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Cell Cycle Volume 14, 2015 - Issue 21
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The oncolytic peptide LTX-315 triggers necrotic cell death

Sabrina ForveilleMetabolomics and Cell Biology Platforms; Gustave Roussy Comprehensive Cancer Institute; Villejuif, France;Equipe 11 labellisée Ligue contre le Cancer; Center de Recherche des Cordeliers; INSERM U 1138; Paris, France;Université Paris Descartes; Sorbonne Paris Cité; Paris, France;Université Pierre et Marie Curie; Paris, France
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Heng ZhouMetabolomics and Cell Biology Platforms; Gustave Roussy Comprehensive Cancer Institute; Villejuif, France;Equipe 11 labellisée Ligue contre le Cancer; Center de Recherche des Cordeliers; INSERM U 1138; Paris, France;Université Paris Descartes; Sorbonne Paris Cité; Paris, France;Université Pierre et Marie Curie; Paris, France;University of Paris Sud XI; Kremlin Bicêtre, France
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Allan SauvatMetabolomics and Cell Biology Platforms; Gustave Roussy Comprehensive Cancer Institute; Villejuif, France;Equipe 11 labellisée Ligue contre le Cancer; Center de Recherche des Cordeliers; INSERM U 1138; Paris, France;Université Paris Descartes; Sorbonne Paris Cité; Paris, France;Université Pierre et Marie Curie; Paris, France
,
Lucillia BezuMetabolomics and Cell Biology Platforms; Gustave Roussy Comprehensive Cancer Institute; Villejuif, France;Equipe 11 labellisée Ligue contre le Cancer; Center de Recherche des Cordeliers; INSERM U 1138; Paris, France;Université Paris Descartes; Sorbonne Paris Cité; Paris, France;Université Pierre et Marie Curie; Paris, France;University of Paris Sud XI; Kremlin Bicêtre, France
,
Kevin MüllerMetabolomics and Cell Biology Platforms; Gustave Roussy Comprehensive Cancer Institute; Villejuif, France;Equipe 11 labellisée Ligue contre le Cancer; Center de Recherche des Cordeliers; INSERM U 1138; Paris, France;Université Paris Descartes; Sorbonne Paris Cité; Paris, France;Université Pierre et Marie Curie; Paris, France;University of Paris Sud XI; Kremlin Bicêtre, France
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Peng LiuMetabolomics and Cell Biology Platforms; Gustave Roussy Comprehensive Cancer Institute; Villejuif, France;Equipe 11 labellisée Ligue contre le Cancer; Center de Recherche des Cordeliers; INSERM U 1138; Paris, France;Université Paris Descartes; Sorbonne Paris Cité; Paris, France;Université Pierre et Marie Curie; Paris, France;University of Paris Sud XI; Kremlin Bicêtre, France
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Laurence ZitvogelUniversity of Paris Sud XI; Kremlin Bicêtre, France;Department of Immuno-Oncology; Institut de Cancérologie Gustave Roussy Cancer Campus; Villejuif, France;Institut National de la Santé et de la Recherche Medicale (INSERM), U1015; Villejuif, France;Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507; Villejuif, France
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Gérard PierronGustave Roussy Comprehensive Cancer Center; Villejuif; France CNRS; UMR8122, Villejuif, France
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Øystein RekdalUniversity of Tromsø; Institute of Medical Biology; Tromsø, Norway;Lytix Biopharma; Oslo, Norway
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Oliver KeppMetabolomics and Cell Biology Platforms; Gustave Roussy Comprehensive Cancer Institute; Villejuif, France;Equipe 11 labellisée Ligue contre le Cancer; Center de Recherche des Cordeliers; INSERM U 1138; Paris, France;Université Paris Descartes; Sorbonne Paris Cité; Paris, France;Université Pierre et Marie Curie; Paris, FranceCorrespondence[email protected] [email protected]
&
Guido KroemerMetabolomics and Cell Biology Platforms; Gustave Roussy Comprehensive Cancer Institute; Villejuif, France;Equipe 11 labellisée Ligue contre le Cancer; Center de Recherche des Cordeliers; INSERM U 1138; Paris, France;Université Paris Descartes; Sorbonne Paris Cité; Paris, France;Université Pierre et Marie Curie; Paris, France;Pôle de Biologie; Hôpital Européen Georges Pompidou; AP-HP; Paris, France;Karolinska Institute; Department of Women's and Children's Health; Karolinska University Hospital; Stockholm, SwedenCorrespondence[email protected] [email protected]
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Pages 3506-3512 | Received 31 Jul 2015, Accepted 07 Sep 2015, Published online: 13 Nov 2015

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Izabela Rusiecka, Iwona Gągało & Ivan Kocić. (2022) Cell-penetrating peptides improve pharmacokinetics and pharmacodynamics of anticancer drugs. Tissue Barriers 10:1.
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Janne Nestvold, Meng-Yu Wang, Ketil A. Camilio, Severin Zinöcker, Torunn Elisabeth Tjelle, Alf Lindberg, Bengt Erik Haug, Gunnar Kvalheim, Baldur Sveinbjørnsson & Øystein Rekdal. (2017) Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model. OncoImmunology 6:8.
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Antonella Sistigu, Gwenola Manic & Ilio Vitale. (2016) LTX-315, CAPtivating immunity with necrosis. Cell Cycle 15:9, pages 1176-1177.
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Articles from other publishers (24)

Hanmeng Liu, Wei Shen, Wanguo Liu, Zexin Yang, Dengke Yin & Chunsheng Xiao. (2024) From oncolytic peptides to oncolytic polymers: A new paradigm for oncotherapy. Bioactive Materials 31, pages 206-230.
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Estefanía Fandiño-Devia, Gloria A. Santa-González, Maria C. Klaiss-Luna, Ibeth Guevara-Lora, Verónica Tamayo & Marcela Manrique-Moreno. (2023) ΔM4: Membrane-Active Peptide with Antitumoral Potential against Human Skin Cancer Cells. Membranes 13:7, pages 671.
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Hamid Aria & Marzieh Rezaei. (2023) Immunogenic cell death inducer peptides: A new approach for cancer therapy, current status and future perspectives. Biomedicine & Pharmacotherapy 161, pages 114503.
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Hao Yin, Xingyan Fu, Hanyu Gao, Han Gao, Yannan Ma, Xitong Chen, Xueqi Zhang, Shan-Shan Du & Yun-Kun Qi. (2023) Hybrid peptide NTP-217 triggers ROS-mediated rapid necrosis in liver cancer cells by induction of mitochondrial leakage. Frontiers in Oncology 12.
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Xuan Yi, Pengqi Wan, Wei Shen, Xiaonong Zhang, Peng Zhang & Chunsheng Xiao. (2023) Synthetic lipo-polylysine with anti-cancer activity. Biomaterials Science.
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Hao Yin, Xi-tong Chen, Qiao-na Chi, Yan-nan Ma, Xing-yan Fu, Shan-shan Du, Yun-kun Qi & Ke-wei Wang. (2022) The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus. Acta Pharmacologica Sinica 44:1, pages 201-210.
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Long Hua, Pengfei Lei & Yihe Hu. (2022) Construction and validation model of necroptosis-related gene signature associates with immunity for osteosarcoma patients. Scientific Reports 12:1.
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Olga S. Troitskaya, Diana D. Novak, Vladimir A. Richter & Olga A. Koval. (2022) Immunogenic Cell Death in Cancer Therapy. Acta Naturae 14:1, pages 40-53.
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Tianyu Tang, Xing Huang, Gang Zhang, Minghao Lu, Zhengtao Hong, Meng Wang, Junming Huang, Xiao Zhi & Tingbo Liang. (2022) Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis. Journal for ImmunoTherapy of Cancer 10:3, pages e004129.
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Ilio Vitale, Takahiro Yamazaki, Erik Wennerberg, Baldur Sveinbjørnsson, Øystein Rekdal, Sandra Demaria & Lorenzo Galluzzi. (2021) Targeting Cancer Heterogeneity with Immune Responses Driven by Oncolytic Peptides. Trends in Cancer 7:6, pages 557-572.
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Cuiyu Zhong, Lei Zhang, Lin Yu, Jiandong Huang, Songyin Huang & Yandan Yao. (2021) A Review for Antimicrobial Peptides with Anticancer Properties: Re-purposing of Potential Anticancer Agents. BIO Integration 1:4, pages 156-167.
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Wei Shen, Yu Zhang, Pengqi Wan, Lin An, Peng Zhang, Chunsheng Xiao & Xuesi Chen. (2020) Antineoplastic Drug‐Free Anticancer Strategy Enabled by Host‐Defense‐Peptides‐Mimicking Synthetic Polypeptides. Advanced Materials 32:36.
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Gloria A. Santa-González, Edwin Patiño-González & Marcela Manrique-Moreno. (2020) Cell cycle progression data on human skin cancer cells with anticancer synthetic peptide LTX-315 treatment. Data in Brief 30, pages 105443.
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Lorenzo Galluzzi, Ilio Vitale, Sarah Warren, Sandy Adjemian, Patrizia Agostinis, Aitziber Buqué Martinez, Timothy A Chan, George Coukos, Sandra Demaria, Eric Deutsch, Dobrin Draganov, Richard L Edelson, Silvia C Formenti, Jitka Fucikova, Lucia Gabriele, Udo S Gaipl, Sofia R Gameiro, Abhishek D Garg, Encouse Golden, Jian Han, Kevin J Harrington, Akseli Hemminki, James W Hodge, Dewan Md Sakib Hossain, Tim Illidge, Michael Karin, Howard L Kaufman, Oliver Kepp, Guido Kroemer, Juan Jose Lasarte, Sherene Loi, Michael T Lotze, Gwenola Manic, Taha Merghoub, Alan A Melcher, Karen L Mossman, Felipe Prosper, Øystein Rekdal, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Mark J Smyth, Radek Spisek, John Stagg, Bryan E Strauss, Daolin Tang, Kazuki Tatsuno, Stefaan W van Gool, Peter Vandenabeele, Takahiro Yamazaki, Dmitriy Zamarin, Laurence Zitvogel, Alessandra Cesano & Francesco M Marincola. (2020) Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. Journal for ImmunoTherapy of Cancer 8:1, pages e000337.
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Nina Louise Jebsen, Torunn Oveland Apelseth, Hans Kristian Haugland, Øystein Rekdal, Hamina Patel, Bjørn Tore Gjertsen & Dag Eirik Jøssang. (2019) Enhanced T-lymphocyte infiltration in a desmoid tumor of the thoracic wall in a young woman treated with intratumoral injections of the oncolytic peptide LTX-315: a case report. Journal of Medical Case Reports 13:1.
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Ketil A. Camilio, Meng-Yu Wang, Brynjar Mauseth, Stein Waagene, Gunnar Kvalheim, Øystein Rekdal, Baldur Sveinbjørnsson & Gunhild M. Mælandsmo. (2019) Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model. Breast Cancer Research 21:1.
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Heng Zhou, Laura Mondragón, Wei Xie, Brynjar Mauseth, Marion Leduc, Allan Sauvat, Lígia C. Gomes-da-Silva, Sabrina Forveille, Kristina Iribarren, Sylvie Souquere, Lucillia Bezu, Peng Liu, Liwei Zhao, Laurence Zitvogel, Baldur Sveinbjørnsson, J. Johannes Eksteen, Øystein Rekdal, Oliver Kepp & Guido Kroemer. (2018) Oncolysis with DTT-205 and DTT-304 generates immunological memory in cured animals. Cell Death & Disease 9:11.
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Ewa Pasquereau-Kotula, Justine Habault, Guido Kroemer & Jean-Luc Poyet. (2018) The anticancer peptide RT53 induces immunogenic cell death. PLOS ONE 13:8, pages e0201220.
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Jacob P. van Vloten, Samuel T. Workenhe, Sarah K. Wootton, Karen L. Mossman & Byram W. Bridle. (2018) Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies. The Journal of Immunology 200:2, pages 450-458.
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Baldur Sveinbjørnsson, Ketil Andre Camilio, Bengt Erik Haug & Øystein Rekdal. (2017) LTX-315: a first-in-class oncolytic peptide that reprograms the tumor microenvironment. Future Medicinal Chemistry 9:12, pages 1339-1344.
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Berthony Deslouches & Y. Peter Di. (2017) Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications. Oncotarget 8:28, pages 46635-46651.
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Heng Zhou, Allan Sauvat, Lígia C Gomes-da-Silva, Sylvère Durand, Sabrina Forveille, Kristina Iribarren, Takahiro Yamazaki, Sylvie Souquere, Lucillia Bezu, Kevin Müller, Marion Leduc, Peng Liu, Liwei Zhao, Aurélien Marabelle, Laurence Zitvogel, Øystein Rekdal, Oliver Kepp & Guido Kroemer. (2016) The oncolytic compound LTX-401 targets the Golgi apparatus. Cell Death & Differentiation 23:12, pages 2031-2041.
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T Yamazaki, J M Pitt, M Vétizou, A Marabelle, C Flores, Ø Rekdal, G Kroemer & L Zitvogel. (2016) The oncolytic peptide LTX-315 overcomes resistance of cancers to immunotherapy with CTLA4 checkpoint blockade. Cell Death & Differentiation 23:6, pages 1004-1015.
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H Zhou, S Forveille, A Sauvat, T Yamazaki, L Senovilla, Y Ma, P Liu, H Yang, L Bezu, K Müller, L Zitvogel, Ø Rekdal, O Kepp & G Kroemer. (2016) The oncolytic peptide LTX-315 triggers immunogenic cell death. Cell Death & Disease 7:3, pages e2134-e2134.
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