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Cancer Biology & Therapy Volume 18, 2017 - Issue 11
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Research Paper

The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis

Batzaya DavaadelgerDepartment of Cell and Molecular Medicine, Rush University Medical Center, Chicago, IL, USA
,
Ricardo E. PerezDepartment of Cell and Molecular Medicine, Rush University Medical Center, Chicago, IL, USA
,
Yalu ZhouDepartment of Cell and Molecular Medicine, Rush University Medical Center, Chicago, IL, USA
,
Lei DuanDepartment of Cell and Molecular Medicine, Rush University Medical Center, Chicago, IL, USA
,
Steven GitelisDepartment of Orthopedic Oncology, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA
&
Carl G. MakiDepartment of Cell and Molecular Medicine, Rush University Medical Center, Chicago, IL, USACorrespondence[email protected]
Pages 895-903 | Received 17 May 2017, Accepted 17 Jun 2017, Published online: 17 Nov 2017

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Changhui Li, Shouyun Zhang, Tongguo Qiu, Yuanji Wang, David M. Ricketts & Chao Qi. (2019) Upregulation of long non-coding RNA NNT-AS1 promotes osteosarcoma progression by inhibiting the tumor suppressive miR-320a. Cancer Biology & Therapy 20:4, pages 413-422.
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Lei Duan, Ricardo E. Perez & Carl G. Maki. (2019) Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a. Cancer Biology & Therapy 20:3, pages 252-260.
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Articles from other publishers (8)

Lucia Haronikova, Ondrej Bonczek, Pavlina Zatloukalova, Filip Kokas-Zavadil, Martina Kucerikova, Philip J. Coates, Robin Fahraeus & Borivoj Vojtesek. (2021) Resistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them?. Cellular & Molecular Biology Letters 26:1.
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Cong Zhou & Shiwei Duan. (2020) The Role of Long Non-Coding RNA NNT-AS1 in Neoplastic Disease. Cancers 12:11, pages 3086.
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Shomereeta Roy, Audrey Laroche-Clary, Stephanie Verbeke, Marie-Alix Derieppe & Antoine Italiano. (2020) MDM2 Antagonists Induce a Paradoxical Activation of Erk1/2 through a P53-Dependent Mechanism in Dedifferentiated Liposarcomas: Implications for Combinatorial Strategies. Cancers 12:8, pages 2253.
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Maria Chiara Proto, Donatella Fiore, Giovanni Forte, Paola Cuozzo, Anna Ramunno, Caterina Fattorusso, Patrizia Gazzerro, Maria Pascale & Silvia Franceschelli. (2019) Tetra-substituted pyrrole derivatives act as potent activators of p53 in melanoma cells. Investigational New Drugs 38:3, pages 634-649.
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Edward M. Greenfield, Christopher D. Collier & Patrick J. Getty. 2020. Current Advances in the Science of Osteosarcoma. Current Advances in the Science of Osteosarcoma 141 155 .
S. TokiE. KobayashiA. YoshidaK. OguraS. WakaiS. YoshimotoK. YonemoriA. Kawai. (2019) A clinical comparison between dedifferentiated low-grade osteosarcoma and conventional osteosarcoma. The Bone & Joint Journal 101-B:6, pages 745-752.
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Stephanie L. Celano, Lisette P. Yco, Matthew G. Kortus, Abigail R. Solitro, Hakan Gunaydin, Mark Scott, Edward Spooner, Ronan C. O'Hagan, Peter Fuller, Katie R. Martin, Stuart D. Shumway & Jeffrey P. MacKeigan. (2019) Identification of Kinases Responsible for p53-Dependent Autophagy. iScience 15, pages 109-118.
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Fernando M. Simabuco, Mirian G. Morale, Isadora C.B. Pavan, Ana P. Morelli, Fernando R. Silva & Rodrigo E. Tamura. (2018) p53 and metabolism: from mechanism to therapeutics. Oncotarget 9:34, pages 23780-23823.
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