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Cancer Biology & Therapy Volume 16, 2015 - Issue 2
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Research Papers

Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer

Satsuki MashikoDepartment of Obstetrics and Gynecology; Tohoku University Graduate School of Medicine; Sendai, Japan
,
Kazuyuki KitataniDepartment of Obstetrics and Gynecology; Tohoku University Graduate School of Medicine; Sendai, Japan;Tohoku Medical Megabank Organization; Tohoku University; Sendai, JapanCorrespondence[email protected] [email protected]
,
Masafumi ToyoshimaDepartment of Obstetrics and Gynecology; Tohoku University Graduate School of Medicine; Sendai, JapanCorrespondence[email protected] [email protected]
,
Atsuhiko IchimuraDivision of Molecular Medicine and Therapy, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
,
Takashi DanDivision of Molecular Medicine and Therapy, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
,
Toshinori UsuiDepartment of Obstetrics and Gynecology; Tohoku University Graduate School of Medicine; Sendai, Japan;Tohoku Medical Megabank Organization; Tohoku University; Sendai, Japan
,
Masumi IshibashiDepartment of Obstetrics and Gynecology; Tohoku University Graduate School of Medicine; Sendai, Japan
,
Shogo ShigetaDepartment of Obstetrics and Gynecology; Yamagata University Faculty of Medicine; Yamagata, Japan
,
Satoru NagaseDepartment of Obstetrics and Gynecology; Tohoku University Graduate School of Medicine; Sendai, Japan
,
Toshio MiyataDivision of Molecular Medicine and Therapy, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
&
Nobuo YaegashiDepartment of Obstetrics and Gynecology; Tohoku University Graduate School of Medicine; Sendai, Japan
 show all
Pages 253-260 | Received 04 Jun 2014, Accepted 18 Dec 2014, Published online: 10 Mar 2015

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Crossref
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Crossref
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Crossref
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Crossref
P.A. van Dam, A. Coelho & C. Rolfo. (2017) Is there a role for urokinase-type plasminogen activator inhibitors as maintenance therapy in patients with ovarian cancer?. European Journal of Surgical Oncology (EJSO) 43:2, pages 252-257.
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C Ricciardelli, N A Lokman, M P Ween & M K Oehler. (2016) WOMEN IN CANCER THEMATIC REVIEW: Ovarian cancer–peritoneal cell interactions promote extracellular matrix processing. Endocrine-Related Cancer 23:11, pages T155-T168.
Crossref
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Crossref
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Crossref
S Shigeta, M Toyoshima, K Kitatani, M Ishibashi, T Usui & N Yaegashi. (2015) Transferrin facilitates the formation of DNA double-strand breaks via transferrin receptor 1: the possible involvement of transferrin in carcinogenesis of high-grade serous ovarian cancer. Oncogene 35:27, pages 3577-3586.
Crossref
Veronica R. Placencio & Yves A. DeClerck. (2015) Plasminogen Activator Inhibitor-1 in Cancer: Rationale and Insight for Future Therapeutic Testing. Cancer Research 75:15, pages 2969-2974.
Crossref

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