1,594
Views
43
CrossRef citations to date
0
Altmetric
Research Paper

Downregulation of phosphoglycerate dehydrogenase inhibits proliferation and enhances cisplatin sensitivity in cervical adenocarcinoma cells by regulating Bcl-2 and caspase-3

, , , , , & show all
Pages 541-548 | Received 03 Sep 2014, Accepted 06 Feb 2015, Published online: 09 Apr 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Xiaoya Zhao, Jianfei Fu, Wanfen Tang, Liangliang Yu & Wenxia Xu. (2020) Inhibition of Serine Metabolism Promotes Resistance to Cisplatin in Gastric Cancer. OncoTargets and Therapy 13, pages 4833-4842.
Read now
Chuchu Zhao, Ermei Lu, Xiaoli Hu, Huihui Cheng, Jian-An Zhang & Xueqiong Zhu. (2018) S100A9 regulates cisplatin chemosensitivity of squamous cervical cancer cells and related mechanism. Cancer Management and Research 10, pages 3753-3764.
Read now
Hongfang Li, Gaogao Sun, Chang Liu, Jing Wang, Rong Jing, Jie Wang, Xiaohuan Zhao, Xiaoyan Xu & Yongxiu Yang. (2017) PBX3 is associated with proliferation and poor prognosis in patients with cervical cancer. OncoTargets and Therapy 10, pages 5685-5694.
Read now
Yun Xian, Shu Zhang, Xudong Wang, Jin Qin, Wei Wang & Han Wu. (2016) Phosphoglycerate dehydrogenase is a novel predictor for poor prognosis in gastric cancer. OncoTargets and Therapy 9, pages 5553-5560.
Read now

Articles from other publishers (39)

Tugba Elgun, Asiye Gok Yurttas, Kamil Cinar, Sennur Ozcelik & Ahmet Gul. (2023) Effect of aza-BODIPY-photodynamic therapy on the expression of carcinoma-associated genes and cell death mode. Photodiagnosis and Photodynamic Therapy 44, pages 103849.
Crossref
Lei Hua, Yang Song, Jie Min, Ronglin Wang, Hong Li, Liaoliao Zhu, Yongdong Guo, Dongxue Gan, Shanshan Li, Peixiang Ma, Cheng Yang, Jing Yang, Jingjie Shi, Junqiang Li & Haichuan Su. (2023) AKR7A3 modulates the metastasis of pancreatic ductal adenocarcinoma through regulating PHGDH ‐suppressed autophagy . Cancer Science 114:8, pages 3101-3113.
Crossref
Wei Sun, Erhu Zhao & Hongjuan Cui. (2022) Target enzymes in serine‐glycine‐one‐carbon metabolic pathway for cancer therapy. International Journal of Cancer 152:12, pages 2446-2463.
Crossref
Yesim Gökmen-Polar, Yuan Gu, Alper Polar, Xiaoping Gu & Sunil S. Badve. (2023) The Role of ESRP1 in the Regulation of PHGDH in Estrogen Receptor–Positive Breast Cancer. Laboratory Investigation 103:3, pages 100002.
Crossref
Xijia Zhou, Chang Tian, Yingshu Cao, Min Zhao & Ke Wang. (2023) The role of serine metabolism in lung cancer: From oncogenesis to tumor treatment. Frontiers in Genetics 13.
Crossref
Rao Yu, Hao Zhang, Rong Wang & Lin Xiao. (2022) Low expression of MYCN promotes cisplatin resistance by suppressing cisplatin‑induced apoptosis in epithelial ovarian cancer. Oncology Letters 24:6.
Crossref
Yun Zhang, Zhe Liu, Xueliang Wang, Hui Jian, Haihan Xiao & Tingyi Wen. (2022) SHMT2 promotes cell viability and inhibits ROS-dependent, mitochondrial-mediated apoptosis via the intrinsic signaling pathway in bladder cancer cells. Cancer Gene Therapy 29:10, pages 1514-1527.
Crossref
Yiqun Liu, Jianrong Wang, Qin Wang, Feng Han, Lili Shi, Chao Han, Zhenwu Huang & Liang Xu. (2022) Effects of insufficient serine on health and selenoprotein expression in rats and their offspring. Frontiers in Nutrition 9.
Crossref
Reyhaneh Farghadani & Rakesh Naidu. 2022. Regulation and Dysfunction of Apoptosis. Regulation and Dysfunction of Apoptosis.
Lei Jin, Karrie Mei-Yee Kiang, Stephen Yin Cheng & Gilberto Ka-Kit Leung. (2022) Pharmacological inhibition of serine synthesis enhances temozolomide efficacy by decreasing O6-methylguanine DNA methyltransferase (MGMT) expression and reactive oxygen species (ROS)-mediated DNA damage in glioblastoma. Laboratory Investigation 102:2, pages 194-203.
Crossref
Yuping Tan, Xia Zhou, Yanqiu Gong, Kun Gou, Youfu Luo, Da Jia, Lunzhi Dai, Yinglan Zhao & Qingxiang Sun. (2021) Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors. Cellular and Molecular Life Sciences 79:1.
Crossref
Xia Zhou, Yuping Tan, Kun Gou, Lei Tao, Yuan Luo, Yue Zhou, Zeping Zuo, Qingxiang Sun, Youfu Luo & Yinglan Zhao. (2021) Discovery of novel inhibitors of human phosphoglycerate dehydrogenase by activity-directed combinatorial chemical synthesis strategy. Bioorganic Chemistry 115, pages 105159.
Crossref
Fang Wang, Chun-Shuang Xu, Wei-Hua Chen, Shi-Wei Duan, Shu-Jun Xu, Jun-Jie Dai & Qin-Wen Wang. (2021) Identification of Blood-Based Glycolysis Gene Associated with Alzheimer’s Disease by Integrated Bioinformatics Analysis. Journal of Alzheimer's Disease 83:1, pages 163-178.
Crossref
Mingxue Li, Canrong Wu, Yueying Yang, Mengzhu Zheng, Silin Yu, Jinhui Wang, Lixia Chen & Hua Li. (2021) 3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment. Cellular Oncology 44:3, pages 541-556.
Crossref
Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng, Guo-Qiang Lin, Dingding Gao & Ping Tian. (2021) A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism. European Journal of Medicinal Chemistry 217, pages 113379.
Crossref
Xiaohan Gao, Yan Wang, Fang Lu, Xu Chen, Di Yang, Yiren Cao, Weimin Zhang, Jie Chen, Leilei Zheng, Guangchao Wang, Ming Fu, Liying Ma, Yongmei Song & Qimin Zhan. (2021) Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl‐2/caspase‐3 pathway. Journal of Extracellular Vesicles 10:5.
Crossref
Eun Kyung Kim, Hye Min Kim & Ja Seung Koo. (2021) Expression of Glucose Metabolism-Related Proteins in Adrenal Neoplasms. Pathobiology 88:6, pages 424-433.
Crossref
Jiawei Xiang, Lei Tao, Yue Zhou, Yuping Tan, Zicheng Li, Yinglan Zhao, Qingxiang Sun & Youfu Luo. (2020) Synthesis and biological evaluation of innovative thiourea derivatives as PHGDH inhibitors. Chemical Papers 74:11, pages 3873-3886.
Crossref
Albert M. Li & Jiangbin Ye. (2020) The PHGDH enigma: Do cancer cells only need serine or also a redox modulator?. Cancer Letters 476, pages 97-105.
Crossref
Veronica Cocetta, Eugenio Ragazzi & Monica Montopoli. 2020. 107 164 .
Tetsuyuki Takahashi, Hirona Ichikawa, Yuuki Morimoto, Koichi Tsuneyama & Takao Hijikata. (2019) Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating γ-glutamyl cyclotransferase expression. Biochemical and Biophysical Research Communications 516:2, pages 388-396.
Crossref
Mengzhu Zheng, Jing Guo, Jiamin Xu, Kaiyin Yang, Ruotian Tang, Xiaoxia Gu, Hua Li & Lixia Chen. (2019) Ixocarpalactone A from dietary tomatillo inhibits pancreatic cancer growth by targeting PHGDH. Food & Function 10:6, pages 3386-3395.
Crossref
Lauren E Wilson, Zongli Xu, Sophia Harlid, Alexandra J White, Melissa A Troester, Dale P Sandler & Jack A Taylor. (2019) Alcohol and DNA Methylation: An Epigenome-Wide Association Study in Blood and Normal Breast Tissue. American Journal of Epidemiology 188:6, pages 1055-1065.
Crossref
Haomeng Zhang, Yao Lu, Jun Wang, Tian Zhang, Chuan Dong, Xiaoxiang Li, Xinli Wang, Qiong Ma, Tongtao Yang & Yong Zhou. (2019) Downregulation of the long non‑coding RNA FOXD2‑AS1 inhibits cell proliferation, migration and invasion in osteosarcoma. Molecular Medicine Reports.
Crossref
Renata Kujundžić, Višnja Stepanić, Lidija Milković, Ana Gašparović, Marko Tomljanović & Koraljka Trošelj. (2019) Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer. International Journal of Molecular Sciences 20:5, pages 1180.
Crossref
Gregory A. Grant. (2018) D-3-Phosphoglycerate Dehydrogenase. Frontiers in Molecular Biosciences 5.
Crossref
Sandra Kotz, Maximilian Kullmann, Ganna V. Kalayda, Nadine Dyballa‐Rukes, Ulrich Jaehde & Sabine Metzger. (2018) Optimized two‐dimensional gel electrophoresis in an alkaline pH range improves the identification of intracellular CFDA‐cisplatin‐protein adducts in ovarian cancer cells. ELECTROPHORESIS 39:12, pages 1488-1496.
Crossref
Judith E. Unterlass, Arnaud Baslé, Timothy J. Blackburn, Julie Tucker, Céline Cano, Martin E.M. Noble & Nicola J. Curtin. (2016) Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget 9:17, pages 13139-13153.
Crossref
Xia Yang, Da-Ni Zhong, Hui Qin, Pei-Rong Wu, Kang-Lai Wei, Gang Chen, Rong-Quan He & Jin-Cai Zhong. (2017) Caspase-3 over-expression is associated with poor overall survival and clinicopathological parameters in breast cancer: a meta-analysis of 3091 cases. Oncotarget 9:9, pages 8629-8641.
Crossref
Zhiwang Song, Chan Feng, Yonglin Lu, Yun Lin & Chunyan Dong. (2018) PHGDH is an independent prognosis marker and contributes cell proliferation, migration and invasion in human pancreatic cancer. Gene 642, pages 43-50.
Crossref
Sandra Lee, Marianne S. Rose, Vikrant V. Sahasrabuddhe, Rachel Zhao & Máire A. Duggan. (2017) Tissue-based Immunohistochemical Biomarker Accuracy in the Diagnosis of Malignant Glandular Lesions of the Uterine Cervix: A Systematic Review of the Literature and Meta-Analysis. International Journal of Gynecological Pathology 36:4, pages 310-322.
Crossref
Séverine Ravez, Quentin Spillier, Romain Marteau, Olivier Feron & Raphaël Frédérick. (2016) Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy. Journal of Medicinal Chemistry 60:4, pages 1227-1237.
Crossref
Xiaopeng Zhang, Chunchen Pan, Lei Zhou, Zhaogen Cai, Shufang Zhao & Donghong Yu. (2016) Knockdown of ST6Gal-I increases cisplatin sensitivity in cervical cancer cells. BMC Cancer 16:1.
Crossref
J. R. Hens, I. Sinha, F. Perodin, T. Cooper, R. Sinha, J. Plummer, C. E. Perrone & D. Orentreich. (2016) Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice. BMC Cancer 16:1.
Crossref
Jinhong Zhu, Jianqun Ma, Xudong Wang, Tianjiao Ma, Shu Zhang, Wei Wang, Xiaoyu Zhou & Jiahai Shi. (2016) High Expression of PHGDH Predicts Poor Prognosis in Non–Small Cell Lung Cancer. Translational Oncology 9:6, pages 592-599.
Crossref
Yingying Li, Sunan Wang, Yangkun Wang & Xingzhen Zeng. (2016) Pathological characteristics and immunophenotype analysis of cervical intraepithelial neoplasia. Oncology and Translational Medicine 2:6, pages 285-289.
Crossref
Lei Xing, Christopher J. Martyniuk, Crystal Esau, Dillon F. Da Fonte & Vance L. Trudeau. (2016) Proteomic profiling reveals dopaminergic regulation of progenitor cell functions of goldfish radial glial cells in vitro. Journal of Proteomics 144, pages 123-132.
Crossref
Xiao-qin Jia, Shu Zhang, Hui-jun Zhu, Wei Wang, Jin-hong Zhu, Xu-dong Wang & Jian-feng Qiang. (2016) Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer. Translational Oncology 9:3, pages 191-196.
Crossref
Fang Wang, Chun-shuang Xu, Wei-hua Chen, Shiwei Duan, Shu-jun Xu, Jun-jie Dai & Qin-wen Wang. (2021) A Glycolysis Gene Methylation Prediction Model Based on Explainable Machine Learning for Alzheimer's Disease. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.