1,722
Views
41
CrossRef citations to date
0
Altmetric
Research Paper

Metformin inhibits prostate cancer cell proliferation, migration, and tumor growth through upregulation of PEDF expression

, , , , , & show all
Pages 507-514 | Received 04 Jan 2016, Accepted 14 Feb 2016, Published online: 11 Apr 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Seyed Sadegh Eslami, Davod Jafari, Hamed Montazeri, Majid Sadeghizadeh & Parastoo Tarighi. (2021) Combination of Curcumin and Metformin Inhibits Cell Growth and Induces Apoptosis without Affecting the Cell Cycle in LNCaP Prostate Cancer Cell Line. Nutrition and Cancer 73:6, pages 1026-1039.
Read now
Jianxin Xu, Xuejiao Fang, Luye Long, Sixuan Wang, Shihan Qian & Jianxin Lyu. (2021) HMGA2 promotes breast cancer metastasis by modulating Hippo-YAP signaling pathway. Cancer Biology & Therapy 22:1, pages 5-11.
Read now
Xiao Chen, Dong-Dong Wang & Zhi-Ping Li. (2020) Time course and dose effect of metformin on weight in patients with different disease states. Expert Review of Clinical Pharmacology 13:10, pages 1169-1177.
Read now

Articles from other publishers (38)

Saheed Oluwasina Oseni, Corey Naar, Mirjana Pavlović, Waseem Asghar, James X. Hartmann, Gregg B. Fields, Nwadiuto Esiobu & James Kumi-Diaka. (2023) The Molecular Basis and Clinical Consequences of Chronic Inflammation in Prostatic Diseases: Prostatitis, Benign Prostatic Hyperplasia, and Prostate Cancer. Cancers 15:12, pages 3110.
Crossref
Zhaoli Chu, Yao Tan, Chenxing Xu, Dongting Zhangsun & Xiaopeng Zhu. (2023) Potential Mechanisms of Metformin-Induced Apoptosis in HeLa Cells. Biomolecules 13:6, pages 950.
Crossref
Fabrizio Fontana, Martina Anselmi & Patrizia Limonta. (2023) Unraveling the Peculiar Features of Mitochondrial Metabolism and Dynamics in Prostate Cancer. Cancers 15:4, pages 1192.
Crossref
Nan Fang Wang, Toni Rose Jue, Jeff Holst & Jennifer H. Gunter. (2022) Systematic review of antitumour efficacy and mechanism of metformin activity in prostate cancer models. BJUI Compass 4:1, pages 44-58.
Crossref
Emuejevoke Olokpa, Sammed N. Mandape, Siddharth Pratap & La Monica V. Stewart. (2022) Metformin regulates multiple signaling pathways within castration-resistant human prostate cancer cells. BMC Cancer 22:1.
Crossref
Emad Jafarzadeh, Vahideh Montazeri, Shima Aliebrahimi, Ahmad Habibian Sezavar, Mohammad H. Ghahremani & Seyed Nasser Ostad. (2022) Combined regimens of cisplatin and metformin in cancer therapy: A systematic review and meta-analysis. Life Sciences 304, pages 120680.
Crossref
Masataka Majima, Kanako Hosono, Yoshiya Ito & Hideki Amano. (2022) Biologically active lipids in the regulation of lymphangiogenesis in disease states. Pharmacology & Therapeutics 232, pages 108011.
Crossref
Mirian Galliote Morale, Rodrigo Esaki Tamura & Ileana Gabriela Sanchez Rubio. (2022) Metformin and Cancer Hallmarks: Molecular Mechanisms in Thyroid, Prostate and Head and Neck Cancer Models. Biomolecules 12:3, pages 357.
Crossref
Chin-Hsiao Tseng. (2022) The Effect of Metformin on Male Reproductive Function and Prostate: An Updated Review. The World Journal of Men's Health 40:1, pages 11.
Crossref
Zhuo Wang, Jieliang Zuo, Linlin Zhang, Zhenghua Zhang & Yongpeng Wei. (2022) Plantamajoside promotes metformin-induced apoptosis, autophagy and proliferation arrest of liver cancer cells via suppressing Akt/GSK3β signaling. Human & Experimental Toxicology 41, pages 096032712210788.
Crossref
Ying Wu, Xuexin Chen, Simeng Jiao & Yiqian Wang. (2021) Upregulated pigment epithelium-derived factor (PEDF) promotes trophoblast apoptosis and inhibits invasion in preeclampsia. Reproductive Biology 21:4, pages 100576.
Crossref
Bin Shi, Xinyu Hu, Huimin He & Wenzheng Fang. (2021) Metformin suppresses breast cancer growth via inhibition of cyclooxygenase‑2. Oncology Letters 22:2.
Crossref
Zhongwei Chen, Zhen Zeng, Shanshan Zhu, Ying Zeng, Qihuang Lin, Lianzhong Luo & Xuan Hong. (2021) Effects of different combined regimens of cisplatin, metformin, and quercetin on nasopharyngeal carcinoma cells and subcutaneous xenografts. Scientific Reports 11:1.
Crossref
Ying Jiang, Hanbing Song, Ling Jiang, Yu Qiao, Dan Yang, Donghua Wang & Ji Li. (2020) Silybin Prevents Prostate Cancer by Inhibited the ALDH1A1 Expression in the Retinol Metabolism Pathway. Frontiers in Cell and Developmental Biology 8.
Crossref
Shankargouda Patil. (2020) Metformin treatment decreases the expression of cancer stem cell marker CD44 and stemness related gene expression in primary oral cancer cells. Archives of Oral Biology 113, pages 104710.
Crossref
De-Rong Tang, Cheng-Lin Li, Ke-Ping Xu, Qing-Quan Wu, Qi-You Chen, Jun-Jie Lv, Jian Ji, Bao Zang, Chen Chen, Biao Gu & Jian-Qiang Zhao. (2020) Pigment Epithelium-Derived Factor Promotes the Growth and Migration of Human Esophageal Squamous Cell Carcinoma. Frontiers in Oncology 9.
Crossref
Sho-ichi Yamagishi, Yoshinori Koga, Ami Sotokawauchi, Naoki Hashizume, Suguru Fukahori, Takanori Matsui & Minoru Yagi. (2019) Therapeutic Potential of Pigment Epithelium-derived Factor in Cancer. Current Pharmaceutical Design 25:3, pages 313-324.
Crossref
Seniz Inanc, Didem Keles, Gorkem Eskiizmir, Yasemin Basbinar & Gulgun Oktay. (2019) METFORMIN AND DICHOLOROACETATE COMBINATION EXERT A SYNERGISTIC EFFECT ON CELL VIABILITY OF ORAL SQUAMOUS CELL CARCINOMA. ENT Updates.
Crossref
Wen-Tsung Huang, Inn-Wen Chong, Hsiu-Lin Chen, Chia-Yang Li, Chong-Chao Hsieh, Hsuan-Fu Kuo, Chia-Yuan Chang, Yung-Hsiang Chen, Yu-Peng Liu, Chi-Yu Lu, Yu-Ru Liu & Po-Len Liu. (2019) Pigment epithelium-derived factor inhibits lung cancer migration and invasion by upregulating exosomal thrombospondin 1. Cancer Letters 442, pages 287-298.
Crossref
Monica Tyagi, Manjinder S. Cheema, Deanna Dryhurst, Christopher H. Eskiw & Juan Ausió. (2018) Metformin alters H2A.Z dynamics and regulates androgen dependent prostate cancer progression. Oncotarget 9:97, pages 37054-37068.
Crossref
Shantanu Pradhan, John L. Sperduto, Cindy J. Farino & John H. Slater. (2018) Engineered In Vitro Models of Tumor Dormancy and Reactivation. Journal of Biological Engineering 12:1.
Crossref
Pei-Yi Wu, Yueh-Chien Lin, Yuan-Li Huang, Wei-Min Chen, Chien-Chin Chen & Hsinyu Lee. (2018) Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer. Cancers 10:11, pages 413.
Crossref
Giacomo Biagiotti, Maria Cristina Ligi, Stefano Fedeli, Erica Pranzini, Tania Gamberi, Stefano Cicchi & Paolo Paoli. (2018) Metformin salts with oxidized multiwalled carbon nanotubes: In vitro biological activity and inhibition of CNT internalization. Journal of Drug Delivery Science and Technology 47, pages 254-258.
Crossref
Ritwika Mallik & Tahseen A. Chowdhury. (2018) Metformin in cancer. Diabetes Research and Clinical Practice 143, pages 409-419.
Crossref
Cuiping Bao, Nancy L Pedersen, Rongrong Yang, Anna Marseglia, Weige Xu, Yaogang Wang, Xiuying Qi & Weili Xu. (2018) Diabetes in midlife and risk of cancer in late life: A nationwide Swedish twin study. International Journal of Cancer 143:4, pages 793-800.
Crossref
Shuben Sun, Fanger Gong, Ping Liu & Qilong Miao. (2018) Metformin combined with quercetin synergistically repressed prostate cancer cells via inhibition of VEGF/PI3K/Akt signaling pathway. Gene 664, pages 50-57.
Crossref
Chenglai Xia, Shaofen Liang, Zhihong He, Xiaolan Zhu, Ruihong Chen & Jinman Chen. (2018) Metformin, a first-line drug for type 2 diabetes mellitus, disrupts the MALAT1/miR-142-3p sponge to decrease invasion and migration in cervical cancer cells. European Journal of Pharmacology 830, pages 59-67.
Crossref
Breno C. Landim, Mariana M. de Jesus, Beatriz P. Bosque, Renata G. Zanon, Claudio V. da Silva, Rejane M. Góes & Daniele L. Ribeiro. (2018) Stimulating effect of palmitate and insulin on cell migration and proliferation in PNT1A and PC3 prostate cells: Counteracting role of metformin. The Prostate 78:10, pages 731-742.
Crossref
Feixue Feng, Jianping Zhang, Xiaoxuan Fan, Fang Yuan, Yinghao Jiang, Ruihua Lv & Yanxia Ma. (2017) Downregulation of Rab27A contributes to metformin-induced suppression of breast cancer stem cells. Oncology Letters 14:3, pages 2947-2953.
Crossref
Julien Daubriac, Unnati M Pandya, Kuang-Tzu Huang, Savvas C Pavlides, Patricia Gama, Stephanie V Blank, Pratibha Shukla, Susan E Crawford & Leslie I Gold. (2017) Hormonal and Growth Regulation of Epithelial and Stromal Cells From the Normal and Malignant Endometrium by Pigment Epithelium-Derived Factor. Endocrinology 158:9, pages 2754-2773.
Crossref
Uzoagu Okonkwo & Luisa DiPietro. (2017) Diabetes and Wound Angiogenesis. International Journal of Molecular Sciences 18:7, pages 1419.
Crossref
André Sarmento-Cabral, Fernando L-López, Manuel D. Gahete, Justo P. Castaño & Raúl M. Luque. (2017) Metformin Reduces Prostate Tumor Growth, in a Diet-Dependent Manner, by Modulating Multiple Signaling Pathways. Molecular Cancer Research 15:7, pages 862-874.
Crossref
T Yu, C Wang, J Yang, Y Guo, Y Wu & X Li. (2017) Metformin inhibits SUV39H1-mediated migration of prostate cancer cells. Oncogenesis 6:5, pages e324-e324.
Crossref
Yuan Chen, Lei Fang, Jiali Zhang, Gefei Li, Mengni Ma, Changxi Li, Jianxin Lyu & Qing Meng. (2017) Blockage of Glyoxalase I Inhibits Colorectal Tumorigenesis and Tumor Growth via Upregulation of STAT1, p53, and Bax and Downregulation of c-Myc and Bcl-2. International Journal of Molecular Sciences 18:3, pages 570.
Crossref
Chenglai Xia, Ruihong Chen, Jinman Chen, Qianqian Qi, Yanbin Pan, Lanying Du, Guohong Xiao & Shibo Jiang. (2017) Combining metformin and nelfinavir exhibits synergistic effects against the growth of human cervical cancer cells and xenograft in nude mice. Scientific Reports 7:1.
Crossref
Yi-Chao Hou, Qiang Hu, Jiao Huang, Jing-Yuan Fang & Hua Xiong. (2016) Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis. Oncotarget 8:5, pages 8843-8853.
Crossref
Jun XiaoHaibo Yu. (2017) Gemcitabine Conjugated Chitosan and Double Antibodies (Abc-GC-Gemcitabine Nanoparticles) Enhanced Cytoplasmic Uptake of Gemcitabine and Inhibit Proliferation and Metastasis In Human SW1990 Pancreatic Cancer Cells. Medical Science Monitor 23, pages 1613-1620.
Crossref
Ruijie Sun, Xiaojie Ma, Xiaolan Cai, Xinliang Pan & Dayu Liu. (2016) The effect and mechanism of action of metformin on in vitro FaDu cell proliferation. Journal of International Medical Research 44:5, pages 1049-1054.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.