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Review

The Role of Metabolic Biomarkers in Drug Toxicity Studies

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Pages 301-311 | Received 21 Jun 2007, Accepted 04 Aug 2007, Published online: 09 Oct 2008

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Anshoo Gautam & Lipsy Goyal. 2021. Epigenetics and Metabolomics. Epigenetics and Metabolomics 401 420 .
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Elena Balashova, Dmitry Maslov & Petr Lokhov. (2018) A Metabolomics Approach to Pharmacotherapy Personalization. Journal of Personalized Medicine 8:3, pages 28.
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Liqiang Gu, Huiyan Shi, Ruowen Zhang, Zhe Wei, Kai-Shun Bi & Xiao-Hui Chen. (2017) Simultaneous Determination of Five Specific and Sensitive Nephrotoxicity Biomarkers in Serum and Urine Samples of Four Drug-Induced Kidney Injury Models. Journal of Chromatographic Science 55:1, pages 60-68.
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Jian Shi, Bei Cao, Xin-Wen Wang, Ji-Ye Aa, Jin-Ao Duan, Xuan-Xuan Zhu, Guang-Ji Wang & Chang-Xiao Liu. (2016) Metabolomics and its application to the evaluation of the efficacy and toxicity of traditional Chinese herb medicines. Journal of Chromatography B 1026, pages 204-216.
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Drupad K. Trivedi & Ray K. Iles. (2014) Do not just do it, do it right: urinary metabolomics -establishing clinically relevant baselines. Biomedical Chromatography 28:11, pages 1491-1501.
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O.P. Trifonova, P.G. Lokhov & A.I. Archakov. (2014) Metabolic profiling of human blood. Biomeditsinskaya Khimiya 60:3, pages 281-294.
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Oxana TrifonovaPetr LokhovAlexander Archakov. (2013) Postgenomics Diagnostics: Metabolomics Approaches to Human Blood Profiling. OMICS: A Journal of Integrative Biology 17:11, pages 550-559.
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Adil Mardinoglu, Francesco Gatto & Jens Nielsen. (2013) Genome-scale modeling of human metabolism - a systems biology approach. Biotechnology Journal 8:9, pages 985-996.
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O. P. Trifonova, P. G. Lokhov & A. I. Archakov. (2013) Metabolic profiling of human blood. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 7:3, pages 179-186.
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Jun He, Jun Chen, Laiyan Wu, Guangyu Li & Ping Xie. (2012) Metabolic Response to Oral Microcystin-LR Exposure in the Rat by NMR-Based Metabonomic Study. Journal of Proteome Research 11:12, pages 5934-5946.
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Bruce A. Fowler. 2012. Molecular, Clinical and Environmental Toxicology. Molecular, Clinical and Environmental Toxicology 459 470 .
Warwick B Dunn, David Broadhurst, Paul Begley, Eva Zelena, Sue Francis-McIntyre, Nadine Anderson, Marie Brown, Joshau D Knowles, Antony Halsall, John N Haselden, Andrew W Nicholls, Ian D Wilson, Douglas B Kell & Royston Goodacre. (2011) Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nature Protocols 6:7, pages 1060-1083.
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Iola F. Duarte. (2011) Following dynamic biological processes through NMR-based metabonomics: A new tool in nanomedicine?. Journal of Controlled Release 153:1, pages 34-39.
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Jiye Aa, Feng Shao, Guangji Wang, Qing Huang, Weibin Zha, Bei Yan, Tian Zheng, Linsheng Liu, Bei Cao, Jian Shi, Mengjie Li, Chunyan Zhao, Xinwen Wang & Zimei Wu. (2010) Gas chromatography time-of-flight mass spectrometry based metabolomic approach to evaluating toxicity of triptolide. Metabolomics 7:2, pages 217-225.
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Hye-ji Yang, Myung-Joo Choi, He Wen, Hyuk Nam Kwon, Kyung Hee Jung, Sang-Won Hong, Joon Mee Kim, Soon-Sun Hong & Sunghyouk Park. (2011) An Effective Assessment of Simvastatin-Induced Toxicity with NMR-Based Metabonomics Approach. PLoS ONE 6:2, pages e16641.
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Mamas Mamas, Warwick B. Dunn, Ludwig Neyses & Royston Goodacre. (2010) The role of metabolites and metabolomics in clinically applicable biomarkers of disease. Archives of Toxicology 85:1, pages 5-17.
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Haiying Zhang, Laura Patrone, John Kozlosky, Lindsay Tomlinson, Greg Cosma & Joseph Horvath. (2010) Pooled Sample Strategy in Conjunction with High-Resolution Liquid Chromatography−Mass Spectrometry-Based Background Subtraction to Identify Toxicological Markers in Dogs Treated with Ibipinabant. Analytical Chemistry 82:9, pages 3834-3839.
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Kuresh A. Youdim & Kenneth C. Saunders. (2010) A review of LC–MS techniques and high-throughput approaches used to investigate drug metabolism by cytochrome P450s. Journal of Chromatography B 878:17-18, pages 1326-1336.
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Eva ZelenaWarwick B. DunnDavid BroadhurstSue Francis-McIntyreKathleen M. CarrollPaul BegleySteve O’HaganJoshua D. KnowlesAntony HalsallIan D. WilsonDouglas B. Kell. (2009) Development of a Robust and Repeatable UPLC−MS Method for the Long-Term Metabolomic Study of Human Serum. Analytical Chemistry 81:4, pages 1357-1364.
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