2,288
Views
43
CrossRef citations to date
0
Altmetric
Reports

Nuclear localized Akt enhances breast cancer stem-like cells through counter-regulation of p21Waf1/Cip1 and p27kip1

, , , , , & show all
Pages 2109-2120 | Received 13 Feb 2015, Accepted 11 Apr 2015, Published online: 17 Jun 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Pooneh Mokarram, Mohammed Albokashy, Maryam Zarghooni, Mohammad Amin Moosavi, Zahra Sepehri, Qi Min Chen, Andrzej Hudecki, Aliyeh Sargazi, Javad Alizadeh, Adel Rezaei Moghadam, Mohammad Hashemi, Hesam Movassagh, Thomas Klonisch, Ali Akbar Owji, Marek J. Łos & Saeid Ghavami. (2017) New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets. Autophagy 13:5, pages 781-819.
Read now

Articles from other publishers (42)

Cristina Panuzzo, Lucrezia Pironi, Alessandro Maglione, Simone Rocco, Serena Stanga, Chiara Riganti, Joanna Kopecka, Muhammad Shahzad Ali, Barbara Pergolizzi, Enrico Bracco & Daniela Cilloni. (2023) mTORC2 Is Activated under Hypoxia and Could Support Chronic Myeloid Leukemia Stem Cells. International Journal of Molecular Sciences 24:2, pages 1234.
Crossref
Lingyun Li, Mengzhen Li, Minxuan Wang, Limin Zhang, Yao Yu, Jiatao Zhang, Bing Ma & Weizhi Wang. (2022) A “Cell Space Station” for Spatiotemporal Molecular Manipulation of Immune Checkpoint. ACS Nano 16:10, pages 16332-16342.
Crossref
Sakshi Gupta, Mukund Kumar, Soumi Chaudhuri & Arun Kumar. (2022) The non‐canonical nuclear functions of key players of the PI3K‐AKT‐MTOR pathway. Journal of Cellular Physiology 237:8, pages 3181-3204.
Crossref
Fabian M. Troschel, Heike Palenta, Katrin Borrmann, Kristin Heshe, San Hue Hua, George W. Yip, Ludwig Kiesel, Hans Theodor Eich, Martin Götte & Burkhard Greve. (2021) Knockdown of the prognostic cancer stem cell marker Musashi-1 decreases radio-resistance while enhancing apoptosis in hormone receptor-positive breast cancer cells via p21WAF1/CIP1. Journal of Cancer Research and Clinical Oncology 147:11, pages 3299-3312.
Crossref
Ying Ma, Jun Weng, Ning Wang, Yilei Zhang, Nagahiro Minato & Li Su. (2021) A novel nuclear localization region in SIPA1 determines protein nuclear distribution and epirubicin-sensitivity of breast cancer cells. International Journal of Biological Macromolecules 180, pages 718-728.
Crossref
Ya-Hui Wang, Yu-Tzu Chan, Tsai-Hsien Hung, Jung-Tung Hung, Ming-Wei Kuo, Sheng-Hung Wang, Yenlin Huang, Yu-Ju Lin, Shin-Cheh Chen, Jyh-Cherng Yu, Jen-Chine Wu, John Yu & Alice L. Yu. (2021) Transmembrane and coiled-coil domain family 3 (TMCC3) regulates breast cancer stem cell and AKT activation. Oncogene 40:16, pages 2858-2871.
Crossref
Angela Russo, Jose A. Colina, Junlone Moy, Seth Baligod, Austin A. Czarnecki, Peter Varughese, Daniel D. Lantvit, Matthew J. Dean & Joanna E. Burdette. (2021) Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2. Cell Death & Disease 12:4.
Crossref
Gustavo Ulises Martinez-Ruiz & Abigail Morales-Sanchez. 2021. YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer. YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer 39 57 .
Kamini Kaushal & Suresh Ramakrishna. (2020) Deubiquitinating Enzyme-Mediated Signaling Networks in Cancer Stem Cells. Cancers 12:11, pages 3253.
Crossref
Lijuan He, Dong Shen, Jianmei Li & Weidong Mao. (2020) RETRACTED: Alpinumisoflavone suppresses human Glioblastoma cell growth and induces cell cycle arrest through activating peroxisome proliferator‐activated receptor‐γ . The Anatomical Record 303:11, pages 2801-2810.
Crossref
Tao LIU, Yu SUN, Shengzhuang YANG & Xiangsen LIANG. (2020) Inhibitory Effect of Selenium on Esophagus Cancer Cells and the Related Mechanism. Journal of Nutritional Science and Vitaminology 66:5, pages 456-461.
Crossref
D Schulz, M Streller, G Piendl, G Brockhoff, T E Reichert, A N Menevse, P Beckhove, M G Hautmann, R J Bauer & T Ettl. (2020) Differential localization of PD-L1 and Akt-1 involvement in radioresistant and radiosensitive cell lines of head and neck squamous cell carcinoma. Carcinogenesis 41:7, pages 984-992.
Crossref
Yi Yu, Yuyan Xiong, Diogo Ladeiras, Zhihong Yang & Xiu-Fen Ming. (2019) Myosin 1b Regulates Nuclear AKT Activation by Preventing Localization of PTEN in the Nucleus. iScience 19, pages 39-53.
Crossref
Alberto Bavelloni, Enrico Focaccia, Manuela Piazzi, Mirco Raffini, Valeriana Cesarini, Sara Tomaselli, Arianna Orsini, Stefano Ratti, Irene Faenza, Lucio Cocco, Angela Gallo & William L. Blalock. (2019) AKT‐dependent phosphorylation of the adenosine deaminases ADAR‐1 and ‐2 inhibits deaminase activity. The FASEB Journal 33:8, pages 9044-9061.
Crossref
Thu H Truong, Amy R Dwyer, Caroline H Diep, Hsiangyu Hu, Kyla M Hagen & Carol A Lange. (2019) Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem Cell and Proliferative Breast Cancer Cell Fates. Endocrinology 160:2, pages 430-446.
Crossref
Larissa Leggieri Coa, Thiago Ferreira Abreu, Alexandre Keiji Tashima, Janaina Green, Renata Castiglioni Pascon, Marcelo Afonso Vallim & Joel Machado-Jr. (2019) AKT/protein kinase B associates with β-actin in the nucleus of melanoma cells. Bioscience Reports 39:1.
Crossref
Matilde Y. Follo, Stefano Ratti, Lucia Manzoli, Giulia Ramazzotti, Irene Faenza, Roberta Fiume, Sara Mongiorgi, Pann Ghill Suh, James A. McCubrey & Lucio Cocco. 2020. Lipid Signaling in Human Diseases. Lipid Signaling in Human Diseases 291 308 .
Qiong Wu, Kangdi Zheng, Xiaoting Huang, Li Li & Wenjie Mei. (2018) Tanshinone-IIA-Based Analogues of Imidazole Alkaloid Act as Potent Inhibitors To Block Breast Cancer Invasion and Metastasis in Vivo. Journal of Medicinal Chemistry 61:23, pages 10488-10501.
Crossref
Koyel Chakravarty & D.C. Dalal. (2018) Mathematical modelling of liposomal drug release to tumour. Mathematical Biosciences 306, pages 82-96.
Crossref
A.A. Peyvandi, H.-A. Abbaszadeh, N. Ahmady Roozbahany, A. Pourbakht, S. Khoshsirat, H. Haddadzade Niri, H. Peyvandi & S. Niknazar. (2018) Deferoxamine promotes mesenchymal stem cell homing in noise-induced injured cochlea through PI3K/AKT pathway. Cell Proliferation 51:2, pages e12434.
Crossref
Youming Ding, Xiaoyan Chen, Bin Wang, Bin Yu & Jianhui Ge. (2018) Deubiquitinase inhibitor b-AP15 activates endoplasmic reticulum (ER) stress and inhibits Wnt/Notch1 signaling pathway leading to the reduction of cell survival in hepatocellular carcinoma cells. European Journal of Pharmacology 825, pages 10-18.
Crossref
Klaudia Szymonowicz, Sebastian Oeck, Nathalie Malewicz & Verena Jendrossek. (2018) New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response. Cancers 10:3, pages 78.
Crossref
Zhenjun Huang, Weilun Fang, Weihua Liu, Li Wang, Bin Liu, Shiming Liu & Shaojun Liu. (2018) Aspirin induces Beclin-1-dependent autophagy of human hepatocellular carcinoma cell. European Journal of Pharmacology 823, pages 58-64.
Crossref
Dandan Han, Jian Gao, Xiaolong Gu, Jan Georg Hengstler, Limei Zhang, Muhammad Shahid, Tariq Ali & Bo Han. (2017) P21Waf1/Cip1 depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway. Archives of Toxicology 92:2, pages 679-692.
Crossref
Hongzhi Du, Yang Liu, Xudong Chen, Xiaowen Yu, Xiaoying Hou, Hongyang Li, Meixiao Zhan, Sensen Lin, Ligong Lu, Shengtao Yuan & Li Sun. (2018) DT-13 synergistically potentiates the sensitivity of gastric cancer cells to topotecan via cell cycle arrest in vitro and in vivo. European Journal of Pharmacology 818, pages 124-131.
Crossref
Vijayalakshmi Rajendran & Mayur Vilas Jain. 2018. Cancer Stem Cells. Cancer Stem Cells 89 95 .
Andrzej Hudecki, Joanna Gola, Saeid Ghavami, Magdalena Skonieczna, Jarosław Markowski, Wirginia Likus, Magdalena Lewandowska, Wojciech Maziarz & Marek J. Los. (2017) Structure and properties of slow-resorbing nanofibers obtained by (co-axial) electrospinning as tissue scaffolds in regenerative medicine. PeerJ 5, pages e4125.
Crossref
Haviryaji S.G. Kalluri, John S. Kuo & Robert J. Dempsey. (2017) Chronic D609 treatment interferes with cell cycle and targets the expression of Olig2 in Glioma Stem like Cells. European Journal of Pharmacology 814, pages 81-86.
Crossref
Birgit Janicke, Andreas Kårsnäs, Peter Egelberg & Kersti Alm. (2017) Label-free high temporal resolution assessment of cell proliferation using digital holographic microscopy. Cytometry Part A 91:5, pages 460-469.
Crossref
Deeksha Pal, Venkatesh Kolluru, Balaji Chandrasekaran, Becca V. Baby, Masarath Aman, Suman Suman, Suman Sirimulla, Mary Ann Sanders, Houda Alatassi, Murali K. Ankem & Chendil Damodaran. (2017) Targeting aberrant expression of Notch-1 in ALDH + cancer stem cells in breast cancer . Molecular Carcinogenesis 56:3, pages 1127-1136.
Crossref
A R Garcia-Rendueles, J S Rodrigues, M E R Garcia-Rendueles, M Suarez-Fariña, S Perez-Romero, F Barreiro, I Bernabeu, J Rodriguez-Garcia, L Fugazzola, T Sakai, F Liu, J Cameselle-Teijeiro, S B Bravo & C V Alvarez. (2016) Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer. Oncogene 36:5, pages 652-666.
Crossref
Whasun Lim, Sunwoo Park, Fuller W. Bazer & Gwonhwa Song. (2016) Apigenin Reduces Survival of Choriocarcinoma Cells by Inducing Apoptosis via the PI3K/AKT and ERK1/2 MAPK Pathways. Journal of Cellular Physiology 231:12, pages 2690-2699.
Crossref
Carmen RiosGianluca D'IppolitoKevin M. CurtisGaëtan J.-R. DelcroixLourdes A. GomezJimmy El HokayemMegan RiegerRicardo ParrondoAlicia de las PozasCarlos Perez-StableGuy A. HowardPaul C. Schiller. (2016) Low Oxygen Modulates Multiple Signaling Pathways, Increasing Self-Renewal, While Decreasing Differentiation, Senescence, and Apoptosis in Stromal MIAMI Cells. Stem Cells and Development 25:11, pages 848-860.
Crossref
Y Gu, W Zheng, J Zhang, X Gan, X Ma, Z Meng, T Chen, X Lu, Z Wu, W Huang & R Xu. (2016) Aberrant activation of CaMKIIγ accelerates chronic myeloid leukemia blast crisis. Leukemia 30:6, pages 1282-1289.
Crossref
Weidong Bing, Xinyan Pang, Qingxi QU, Xiao Bai, Wenwen Yang, Yanwen Bi & Xiaolu Bi. (2016) Simvastatin improves the homing of BMSC s via the PI 3K/ AKT /miR‐9 pathway . Journal of Cellular and Molecular Medicine 20:5, pages 949-961.
Crossref
Adriana Fraga Costa, Sara Zago Gomes, Aline R. Lorenzon-Ojea, Mariane Martucci, Miriam Rubio Faria, Décio dos Santos PintoJr.Jr., Sergio F. Oliveira, Francesca Ietta, Luana Paulesu & Estela Bevilacqua. (2016) Macrophage migration inhibitory factor induces phosphorylation of Mdm2 mediated by phosphatidylinositol 3-kinase/Akt kinase: Role of this pathway in decidual cell survival. Placenta 41, pages 27-38.
Crossref
Mayur V. Jain, Ahmad Shareef, Wirginia Likus, Artur Cieślar-Pobuda, Saeid Ghavami & Marek J. Łos. (2016) Inhibition of miR301 enhances Akt-mediated cell proliferation by accumulation of PTEN in nucleus and its effects on cell-cycle regulatory proteins. Oncotarget 7:15, pages 20953-20965.
Crossref
Wirginia Likus, Krzysztof Siemianowicz, Konrad Bieńk, Małgorzata Pakuła, Himani Pathak, Chhanda Dutta, Qiong Wang, Shahla Shojaei, Yehuda G. Assaraf, Saeid Ghavami, Artur Cieślar-Pobuda & Marek J. Łos. (2016) Could drugs inhibiting the mevalonate pathway also target cancer stem cells?. Drug Resistance Updates 25, pages 13-25.
Crossref
L Qiu, J Wu, C Pan, X Tan, J Lin, R Liu, S Chen, R Geng & W Huang. (2016) Downregulation of CDC27 inhibits the proliferation of colorectal cancer cells via the accumulation of p21Cip1/Waf1. Cell Death & Disease 7:1, pages e2074-e2074.
Crossref
Farhan Hussain, Sandeep Mittal, Nirmal Joshee & Prahlad Parajuli. 2016. The Benefits of Natural Products for Neurodegenerative Diseases. The Benefits of Natural Products for Neurodegenerative Diseases 79 94 .
Thorsten Schaefer, Hui Wang, Perihan Mir, Martina Konantz, Tamara C. Pereboom, Anna M. Paczulla, Britta Merz, Tanja Fehm, Sven Perner, Oliver C. Rothfuss, Lothar Kanz, Klaus Schulze-Osthoff & Claudia Lengerke. (2015) Molecular and functional interactions between AKT and SOX2 in breast carcinoma. Oncotarget 6:41, pages 43540-43556.
Crossref
Donatella Malanga, Carmela De Marco, Ilaria Guerriero, Fabiana Colelli, Nicola Rinaldo, Marianna Scrima, Teresa Mirante, Claudia De Vitis, Pietro Zoppoli, Michele Ceccarelli, Miriam Riccardi, Maria Ravo, Alessandro Weisz, Antonella Federico, Renato Franco, Gaetano Rocco, Rita Mancini, Antonia Rizzuto, Elio Gulletta, Gennaro Ciliberto & Giuseppe Viglietto. (2015) The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells. Oncotarget 6:40, pages 42667-42686.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.