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Kamil Kuca, Kamil Musilek, Daniel Jun, Eugenie Nepovimova, Ondrej Soukup, Jan Korabecny, Tanos C. C. França, Alexandre A. de Castro, Ondrej Krejcar, Elaine F. F. da Cunha & Teodorico C. Ramalho. (2020) Oxime K074 – in vitro and in silico reactivation of acetylcholinesterase inhibited by nerve agents and pesticides. Toxin Reviews 39:2, pages 157-166.
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Mohamed B. Abou-Donia, Briana Siracuse, Natasha Gupta & Ashly Sobel Sokol. (2016) Sarin (GB, O-isopropyl methylphosphonofluoridate) neurotoxicity: critical review. Critical Reviews in Toxicology 46:10, pages 845-875.
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Juliana O.S. Giacoppo, Tanos C.C. França, Kamil Kuča, Elaine F.F. da Cunha, Ruben Abagyan, Daiana T. Mancini & Teodorico C. Ramalho. (2015) Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents. Journal of Biomolecular Structure and Dynamics 33:9, pages 2048-2058.
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Kamil Kuca, Kamil Musilek, Daniel Jun, Miroslav Pohanka, Kallol Kumar Ghosh & Martina Hrabinova. (2010) Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry 25:4, pages 509-512.
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Kamil Kuca, Jiri Cabal, Daniel Jun & Vit Koleckar. (2008) In Vitro Comparison of Two Most Promising H-Oximes (HI-6 and HLö-7) and Currently Commercially Available Reactivators Pralidoxime and Obidoxime in Reactivation of Cyclosarin-Inhibited Human Cholinesterases. Toxicology Mechanisms and Methods 18:4, pages 329-333.
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Kamil Musilek, Ondrej Holas, Kamil Kuca, Daniel Jun, Vlastimil Dohnal, Veronika Opletalova & Martin Dolezal. (2008) Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry 23:1, pages 70-76.
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Daniel Jun, Kamil Kuca, Jan Picha, Vit Koleckar & Jan Marek. (2008) Potency of Novel Oximes to Reactivate Sarin Inhibited Human Cholinesterases. Drug and Chemical Toxicology 31:1, pages 1-9.
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Kamil Musilek, Ondrej Holas, Kamil Kuca, Daniel Jun, Vlastimil Dohnal & Martin Dolezal. (2007) Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry 22:4, pages 425-432.
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Kamil Kuca, Daniel Jun & Jiri Bajgar. (2007) Currently Used Cholinesterase Reactivators Against Nerve Agent Intoxication: Comparison of Their Effectivity in Vitro. Drug and Chemical Toxicology 30:1, pages 31-40.
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Martina Hrabinova, Kamil Musilek, Daniel Jun & Kamil Kuca. (2006) New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin. Journal of Enzyme Inhibition and Medicinal Chemistry 21:5, pages 515-519.
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Kamil Kuca, Jiri Cabal, Daniel Jun & Martina Hrabinova. (2006) In Vitro Evaluation of Acetylcholinesterase Reactivators as Potential Antidotes Against Tabun Nerve Agent Poisonings. Drug and Chemical Toxicology 29:4, pages 443-449.
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Articles from other publishers (30)
Kamil Kuca, Jorge Alberto Valle da Silva, Eugenie Nepovimova, Ngoc Lam Pham, Wenda Wu, Martin Valis, Qinghua Wu & Tanos Celmar Costa França. (2023) Pralidoxime-like reactivator with increased lipophilicity - Molecular modeling and in vitro study. Chemico-Biological Interactions, pages 110734.
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Alexandre de Castro, Daniel Polisel, Bruna Pereira, Elaine da Cunha, Kamil Kuca, Eugenie Nepovimova & Teodorico Ramalho. (2020) Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects. International Journal of Molecular Sciences 21:18, pages 6510.
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Daniel A. Polisel, Alexandre A. de Castro, Daiana T. Mancini, Elaine F.F. da Cunha, Tanos C.C. França, Teodorico C. Ramalho & Kamil Kuca. (2019) Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects. Chemico-Biological Interactions 309, pages 108671.
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J. Bajgar, J. Kassa, T. Kucera, K. Musilek, D. Jun & K. Kuca. (2019) Some Possibilities to Study New Prophylactics against Nerve Agents. Mini-Reviews in Medicinal Chemistry 19:12, pages 970-979.
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Kamil Kuca, Eugenie Nepovimova, Qinghua Wu, Felipe Rodrigues de Souza, Teodorico de Castro Ramalho, Tanos Celmar Costa Franca & Kamil Musilek. (2018) Experimental hydrophilic reactivator: bisoxime with three positive charges. Chemical Papers 73:3, pages 777-782.
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Kamil Kuca, Kamil Musilek, Daniel Jun, Jana Zdarova-Karasova, Eugenie Nepovimova, Ondrej Soukup, Martina Hrabinova, John Mikler, Tanos C. C. Franca, Elaine F. F. Da Cunha, Alexandre A. De Castro, Martin Valis & Teodorico C. Ramalho. (2018) A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase. BMC Pharmacology and Toxicology 19:1.
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K. Kuca, J. Korabecny, R. Dolezal, E. Nepovimova, O. Soukup, L. Gorecki & K. Musilek. (2017) Tetroxime: reactivation potency – in vitro and in silico study. RSC Advances 7:12, pages 7041-7045.
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Juliana O. S. de Giacoppo, Willian E. A. de Lima, Kamil Kuča, Elaine F. F. da Cunha, Tanos C. C. França & Teodorico C. de Ramalho. (2014) CHEMICAL WARFARE: PERSPECTIVES ON REACTIVATING THE ENZYME ACETYLCHOLINESTERASE INHIBITED BY ORGANOPHOSPHATES. Military Medical Science Letters 83:4, pages 165-177.
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Pavel Kopel, Karel Dolezal, Vratislav Langer, Daniel Jun, Vojtech Adam, Kamil Kuca & Rene Kizek. (2014) Trithiocyanurate Complexes of Iron, Manganese and Nickel and Their Anticholinesterase Activity. Molecules 19:4, pages 4338-4354.
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Vasil N. Atanasov, Iskra Petrova & Christophor Dishovsky. (2013) In vitro investigation of efficacy of new reactivators on OPC inhibited rat brain acetylcholinesterase. Chemico-Biological Interactions 203:1, pages 139-143.
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Paul M. Lundy, Murray G. Hamilton, Thomas W. Sawyer & John Mikler. (2011) Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning. Toxicology 285:3, pages 90-96.
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Kamil Kuča, Kamil Musílek, Jana Karasová, Daniel Jun, Ondřej Soukup, Miroslav Pohanka, Kallol Kumar Ghosh & Martina Hrabinová. (2011) ON THE UNIVERSALITY OF OXIME HLö-7 - ANTIDOTE FOR CASE OF THE NERVE AGENT POISONING. Military Medical Science Letters 80:2, pages 80-84.
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Daniel Jun, Petr Stodulka, Martina Hrabinova, Miroslav Pohanka, Bohuslav Doleza & Kamil Kuca. (2011) TLC analysis of twelve different salts of oxime HI-6 — Reactivator of nerve agent inhibited AChE. Journal of Planar Chromatography – Modern TLC 24:2, pages 105-107.
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Alessandra Antunes Dos Santos, Danúbia Bonfanti Dos Santos, Alcir Luiz Dafre, Andreza Fabro De Bem, Diogo Onofre Souza, João Batista Teixeira Da Rocha, Kamil Kuca & Marcelo Farina. (2010)
In vitro
Reactivating Effects of Standard and Newly Developed Oximes on Malaoxon‐Inhibited Mouse Brain Acetylcholinesterase
. Basic & Clinical Pharmacology & Toxicology 107:3, pages 768-773.
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Kamil Kuca, Jiri Cabal, Daniel Jun, Kamil Musilek, Ondrej Soukup, Miroslav Pohanka, Jaroslav Pejchal, Kyung-Ae Oh, Garp Yeol Yang & Young-Sik Jung. (2010) Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker. Environmental Toxicology and Pharmacology 30:1, pages 85-87.
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Kamil Kuča, Kamil Musílek, Daniel Jun, Miroslav Pohanka, Jana Žďárová Karasová, Ladislav Novotný & Lucie Musilová. (2009) Could oxime HI-6 really be considered as "broad-spectrum" antidote?. Journal of Applied Biomedicine 7:3, pages 143-149.
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Kamil Musilek, Jiri Kucera, Daniel Jun, Vlastimil Dohnal, Veronika Opletalova & Kamil Kuca. (2008) Monoquaternary pyridinium salts with modified side chain—synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry 16:17, pages 8218-8223.
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Kamil Musilek, Daniel Jun, Jiri Cabal, Jiri Kassa, Frank Gunn-Moore & Kamil Kuca. (2007)
Design of a Potent Reactivator of Tabun-Inhibited AcetylcholinesteraseSynthesis and Evaluation of (
E
)-1-(4-Carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene Dibromide (K203)
. Journal of Medicinal Chemistry 50:22, pages 5514-5518.
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Kamil Musilek, Ondrej Holas, Daniel Jun, Vlastimil Dohnal, Frank Gunn-Moore, Veronika Opletalova, Martin Dolezal & Kamil Kuca. (2007) Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker—Preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry 15:21, pages 6733-6741.
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J. Bajgar, K. Kuca, J. Fusek, J. Karasova, J. Kassa, J. Cabal, D. Jun & V. Blaha. (2007) Inhibition of blood cholinesterases following intoxication with VX and its derivatives. Journal of Applied Toxicology 27:5, pages 458-463.
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Kamil Kuca, Kamil Musilek, Martin Paar, Daniel Jun, Petr Stodulka, Martina Hrabinova & Jan Marek. (2007) Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator. Molecules 12:8, pages 1964-1972.
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Kamil Musilek, Kamil Kuca, Vlastimil Dohnal, Daniel Jun, Jan Marek & Vit Koleckar. (2007) Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator. Molecules 12:8, pages 1755-1761.
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Kamil Musilek, Ondrej Holas, Kamil Kuca, Daniel Jun, Vlastimil Dohnal, Veronika Opletalova & Martin Dolezal. (2007) Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker—Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters 17:11, pages 3172-3176.
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Kamil Musílek, Kamil Kuča, Daniel Jun & Martin Doležal. (2007) In vitro reactivation potency of bispyridinium (E)-but-2-ene linked acetylcholinesterase reactivators against tabun-inhibited acetylcholinesterase. Journal of Applied Biomedicine 5:1, pages 25-30.
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K. Kuča, V. Račáková & D. Jun. (2007) Structure—activity relationships for in vitro oxime reactivation of chlorpyrifos-inhibited acetylcholinesterase. Chemical Papers 61:4.
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Kamil Musílek, Kamil Kuča & Daniel Jun. (2007) Evaluation of Potency of Known Oximes (Pralidoxime, Trimedoxime, HI-6, Methoxime, Obidoxime) to in vitro Reactivate Acetylcholinesterase Inhibited by Pesticides (Chlorpyrifos and Methylchlorpyrifos and Nerve Agent (Russian VX). Acta Medica (Hradec Kralove, Czech Republic) 50:3, pages 203-206.
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Kamil Musilek, Ondrej Holas, Kamil Kuca, Daniel Jun, Vlastimil Dohnal & Martin Dolezal. (2006) Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters 16:21, pages 5673-5676.
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Kyung-Ae Oh, Garp Yeol Yang, Daniel Jun, Kamil Kuca & Young-Sik Jung. (2006) Bis-pyridiumaldoxime reactivators connected with CH2O(CH2) OCH2 linkers between pyridinium rings and their reactivity against VX. Bioorganic & Medicinal Chemistry Letters 16:18, pages 4852-4855.
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Veronika Račáková, Daniel Jun, Veronika Opletalová & Kamil Kuča. (2006) Reactivation of acetycholinesterase inhibited by the pesticide chlorpyrifos. Journal of Applied Biomedicine 4:3, pages 147-151.
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Kamil Kuča, Jan Pícha & Daniel Jun. (2006) Reactivation Potency of New Group of Acetylcholinesterase Reactivators and Their Comparison with Currently Available Oximes. Acta Medica (Hradec Kralove, Czech Republic) 49:4, pages 233-235.
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