticapa Marcela, Lopez-Ramos Maria, Diaz Cedillo Francisco, Garcimarero-Espino E. Alejandra, Mateu-Armand Virginia & Ortiz-Ake Yazmin. (2020) Design and synthesis of a new furan-steroid-propanone derivative using some chemical strategies. Steroids 160, pages 108654.
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Adeoye Adeniyi, Alex Asase, Patrick K. Ekpe, Bismark K. Asitoakor, Anthony Adu-Gyamfi & Prosper Y. Avekor. (2018) Ethnobotanical study of medicinal plants from Ghana; confirmation of ethnobotanical uses, and review of biological and toxicological studies on medicinal plants used in Apra Hills Sacred Grove. Journal of Herbal Medicine 14, pages 76-87.
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Roman Pavela, Filippo Maggi, Giulio Lupidi, Hélène Mbuntcha, Verlaine Woguem, Hilaire Macaire Womeni, Luciano Barboni, Léon Azefack Tapondjou & Giovanni Benelli. (2017) Clausena anisata and Dysphania ambrosioides essential oils: from ethno-medicine to modern uses as effective insecticides. Environmental Science and Pollution Research 25:11, pages 10493-10503.
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Ashutosh Sharma, Rosario del Carmen Flores-Vallejo, Alexandre Cardoso-Taketa & María Luisa Villarreal. (2017) Antibacterial activities of medicinal plants used in Mexican traditional medicine. Journal of Ethnopharmacology 208, pages 264-329.
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Emmanuel Kofi Kumatia, Kofi Annan, Rita Akosua Dickson, Abraham Yeboah Mensah, Isaac Kingsley Amponsah, Alfred A. Appiah, Nguyen Hu Tung, Dominic Adotey Edoh & Solomon Habtemariam. (2017) Anti-inflammatory and Analgesic Effects in Rodent Models of Ethanol Extract of Clausena anisata Roots and their Chemical Constituents . Natural Product Communications 12:1, pages 1934578X1701200.
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Lingzhi Wang, Do Dang Khoa Phan, Jingwen Zhang, Pei-Shi Ong, Win Lwin Thuya, Ross Soo, Andrea Li-Ann Wong, Wei Peng Yong, Soo Chin Lee, Paul Chi-Lui Ho, Gautam Sethi & Boon Cher Goh. (2016) Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development. Oncotarget 7:28, pages 44790-44802.
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Simplice Joel Ndendoung Tatsimo, Jean-De-Dieu Tamokou, Marc Lamshöft, Ferdinand Talontsi Mouafo, Alain Meli Lannang, Prodipta Sarkar, Prasanta Kumar Bag & Michael Spiteller. (2014) LC-MS guided isolation of antibacterial and cytotoxic constituents from Clausena anisata. Medicinal Chemistry Research 24:4, pages 1468-1479.
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Mengqiang Liu, Minshan Hu, Qian Jiang, Zhiyun Lu, Yan Huang, Yanfei Tan & Qing Jiang. (2015) A novel coumarin derivative as a sensitive probe for tracing intracellular pH changes. RSC Advances 5:21, pages 15778-15783.
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Qin-Gang Tan & Xiao-Dong Luo. (2011) Meliaceous Limonoids: Chemistry and Biological Activities. Chemical Reviews 111:11, pages 7437-7522.
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V. Vinod, P.K. Tiwari & G.P. Meshram. (2011) Evaluation of mutagenic and antimutagenic activities of neem (Azadirachta indica) seed oil in the in vitro Ames Salmonella/microsome assay and in vivo mouse bone marrow micronucleus test. Journal of Ethnopharmacology 134:3, pages 931-937.
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Carolien J. P. van den Bout-van den Beukel, Omar J. M. Hamza, Mainen J. Moshi, Mecky I. N. Matee, Frans Mikx, David M. Burger, Peter P. Koopmans, Paul E. Verweij, Willem G. E. J. Schoonen & André J. A. M. van der Ven. (2008) Evaluation of Cytotoxic, Genotoxic and CYP450 Enzymatic Competition Effects of Tanzanian Plant Extracts Traditionally Used for Treatment of Fungal Infections. Basic & Clinical Pharmacology & Toxicology 102:6, pages 515-526.
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Hyun‐Ock Pae, Hyuncheol Oh, Young‐Gab Yun, Gi‐Su Oh, Seon Il Jang, Kee‐Myoung Hwang, Tae‐Oh Kwon, Ho‐Sub Lee & Hun‐Taeg Chung. (2002) Imperatorin, a Furanocoumarin from Angelica dahurica (Umbelliferae), Induces Cytochrome c‐Dependent Apoptosis in Human Promyelocytic Leukaemia, HL‐60 Cells . Pharmacology & Toxicology 91:1, pages 40-48.
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A. Akhila, G. Adam, K. Rani, J. Schmidt & B. SchneiderA. Akhila & K. Rani. 1999. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products 47 149 .
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Cecil Miller, Andre Castonguay & Robert W. Teel. (1996) Modulation of the mutagenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by phenolic compounds. Mutation Research/Genetic Toxicology 368:3-4, pages 221-233.
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Donald E. Champagne, Opender Koul, Murray B. Isman, Geoffrey G.E. Scudder & G.H. Neil Towers. (1992) Biological activity of limonoids from the rutales. Phytochemistry 31:2, pages 377-394.
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