1,485
Views
52
CrossRef citations to date
0
Altmetric
Report

From hair to heart: nestin-expressing hair-follicle-associated pluripotent (HAP) stem cells differentiate to beating cardiac muscle cells

, , , , , , & show all
Pages 2362-2366 | Received 24 Feb 2015, Accepted 13 Apr 2015, Published online: 17 Jun 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Yasuyuki Amoh & Robert M. Hoffman. (2017) Hair follicle-associated-pluripotent (HAP) stem cells. Cell Cycle 16:22, pages 2169-2175.
Read now
Aiko Yamazaki, Kohya Obara, Natsuko Tohgi, Kyoumi Shirai, Sumiyuki Mii, Yuko Hamada, Nobuko Arakawa, Ryoichi Aki, Robert M. Hoffman & Yasuyuki Amoh. (2017) Implanted hair-follicle-associated pluripotent (HAP) stem cells encapsulated in polyvinylidene fluoride membrane cylinders promote effective recovery of peripheral nerve injury. Cell Cycle 16:20, pages 1927-1932.
Read now
Natsuko Tohgi, Koya Obara, Masateru Yashiro, Yuko Hamada, Nobuko Arakawa, Sumiyuki Mii, Ryoichi Aki, Robert M. Hoffman & Yasuyuki Amoh. (2017) Human hair-follicle associated pluripotent (hHAP) stem cells differentiate to cardiac-muscle cells. Cell Cycle 16:1, pages 95-99.
Read now
Aiko Yamazaki, Yuko Hamada, Nobuko Arakawa, Masateru Yashiro, Sumiyuki Mii, Ryoichi Aki, Katsumasa Kawahara, Robert M. Hoffman & Yasuyuki Amoh. (2016) Early-age-dependent selective decrease of differentiation potential of hair-follicle-associated pluripotent (HAP) stem cells to beating cardiac-muscle cells. Cell Cycle 15:19, pages 2619-2625.
Read now
Wenluo Cao, Lingna Li, Satoshi Kajiura, Yasuyuki Amoh, Yuying Tan, Fang Liu & Robert M. Hoffman. (2016) Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment. Cell Cycle 15:8, pages 1093-1098.
Read now
Aiko Yamazaki, Masateru Yashiro, Sumiyuki Mii, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Katsumasa Kawahara, Robert M. Hoffman & Yasuyuki Amoh. (2016) Isoproterenol directs hair follicle-associated pluripotent (HAP) stem cells to differentiate in vitro to cardiac muscle cells which can be induced to form beating heart-muscle tissue sheets. Cell Cycle 15:5, pages 760-765.
Read now
Aisada Uchugonova, Wenluo Cao, Robert M Hoffman & Karsten Koenig. (2015) Comparison of label-free and GFP multiphoton imaging of hair follicle-associated pluripotent (HAP) stem cells in mouse whiskers. Cell Cycle 14:21, pages 3430-3433.
Read now

Articles from other publishers (45)

Koya Obara, Kyoumi Shirai, Yuko Hamada, Nobuko Arakawa, Ayami Hasegawa, Nanako Takaoka, Ryoichi Aki, Robert M. Hoffman & Yasuyuki Amoh. (2023) Direct implantation of hair-follicle-associated pluripotent (HAP) stem cells repairs intracerebral hemorrhage and reduces neuroinflammation in mouse model. PLOS ONE 18:1, pages e0280304.
Crossref
Lei Wang, Xiaonan Liu & Ke Shen. 2022. Biofabrication for Orthopedics. Biofabrication for Orthopedics 423 459 .
Koya Obara, Jose Reynoso, Yuko Hamada, Yusuke Aoki, Yutaro Kubota, Noriyuki Masaki, Yasuyuki Amoh & Robert M. Hoffman. (2022) Hair follicle associated pluripotent (HAP) stem cells jump from transplanted whiskers to pelage follicles and stimulate hair growth. Scientific Reports 12:1.
Crossref
Nanako Takaoka, Michiko Yamane, Koya Obara, Kyoumi Shirai, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Robert M. Hoffman & Yasuyuki Amoh. (2022) Hair-follicle-associated pluripotent (HAP) stem cells differentiate into mature beating cardiomyocyte sheets on flexible substrates in vitro. Medical Molecular Morphology 55:3, pages 248-257.
Crossref
Alyssa PetersonLakshmi S. Nair. (2022) Hair Follicle Stem Cells for Tissue Regeneration. Tissue Engineering Part B: Reviews 28:4, pages 695-706.
Crossref
Koya Obara, Kyoumi Shirai, Yuko Hamada, Nobuko Arakawa, Michiko Yamane, Nanako Takaoka, Ryoichi Aki, Robert M. Hoffman & Yasuyuki Amoh. (2022) Chronic spinal cord injury functionally repaired by direct implantation of encapsulated hair-follicle-associated pluripotent (HAP) stem cells in a mouse model: Potential for clinical regenerative medicine. PLOS ONE 17:1, pages e0262755.
Crossref
Krisztián Pajer & Antal Nógrádi. 2022. Peripheral Nerve Tissue Engineering and Regeneration. Peripheral Nerve Tissue Engineering and Regeneration 403 414 .
Fayrouz Bazina, Sabine M. Brouxhon & Stephanos Kyrkanides. (2021) Reprogramming oral epithelial keratinocytes into a pluripotent phenotype for tissue regeneration. Clinical and Experimental Dental Research 7:6, pages 1112-1121.
Crossref
Michiko Yamane, Nanako Takaoka, Koya Obara, Kyoumi Shirai, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Robert M. Hoffman & Yasuyuki Amoh. (2021) Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Extensively Differentiate to Tyrosine-Hydroxylase-Expressing Dopamine-Secreting Neurons. Cells 10:4, pages 864.
Crossref
Hanluo Li, Federica Francesca Masieri, Marie Schneider, Alexander Bartella, Sebastian Gaus, Sebastian Hahnel, Rüdiger Zimmerer, Ulrich Sack, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Jan-Christoph Simon, Bernd Lethaus & Vuk Savkovic. (2021) The Middle Part of the Plucked Hair Follicle Outer Root Sheath Is Identified as an Area Rich in Lineage-Specific Stem Cell Markers. Biomolecules 11:2, pages 154.
Crossref
Carrie A. Kubiak, Joey Grochmal, Theodore A. Kung, Paul S. Cederna, Rajiv Midha & Stephen W.P. Kemp. (2019) Stem‐cell–based therapies to enhance peripheral nerve regeneration. Muscle & Nerve 61:4, pages 449-459.
Crossref
Yixu Jiang, Feilin Liu, Fei Zou, Yingyao Zhang, Bo Wang, Yuying Zhang, Aobo Lian, Xing Han, Zinan Liu, Xiaomei Liu, Minghua Jin, Dianliang Wang, Gang Li & Jinyu Liu. (2019) PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis. Stem Cell Research & Therapy 10:1.
Crossref
Kyoumi Shirai, Koya Obara, Natsuko Tohgi, Aiko Yamazaki, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Shree Ram Singh, Robert M. Hoffman & Yasuyuki Amoh. (2019) Expression of anti-aging type-XVII collagen (COL17A1/BP180) in hair follicle-associated pluripotent (HAP) stem cells during differentiation. Tissue and Cell 59, pages 33-38.
Crossref
Koya Obara, Natsuko Tohgi, Sumiyuki Mii, Yuko Hamada, Nobuko Arakawa, Ryoichi Aki, Shree Ram Singh, Robert M. Hoffman & Yasuyuki Amoh. (2019) Hair-follicle-associated pluripotent stem cells derived from cryopreserved intact human hair follicles sustain multilineage differentiation potential. Scientific Reports 9:1.
Crossref
Yong‑Hee Kim, Bang‑Jin Kim, Seok‑Man Kim, Sun‑Uk Kim & Buom‑Yong Ryu. (2019) Induction of cardiomyocyte‑like cells from hair follicle cells in mice. International Journal of Molecular Medicine.
Crossref
Koya Obara, Natsuko Tohgi, Kyoumi Shirai, Sumiyuki Mii, Yuko Hamada, Nobuko Arakawa, Ryoichi Aki, Shree Ram Singh, Robert M. Hoffman & Yasuyuki Amoh. (2018) Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Encapsulated on Polyvinylidene Fluoride Membranes (PFM) Promote Functional Recovery from Spinal Cord Injury. Stem Cell Reviews and Reports 15:1, pages 59-66.
Crossref
Yanan Zhang, Jiancheng Wang, Weijun Huang, Jianye Cai, Junhui Ba, Yi Wang, Qiong Ke, Yinong Huang, Xin Liu, Yuan Qiu, Qiying Lu, Xin Sui, Yue Shi, Tao Wang, Huiyong Shen, Yuanjun Guan, Ying Zhou, Yuan Chen, Maosheng Wang & Andy Peng Xiang. (2018) Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation. Nature Communications 9:1.
Crossref
Dongmei Xie, Yan Liao, Binyuan Wu, Yang Chen, Wanwen Lin, Dihan Lu, Shanquan Gao, Shuanghua Zhu, Chaoquan Peng & Mei Hua Jiang. (2018) Cardiac Nestin<sup>+</sup> Cells Derived from Early Stage of Dilated Cardiomyopathy Enhanced the Survival of the Doxorubicin-Injured Cardiac Muscle HL-1 Cells. International Heart Journal 59:1, pages 180-189.
Crossref
Angel Fernandez Flores, Adrian Varela-Vazquez, Maria D. Mayan & Eduardo Fonseca. (2018) Expression of connexin 43 in the human hair follicle: emphasis on the connexin 43 protein levels in the bulge and through the keratinization process. Journal of Cutaneous Pathology 45:1, pages 8-15.
Crossref
Robert M. Hoffman & Yasuyuki Amoh. 2018. 23 28 .
William D. Ehringer & Kristyn H. Smith. 2018. Practical Aspects of Hair Transplantation in Asians. Practical Aspects of Hair Transplantation in Asians 87 105 .
Robert M. Hoffman & Yasuyuki Amoh. 2018. Somatic Stem Cells. Somatic Stem Cells 241 254 .
Fang Liu & Robert M. Hoffman. 2018. 3D Sponge-Matrix Histoculture. 3D Sponge-Matrix Histoculture 145 162 .
Robert M. Hoffman. 2019. Skin Stem Cells. Skin Stem Cells 385 392 .
Robert M. Hoffman. (2017) The Advantages of Using Fluorescent Proteins for In Vivo Imaging. Current Protocols Essential Laboratory Techniques 15:1.
Crossref
Timo Schomann, Laura Mezzanotte, John C. M. J. De Groot, Marcelo N. Rivolta, Sanne H. Hendriks, Johan H. M. Frijns & Margriet A. Huisman. (2017) Neuronal differentiation of hair-follicle-bulge-derived stem cells co-cultured with mouse cochlear modiolus explants. PLOS ONE 12:10, pages e0187183.
Crossref
Renfu Quan, Weibin Du, Xuan Zheng, Shichao Xu, Qiang Li, Xing Ji, Ximei Wu, Rongxue Shao & Disheng Yang. (2017) VEGF165 induces differentiation of hair follicle stem cells into endothelial cells and plays a role in in vivo angiogenesis . Journal of Cellular and Molecular Medicine 21:8, pages 1593-1604.
Crossref
Kyoumi Shirai, Yuko Hamada, Nobuko Arakawa, Aiko Yamazaki, Natsuko Tohgi, Ryoichi Aki, Sumiyuki Mii, Robert M. Hoffman & Yasuyuki Amoh. (2017) Hypoxia Enhances Differentiation of Hair Follicle-Associated-Pluripotent (HAP) Stem Cells to Cardiac-Muscle Cells. Journal of Cellular Biochemistry 118:3, pages 554-558.
Crossref
Qiong Shen, Weirong Yu, Yong Fang, Min Yao & Penggao Yang. (2017) Beta-catenin can induce hair follicle stem cell differentiation into transit-amplifying cells through c-myc activation. Tissue and Cell 49:1, pages 28-34.
Crossref
Tingting BaiFeilin LiuFei ZouGuifang ZhaoYixu JiangLi LiuJiahong ShiDeshun HaoQi ZhangTong ZhengYingyao ZhangMingsheng LiuShilun LiLiangchen QiJin Yu Liu. (2017) Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16. Stem Cells and Development 26:2, pages 113-122.
Crossref
Aya Yoshimura, Naoki Adachi, Hitomi Matsuno, Masaki Kawamata, Yusuke Yoshioka, Hisae Kikuchi, Haruki Odaka, Tadahiro Numakawa, Hiroshi Kunugi, Takahiro Ochiya & Yoshitaka Tamai. (2017) The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking neural stem cell-derived extracellular vesicles . Disease Models & Mechanisms.
Crossref
Wenru Pan, Karlea L. Kremer, Xenia Kaidonis, Victoria E. Ludlow, Mary‐Louise Rogers, Jianling Xie, Christopher G. Proud & Simon A. Koblar. (2016) Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells. International Journal of Developmental Neuroscience 53:1, pages 90-98.
Crossref
Nimantana He, Zhenguo Dong, Bing Zhu, Mingtu Nuo, Shorgan Bou & Dongjun Liu. (2016) Expression of pluripotency markers in Arbas Cashmere goat hair follicle stem cells. In Vitro Cellular & Developmental Biology - Animal 52:7, pages 782-788.
Crossref
Kulraj Singh Bhangra, Francesca Busuttil, James B. Phillips & Ahad A. Rahim. (2016) Using Stem Cells to Grow Artificial Tissue for Peripheral Nerve Repair. Stem Cells International 2016, pages 1-18.
Crossref
Robert M. Hoffman, Satoshi Kajiura, Wenluo Cao, Fang Liu & Yasuyuki Amoh. 2016. Biobanking and Cryopreservation of Stem Cells. Biobanking and Cryopreservation of Stem Cells 191 198 .
Yasuyuki Amoh, Kensei Katsuoka & Robert M. Hoffman. 2016. Multipotent Stem Cells of the Hair Follicle. Multipotent Stem Cells of the Hair Follicle 21 32 .
Lingna Li & Robert M. Hoffman. 2016. Multipotent Stem Cells of the Hair Follicle. Multipotent Stem Cells of the Hair Follicle 15 20 .
John Mignone, Natalia Peunova & Grigori Enikolopov. 2016. Multipotent Stem Cells of the Hair Follicle. Multipotent Stem Cells of the Hair Follicle 7 14 .
Masateru Yashiro, Sumiyuki Mii, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Katsumasa Kawahara, Robert M. Hoffman & Yasuyuki Amoh. 2016. Multipotent Stem Cells of the Hair Follicle. Multipotent Stem Cells of the Hair Follicle 151 159 .
Wenluo Cao, Fang Liu, Yasuyuki Amoh & Robert M. Hoffman. 2016. Multipotent Stem Cells of the Hair Follicle. Multipotent Stem Cells of the Hair Follicle 145 150 .
Robert M. Hoffman. 2016. Multipotent Stem Cells of the Hair Follicle. Multipotent Stem Cells of the Hair Follicle 1 5 .
Wenluo Cao, Lingna Li, Benjamin Tran, Satoshi Kajiura, Yasuyuki Amoh, Fang Liu & Robert M. Hoffman. (2015) Extensive Hair Shaft Growth after Mouse Whisker Follicle Isolation, Cryopreservation and Transplantation in Nude Mice. PLOS ONE 10:12, pages e0145997.
Crossref
Ameneh OmidiIraj Ragerdi KashaniMohammad AkbariKeywan MortezaeeSoudabeh GhasemiCordian BeyerAdib Zendedel. (2015) Homing of allogeneic nestin-positive hair follicle-associated pluripotent stem cells after maternal transplantation in experimental model of cortical dysplasia. Biochemistry and Cell Biology 93:6, pages 619-625.
Crossref
Nkemcho Ojeh, Irena Pastar, Marjana Tomic-Canic & Olivera Stojadinovic. (2015) Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications. International Journal of Molecular Sciences 16:10, pages 25476-25501.
Crossref
Wenluo Cao, Lingna Li, Sumiyuki Mii, Yasuyuki Amoh, Fang Liu & Robert M. Hoffman. (2015) Extensive Hair-Shaft Elongation by Isolated Mouse Whisker Follicles in Very Long-Term Gelfoam® Histoculture. PLOS ONE 10:9, pages e0138005.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.