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Cancer Biology & Therapy Volume 16, 2015 - Issue 11
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Research Papers

Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model

Einav Mayzlish-GatiInstitute of Plant Sciences; ARO; Volcani Center; Bet Dagan, Israel
,
Dana LauferInstitute of Plant Sciences; ARO; Volcani Center; Bet Dagan, Israel;Faculty of Engineering Sciences; The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering; Ben-Gurion University of the Negev; Beer-Sheva, Israel
,
Christopher F GrivasDepartment of Human Science; SNHS; Georgetown University; Washington, DCUSA
,
Julia ShaknofInstitute of Plant Sciences; ARO; Volcani Center; Bet Dagan, Israel
,
Amiram SananesInstitute of Plant Sciences; ARO; Volcani Center; Bet Dagan, Israel;Faculty of Engineering Sciences; The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering; Ben-Gurion University of the Negev; Beer-Sheva, Israel
,
Ariel BierInstitute of Plant Sciences; ARO; Volcani Center; Bet Dagan, Israel
,
Shani Ben-HaroshFaculty of Engineering Sciences; The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering; Ben-Gurion University of the Negev; Beer-Sheva, Israel
,
Eduard BelausovInstitute of Plant Sciences; ARO; Volcani Center; Bet Dagan, Israel
,
Michael D JohnsonDepartment of Oncology; Georgetown University Medical Center; Washington, DCUSA;The Lombardi Comprehensive Cancer Center; Georgetown University Medical Center; Washington, DCUSA
,
Emma ArtusoDepartment of Chemistry; University of Turin; Torino, Italy
,
Oshrat LeviInstitute of Animal Sciences; Volcani Center; Bet Dagan, Israel
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Ola GeninInstitute of Animal Sciences; Volcani Center; Bet Dagan, Israel
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Cristina PrandiDepartment of Chemistry; University of Turin; Torino, Italy
,
Isam KhalailaFaculty of Engineering Sciences; The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering; Ben-Gurion University of the Negev; Beer-Sheva, Israel
,
Mark PinesInstitute of Animal Sciences; Volcani Center; Bet Dagan, Israel
,
Ronit I YardenDepartment of Human Science; SNHS; Georgetown University; Washington, DCUSA;The Lombardi Comprehensive Cancer Center; Georgetown University Medical Center; Washington, DCUSA
,
Yoram KapulnikInstitute of Plant Sciences; ARO; Volcani Center; Bet Dagan, Israel
&
Hinanit KoltaiInstitute of Plant Sciences; ARO; Volcani Center; Bet Dagan, IsraelCorrespondence[email protected]
 show all
Pages 1682-1688 | Received 05 Jan 2015, Accepted 03 Jul 2015, Published online: 19 Oct 2015

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Kai Jiang & Tadao Asami. (2018) Chemical regulators of plant hormones and their applications in basic research and agriculture . Bioscience, Biotechnology, and Biochemistry 82:8, pages 1265-1300.
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Zhaoyong Kang, Yujie Yan, Ruirui Lu, Xiaoqi Dong, Jun Xu, Dong Zheng, Suhua Li, Qingzhi Gao & Shengnan Liu. (2023) Synthesis and Biological Profiling of Novel Strigolactone Derivatives for Arabidopsis Growth and Development . Journal of Agricultural and Food Chemistry 71:34, pages 12859-12874.
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Matteo Biolatti, Marco Blangetti, Melissa Baggieri, Antonella Marchi, Silvia Gioacchini, Greta Bajetto, Davide Arnodo, Paola Bucci, Raoul Fioravanti, Maedeh Kojouri, Matteo Bersani, Giulia D’Arrigo, Lydia Siragusa, Simone Ghinato, Marco De Andrea, Francesca Gugliesi, Camilla Albano, Selina Pasquero, Ivan Visentin, Emilio D’Ugo, Francesca Esposito, Paolo Malune, Enzo Tramontano, Cristina Prandi, Francesca Spyrakis, Fabio Magurano & Valentina Dell’Oste. (2023) Strigolactones as Broad-Spectrum Antivirals against β-Coronaviruses through Targeting the Main Protease M pro . ACS Infectious Diseases 9:7, pages 1310-1318.
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Shu-Ting Yang, Jin-Bao Fan, Ting-Ting Liu, Shuai Ning, Jia-Hao Xu, Ying-Jun Zhou & Xu Deng. (2022) Development of Strigolactones as Novel Autophagy/Mitophagy Inhibitors against Colorectal Cancer Cells by Blocking the Autophagosome–Lysosome Fusion. Journal of Medicinal Chemistry 65:14, pages 9706-9717.
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Gizem Antika, Zeynep Özlem Cinar, Esma Seçen, Mehmet Özbil, Esra Tokay, Feray Köçkar, Cristina Prandi & Tugba Boyunegmez Tumer. (2022) Strigolactone Analogs: Two New Potential Bioactiphores for Glioblastoma. ACS Chemical Neuroscience 13:5, pages 572-580.
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Cristina Prandi, Yoram Kapulnik & Hinanit Koltai. (2021) Strigolactones: Phytohormones with Promising Biomedical Applications. European Journal of Organic Chemistry 2021:29, pages 4019-4026.
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Valentina Dell’Oste, Francesca Spyrakis & Cristina Prandi. (2021) Strigolactones, from Plants to Human Health: Achievements and Challenges. Molecules 26:15, pages 4579.
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Yuliya Krasylenko, George Komis, Sofiia Hlynska, Tereza Vavrdová, Miroslav Ovečka, Tomáš Pospíšil & Jozef Šamaj. (2021) GR24, A Synthetic Strigolactone Analog, and Light Affect the Organization of Cortical Microtubules in Arabidopsis Hypocotyl Cells. Frontiers in Plant Science 12.
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Maria Tannous, Fabrizio Caldera, Gjylije Hoti, Umberto Dianzani, Roberta Cavalli & Francesco Trotta. 2021. Supramolecules in Drug Discovery and Drug Delivery. Supramolecules in Drug Discovery and Drug Delivery 247 283 .
Matteo Biolatti, Marco Blangetti, Giulia D’Arrigo, Francesca Spyrakis, Paola Cappello, Camilla Albano, Paolo Ravanini, Santo Landolfo, Marco De Andrea, Cristina Prandi & Valentina Dell’Oste. (2020) Strigolactone Analogs Are Promising Antiviral Agents for the Treatment of Human Cytomegalovirus Infection. Microorganisms 8:5, pages 703.
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Begum Kurt, Adem Ozleyen, Gizem Antika, Yakup Berkay Yilmaz & Tugba Boyunegmez Tumer. (2020) Multitarget Profiling of a Strigolactone Analogue for Early Events of Alzheimer’s Disease: In Vitro Therapeutic Activities against Neuroinflammation. ACS Chemical Neuroscience 11:4, pages 501-507.
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Stefano Nejrotti, Marta Iannicelli, Salwa Simona Jamil, Davide Arnodo, Marco Blangetti & Cristina Prandi. (2020) Natural deep eutectic solvents as an efficient and reusable active system for the Nazarov cyclization. Green Chemistry 22:1, pages 110-117.
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Paloma Carrillo, Beatriz Martínez-Poveda, Miguel Ángel Medina & Ana R. Quesada. (2019) The strigolactone analog GR-24 inhibits angiogenesis in vivo and in vitro by a mechanism involving cytoskeletal reorganization and VEGFR2 signalling. Biochemical Pharmacology 168, pages 366-383.
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Cristina Prandi & Ernesto G Occhiato. (2019) From synthetic control to natural products: a focus on N -heterocycles . Pest Management Science 75:9, pages 2385-2402.
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Mohammed Nihal Hasan, Syed Shoeb Razvi, Hani Choudhry, Mohammed A. Hassan, Said Salama Moselhy, Taha Abduallah Kumosani, Mazin A. Zamzami, Khalid Omer Abualnaja, Majed A. Halwani, Abdulrahman Labeed Al-Malki, Jiannis Ragoussis, Wei Wu, Christian Bronner, Tadao Asami & Mahmoud Alhosin. (2019) Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line. Analytical Cellular Pathology 2019, pages 1-10.
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Monica Argenziano, Chiara Lombardi, Benedetta Ferrara, Francesco Trotta, Fabrizio Caldera, Marco Blangetti, Hinanit Koltai, Yoram Kapulnik, Ronit Yarden, Luca Gigliotti, Umberto Dianzani, Chiara Dianzani, Cristina Prandi & Roberta Cavalli. (2018) Glutathione/pH-responsive nanosponges enhance strigolactone delivery to prostate cancer cells. Oncotarget 9:88, pages 35813-35829.
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Tugba Boyunegmez Tumer, Berkay Yılmaz, Adem Ozleyen, Begum Kurt, Tugba Taskın Tok, Kemal Melik Taskin & Seda Savranoglu Kulabas. (2018) GR24, a synthetic analog of Strigolactones, alleviates inflammation and promotes Nrf2 cytoprotective response: In vitro and in silico evidences. Computational Biology and Chemistry 76, pages 179-190.
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Mohammed Nihal Hasan, Syed S. I. Razvi, Abudukadeer Kuerban, Khadijah Saeed Balamash, Widad M. Al-Bishri, Khalid Omar Abulnaja, Hani Choudhry, Jehan A. Khan, Said Salama Moselhy, Zamzami Ma, Taha A. Kumosani, Abdulrahman L. Al-Malki, Mahmoud Alhosin & Tadao Asami. (2018) Strigolactones—a novel class of phytohormones as anti-cancer agentsストリゴラクトン: 抗癌剤としての新しい植物ホルモン. Journal of Pesticide Science 43:3, pages 168-172.
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Elena Sanchez, Emma Artuso, Chiara Lombardi, Ivan Visentin, Beatrice Lace, Wajeeha Saeed, Marco L Lolli, Piermichele Kobauri, Zahid Ali, Francesca spyrakis, Pilar Cubas, Francesca Cardinale & Cristina Prandi. (2018) Structure–activity relationships of strigolactones via a novel, quantitative in planta bioassay. Journal of Experimental Botany 69:9, pages 2333-2343.
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Binne Zwanenburg & Daniel Blanco-Ania. (2018) Strigolactones: new plant hormones in the spotlight. Journal of Experimental Botany 69:9, pages 2205-2218.
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Mohammed Nihal Hasan, Hani Choudhry, Syed Shoeb Razvi, Said Salama Moselhy, Taha Abduallah Kumosani, Mazin A. Zamzami, Ziad Omran, Majed A. Halwani, Salim Al-Babili, Khalid Omer Abualnaja, Abdulrahman Labeed Al-Malki, Mahmoud Alhosin & Tadao Asami. (2018) Synthetic strigolactone analogues reveal anti-cancer activities on hepatocellular carcinoma cells. Bioorganic & Medicinal Chemistry Letters 28:6, pages 1077-1083.
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Shalem Raju Modi & Tarja Kokkola. (2018) Strigolactone GR24 upregulates target genes of the cytoprotective transcription factor Nrf2 in skeletal muscle. F1000Research 7, pages 1459.
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Shalem Raju Modi & Tarja Kokkola. (2018) Strigolactone GR24 upregulates Nrf2 target genes and may protect against oxidative stress in skeletal muscle. F1000Research 7, pages 1459.
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Jun-Xia Zheng, Yu-Shui Han, Jin-Cai Wang, Hui Yang, Hao Kong, Kang-Jia Liu, Si-Yu Chen, Yi-Rui Chen, Yi-Qun Chang, Wei-Min Chen, Jia-Liang Guo & Ping-Hua Sun. (2018) Strigolactones: a plant phytohormone as novel anti-inflammatory agents. MedChemComm 9:1, pages 181-188.
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Mendelovich Maayan, Shoshan Monick, Fridlender Marcelo, Mazuz Moran, Namder Dvora, Nallathambi Rameshprabu, Selvaraj Gopinath, Kumari Puja, Ion Aurel, Wininger Smadar, Nasser Ahmad, Samara Mohamed, Sharvit Yaacov, Kapulnik Yoram, Dudai Native & Koltai Hinanit. (2017) Effect of Ephedra foeminea active compounds on cell viability and actin structures in cancer cell lines. Journal of Medicinal Plants Research 11:43, pages 690-702.
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Stefano Nejrotti, Gabriele Prina Cerai, Alberto Oppedisano, Andrea Maranzana, Ernesto G. Occhiato, Dina Scarpi, Annamaria Deagostino & Cristina Prandi. (2017) A Gold(I)-Catalyzed Oxidative Rearrangement of Heterocycle-Derived 1,3-Enynes Provides an Efficient and Selective Route to Divinyl Ketones. European Journal of Organic Chemistry 2017:41, pages 6228-6238.
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Chiara Lombardi, Emma Artuso, Eleonora Grandi, Marco Lolli, Francesca Spirakys, Emanuele Priola & Cristina Prandi. (2017) Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step. Organic & Biomolecular Chemistry 15:38, pages 8218-8231.
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Maurizio Vurro, Cristina Prandi & Francesca Baroccio. (2016) Strigolactones: how far is their commercial use for agricultural purposes?. Pest Management Science 72:11, pages 2026-2034.
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Beatrice Lace & Cristina Prandi. (2016) Shaping Small Bioactive Molecules to Untangle Their Biological Function: A Focus on Fluorescent Plant Hormones. Molecular Plant 9:8, pages 1099-1118.
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Michael P. Croglio, Jefferson M. Haake, Colin P. Ryan, Victor S. Wang, Jennifer Lapier, Jamie P. Schlarbaum, Yaron Dayani, Emma Artuso, Cristina Prandi, Hinanit Koltai, Keli Agama, Yves Pommier, Yu Chen, Lucas Tricoli, Jeannine R. LaRocque, Christopher Albanese & Ronit I. Yarden. (2016) Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair. Oncotarget 7:12, pages 13984-14001.
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Marcelo Fridlender, Yoram Kapulnik & Hinanit Koltai. (2015) Plant derived substances with anti-cancer activity: from folklore to practice. Frontiers in Plant Science 6.
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