12
Views
35
CrossRef citations to date
0
Altmetric
Original Articles

Subnormal expression of cell‐mediated and humoral immune responses in progeny disposed toward a high incidence of tumors after in utero exposure to benzo[a]pyrene

&
Pages 569-584 | Received 21 May 1983, Accepted 11 Jun 1984, Published online: 20 Oct 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (14)

Ivy Moffat, Nikolai L. Chepelev, Sarah Labib, Julie Bourdon-Lacombe, Byron Kuo, Julie K. Buick, France Lemieux, Andrew Williams, Sabina Halappanavar, Amal I Malik, Mirjam Luijten, Jiri Aubrecht, Daniel R. Hyduke, Albert J. Fornace$suffix/text()$suffix/text(), Carol D. Swartz, Leslie Recio & Carole L. Yauk. (2015) Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water. Critical Reviews in Toxicology 45:1, pages 1-43.
Read now
Paul Urso, Yungri G. Wirsiy, Mitchell D. Cohen & Bernard Adkins$suffix/text()$suffix/text(). (2010) Changes in biologic and/or immunologic parameters induced by intratracheal instillation of pregnant mice with benzo(α)pyrene are potentially confounded by anesthesia. Inhalation Toxicology 22:7, pages 571-579.
Read now
P. Urso, Y.G. Wirsiy, W. Zhang & P.J. Moolenaar-Wirsiy. (2008) Alterations in CD4, CD8, Vγ3, Vγδ, and/or V βT-Lymphocyte Expression in Lymphoid Tissues of Progeny After In Utero Exposure to Benzo(α)pyrene. Journal of Immunotoxicology 5:3, pages 293-306.
Read now
Pamela J. Moolenaar-Wirsiy, Yungri G. Wirsiy & Paul Urso. (2007) Presence of CD4+ SP and DP (γδ, αβ) T-Cells Expressing BPDE-DNA Adducts in Progeny of Mouse Dams Exposed to Benzo(α) pyrene at Mid-Gestation. Journal of Immunotoxicology 4:4, pages 267-277.
Read now
Mark E. Lee & Paul Urso. (2007) Suppression of T Lymphocyte Proliferation to Antigenic and Mitogenic Stimuli by Benzo(α)pyrene and 2-Aminofluorene Metabolites. Immunopharmacology and Immunotoxicology 29:3-4, pages 425-438.
Read now
J. W. Rodriguez, M. J. Kohan, L. C. King & W. G. Kirlin. (2002) DETECTION OF DNA ADDUCTS IN DEVELOPING CD4+CD8+ THYMOCYTES AND SPLENOCYTES FOLLOWING IN UTERO EXPOSURE TO BENZO[a]PYRENE. Immunopharmacology and Immunotoxicology 24:3, pages 365-381.
Read now
G. O. Wolisi, Godwin O. Wolisi, J. Majekodunmi, G. B. Bailey & P. Urso. (2001) IMMUNOMODULATION IN PROGENY FROM THYMECTOMIZED PRIMIPAROUS MICE EXPOSED TO BENZO(a)PYRENE DURING MID-PREGNANCY. Immunopharmacology and Immunotoxicology 23:2, pages 267-280.
Read now
J. W. Rodriguez, W. G. Kirlin, Y. G. Wirsiy, S. Matheravidathu, T. W. Hodge & Urso P. (1999) Maternal Exposure to Benzo[A]Pyrene Alters Development of T Lymphocytes in Offspring. Immunopharmacology and Immunotoxicology 21:2, pages 379-396.
Read now
Mark Lee, Ward Kirlin, Melanie Sturmp, Jose Rodriguez & Paul Urso. (1996) Variation in the Response of T Cells to Concanavalin a After In Vitro Exposure to Benzo[A]Pyrene and 2-Aminof'luorene. Immunopharmacology and Immunotoxicology 18:2, pages 309-321.
Read now
S. D. Holladay & B. J. Smith. (1994) Fetal hematopoietic alterations after maternal exposure to benzo[a]pyrene: A cytometric evaluation. Journal of Toxicology and Environmental Health 42:3, pages 259-273.
Read now
S. N. Das, B. N. Paul, A. K. Saxena & P. K. Ray. (1990) Effect of In Utero Exposure to Hexachlorocyclohexane on the Developing Immune System of Mice. Immunopharmacology and Immunotoxicology 12:2, pages 293-310.
Read now
Paul Urso, Mark C. Ryan & Judith S. Bennett. (1988) Changes in Peripheral Blood Cells in Mice After Injection with Benzo(A)Pyrene During Pregnancy. Immunopharmacology and Immunotoxicology 10:2, pages 179-193.
Read now
Paul Urso, Nazareth Gengozian, Randall M. Rossi & Ray A. Johnson. (1986) Suppression of Humoral and Cell-Mediated Immune Responses in Vitro by Benzo (A) Pyrene. Immunopharmacology and Immunotoxicology 8:2, pages 223-241.
Read now

Articles from other publishers (21)

Amar Preet Kaur, Nimisha Saxena & Nimai C. Chandra. (2019) Differential response of T cells to an immunogen, a mitogen and a chemical carcinogen in a mouse model system. Journal of Biochemical and Molecular Toxicology 33:5, pages e22290.
Crossref
Ellen Webb, Julie Moon, Larysa Dyrszka, Brian Rodriguez, Caroline Cox, Heather Patisaul, Sheila Bushkin & Eric London. (2018) Neurodevelopmental and neurological effects of chemicals associated with unconventional oil and natural gas operations and their potential effects on infants and children. Reviews on Environmental Health 33:1, pages 3-29.
Crossref
Lisbeth A. Boule & B. Paige Lawrence. 2016. Environmental Influences on the Immune System. Environmental Influences on the Immune System 21 54 .
Nikolai L. Chepelev, Ivy D. Moffat, Wayne J. Bowers & Carole L. Yauk. (2015) Neurotoxicity may be an overlooked consequence of benzo[a]pyrene exposure that is relevant to human health risk assessment. Mutation Research/Reviews in Mutation Research 764, pages 64-89.
Crossref
Catherine Lombard, Venkatesh L. Hegde, Mitzi Nagarkatti & Prakash S. Nagarkatti. (2011) Perinatal Exposure to Δ 9 -Tetrahydrocannabinol Triggers Profound Defects in T Cell Differentiation and Function in Fetal and Postnatal Stages of Life, Including Decreased Responsiveness to HIV Antigens . Journal of Pharmacology and Experimental Therapeutics 339:2, pages 607-617.
Crossref
Bethany Winans, Michael C. Humble & B. Paige Lawrence. (2011) Environmental toxicants and the developing immune system: A missing link in the global battle against infectious disease?. Reproductive Toxicology 31:3, pages 327-336.
Crossref
Paul Urso & Mary K. Kramer. (2008) The role of adherent cells in the immunosuppressed state of mouse progeny transplacentally exposed to benzo(α)pyrene. In Vitro Cellular & Developmental Biology - Animal 44:7, pages 273-279.
Crossref
Sheung P. Ng, Allen E. Silverstone, Zhi-Wei Lai & Judith T. Zelikoff. (2006) Effects of Prenatal Exposure to Cigarette Smoke on Offspring Tumor Susceptibility and Associated Immune Mechanisms. Toxicological Sciences 89:1, pages 135-144.
Crossref
Steven Holladay, S Ansar Ahmed & Benny Blaylock. 2004. Developmental Immunotoxicology. Developmental Immunotoxicology 215 227 .
Steven Holladay, Terry Hrubec & Benny Blaylock. 2004. Developmental Immunotoxicology. Developmental Immunotoxicology 139 152 .
Steven Holladay, M Renee Prater & Benny Blaylock. 2004. Developmental Immunotoxicology. Developmental Immunotoxicology 65 76 .
. 2004. Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical Approach - Volume I: Principles and Methods of Immunotoxicology. Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical Approach - Volume I: Principles and Methods of Immunotoxicology 327 354 .
Tomoaki INOUE & Ikuo HORII. (2002) Effects on fetal thymocyte populations and postnatal T-cell-dependent immune functions after maternal exposure to 5-fluorouracil during pregnancy in mice.. The Journal of Toxicological Sciences 27:2, pages 79-86.
Crossref
R R Dietert, R A Etzel, D Chen, M Halonen, S D Holladay, A M Jarabek, K Landreth, D B Peden, K Pinkerton, R J Smialowicz & T Zoetis. (2000) Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summary.. Environmental Health Perspectives 108:suppl 3, pages 483-490.
Crossref
S D Holladay & R J Smialowicz. (2000) Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure.. Environmental Health Perspectives 108:suppl 3, pages 463-473.
Crossref
S.D Holladay, S.A Smith, E.G Besteman, A.S.M.I Deyab, R.M Gogal, T Hrubec, J.L Robertson & S.A Ahmed. (1998) Benzo[a]pyrene-induced hypocellularity of the pronephros in tilapia (Oreochromis niloticus) is accompanied by alterations in stromal and parenchymal cells and by enhanced immune cell apoptosis. Veterinary Immunology and Immunopathology 64:1, pages 69-82.
Crossref
S D Holladay & M I Luster. (1996) Alterations in fetal thymic and liver hematopoietic cells as indicators of exposure to developmental immunotoxicants.. Environmental Health Perspectives 104:suppl 4, pages 809-813.
Crossref
Z.L. Lummus & G. Henningsen. (1995) Modulation of T-cell ontogeny by transplacental benzo(a)pyrene. International Journal of Immunopharmacology 17:4, pages 339-350.
Crossref
Dorothy P. McCabe & Edward J. Flynn. (1990) Deposition of low dose benzo(a)pyrene into fetal tissue: Influence of protein binding. Teratology 41:1, pages 85-95.
Crossref
R.A. Lindemann & N.-H. Park. (1989) The effects of benzo(a)pyrene, nicotine, and tobacco-specific N-nitrosamines on the generation of human lymphokine-activated killer cells. Archives of Oral Biology 34:4, pages 283-287.
Crossref
P. Urso & R.A. Johnson. (1987) Early changes in T lymphocytes and subsets of mouse progeny defective as adults in controlling growth of a syngeneic tumor after in utero insult with benzo(a)pyrene. Immunopharmacology 14:1, pages 1-10.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.