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AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol

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Pages 2520-2536 | Received 24 Apr 2015, Accepted 15 May 2015, Published online: 17 Jul 2015

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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Hani Choudhry & Adrian L. Harris. (2018) Advances in Hypoxia-Inducible Factor Biology. Cell Metabolism 27:2, pages 281-298.
Crossref
Sari Karppinen, Sandra L. Hänninen, Risto Rapila & Pasi Tavi. (2018) Sarcoplasmic reticulum Ca 2+ -induced Ca 2+ release regulates class IIa HDAC localization in mouse embryonic cardiomyocytes . Physiological Reports 6:2, pages e13522.
Crossref
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Crossref
Ming Xia, Qian Ding, Zhidan Zhang & Qinggen Feng. (2016) Remote Limb Ischemic Preconditioning Protects Rats Against Cerebral Ischemia via HIF-1α/AMPK/HSP70 Pathway. Cellular and Molecular Neurobiology 37:6, pages 1105-1114.
Crossref
Ming Ye, Zejun Fang, Hongqian Gu, Rui Song, Jiangwei Ye, Hongzhang Li, Zhiguang Wu, Shenghui Zhou, Peng Li, Xiang Cai, Xiaokun Ding & Songshan Yu. (2017) Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1α under hypoxia condition. Tumor Biology 39:6, pages 101042831770503.
Crossref
Álvaro Marín-Hernández, Juan Carlos Gallardo-Pérez, Ileana Hernández-Reséndiz, Isis Del Mazo-Monsalvo, Diana Xochiquetzal Robledo-Cadena, Rafael Moreno-Sánchez & Sara Rodríguez-Enríquez. (2017) Hypoglycemia Enhances Epithelial-Mesenchymal Transition and Invasiveness, and Restrains the Warburg Phenotype, in Hypoxic HeLa Cell Cultures and Microspheroids. Journal of Cellular Physiology 232:6, pages 1346-1359.
Crossref
Hiroki Mikami, Youhei Saito, Namiko Okamoto, Ayana Kakihana, Takahisa Kuga & Yuji Nakayama. (2017) Requirement of Hsp105 in CoCl 2 -induced HIF-1α accumulation and transcriptional activation. Experimental Cell Research 352:2, pages 225-233.
Crossref
Randa Abdel MalikNina ZippelTimo FrömelJuliana HeidlerSven ZukunftBarbara WalzogNariman AnsariFrancesco PampaloniSusanne WingertMichael A. RiegerIlka WittigBeate FisslthalerIngrid Fleming. (2017) AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis. Circulation Research 120:1, pages 99-109.
Crossref
Yixuan Li & Edward Seto. (2016) HDACs and HDAC Inhibitors in Cancer Development and Therapy. Cold Spring Harbor Perspectives in Medicine 6:10, pages a026831.
Crossref
Antero Salminen, Anu Kauppinen & Kai Kaarniranta. (2016) AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions. Cellular Signalling 28:8, pages 887-895.
Crossref
Antero Salminen, Kai Kaarniranta & Anu Kauppinen. (2016) AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms. Biogerontology 17:4, pages 655-680.
Crossref
Chengqian Yin, Dan He, Shuyang Chen, Xiaoling Tan & Nianli Sang. (2016) Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate. Oncotarget 7:30, pages 47494-47510.
Crossref
Thomas Kietzmann, Daniela Mennerich & Elitsa Y. Dimova. (2016) Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity. Frontiers in Cell and Developmental Biology 4.
Crossref
Eros Di Giorgio & Claudio Brancolini. (2016) Regulation of class IIa HDAC activities: it is not only matter of subcellular localization. Epigenomics 8:2, pages 251-269.
Crossref
Philippe Naquet, Caroline Giessner & Franck Galland. (2016) Metabolic adaptation of tissues to stress releases metabolites influencing innate immunity. Current Opinion in Immunology 38, pages 30-38.
Crossref
Shuyang Chen & Nianli Sang. (2016) Hypoxia-Inducible Factor-1: A Critical Player in the Survival Strategy of Stressed Cells. Journal of Cellular Biochemistry 117:2, pages 267-278.
Crossref
Salminen Antero, Kaarniranta Kai & Kauppinen Anu. (2016) Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases. Aging and disease 7:2, pages 180.
Crossref
Jielai Yang, Dongdong Cheng, Shumin Zhou, Bin Zhu, Tu Hu & Qingcheng Yang. (2015) Overexpression of X-Box Binding Protein 1 (XBP1) Correlates to Poor Prognosis and Up-Regulation of PI3K/mTOR in Human Osteosarcoma. International Journal of Molecular Sciences 16:12, pages 28635-28646.
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