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Toxicology Mechanisms and Methods Volume 19, 2009 - Issue 5
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Research Article

A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice

Jiri KassaDepartment of Toxicology, Faculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech RepublicCorrespondence[email protected]
,
Jana Zdarova KarasovaDepartment of Toxicology, Faculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic
,
Kamil MusilekDepartment of Toxicology, Faculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic
&
Kamil Kuca
Pages 346-350 | Received 16 Mar 2009, Accepted 04 May 2009, Published online: 01 Jun 2009

Citations (8)

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Read on this site (2)

Jiri Bajgar, Petr Hajek, Jiri Kassa, Dasa Slizova, Otakar Krs, Jana Zdarova Karasova, Josef Fusek, Lukas Capek & Victor A. Voicu. (2012) Combined approach to demonstrate acetylcholinesterase activity changes in the rat brain following tabun intoxication and its treatment. Toxicology Mechanisms and Methods 22:1, pages 60-66.
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Jiri Kassa, Jana Zdarova Karasova, Filip Caisberger & Jiri Bajgar. (2009) The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of soman poisoning in rats and mice. Toxicology Mechanisms and Methods 19:9, pages 547-551.
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Articles from other publishers (6)

Lukas Gorecki, Ondrej Soukup, Tomas Kucera, David Malinak, Daniel Jun, Kamil Kuca, Kamil Musilek & Jan Korabecny. (2018) Oxime K203: a drug candidate for the treatment of tabun intoxication. Archives of Toxicology 93:3, pages 673-691.
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Evica Antonijevic, Kamil Musilek, Kamil Kuca, Danijela Djukic-Cosic, Slavica Vucinic & Biljana Antonijevic. (2016) Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor. NeuroToxicology 55, pages 33-39.
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H. Kalász, S. M. Nurulain, G. Veress, S. Antus, F. Darvas, E. Adeghate, A. Adem, F. Hashemi & K. Tekes. (2015) Mini review on blood-brain barrier penetration of pyridinium aldoximes. Journal of Applied Toxicology 35:2, pages 116-123.
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Jiri Kassa, Jana Zdarova Karasova, Vendula Sepsova & Filip Caisberger. (2011) The Benefit of Combinations of Oximes for the Reactivating and Therapeutic Efficacy of Antidotal Treatment of Sarin Poisoning in Rats and Mice. Basic & Clinical Pharmacology & Toxicology 109:1, pages 30-34.
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Jiří Kassa & Jana Žďárová Karasová. (2011) A COMPARISON OF THE NEUROPROTECTIVE EFFICACY OF INDIVIDUAL OXIMES (HI-6, TRIMEDOXIME, K203) AND THEIR MIXTURES (HI-6 + TRIMEDOXIME, HI-6 + K203) IN CYCLOSARIN-POISONED RATS. Military Medical Science Letters 80:1, pages 12-20.
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Daniel Jun, Lucie Musilova, Miroslav Pohanka, Young-Sik Jung, Pavel Bostik & Kamil Kuca. (2010) Reactivation of Human Acetylcholinesterase and Butyrylcholinesterase Inhibited by Leptophos-Oxon with Different Oxime Reactivators in Vitro. International Journal of Molecular Sciences 11:8, pages 2856-2863.
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