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Original Articles

How toxic is 2,3,7,8‐tetrachlorodibenzodioxin to humans?

Pages 261-271 | Received 03 Oct 1989, Accepted 17 Mar 1990, Published online: 20 Oct 2009

References

  • Akins , J. R. , Waldrep , K. and Bernert , J T. Jr. 1989 . The estimation of total serum lipids by a completely enzymatic summation method . Clin. Chim. Acta. , 184 : 219 – 226 .
  • Allen , J. R. , Barsotti , D. A. , Lambrecht , L. K. and Van Miller , J. P. 1979 . Reproductive effects of halogenated aromatic hydrocarbons on nonhuman primates . Ann. N. Y. Acad. Sci. , 320 : 419 – 425 .
  • Andrews , J. S. Jr. , Garrett , W. A. Jr. , Patterson , D. C. Jr. , Needham , L. L. , Roberts , D. W. , Bagby , J. R. , Anderson , J. E. , Hoffman , R. E. and Schramm , W. 1989 . 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin levels in adipose tissue of persons with no known exposure and in exposed persons . Chemosphere , 18 : 499 – 506 .
  • Bonati , M. and Garattini , S. 1988 . “ Pharmacokinetics of caffeine ” . In ISI Atlas of Science: Pharmacology , 33 – 39 . Philadelphia : Institute for Scientific Information .
  • Bowman , R. E. , Schantz , S. L. , Weerasinghe , N. C. A. , Gross , M. L. and Barsotti , D. A. 1989 . Chronic dietary intake of 2,3,7,8‐tetrachlorodibenzodioxin at 5 and 25 parts per trillion in the monkey: TCDD kinetics and dose‐effect estimate of reproductive toxicity . Chemosphere , 18 : 243 – 252 .
  • Byard , J. L. 1987 . The toxicological significance of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin and related compounds in human adipose tissue . Toxicol. Environ. Health , 22 : 381 – 403 .
  • Caramaschi , F. , Del Corno , G. , Favaretti , C. , Giambelluca , S. E. , Montesarchio , E. and Fara , G. M. 1981 . Chloracne following environmental contamination by TCDD in Seveso, Italy . Int. J. Epidemiol. , 10 : 135 – 143 .
  • 1988a . 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin exposure in humans—Seveso Italy . Morbid. Mortal. Weekly Rep. , 37 : 733 – 736 . CDC Preliminary Report
  • 1988b . Serum, 2,3,7,8‐TCDD levels in the Air Force health study participants—Preliminary report . Morbid. Mortal. Weekly Report , 37 : 309 – 313 . CDD Preliminary Report
  • EPA Risk Assessment Forum . March 1989 . Interim assessment for estimating the risk associated with exposures to mixtures of chlorinated dibenzo‐p‐dioxins (CDDs) and dibenzofurans (CDFs) and update March , U.S. EPA, EPA/625/3–89
  • Goldstein , J. A. , Linko , P. and Bergman , H. 1982 . Induction of porphyria in the rat by chronic versus acute exposure to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin . Biochem. Pharmacol. , 31 : 1607 – 1613 .
  • Jensen , A. A. 1987 . Polychlorinated biphenyls (PCBs), polychlorodibenzo‐p‐dioxins (PCDDs) and polychlorodibenzfurans (PCDFs) in human milk, blood, and adipose tissue . Sci. Total Environ. , 64 : 259 – 293 .
  • Kimbrough , R. D. , Gaines , T. B. and Under , R. E. 1971 . The ultrastructure of livers of rats fed DDT and dieldrin . Arch. Environ. Health , 22 : 460 – 467 .
  • Kociba , R. J. , Keeler , P. A. , Park , C. N. and Gehring , P. J. 1976 . 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD); Results of a 13‐week oral toxicity study in rats . Toxicol. Appl. Pharmacol. , 35 : 553 – 574 .
  • Kociba , R. J. , Keyes , D. J. , Beyer , D. E. , Carreon , R. M. , Wade , C. E. , Dittenber , D. , Kalnins , R. , Frauson , L. , Park , C. N. , Barnard , S. , Hummel , R. and Humiston , C. G. 1978 . Results of a two year chronic toxicity and oncogenicity study of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) in rats . Appl. Pharmacol. , 46 : 279 – 303 .
  • Kreiss , K. , Zack , M. , Kimbrough , R. D. , Needham , L. L. , Smrek , A. L. and Jones , B. T. 1981a . Association of blood pressure and PCB levels in cross‐sectional community study./ . Am. Med. Assoc. , 245 : 2505 – 2509 .
  • Kreiss , K. , Zack , M. , Kimbrough , R. D. , Needham , L. L. , Smrek , A. L. and Jones , B. T. 1981b . Cross‐sectional study of a community with exceptional exposure to DDT . J. Am. Med. Assoc. , 245 : 1926 – 1930 .
  • Mastroiacovo , P. , Spagnolo , A. , Marni , E. , Meazza , L. , Bertollini , R. and Segni , G. 1988 . Birth defects in the Seveso area after TCDD contamination . J. Am. Med. Assoc. , 259 : 1668 – 1672 .
  • McConnell , E. E. , Lucier , G. W. , Rumbaugh , R. C. , Albro , P. F. , Harvan , D. J. , Hass , J. R. and Harris , M. W. 1984 . Dioxin in soil: Bioavailability after ingestion by rats and guinea pigs . Science , 223 : 1077 – 1079 .
  • McNulty , W. P. , Nielsen‐Smith , K. A. , Lay , J. O. Jr. , Lippstreu , D. L. , Kangas , N. L. , Lyons , P. A. and Gross , M. L. 1982 . Persistence of TCDD in monkey adipose tissue . Food Chem. Toxicol. , 20 : 985 – 987 .
  • Mocarelli , P. , Marocchi , A. , Brambilla , P. , Gerthoux , P. , Young , D. S. and Mantel , N. 1986 . Clinical laboratory manifestations of exposure to dioxin in children: A six year study of the effects of an environmental disaster near Seveso, Italy . J. Am. Med. Assoc. , 256 : 2687 – 2695 .
  • Ogaki , J. , Takayama , K. , Miyata , H. and Kashimoto , T. 1987 . Levels of PCDDs and PCDFs in human tissues and various foodstuffs in Japan . Chemosphere , 16 : 2047 – 2056 .
  • Olson , J. R. 1986 . Metabolism and disposition of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in guinea pigs . Toxicol. Appl. Pharmacol. , 85 : 263 – 273 .
  • Olson , J. R. , Gasiewicz , T. A. and Neal , R. A. 1980 . Tissue distribution, excretion, and metabolism of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) in the golden Syrian hamster . Toxicol. Appl. Pharmacol. , 56 : 78 – 85 .
  • Patterson , D. G. , Hoffman , R. E. , Needham , L. L. , Roberts , D. W. , Bagby , J. R. , Pirkle , J. L. , Falk , H. , Sampson , E. J. and Houk , V. N. 1986a . 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin levels in adipose tissue of exposed and control persons in Missouri. An interim report . J. Am. Med. Assoc. , 256 : 2683 – 2686 .
  • Patterson , D. G. , Holler , J. S. , Smith , J. S. , Liddle , J. A. , Sampson , E. J. and Needham , L. L. 1986b . Human adipose data for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in certain U.S. samples . Chemosphere , 15 : 2055 – 2060 .
  • Patterson , D. G. , Holler , J. S. , Smith , S. J. , Liddle , J. A. , Sampson , E. J. and Needham , L. L. 1987 . Human adipose data for 2,3,7,8‐tetrachlorodibenzodioxin in certain U.S. samples . Chemosphere , 15 : 2055 – 2060 .
  • Patterson , D. J. Jr. , Fingerhut , M. A. , Roberts , D. W. , Needham , L. L. , Haring Sweeney , M. , Marlow , D. A. , Andrews , J. S. Jr. and Halperin , W. E. 1989 . Levels of polychlorinated dibenzo‐p‐dioxins (PCDDs) and dibenzofurans (PCDFs) in workers exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin . Am. J. Ind. Med. , 16 : 135 – 146 .
  • Pirkle , J. L. , Wolfe , W. H. , Patterson , D. G. , Needham , L L. , Michalek , J. E. , Miner , J. C. , Peterson , M. R. and Phillips , D. L. 1989 . Estimate of the halflife of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in Vietnam veterans of Operation Ranch Hand . J. Toxicol. Environ. Health , 27 : 165 – 171 .
  • Pocchiari , F. , Silano , V. and Zampieri , A. 1979 . Human health effects from accidental release of tetrachlorodibenzo‐p‐dioxin (TCDD) at Seveso, Italy . Ann. N.Y. Acad. Sci. , 320 : 311 – 320 .
  • Rao , M. S. , Subbarao , V. , Prasad , J. D. and Scrapelli , D. C. 1988 . Carcinogenicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in the Syrian golden hamster . Carcinogenesis , 9 : 1677 – 1679 .
  • Ryan , J. J. , Schecter , A. , Lizotte , R. , Sun , W. F. and Miller , L. 1985 . Tissue distribution of dioxins and furans in humans from the general population . Chemosphere , 14 : 929 – 932 .
  • Schecter , A. and Ryan , J. J. 1988 . Polychlorinated dibenzo‐p‐dioxin and dibenzofuran levels in human adipose tissues from workers 32 years after occupational exposure to 2,3,7,8‐TCDD . Chemosphere , 17 : 915 – 920 .
  • Schecter , A. , Ryan , J. J. and Constable , J. D. 1987a . Polychlorinated dibenzo‐p‐dioxin and polychlorinated dibenzofuran levels in human breast milk from Vietnam compared with cow's milk and human breast milk from the North American continent . Chemosphere , 16 : 2003 – 2016 .
  • Schecter , A. , Constable , J. D. , Arghestani , S. , Tong , H. and Gross , M. L. 1987b . Elevated levels of 2,3,7,8‐tetrachlorodibenzodioxin in adipose tissue of certain U.S. veterans of the Vietnam war . Chemosphere , 16 : 1997 – 2002 .
  • Schecter , A. , Dekin , A. , Weerasinghe , N. C. A. , Arghestani , S. and Gross , M. 1988b . Sources of dioxins in the environment: A study of PCDDs and PCDFs in ancient frozen Eskimo tissue . Chemosphere , 17 : 627 – 634 .
  • Thoma , H. , Mucke , W. and Kretschmer , E. 1989 . Concentrations of PCDD and PCDF in human fat and liver samples . Chemosphere , 18 : 491 – 498 .
  • Umbreit , T. H. , Hesse , E. J. and Gallo , M. A. 1988 . Bioavailability and cytochrome P‐450 induction from 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin contaminated soils from Times Beach, Missouri and Newark, New Jersey . Drug Chem. Toxicol. , 11 : 405 – 418 .
  • Van Miller , J. P. , Marlar , R. J. and Allen , J. R. 1976 . Tissue distribution and excretion of tritiated tetrachlorodibenzo‐p‐dioxin in non‐human primates and rats . Food Cosmet. Toxicol. , 14 : 31 – 34 .

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