Supplemental material
Cell Cycle
Volume 14, 2015 - Issue 15
Open access
3,475
Views
72
CrossRef citations to date
0
Altmetric
Report
AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol
Shuyang ChenDepartment of Biology and Graduate Program of Biological Sciences; CoAS; Department of Pathology & Laboratory Medicine; DUCOM; Drexel University; Philadelphia, PAUSA
, Chengqian YinDepartment of Biology and Graduate Program of Biological Sciences; CoAS; Department of Pathology & Laboratory Medicine; DUCOM; Drexel University; Philadelphia, PAUSA
, Taotao LaoDepartment of Biology and Graduate Program of Biological Sciences; CoAS; Department of Pathology & Laboratory Medicine; DUCOM; Drexel University; Philadelphia, PAUSA
, Dongming LiangDepartment of Biology and Graduate Program of Biological Sciences; CoAS; Department of Pathology & Laboratory Medicine; DUCOM; Drexel University; Philadelphia, PAUSA
, Dan HeDepartment of Biology and Graduate Program of Biological Sciences; CoAS; Department of Pathology & Laboratory Medicine; DUCOM; Drexel University; Philadelphia, PAUSA
, Chenguang WangInstitute of Radiation Medicine; The Chinese Academy of Medical Sciences; Tianjin, China;Department of Radiation Protection; Peking Union Medical College; Beijing, China
& Nianli SangDepartment of Biology and Graduate Program of Biological Sciences; CoAS; Department of Pathology & Laboratory Medicine; DUCOM; Drexel University; Philadelphia, PAUSA;Sydney Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PAUSACorrespondence[email protected]
show all
Pages 2520-2536
|
Received 24 Apr 2015, Accepted 15 May 2015, Published online: 17 Jul 2015
Related Research Data
Acetylation Negatively Regulates Glycogen Phosphorylase by Recruiting Protein Phosphatase 1
Source:
Elsevier BV
AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
Source:
Ovid Technologies (Wolters Kluwer Health)
Two mutations impair the stability and function of ubiquitin-activating enzyme (E1)
Source:
Wiley-Blackwell
Histone Deacetylase Inhibitors Synergize p300 Autoacetylation that Regulates Its Transactivation Activity and Complex Formation
Source:
American Association for Cancer Research (AACR)
5'-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments
Source:
American Society for Microbiology
Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions ITS STABILIZATION BY HYPOXIA DEPENDS ON REDOX-INDUCED CHANGES
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
A New Family of Human Histone Deacetylases Related toSaccharomyces cerevisiaeHDA1p
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Hypoxia-Inducible Factors, Stem Cells, and Cancer
Source:
Elsevier BV
Histone Deacetylase Inhibitors Repress the Transactivation Potential of Hypoxia-inducible Factors Independently of Direct Acetylation of HIF-α
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Regulation and Destabilization of HIF-1α by ARD1-Mediated Acetylation
Source:
Elsevier BV
Regulation of Cellular Metabolism by Protein Lysine Acetylation
Source:
American Association for the Advancement of Science (AAAS)
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
Source:
Elsevier BV
AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol
Source:
Figshare
Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels
Source:
American Society for Microbiology
Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch
Source:
American Association for the Advancement of Science (AAAS)
Effects of Histone Deacetylase Inhibitors on HIF-1
Source:
Informa UK Limited
Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes
Source:
Elsevier BV
AMP-activated Protein Kinase Regulates β-Catenin Transcription via Histone Deacetylase 5
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Regulation of the HIF-1α level is essential for hematopoietic stem cells
Source:
Elsevier BV
AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol
Source:
Figshare
Multiplex Genome Engineering Using CRISPR/Cas Systems
Source:
American Association for the Advancement of Science (AAAS)
Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux
Source:
American Association for the Advancement of Science (AAAS)
Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5
Source:
Proceedings of the National Academy of Sciences
HDAC6 is a microtubule-associated deacetylase
Source:
Springer Nature
Histone Deacetylase Inhibitors Induce VHL and Ubiquitin-Independent Proteasomal Degradation of Hypoxia-Inducible Factor 1
Source:
American Society for Microbiology
The von Hippel–Lindau protein, HIF hydroxylation, and oxygen sensing
Source:
Elsevier BV
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing
Source:
American Association for the Advancement of Science (AAAS)
HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
Source:
Proceedings of the National Academy of Sciences
AMP-ACTIVATED PROTEIN KINASE REGULATES GLUT4 TRANSCRIPTION BY PHOSPHORYLATING HISTONE DEACETYLASE 5
Source:
American Diabetes Association
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.
Source:
Springer Science and Business Media LLC
Class II Histone Deacetylases Are Associated with VHL-Independent Regulation of Hypoxia-Inducible Factor 1α
Source:
American Association for Cancer Research (AACR)
Regulation of hypoxia-inducible factor 1 is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
Source:
Proceedings of the National Academy of Sciences
Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development
Source:
American Society for Microbiology
AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol
Source:
figshare Academic Research System
FK228 inhibits Hsp90 chaperone function in K562 cells via hyperacetylation of Hsp70
Source:
Elsevier BV
Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Class II Histone Deacetylases: from Sequence to Function, Regulation, and Clinical Implication
Source:
American Society for Microbiology
Interaction between HIF-1α (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1α
Source:
Federation of European Biochemical Societies. Published by Elsevier B.V.
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Source:
Proceedings of the National Academy of Sciences
Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation
Source:
American Association for the Advancement of Science (AAAS)
Histone Deacetylase Inhibitors: The Epigenetic Therapeutics That Repress Hypoxia-Inducible Factors
Source:
Hindawi Limited
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
Source:
Springer Science and Business Media LLC
Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level
Source:
American Physiological Society
Hypoxia-Inducible Factors in Physiology and Medicine
Source:
Elsevier BV
Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
Source:
Springer Nature
Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth
Source:
Elsevier BV
AMP-activated protein kinase activity during metabolic rate depression in the hypoxic goldfish, Carassius auratus
Source:
The Company of Biologists
Cardiac-Specific Overexpression of HIF-1α Prevents Deterioration of Glycolytic Pathway and Cardiac Remodeling in Streptozotocin-Induced Diabetic Mice
Source:
Elsevier BV
Arrest-defective-1 Protein, an Acetyltransferase, Does Not Alter Stability of Hypoxia-inducible Factor (HIF)-1α and Is Not Induced by Hypoxia or HIF
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Carboxyl-Terminal Transactivation Activity of Hypoxia-Inducible Factor 1 Is Governed by a von Hippel-Lindau Protein-Independent, Hydroxylation-Regulated Association with p300/CBP
Source:
American Society for Microbiology
HIF-1 regulation: not so easy come, easy go
Source:
Elsevier BV
Histone Deacetylase (HDAC) Inhibitors with a Novel Connecting Unit Linker Region Reveal a Selectivity Profile for HDAC4 and HDAC5 with Improved Activity against Chemoresistant Cancer Cells
Source:
American Chemical Society (ACS)
Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation
Source:
Wiley
HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor
Source:
Elsevier BV
Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR
Source:
Elsevier BV
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
Source:
Springer Science and Business Media LLC
Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase
Source:
Elsevier BV
Nuclear Import of Histone Deacetylase 5 by Requisite Nuclear Localization Signal Phosphorylation
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Hypoxia Inducible Factor-1 as a Target for Neurodegenerative Diseases
Source:
Bentham Science Publishers Ltd.
Hypoxia-Inducible Factor 1 and Cardiovascular Disease
Source:
Annual Reviews
Identification of a signal-responsive nuclear export sequence in class II histone deacetylases.
Source:
American Society for Microbiology
Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy
Source:
Proceedings of the National Academy of Sciences
Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.