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Cell Cycle Volume 14, 2015 - Issue 14
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Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure

Lili GongDepartment of Systems Biology; The University of Texas MD Anderson Cancer Center; Houston, TXUSA;These authors contributed equally to this work.
,
Jeane M GovanDepartment of Systems Biology; The University of Texas MD Anderson Cancer Center; Houston, TXUSA;These authors contributed equally to this work.
,
Elizabeth B EvansDepartment of Systems Biology; The University of Texas MD Anderson Cancer Center; Houston, TXUSA
,
Hui DaiDepartment of Systems Biology; The University of Texas MD Anderson Cancer Center; Houston, TXUSA
,
Edward WangDepartment of Systems Biology; The University of Texas MD Anderson Cancer Center; Houston, TXUSA
,
Szu-Wei LeeDepartment of Molecular and Cellular Oncology; The University of Texas MD Anderson Cancer Center; Houston, TXUSA
,
Hui-Kuan LinDepartment of Molecular and Cellular Oncology; The University of Texas MD Anderson Cancer Center; Houston, TXUSA
,
Alexander J LazarDepartment of Pathology; The University of Texas MD Anderson Cancer Center; Houston, TXUSA
,
Gordon B MillsDepartment of Systems Biology; The University of Texas MD Anderson Cancer Center; Houston, TXUSA
&
Shiaw-Yih LinDepartment of Systems Biology; The University of Texas MD Anderson Cancer Center; Houston, TXUSACorrespondence[email protected]
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Pages 2323-2332 | Received 05 Mar 2015, Accepted 18 Apr 2015, Published online: 15 Jul 2015

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Guiying Sun, Hua Ye, Xiao Wang, Lin Cheng, Pengfei Ren, Jianxiang Shi, Liping Dai, Peng Wang & Jianying Zhang. (2020) Identification of novel autoantibodies based on the protein chip encoded by cancer-driving genes in detection of esophageal squamous cell carcinoma. OncoImmunology 9:1.
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Prerna Malaney, Emily Palumbo, Jonathan Semidey-Hurtado, Jamaal Hardee, Katherine Stanford, Jaymin J. Kathiriya, Deepal Patel, Zhi Tian, Diane Allen-Gipson & Vrushank Davé. (2018) PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer. Cell Cycle 17:8, pages 947-962.
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Zhong Zhang, Sheng-Qi Hou, Jinxue He, Tingting Gu, Yuxin Yin & Wen H. Shen. (2016) PTEN regulates PLK1 and controls chromosomal stability during cell division. Cell Cycle 15:18, pages 2476-2485.
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Takae Brewer, Lamis Yehia, Peter Bazeley & Charis Eng. (2023) Integrating somatic CNV and gene expression in breast cancers from women with PTEN hamartoma tumor syndrome. npj Genomic Medicine 8:1.
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Ginia Ghosh, Sandip Misra, Rachayeeta Ray, Sougata Ghosh Chowdhury & Parimal Karmakar. (2023) Phospho PTEN mediated dephosphorylation of mitotic kinase PLK1 and Aurora Kinase A prevents aneuploidy and preserves genomic stability. Medical Oncology 40:4.
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Casey G. Langdon. (2023) Nuclear PTEN’s Functions in Suppressing Tumorigenesis: Implications for Rare Cancers. Biomolecules 13:2, pages 259.
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Ming Zou, Qin Ke, Qian Nie, Ruili Qi, Xingfei Zhu, Wei Liu, Xuebin Hu, Qian Sun, Jia-Ling Fu, Xiangcheng Tang, Yizhi Liu, David Wan-Cheng Li & Lili Gong. (2022) Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration. Cell Death & Differentiation 29:9, pages 1816-1833.
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Sandip Misra, Sougata Ghosh Chowdhury, Ginia Ghosh, Ananda Mukherjee & Parimal Karmakar. (2022) Both phosphorylation and phosphatase activity of PTEN are required to prevent replication fork progression during stress by inducing heterochromatin. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 825, pages 111800.
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茂林 侯. (2022) Current Situation and Progress of Tumor-Suppressor Gene Related to Gastric Cancer in Liver Metastasis. Advances in Clinical Medicine 12:08, pages 7172-7180.
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Sandip Misra, Ginia Ghosh, Sougata Ghosh Chowdhury & Parimal Karmakar. (2021) Non-canonical function of nuclear PTEN and its implication on tumorigenesis. DNA Repair 107, pages 103197.
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Amanda L. Fry, Amy K. Webster, Julia Burnett, Rojin Chitrakar, L. Ryan Baugh & E. Jane Albert Hubbard. (2021) DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence. PLOS Genetics 17:7, pages e1009650.
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Jun Sun, Wei Wu, Xiaofeng Tang, Feifei Zhang, Cheng Ju, Renfeng Liu, Yiping Liang, Bo Yu, Bin Lv, Yuhong Guo, Duo Zeng, Xuchang Tao, Min Wang, Zhiping Zhang, Changhua Zhang & Xiao-Bin Lv. (2021) HDAC6 inhibitor WT161 performs anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU. Bioscience Reports 41:4.
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Xiao-Qing Wang, Lei Zhang, Zhong-Yuan Xia, Jia-Yin Chen, Yiru Fang & Yu-Qiang Ding. (2021) PTEN in prefrontal cortex is essential in regulating depression-like behaviors in mice. Translational Psychiatry 11:1.
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Hamid Fiuji & Mohammadreza Nassiri. (2020) Gene expression profiling of chromosome 10 in PTEN-knockout (−/−) human neural and mesenchymal stem cells: A system biology study. Gene Reports 21, pages 100895.
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Xinyi Fan, Jeffrey Kraynak, Jonathan P.S. Knisely, Silvia C. Formenti & Wen H. Shen. (2020) PTEN as a Guardian of the Genome: Pathways and Targets. Cold Spring Harbor Perspectives in Medicine 10:9, pages a036194.
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Zhen Liang, Yuzhu Tang, Hao Li, Youjun Xie & Lingling Zhan. (2020) Association of phosphatase and tension homologue deleted on chromosome ten polymorphism rs1903858, but not serum levels with the risk of non–small‐cell lung cancer: A case‐control study. Journal of Clinical Laboratory Analysis 34:8.
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Nahal Haddadi, Glena Travis, Najah T. Nassif, Ann M. Simpson & Deborah J. Marsh. (2020) Toward Systems Pathology for PTEN Diagnostics. Cold Spring Harbor Perspectives in Medicine 10:5, pages a037127.
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Jason Ho, Edward S. Cruise, Ryan J.O. Dowling & Vuk Stambolic. (2020) PTEN Nuclear Functions. Cold Spring Harbor Perspectives in Medicine 10:5, pages a036079.
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Jingyi Yang & Yuxin Yin. (2020) PTEN in Chromatin Remodeling. Cold Spring Harbor Perspectives in Medicine 10:2, pages a036160.
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Kezhou Zhu, Victoria Xie & Suyun Huang. 2020. 1 26 .
Jinfang Zhang, Yu-Ru Lee, Fabin Dang, Wenjian Gan, Archita Venugopal Menon, Jesse M. Katon, Chih-Hung Hsu, John M. Asara, Priyanka Tibarewal, Nicholas R. Leslie, Yang Shi, Pier Paolo Pandolfi & Wenyi Wei. (2019) PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discovery 9:9, pages 1306-1323.
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Nicole Steinbach, Dan Hasson, Deepti Mathur, Elias E Stratikopoulos, Ravi Sachidanandam, Emily Bernstein & Ramon E Parsons. (2019) PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription. Nucleic Acids Research 47:11, pages 5573-5586.
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Jamal M. Bryant & Raymond D. Blind. (2019) Signaling through non-membrane nuclear phosphoinositide binding proteins in human health and disease. Journal of Lipid Research 60:2, pages 299-311.
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Matt C. Danzi, Nick O’Neill, John L. Bixby & Vance P. Lemmon. (2018) Can Chromatin Accessibility be Exploited for Axon Regeneration?. Developmental Neurobiology 78:10, pages 991-997.
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Lili GongFangyuan LiuZhen XiongRuili QiZhongwen LuoXiaodong GongQian NieQian SunYun-Fei LiuWenjie QingLing WangLan ZhangXiangcheng TangShan HuangGen LiHong OuyangMengqing XiangQuan Dong Nguyen, Yizhi LiuDavid Wan-Cheng Li. (2018) Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes. Proceedings of the National Academy of Sciences 115:17.
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David Ullman, David Dorn, Soroush Rais-Bahrami & Jennifer Gordetsky. (2018) Clinical Utility and Biologic Implications of Phosphatase and Tensin Homolog (PTEN) and ETS-related Gene (ERG) in Prostate Cancer. Urology 113, pages 59-70.
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Diego Hernández-Saavedra, Rita S Strakovsky, Patricia Ostrosky-Wegman & Yuan-Xiang Pan. (2017) Epigenetic Regulation of Centromere Chromatin Stability by Dietary and Environmental Factors. Advances in Nutrition 8:6, pages 889-904.
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Sheng-Qi Hou, Meng Ouyang, Andrew Brandmaier, Hongbo Hao & Wen H. Shen. (2017) PTEN in the maintenance of genome integrity: From DNA replication to chromosome segregation. BioEssays 39:10, pages 1700082.
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Andrew Brandmaier, Sheng-Qi Hou, Sandra Demaria, Silvia C. Formenti & Wen H. Shen. (2017) PTEN at the interface of immune tolerance and tumor suppression. Frontiers in Biology 12:3, pages 163-174.
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Matthew G. Cable & R. Lor Randall. 2017. Osteosarcoma - Biology, Behavior and Mechanisms. Osteosarcoma - Biology, Behavior and Mechanisms.
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A. Lester, R. Rapkins, S. Nixdorf, M. Khasraw & K. McDonald. (2016) Combining PARP inhibitors with radiation therapy for the treatment of glioblastoma: Is PTEN predictive of response?. Clinical and Translational Oncology 19:3, pages 273-278.
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Sonia Yu, Fan Yang & Wen H. Shen. (2016) Genome maintenance in the context of 4D chromatin condensation. Cellular and Molecular Life Sciences 73:16, pages 3137-3150.
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Emily A. Nizialek, Madhav Sankunny, Farshad Niazi & Charis Eng. (2016) Cancer-predisposition gene KLLN maintains pericentric H3K9 trimethylation protecting genomic stability . Nucleic Acids Research 44:8, pages 3586-3594.
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