Auranofin inhibition of thioredoxin reductase sensitizes lung neuroendocrine tumor cells (NETs) and small cell lung cancer (SCLC) cells to sorafenib as well as inhibiting SCLC xenograft growth

Spenser S. Johnsona Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USAView further author information

Dijie Liub Department Pediatrics, University of Iowa Hospitals and Clinics, IA, USAView further author information

Jordan T. Ewalda Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USAView further author information

Claudia Robles-Planellsb Department Pediatrics, University of Iowa Hospitals and Clinics, IA, USAView further author information

Casey Pulliama Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USAView further author information

Keegan A. Christensena Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USAView further author information

Khaliunaa Bayanbolda Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USAView further author information

Brian R. Welsc State Hygienic Laboratory, University of Iowa, IA, USAView further author information

Shane R. Solsta Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USAView further author information

M. Sue O’Dorisiob Department Pediatrics, University of Iowa Hospitals and Clinics, IA, USAView further author information

Yusuf Mendad Department of Radiology, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, IA, USAView further author information

Douglas R. Spitza Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USAView further author information

Melissa A. Fatha Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USACorrespondence[email protected]

https://orcid.org/0000-0002-7272-2120 View further author information

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Auranofin inhibition of thioredoxin reductase sensitizes lung neuroendocrine tumor cells (NETs) and small cell lung cancer (SCLC) cells to sorafenib as well as inhibiting SCLC xenograft growth

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Auranofin inhibition of thioredoxin reductase sensitizes lung neuroendocrine tumor cells (NETs) and small cell lung cancer (SCLC) cells to sorafenib as well as inhibiting SCLC xenograft growth

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