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Original Articles

How toxic is 2,3,7,8‐tetrachlorodibenzodioxin to humans?

Pages 261-271 | Received 03 Oct 1989, Accepted 17 Mar 1990, Published online: 20 Oct 2009

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Karl K. Rozman, Laszlo Kerecsen, Marja K. Viluksela, Doris Österle, Erhard Deml, Matti Viluksela, Bernhard U. Stahl, Helmut Greim & John Doull. (1996) A Toxicologist's View of Cancer Risk Assessment. Drug Metabolism Reviews 28:1-2, pages 29-52.
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DennisJ. Paustenbach. (1995) The practice of health risk assessment in the united states (1975–1995): How the U.S. and other countries can benefit from that experience. Human and Ecological Risk Assessment: An International Journal 1:1, pages 29-79.
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DennisJ. Paustenbach, RichardJ. Wenning, Virginia Lau, NatalieW. Harrington, DerralynK. Rennix & AlanH. Parsons. (1992) Recent developments on the hazards posed by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in soil: Implications for setting risk‐based cleanup levels at residential and industrial sites. Journal of Toxicology and Environmental Health 36:2, pages 103-149.
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J.P. Sherry & RaymondE. Clement. (1992) Environmental Chemistry: The Immunoassay Option. Critical Reviews in Analytical Chemistry 23:4, pages 217-300.
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DennisJ. Paustenbach, MaxwellW. Layard, RichardJ. Wenning & RussellE. Keenan. (1991) Risk assessment of 2,3,7,8‐TCDD using a biologically based cancer model: A reevaluation of the Kociba et al. bioassay using 1978 and 1990 histopathology criteria. Journal of Toxicology and Environmental Health 34:1, pages 11-26.
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RenateD. Kimbrough. (1991) 1991 Herbert E. Stokinger Lecture: Uncertainties in Risk Assessment. Applied Occupational and Environmental Hygiene 6:9, pages 759-763.
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RenateD. Kimbrough. (1991) Consumption of fish: Benefits and perceived risk. Journal of Toxicology and Environmental Health 33:1, pages 81-91.
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Paolo Mocarelli, LarryL. Needham, Alessandro Marocchi, DonaldG. Patterson$suffix/text()$suffix/text(), Paolo Brambilla, Pier Mario Gerthoux, Luigi Meazza & Vittorio Carreri. (1991) Serum concentrations of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin and test results from selected residents of Seveso, Italy. Journal of Toxicology and Environmental Health 32:4, pages 357-366.
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RussellE. Keenan, DennisJ. Paustenbach, RichardJ. Wenning & AlanH. Parsons. (1991) Pathology reevaluation of the kociba et al. (1978) bioassay of 2,3,7,8‐TCDD: Implications for risk assessment. Journal of Toxicology and Environmental Health 34:3, pages 279-296.
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Articles from other publishers (24)

Qigui Li & Mark Hickman. (2011) Toxicokinetic and toxicodynamic (TK/TD) evaluation to determine and predict the neurotoxicity of artemisinins. Toxicology 279:1-3, pages 1-9.
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Matthew R. Auer. (2009) Better science and worse diplomacy: negotiating the cleanup of the Swedish and Finnish pulp and paper industry. International Environmental Agreements: Politics, Law and Economics 10:1, pages 65-84.
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Qigui Li & Peter Weina. (2009) Severe Embryotoxicity of Artemisinin Derivatives in Experimental Animals, but Possibly Safe in Pregnant Women. Molecules 15:1, pages 40-57.
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Qigui Li, Yuanzheng Si, Lisa Xie, Jing Zhang & Peter Weina. (2009) Severe embryolethality of artesunate related to pharmacokinetics following intravenous and intramuscular doses in pregnant rats. Birth Defects Research Part B: Developmental and Reproductive Toxicology 86:5, pages 385-393.
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Gail Charnley & Renate D. Kimbrough. (2006) Overview of exposure, toxicity, and risks to children from current levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds in the USA. Food and Chemical Toxicology 44:5, pages 601-615.
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S. Signorini, P. M. Gerthoux, C. Dassi, M. Cazzaniga, P. Brambilla, N. Vincoli & P. Mocarelli. (2000) Environmental exposure to dioxin: the Seveso experience. Andrologia 32:4-5, pages 263-270.
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Wentian Huang & Loren D. Koller. (1999) Effect of a single or repeated dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on T cell subpopulations in the Long-Evans rat. Toxicology Letters 109:1-2, pages 97-104.
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Harald J. Geyer, Karl-Werner Schramm, Irene Scheunert, Klaus Schughart, Jeroen Buters, Wolfgang Wurst, Helmut Greim, Reinhart Kluge, Christian E.W. Steinberg, Antonius Kettrup, Burra Madhukar, James R. Olson & Michael A. Gallo. (1997) Considerations on Genetic and Environmental Factors That Contribute to Resistance or Sensitivity of Mammals Including Humans to Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds. Ecotoxicology and Environmental Safety 36:3, pages 213-230.
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Sean M. Hays, Lesa L. Aylward, Nathan J. Karch & Dennis J. Paustenbach. (1997) The relative susceptibility of animals and humans to the carcinogenic hazard posed by exposure to 2,3,7,8-TCDD: An analysis using standard and internal measures of dose. Chemosphere 34:5-7, pages 1507-1522.
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Lesa L. Aylward, Sean M. Hays, Nathan J. Karch & Dennis J. Paustenbach. (1996) Relative Susceptibility of Animals and Humans to the Cancer Hazard Posed by 2,3,7,8-Tetrachlorodibenzo- p - dioxin Using Internal Measures of Dose . Environmental Science & Technology 30:12, pages 3534-3543.
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J ToppariJ C LarsenP ChristiansenA GiwercmanP GrandjeanL J GuilletteJrJrB JégouT K JensenP JouannetN KeidingH LeffersJ A McLachlanO MeyerJ MüllerE Rajpert-De MeytsT ScheikeR SharpeJ SumpterN E Skakkebaek. (1996) Male reproductive health and environmental xenoestrogens.. Environmental Health Perspectives 104:suppl 4, pages 741-803.
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J. Descotes. 1996. Human Toxicology. Human Toxicology 819 830 .
R. Wennig. 1996. Human Toxicology. Human Toxicology 25 236 .
John Whysner & Gary M. Williams. (1996) 2,3,7,8-Tetrachlorodibenzo-p-dioxin mechanistic data and risk assessment: Gene regulation, cytotoxicity, enhanced cell proliferation, and tumor promotion. Pharmacology & Therapeutics 71:1-2, pages 193-223.
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Mark E. Hahn. 1996. Interconnections Between Human and Ecosystem Health. Interconnections Between Human and Ecosystem Health 9 27 .
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Dietrich Henschler. (2006) Toxizität chlororganischer Verbindungen: Einfluß der Einführung von Chlor in organische Moleküle. Angewandte Chemie 106:19, pages 1997-2012.
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D.L. Arnold, F. Bryce, K. Karpinski, J. Mes, S. Fernie, H. Tryphonas, J. Truelove, P.F. McGuire, D. Burns, J.R. Tanner, R. Stapley, Z.Z. Zawidzka & D. Basford. (1993) Toxicological consequences of aroclor 1254 ingestion by female rhesus (macaca mulatta) monkeys. Part 1B. Prebreeding phase: Clinical and analytical laboratory findings. Food and Chemical Toxicology 31:11, pages 811-824.
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George L. Carlo, Kelly G. Sund & James Baller. (2010) Assessment of dioxin‐related health risks for the Melbourne metropolitan area. Australian Journal of Public Health 17:2, pages 162-168.
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Eva Funseth & Nils-Gunnar Ilbäck. (1992) Effects of2,3,7,8-tetrachlorodibenzo-p-dioxin on blood and spleen natural killer (NK) cell activity in the mouse. Toxicology Letters 60:3, pages 247-256.
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V.C. Armstrong & R.C. Newhook. (1992) Assessing the health risks of priority substances under the Canadian Environmental Protection Act. Regulatory Toxicology and Pharmacology 15, pages 111-121.
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Vít Lang. (1992) Polychlorinated biphenyls in the environment. Journal of Chromatography A 595:1-2, pages 1-43.
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Hans -Peter Lipp, Dieter Schrenk, Thomas Wiesmüller, Hanspaul Hagenmaier & Karl Walter Bock. (1992) Assessment of biological activities of mixtures of polychlorinated dibenzo-p-dioxins (PCDDs) and their constituents in human HepG2 cells. Archives of Toxicology 66:3, pages 220-223.
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P. Mocarelli, L. L. Needham, A. Marocchi, D. G. PattersonJr.Jr., P. Brambilla, P. M. Gerthoux, L. Meazza & V. Carreri. 1992. Environmental Hygiene III. Environmental Hygiene III 211 213 .

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