Advanced search
Publication Cover
Cell Cycle Volume 14, 2015 - Issue 11
Submit an article Journal homepage
1,454
Views
37
CrossRef citations to date
0
Altmetric
Report

Let-7a regulates mammosphere formation capacity through Ras/NF-κB and Ras/MAPK/ERK pathway in breast cancer stem cells

Chongwen XuSecond Department of Thoracic Surgery; First Affiliated Hospital; Medical College of Xi'an Jiaotong University; Xi'an, Shaanxi; PR China
,
Xin SunSecond Department of Thoracic Surgery; First Affiliated Hospital; Medical College of Xi'an Jiaotong University; Xi'an, Shaanxi; PR China
,
Sida QinSecond Department of Thoracic Surgery; First Affiliated Hospital; Medical College of Xi'an Jiaotong University; Xi'an, Shaanxi; PR China
,
Huangzhen WangSecond Department of Thoracic Surgery; First Affiliated Hospital; Medical College of Xi'an Jiaotong University; Xi'an, Shaanxi; PR China
,
Zhiwei ZhengGeneral Surgery; People's Hospital of Rizhao; Rizhao, Shandong, PR China
,
Shaohua XuDepartment of Gynecology; Shanghai First Maternity and Infant Hospital; Tongji University School of Medicine; Shanghai, PR China
,
Gang LuoSecond Department of Thoracic Surgery; First Affiliated Hospital; Medical College of Xi'an Jiaotong University; Xi'an, Shaanxi; PR China
,
Peng LiuSecond Department of Thoracic Surgery; First Affiliated Hospital; Medical College of Xi'an Jiaotong University; Xi'an, Shaanxi; PR China
,
Jian LiuSecond Department of Thoracic Surgery; First Affiliated Hospital; Medical College of Xi'an Jiaotong University; Xi'an, Shaanxi; PR China
,
Ning DuSecond Department of Thoracic Surgery; First Affiliated Hospital; Medical College of Xi'an Jiaotong University; Xi'an, Shaanxi; PR China
,
Yunfeng ZhangSecond Department of Thoracic Surgery; First Affiliated Hospital; Medical College of Xi'an Jiaotong University; Xi'an, Shaanxi; PR China
,
Dapeng LiuSecond Department of Thoracic Surgery; First Affiliated Hospital; Medical College of Xi'an Jiaotong University; Xi'an, Shaanxi; PR China
&
Hong RenSecond Department of Thoracic Surgery; First Affiliated Hospital; Medical College of Xi'an Jiaotong University; Xi'an, Shaanxi; PR ChinaCorrespondence[email protected]
 show all
Pages 1686-1697 | Received 08 Dec 2014, Accepted 12 Mar 2015, Published online: 02 Jun 2015

Citations (37)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Jia-Hong Liang, Qiao-Dong Xu & Song-Gang Gu. (2022) LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis modulates tumorigenesis and cancer stem cell-like properties in liver cancer. Bioengineered 13:2, pages 4285-4300.
Read now
Fei Liu, Yong Tai & Jiqing Ma. (2018) LncRNA NEAT1/let-7a-5p axis regulates the cisplatin resistance in nasopharyngeal carcinoma by targeting Rsf-1 and modulating the Ras-MAPK pathway. Cancer Biology & Therapy 19:6, pages 534-542.
Read now
Ying Shi, Tong Cao, Hua Huang, Chaoqun Lian, Ying Yang, Zhiwei Wang, Jia Ma & Jun Xia. (2017) Arsenic trioxide inhibits cell growth and motility via up-regulation of let-7a in breast cancer cells. Cell Cycle 16:24, pages 2396-2403.
Read now

Articles from other publishers (34)

Sin-Yu Chen, Yi-Ling Chen, Po-Chen Li, Tai-Shan Cheng, Yeh-Shiu Chu, Yi-Shan Shen, Hsin-Tung Chen, Wei-Ni Tsai, Chien-Ling Huang, Martin Sieber, Yuan-Chieh Yeh, Hsiao-Sheng Liu, Chi-Ling Chiang, Chih-Hung Chang, Andrew S. Lee, Yen-Han Tseng, Ly James Lee, Hsiu-Jung Liao, Hon-Kan Yip & Chi-Ying F. Huang. (2024) Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury. Journal of Biomedical Science 31:1.
Crossref
Alejandro Ordaz-Ramos, Olivia Tellez-Jimenez & Karla Vazquez-Santillan. (2023) Signaling pathways governing the maintenance of breast cancer stem cells and their therapeutic implications. Frontiers in Cell and Developmental Biology 11.
Crossref
Ahmed Ismail, Hesham A. El-Mahdy, Ahmed I. Abulsoud, Al-Aliaa M. Sallam, Mahmoud Gomaa Eldeib, Elsayed G.E. Elsakka, Mohamed Bakr Zaki & Ahmed S. Doghish. (2023) Beneficial and detrimental aspects of miRNAs as chief players in breast cancer: A comprehensive review. International Journal of Biological Macromolecules 224, pages 1541-1565.
Crossref
Ramin Eskandani, Mohammad Kazempour, Raheleh Farahzadi, Zohreh Sanaat, Morteza Eskandani, Khosro Adibkia, Somayeh Vandghanooni & Ahad Mokhtarzadeh. (2022) Engineered nanoparticles as emerging gene/drug delivery systems targeting the nuclear factor-κB protein and related signaling pathways in cancer. Biomedicine & Pharmacotherapy 156, pages 113932.
Crossref
Minghan Chen, Chunrui Xu, Ziang Xu, Wei He, Haorui Zhang, Jing Su & Qianqian Song. (2022) Uncovering the dynamic effects of DEX treatment on lung cancer by integrating bioinformatic inference and multiscale modeling of scRNA-seq and proteomics data. Computers in Biology and Medicine 149, pages 105999.
Crossref
Yoser Al Rawi, Saima Shakil Malik & Nosheen Masood. 2022. Breast Cancer: From Bench to Personalized Medicine. Breast Cancer: From Bench to Personalized Medicine 403 417 .
Jing Chen, Runlan Wan, Qinqin Li, Zhenghuan Rao, Yanlin Wang, Lei Zhang & Alexander Tobias Teichmann. (2021) Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer. Cancer Cell International 21:1.
Crossref
Jiang Xu, Zhongzu Zhang, Lu Huang, Jiachao Xiong, Zhenhai Zhou, Honggui Yu, Liang Wu, Zhimin Liu & Kai Cao. (2021) Let-7a suppresses Ewing sarcoma CSCs’ malignant phenotype via forming a positive feedback circuit with STAT3 and lin28. Journal of Bone Oncology 31, pages 100406.
Crossref
Zeynab Aliyari Serej, Ayyub Ebrahimi, Tohid Kazemi, Souzan Najafi, Mohammad Amini, Parastou Nastarin, Elham Baghbani & Behzad Baradaran. (2021) NANOG gene suppression and replacement of let-7 modulate the stemness, invasion, and apoptosis in breast cancer. Gene 801, pages 145844.
Crossref
Elham baghbani, Saeed Noorolyai, Pascal H.G. Duijf, Nicola Silvestris, Saeed Kolahian, Shahryar Hashemzadeh, Amir Baghbanzadeh kojabad, Aisan FallahVazirabad & Behzad Baradaran. (2021) The impact of microRNAs on myeloid-derived suppressor cells in cancer. Human Immunology 82:9, pages 668-678.
Crossref
Sarah Hamdy Ahmed, Nancy A. Espinoza-Sánchez, Ahmed El-Damen, Sarah Atef Fahim, Mohamed A. Badawy, Burkhard Greve, Mohamed El-Shinawi, Martin Götte & Sherif Abdelaziz Ibrahim. (2021) Small extracellular vesicle-encapsulated miR-181b-5p, miR-222-3p and let-7a-5p: Next generation plasma biopsy-based diagnostic biomarkers for inflammatory breast cancer. PLOS ONE 16:4, pages e0250642.
Crossref
Renald Blundell, Jean Claude Grech & Muhammad Ajmal Shah. 2021. Nutraceuticals and Cancer Signaling. Nutraceuticals and Cancer Signaling 145 178 .
Amin Safa, Atefe Abak, Hamed Shoorei, Mohammad Taheri & Soudeh Ghafouri-Fard. (2020) MicroRNAs as regulators of ERK/MAPK pathway: A comprehensive review. Biomedicine & Pharmacotherapy 132, pages 110853.
Crossref
Tianen Wang, Yanfeng Yang, Zhiyong Wang, Xuechong Zhang, Dongsheng Li & Jinxing Wei. (2020) A SNP of miR‐146a is involved in bladder cancer relapse by affecting the function of bladder cancer stem cells via the miR‐146a signallings. Journal of Cellular and Molecular Medicine 24:15, pages 8545-8556.
Crossref
Li-Juan Ma, Jun Wu, En Zhou, Juan Yin & Xu-Ping Xiao. (2020) Molecular mechanism of targeted inhibition of HMGA2 via miRNAlet-7a in proliferation and metastasis of laryngeal squamous cell carcinoma. Bioscience Reports 40:6.
Crossref
Maryam Abolghasemi, Sadra Samavarchi Tehrani, Tooba Yousefi, Ansar Karimian, Ata Mahmoodpoor, Aliakbar Ghamari, Farhad Jadidi‐Niaragh, Mehdi Yousefi, Hossein Samadi Kafil, Milad Bastami, Mahdi Edalati, Shirin Eyvazi, Mohsen Naghizadeh, Niloufar Targhazeh, Bahman Yousefi, Amin Safa, Maryam Majidinia & Vahid Rameshknia. (2019) MicroRNAs in breast cancer: Roles, functions, and mechanism of actions. Journal of Cellular Physiology 235:6, pages 5008-5029.
Crossref
Elisabet Cuyàs, Juan Gumuzio, Sara Verdura, Joan Brunet, Joaquim Bosch-Barrera, Begoña Martin-Castillo, Tomás Alarcón, José Antonio Encinar, Ángel G. Martin & Javier A. Menendez. (2020) The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes. Aging 12:6, pages 4794-4814.
Crossref
Camila Perelló Ferrúa, Roberta Giorgi, Laísa Camerini da Rosa, Cainá Corrêa do Amaral, Gabriele Cordenonzi Ghisleni, Ricardo Tavares Pinheiro & Fernanda Nedel. (2019) MicroRNAs expressed in depression and their associated pathways: A systematic review and a bioinformatics analysis. Journal of Chemical Neuroanatomy 100, pages 101650.
Crossref
Kembra Albracht-Schulte, Samantha Gonzalez, Abigail Jackson, Savanna Wilson, Latha Ramalingam, Nishan Kalupahana & Naima Moustaid-Moussa. (2019) Eicosapentaenoic Acid Improves Hepatic Metabolism and Reduces Inflammation Independent of Obesity in High-Fat-Fed Mice and in HepG2 Cells. Nutrients 11:3, pages 599.
Crossref
Dawei Wu, Jun Zhang, Ying Lu, Song Bo, Lianhong Li, Lu Wang, Qingqing Zhang & Jun Mao. (2018) miR-140-5p inhibits the proliferation and enhances the efficacy of doxorubicin to breast cancer stem cells by targeting Wnt1. Cancer Gene Therapy 26:3-4, pages 74-82.
Crossref
Ramkumar Menon, Chirantan Debnath, Andrew Lai, Dominic Guanzon, Shinjini Bhatnagar, Pallavi K Kshetrapal, Samantha Sheller-Miller & Carlos Salomon. (2019) Circulating Exosomal miRNA Profile During Term and Preterm Birth Pregnancies: A Longitudinal Study. Endocrinology 160:2, pages 249-275.
Crossref
Abdul Q. Khan, Shilpa Kuttikrishnan, Kodappully S. Siveen, Kirti S. Prabhu, Muralitharan Shanmugakonar, Hamda A. Al- Naemi, Mohammad Haris, Said Dermime & Shahab Uddin. (2019) RAS-mediated oncogenic signaling pathways in human malignancies. Seminars in Cancer Biology 54, pages 1-13.
Crossref
Rama Krishna Nimmakayala, Surinder K. Batra & Moorthy P. Ponnusamy. (2019) Unraveling the journey of cancer stem cells from origin to metastasis. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1871:1, pages 50-63.
Crossref
Cheolwon Choi, Nguyen Thi Thao Tran, Trinh Van Ngu, Sae Woong Park, Min Suk Song, Sung Hyun Kim, Yun-Ui Bae, Penchatr Diskul Na Ayudthaya, Javaria Munir, Eunbit Kim, Moo-Jun Baek, Sujung Song, Seongho Ryu & Kee-Hyun Nam. (2018) Promotion of tumor progression and cancer stemness by MUC15 in thyroid cancer via the GPCR/ERK and integrin-FAK signaling pathways. Oncogenesis 7:11.
Crossref
Li Qi, Fang Liu, Feng Zhang, Shuai Zhang, LiYan Lv, Yi Bi & Yan Yu. (2018) lncRNA NEAT1 competes against let-7a to contribute to non-small cell lung cancer proliferation and metastasis. Biomedicine & Pharmacotherapy 103, pages 1507-1515.
Crossref
Mengya ZhaoLin LiJundong ZhouXueyuan CuiQingmei TianYaqing JinYimin Zhu. (2018) MiR-2861 Behaves as a Biomarker of Lung Cancer Stem Cells and Regulates the HDAC5-ERK System Genes. Cellular Reprogramming 20:2, pages 99-106.
Crossref
Xin Sun, Chongwen Xu, Guodong Xiao, Jinying Meng, Jichang Wang, Shou‑Ching Tang, Sida Qin, Ning Du, Gang Li, Hong Ren & Dapeng Liu. (2018) Breast cancer stem-like cells are sensitized to tamoxifen induction of self-renewal inhibition with enforced Let-7c dependent on Wnt blocking. International Journal of Molecular Medicine.
Crossref
Wei Zhang, Xiaozhen Liu, Shan Liu, Ying Qin, Xiaoqi Tian, Fengting Niu, Han Liu, Ning Liu & Yun Niu. (2017) Androgen receptor/let-7a signaling regulates breast tumor-initiating cells. Oncotarget 9:3, pages 3690-3703.
Crossref
C Xu, G Xiao, B Zhang, M Wang, J Wang, D Liu, J Zhang, H Ren & X Sun. (2018) CCAT1 stimulation of the symmetric division of NSCLC stem cells through activation of the Wnt signalling cascade. Gene Therapy 25:1, pages 4-12.
Crossref
Fang Yang, Jing Xu, Lin Tang & Xiaoxiang Guan. (2016) Breast cancer stem cell: the roles and therapeutic implications. Cellular and Molecular Life Sciences 74:6, pages 951-966.
Crossref
Ilianna Zoi, Michalis V. Karamouzis, Christos Adamopoulos & Athanasios G. Papavassiliou. (2016) RANKL Signaling and ErbB Receptors in Breast Carcinogenesis. Trends in Molecular Medicine 22:10, pages 839-850.
Crossref
Amanda Rinkenbaugh & Albert Baldwin. (2016) The NF-κB Pathway and Cancer Stem Cells. Cells 5:2, pages 16.
Crossref
Xin Sun, Shiwen Jiang, Jian Liu, Huangzhen Wang, Yiwen Zhang, Shou-Ching Tang, Jichang Wang, Ning Du, Chongwen Xu, Chenguang Wang, Sida Qin, Jia Zhang, Dapeng Liu, Yunfeng Zhang, Xiaojun Li, Jiansheng Wang, Jun Dong, Xin Wang, Shaohua Xu, Zhen Tao, Fei Xu, Jie Zhou, Tao Wang & Hong Ren. (2015) MiR-208a stimulates the cocktail of SOX2 and β-catenin to inhibit the let-7 induction of self-renewal repression of breast cancer stem cells and formed miR208a/let-7 feedback loop via LIN28 and DICER1. Oncotarget 6:32, pages 32944-32954.
Crossref
Li Zhang & Handong Wang. (2015) Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin. Marine Drugs 13:7, pages 4310-4330.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.