8,423
Views
133
CrossRef citations to date
0
Altmetric
Report

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells

, , , , , , , , , , & show all
Pages 72-83 | Received 26 Aug 2015, Accepted 12 Nov 2015, Published online: 15 Jan 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Mariana Borsa, Sandrine Obba, Felix C Richter, Hanlin Zhang, Thomas Riffelmacher, Joana Carrelha, Ghada Alsaleh, Sten Eirik W. Jacobsen & Anna Katharina Simon. (2023) Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism. Autophagy 0:0.
Read now

Articles from other publishers (132)

Hao-Ran Jin, Jin Wang, Zi-Jing Wang, Ming-Jia Xi, Bi-Han Xia, Kai Deng & Jin-Lin Yang. (2023) Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics. Journal of Hematology & Oncology 16:1.
Crossref
Xiaochuan Zhang, Mengge Dai, Shaotong Li, Meng Li, Bing Cheng, Ting Ma & Zheng Zhou. (2023) The emerging potential role of p62 in cancer treatment by regulating metabolism. Trends in Endocrinology & Metabolism 34:8, pages 474-488.
Crossref
Yandi Sun, Qian He, Jingjia Li, Ze Yang, Mashaal Ahmad, Yindan Lin, Di Wu, Lei Zheng, Jiangtao Li, Ben Wang, Chitty Chen, Yue Hu, Heng Luo & Yan Luo. (2023) A GSTP1-mediated lactic acid signaling promotes tumorigenesis through the PPP oxidative branch. Cell Death & Disease 14:7.
Crossref
Xihe Zhao, Kai Li, Mengyu Chen & Lei Liu. (2023) Metabolic codependencies in the tumor microenvironment and gastric cancer: Difficulties and opportunities. Biomedicine & Pharmacotherapy 162, pages 114601.
Crossref
Nan Niu, Jinfeng Ye, Zhangli Hu, Junbin Zhang & Yun Wang. (2023) Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis. International Journal of Molecular Sciences 24:8, pages 7076.
Crossref
Javad Alizadeh, Mahboubeh Kavoosi, Navjit Singh, Shahrokh Lorzadeh, Amir Ravandi, Biniam Kidane, Naseer Ahmed, Fatima Mraiche, Michael R. Mowat & Saeid Ghavami. (2023) Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer. Cancers 15:8, pages 2195.
Crossref
Yi-Jia Li, Chunyan Zhang, Antons Martincuks, Andreas Herrmann & Hua Yu. (2023) STAT proteins in cancer: orchestration of metabolism. Nature Reviews Cancer 23:3, pages 115-134.
Crossref
Zhangzuo Li, Qi Wang, Xufeng Huang, Mengting Yang, Shujing Zhou, Zhengrui Li, Zhengzou Fang, Yidan Tang, Qian Chen, Hanjin Hou, Li Li, Fei Fei, Qiaowei Wang, Yuqing Wu & Aihua Gong. (2023) Lactate in the tumor microenvironment: A rising star for targeted tumor therapy. Frontiers in Nutrition 10.
Crossref
Jun-Kyu Byun. (2023) Tumor lactic acid: a potential target for cancer therapy. Archives of Pharmacal Research 46:2, pages 90-110.
Crossref
Rachel Kerslake, Suzana Panfilov, Nashrah Mustafa, Marcia Hall, Ioannis Kyrou, Harpal S. Randeva, Emmanouil Karteris & Richard Godfrey. (2022) Elevated Circulating Lactate Levels and Widespread Expression of Its Cognate Receptor, Hydroxycarboxylic Acid Receptor 1 (HCAR1), in Ovarian Cancer. Journal of Clinical Medicine 12:1, pages 217.
Crossref
Man Luo, Junqi Zhu, Jie Ren, Yuxiao Tong, Limin Wang, Shenglin Ma & Jiaoli Wang. (2022) Lactate increases tumor malignancy by promoting tumor small extracellular vesicles production via the GPR81-cAMP-PKA-HIF-1α axis. Frontiers in Oncology 12.
Crossref
Xuewei Zheng, Haodi Ma, Jingjing Wang, Mengjiao Huang, Dongliao Fu, Ling Qin & Qinan Yin. (2022) Energy metabolism pathways in breast cancer progression: The reprogramming, crosstalk, and potential therapeutic targets. Translational Oncology 26, pages 101534.
Crossref
Versha Tripathi, Pooja Jaiswal, Khageswar Sahu, Shovan Kumar Majumder, Dharmendra Kashyap, Hem Chandra Jha, Amit Kumar Dixit & Hamendra Singh Parmar. (2022) Repurposing of metabolic drugs and mitochondrial modulators as an emerging class of cancer therapeutics with a special focus on breast cancer. Advances in Cancer Biology - Metastasis 6, pages 100065.
Crossref
Shao-Liang Yang, Hai-Xia Tan, Zhen-Zhen Lai, Hai-Yan Peng, Hui-Li Yang, Qiang Fu, Hai-Yan Wang, Da-Jin Li & Ming-Qing Li. (2022) An active glutamine/α-ketoglutarate/HIF-1α axis prevents pregnancy loss by triggering decidual IGF1+GDF15+NK cell differentiation. Cellular and Molecular Life Sciences 79:12.
Crossref
Qixin Duan, Shuang Zhang, Yang Wang, Dongming Lu, Yingming Sun & Yongyang Wu. (2022) Proton-coupled monocarboxylate transporters in cancer: From metabolic crosstalk, immunosuppression and anti-apoptosis to clinical applications. Frontiers in Cell and Developmental Biology 10.
Crossref
O. P. Shatova, P. V. Shegay, A. A. Zabolotneva, A. V. Shestopalov & A. D. Kaprin. (2022) Lactate: a New Look at the Role of an Evolutionarily Ancient Metabolite. Journal of Evolutionary Biochemistry and Physiology 58:6, pages 2007-2020.
Crossref
Jia Lin, Geng Liu, Lidian Chen, Hang Fai Kwok & Yao Lin. (2022) Targeting lactate-related cell cycle activities for cancer therapy. Seminars in Cancer Biology 86, pages 1231-1243.
Crossref
Sumana Paul, Saikat Ghosh & Sushil Kumar. (2022) Tumor glycolysis, an essential sweet tooth of tumor cells. Seminars in Cancer Biology 86, pages 1216-1230.
Crossref
Anna Leikeim, Maximiliane Wußmann, Freia F. Schmidt, Nuno G. B. Neto, Franziska Benz, Kendra Tiltmann, Corinna Junger, Michael G. Monaghan, Bastian Schilling & Florian K. Groeber-Becker. (2022) A preclinical model of cutaneous melanoma based on reconstructed human epidermis. Scientific Reports 12:1.
Crossref
Xianxian Duan, Yu Xie, Jing Yu, Xiao Hu, Zhanzhao Liu, Ning Li, Junfang Qin, Lan Lan, Mengci Yuan, Zhanyu Pan & Yue Wang. (2022) MCT4/Lactate Promotes PD-L1 Glycosylation in Triple-Negative Breast Cancer Cells. Journal of Oncology 2022, pages 1-15.
Crossref
Alexey Bogdanov, Andrey Bogdanov, Viacheslav Chubenko, Nikita Volkov, Fedor Moiseenko & Vladimir Moiseyenko. (2022) Tumor acidity: From hallmark of cancer to target of treatment. Frontiers in Oncology 12.
Crossref
Anuraag Bukkuri, Robert A. Gatenby & Joel S. Brown. (2022) GLUT1 production in cancer cells: a tragedy of the commons. npj Systems Biology and Applications 8:1.
Crossref
Yu Ma, Sunkai Ling, Yuan Li, Mingyue Hu, Bo Kong, Peilin Huang & Hui Liu. (2022) Loss of Heterozygosity for KrasG12D Promotes Malignant Phenotype of Pancreatic Ductal Adenocarcinoma by Activating HIF-2α-c-Myc-Regulated Glutamine Metabolism. International Journal of Molecular Sciences 23:12, pages 6697.
Crossref
Katerina Hönigova, Jiri Navratil, Barbora Peltanova, Hana Holcova Polanska, Martina Raudenska & Michal Masarik. (2022) Metabolic tricks of cancer cells. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1877:3, pages 188705.
Crossref
Qi Zhang & Wei Li. (2022) Correlation between amino acid metabolism and self-renewal of cancer stem cells: Perspectives in cancer therapy. World Journal of Stem Cells 14:4, pages 267-286.
Crossref
Lihong Mei, Li Ying, Hongfeng Wang, Guoxiong Xu, Xuanguang Ye & Gao Yang. (2022) 1H NMR-based metabolomics of skin squamous cell carcinoma and peri-tumoral region tissues. Journal of Pharmaceutical and Biomedical Analysis 212, pages 114643.
Crossref
Shagun Sharma, Navneet Agnihotri & Sandeep Kumar. (2022) Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis. Biochemical Pharmacology 198, pages 114943.
Crossref
Haneen A. Basheer, Lina Elsalem, Anwar Salem, Artysha Tailor, Keith Hunter & Kamyar Afarinkia. (2022) The Expression of Glutaminases and their Association with Clinicopathological Parameters in the Head and Neck Cancers. Current Cancer Drug Targets 22:2, pages 169-179.
Crossref
Chenguang Yao, Jun Weng, Lingyun Feng, Wanjun Zhang, Yan Xu, Peijing Zhang, Yoshimasa Tanaka & Li Su. (2022) SIPA1 Enhances Aerobic Glycolysis Through HIF-2α Pathway to Promote Breast Cancer Metastasis. Frontiers in Cell and Developmental Biology 9.
Crossref
Yang Wang, Liuxin Qin, Weiwei Chen, Qing Chen, Jin Sun & Gang Wang. (2021) Novel strategies to improve tumour therapy by targeting the proteins MCT1, MCT4 and LAT1. European Journal of Medicinal Chemistry 226, pages 113806.
Crossref
Salvatore Passarella, Avital Schurr & Piero Portincasa. (2021) Mitochondrial Transport in Glycolysis and Gluconeogenesis: Achievements and Perspectives. International Journal of Molecular Sciences 22:23, pages 12620.
Crossref
Yaolin Xu, Lijie He, Qiang Fu & Junzhe Hu. (2021) Metabolic Reprogramming in the Tumor Microenvironment With Immunocytes and Immune Checkpoints. Frontiers in Oncology 11.
Crossref
Shangxun Zhou, Jiangang Xie, Chaoping Yu, Zhusheng Feng, Kun Cheng, Jingchang Ma, Yuling Wang, Chujun Duan, Yuan Zhang, Boquan Jin, Wen Yin & Ran Zhuang. (2021) CD226 deficiency promotes glutaminolysis and alleviates mitochondria damage in vascular endothelial cells under hemorrhagic shock. The FASEB Journal 35:11.
Crossref
Martina Koncošová, Nikola Vrzáčková, Ivana Křížová, Petra Tomášová, Silvie Rimpelová, Aleš Dvořák, Libor Vítek, Michaela Rumlová, Tomáš Ruml & Jaroslav Zelenka. (2021) Inhibition of Mitochondrial Metabolism Leads to Selective Eradication of Cells Adapted to Acidic Microenvironment. International Journal of Molecular Sciences 22:19, pages 10790.
Crossref
Shen-Han Lee, Monika Golinska & John R. Griffiths. (2021) HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells. Cells 10:9, pages 2371.
Crossref
Alessio Menga, Maria Favia, Iolanda Spera, Maria C Vegliante, Rosanna Gissi, Anna De Grassi, Luna Laera, Annalisa Campanella, Andrea Gerbino, Giovanna Carrà, Marcella Canton, Vera Loizzi, Ciro L Pierri, Gennaro Cormio, Massimiliano Mazzone & Alessandra Castegna. (2021) N ‐acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages . EMBO reports 22:9.
Crossref
Kathy Matuszewska, Madison Pereira, Duncan Petrik, Jack Lawler & Jim Petrik. (2021) Normalizing Tumor Vasculature to Reduce Hypoxia, Enhance Perfusion, and Optimize Therapy Uptake. Cancers 13:17, pages 4444.
Crossref
Vaishali Chandel, Saurabh Maru, Arun Kumar, Ashok Kumar, Ashok Sharma, Brijesh Rathi & Dhruv Kumar. (2021) Role of monocarboxylate transporters in head and neck squamous cell carcinoma. Life Sciences 279, pages 119709.
Crossref
Qi Wu, Xin Yu, Juanjuan Li, Shengrong Sun & Yi Tu. (2021) Metabolic regulation in the immune response to cancer. Cancer Communications 41:8, pages 661-694.
Crossref
Binyan Xu, Rong Hu, Zhao Liang, Tong Chen, Jianyu Chen, Yuxing Hu, Yirong Jiang & Yuhua Li. (2021) Metabolic regulation of the bone marrow microenvironment in leukemia. Blood Reviews 48, pages 100786.
Crossref
Emel Kirbas Cilingir, Elif S. Seven, Yiqun Zhou, Brian M. Walters, Keenan J. Mintz, Raja R. Pandey, Athula H. Wikramanayake, Charles C. Chusuei, Steven Vanni, Regina M. Graham & Roger M. Leblanc. (2021) Metformin derived carbon dots: Highly biocompatible fluorescent nanomaterials as mitochondrial targeting and blood-brain barrier penetrating biomarkers. Journal of Colloid and Interface Science 592, pages 485-497.
Crossref
David Sheikh-Hamad. (2021) Hints for a kidney lactate shuttle and lactomone. American Journal of Physiology-Renal Physiology.
Crossref
Talveen S. Purba, Leïla Berriche & Ralf Paus. (2021) Compartmentalised metabolic programmes in human anagen hair follicles: New targets to modulate epithelial stem cell behaviour, keratinocyte proliferation and hair follicle immune status?. Experimental Dermatology 30:5, pages 645-651.
Crossref
Alla B. Salmina, Ekaterina V. Kharitonova, Yana V. Gorina, Elena A. Teplyashina, Natalia A. Malinovskaya, Elena D. Khilazheva, Angelina I. Mosyagina, Andrey V. Morgun, Anton N. Shuvaev, Vladimir V. Salmin, Olga L. Lopatina & Yulia K. Komleva. (2021) Blood–Brain Barrier and Neurovascular Unit In Vitro Models for Studying Mitochondria-Driven Molecular Mechanisms of Neurodegeneration. International Journal of Molecular Sciences 22:9, pages 4661.
Crossref
Niki M. Zacharias, Lei Wang, Tapati Maity, Li Li, Steven W. Millward, Jose A. Karam, Christopher G. Wood & Neema Navai. (2021) Prolyl Hydroxylase 3 Knockdown Accelerates VHL-Mutant Kidney Cancer Growth In Vivo. International Journal of Molecular Sciences 22:6, pages 2849.
Crossref
Dilara Kiran & Randall J. Basaraba. (2021) Lactate Metabolism and Signaling in Tuberculosis and Cancer: A Comparative Review. Frontiers in Cellular and Infection Microbiology 11.
Crossref
Xingting Bao, Jinhua Zhang, Guomin Huang, Junfang Yan, Caipeng Xu, Zhihui Dou, Chao Sun & Hong Zhang. (2021) The crosstalk between HIFs and mitochondrial dysfunctions in cancer development. Cell Death & Disease 12:2.
Crossref
Weiling XuAllison J. JanochaSerpil C. Erzurum. (2021) Metabolism in Pulmonary Hypertension. Annual Review of Physiology 83:1, pages 551-576.
Crossref
Petr Stepka, Vit Vsiansky, Martina Raudenska, Jaromir Gumulec, Vojtech Adam & Michal Masarik. (2021) Metabolic and Amino Acid Alterations of the Tumor Microenvironment. Current Medicinal Chemistry 28:7, pages 1270-1289.
Crossref
Lu Ding, Xiaonan Xu, Congcong Li, Yi Wang, Xiaohuan Xia & Jialin C. Zheng. (2021) Glutaminase in microglia: A novel regulator of neuroinflammation. Brain, Behavior, and Immunity 92, pages 139-156.
Crossref
Zhen Wei, Xiaoyi Liu, Chunming Cheng, Wei Yu & Ping Yi. (2021) Metabolism of Amino Acids in Cancer. Frontiers in Cell and Developmental Biology 8.
Crossref
Lingling Wang, Shizhen Zhang & Xiaochen Wang. (2021) The Metabolic Mechanisms of Breast Cancer Metastasis. Frontiers in Oncology 10.
Crossref
Go J. Yoshida. (2021) The Harmonious Interplay of Amino Acid and Monocarboxylate Transporters Induces the Robustness of Cancer Cells. Metabolites 11:1, pages 27.
Crossref
梦琦 刘. (2021) Effects of Hypoxia and HIF-1 on Glutamine Metabolism. Bioprocess 11:01, pages 1-8.
Crossref
Soheila Delgir, Milad Bastami, Khandan Ilkhani, Asma Safi, Farhad Seif & Mohammad Reza Alivand. (2021) The pathways related to glutamine metabolism, glutamine inhibitors and their implication for improving the efficiency of chemotherapy in triple-negative breast cancer. Mutation Research/Reviews in Mutation Research 787, pages 108366.
Crossref
Tomas Koltai, Stephan J. Reshkin, Fátima Baltazar & Larry Fliegel. 2021. Prostate Cancer Metabolism. Prostate Cancer Metabolism 271 294 .
Jin G. Jung & Anne Le. 2021. The Heterogeneity of Cancer Metabolism. The Heterogeneity of Cancer Metabolism 173 185 .
Yang Liu, Li-Li Lu, Duo Wen, Dong-Li Liu, Li-Li Dong, Dong-Mei Gao, Xin-Yu Bian, Jian Zhou, Jia Fan & Wei-Zhong Wu. (2020) MiR-612 regulates invadopodia of hepatocellular carcinoma by HADHA-mediated lipid reprogramming. Journal of Hematology & Oncology 13:1.
Crossref
Lakshmipathi Vadlakonda, Meera Indracanti, Suresh K. Kalangi, B. Meher Gayatri, Navya G Naidu & Aramati B. M. Reddy. (2020) The Role of Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer. Journal of Diabetes & Metabolic Disorders 19:2, pages 1731-1775.
Crossref
Kai Li, Jiacheng Cao, Zitong Zhang, Keyan Chen, Tieliang Ma, Wenjie Yang, Shikun Yang, Jianhua Rao & Kai Zhang. (2020) Circular RNA circGSK3B Promotes Cell Proliferation, Migration, and Invasion by Sponging miR-1265 and Regulating CAB39 Expression in Hepatocellular Carcinoma. Frontiers in Oncology 10.
Crossref
Joy X. Wang, Stephen Y.C. Choi, Xiaojia Niu, Ning Kang, Hui Xue, James Killam & Yuzhuo Wang. (2020) Lactic Acid and an Acidic Tumor Microenvironment suppress Anticancer Immunity. International Journal of Molecular Sciences 21:21, pages 8363.
Crossref
Jae Hyung Park, Woo Yang Pyun & Hyun Woo Park. (2020) Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets. Cells 9:10, pages 2308.
Crossref
Zachary A. Bacigalupa & W. Kimryn Rathmell. (2020) Beyond glycolysis: Hypoxia signaling as a master regulator of alternative metabolic pathways and the implications in clear cell renal cell carcinoma. Cancer Letters 489, pages 19-28.
Crossref
Cindy Mendes & Jacinta Serpa. (2020) Revisiting lactate dynamics in cancer—a metabolic expertise or an alternative attempt to survive?. Journal of Molecular Medicine 98:10, pages 1397-1414.
Crossref
Rosa Maria Pascale, Diego Francesco Calvisi, Maria Maddalena Simile, Claudio Francesco Feo & Francesco Feo. (2020) The Warburg Effect 97 Years after Its Discovery. Cancers 12:10, pages 2819.
Crossref
Hee Chan Yoo, Ya Chun Yu, Yulseung Sung & Jung Min Han. (2020) Glutamine reliance in cell metabolism. Experimental & Molecular Medicine 52:9, pages 1496-1516.
Crossref
Florian Keller, Roman Bruch, Richard Schneider, Julia Meier-Hubberten, Mathias Hafner & Rüdiger Rudolf. (2020) A Scaffold-Free 3-D Co-Culture Mimics the Major Features of the Reverse Warburg Effect In Vitro. Cells 9:8, pages 1900.
Crossref
Hongli Jiang, Ning Zhang, Tongzhong Tang, Feng Feng, Haopeng Sun & Wei Qu. (2020) Target the human Alanine/Serine/Cysteine Transporter 2(ASCT2): Achievement and Future for Novel Cancer Therapy. Pharmacological Research 158, pages 104844.
Crossref
Renata Ramalho, Martin Rao, Chao Zhang, Chiara Agrati, Giuseppe Ippolito, Fu-Sheng Wang, Alimuddin Zumla & Markus Maeurer. (2020) Immunometabolism: new insights and lessons from antigen-directed cellular immune responses. Seminars in Immunopathology 42:3, pages 279-313.
Crossref
Alice Turdo, Gaetana Porcelli, Caterina D’Accardo, Simone Di Franco, Francesco Verona, Stefano Forte, Dario Giuffrida, Lorenzo Memeo, Matilde Todaro & Giorgio Stassi. (2020) Metabolic Escape Routes of Cancer Stem Cells and Therapeutic Opportunities. Cancers 12:6, pages 1436.
Crossref
Alexandra M. Kozlov, Asad Lone, Dean H. Betts & Robert C. Cumming. (2020) Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts. Scientific Reports 10:1.
Crossref
Michelangelo Certo, Giancarlo Marone, Amato Paulis, Claudio Mauro & Valentina Pucino. (2019) Lactate: Fueling the fire starter. WIREs Systems Biology and Medicine 12:3.
Crossref
Emily M. E. Barnes, Yitao Xu, Adrian Benito, Lili Herendi, Alexandros P. Siskos, Eric O. Aboagye, Anke Nijhuis & Hector C. Keun. (2020) Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells. British Journal of Cancer 122:9, pages 1298-1308.
Crossref
Alicja Trebinska-Stryjewska, Olga Swiech, Lidia J. Opuchlik, Ewa A. Grzybowska & Renata Bilewicz. (2020) Impact of Medium pH on DOX Toxicity toward HeLa and A498 Cell Lines. ACS Omega 5:14, pages 7979-7986.
Crossref
Fátima Baltazar, Julieta Afonso, Marta Costa & Sara Granja. (2020) Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy. Frontiers in Oncology 10.
Crossref
Valéry L. Payen, Erica Mina, Vincent F. Van Hée, Paolo E. Porporato & Pierre Sonveaux. (2020) Monocarboxylate transporters in cancer. Molecular Metabolism 33, pages 48-66.
Crossref
Maria Letizia Taddei, Laura Pietrovito, Angela Leo & Paola Chiarugi. (2020) Lactate in Sarcoma Microenvironment: Much More than just a Waste Product. Cells 9:2, pages 510.
Crossref
Timothy P. Brown & Vadivel Ganapathy. (2020) Lactate/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon. Pharmacology & Therapeutics 206, pages 107451.
Crossref
Tatiana Mendez, Shawheen Saffari, Janet M. Cowan, Nora M. V. Laver, James D. Baleja & Addy Alt-Holland. (2020) Delineating cell behavior and metabolism of non-melanoma skin cancer in vitro. In Vitro Cellular & Developmental Biology - Animal 56:2, pages 165-180.
Crossref
Marta Obara-Michlewska & Monika Szeliga. (2020) Targeting Glutamine Addiction in Gliomas. Cancers 12:2, pages 310.
Crossref
Line O. Elingaard-Larsen, Michala G. Rolver, Ester E. Sørensen & Stine F. Pedersen. 2022. From Malignant Transformation to Metastasis. From Malignant Transformation to Metastasis 1 38 .
Yixin Sun, Jin Sun, Zhonggui He, Gang Wang, Yang Wang, Dongyang Zhao, Zhenjie Wang, Cong Luo, Chutong Tian & Qikun Jiang. (2019) Monocarboxylate Transporter 1 in Brain Diseases and Cancers. Current Drug Metabolism 20:11, pages 855-866.
Crossref
Karla Vinasco, Hazel M. Mitchell, Nadeem O. Kaakoush & Natalia Castaño-Rodríguez. (2019) Microbial carcinogenesis: Lactic acid bacteria in gastric cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1872:2, pages 188309.
Crossref
Karen G. de la Cruz-López, Leonardo Josué Castro-Muñoz, Diego O. Reyes-Hernández, Alejandro García-Carrancá & Joaquín Manzo-Merino. (2019) Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches. Frontiers in Oncology 9.
Crossref
Irina Kareva. (2019) Metabolism and Gut Microbiota in Cancer Immunoediting, CD8/Treg Ratios, Immune Cell Homeostasis, and Cancer (Immuno)Therapy: Concise Review. Stem Cells 37:10, pages 1273-1280.
Crossref
Matthias Kappler, Ulrike Pabst, Claus Weinholdt, Helge Taubert, Swetlana Rot, Tom Kaune, Johanna Kotrba, Martin Porsch, Antje Güttler, Matthias Bache, Knut Krohn, Fabian Bull, Anne Riemann, Claudia Wickenhauser, Barbara Seliger, Johannes Schubert, Bilal Al-Nawas, Oliver Thews, Ivo Grosse, Dirk Vordermark & Alexander W. Eckert. (2019) Causes and Consequences of A Glutamine Induced Normoxic HIF1 Activity for the Tumor Metabolism. International Journal of Molecular Sciences 20:19, pages 4742.
Crossref
Y-R Yu & P-C Ho. (2019) Sculpting tumor microenvironment with immune system: from immunometabolism to immunoediting. Clinical and Experimental Immunology 197:2, pages 153-160.
Crossref
Chunhua Zhao, Hongjun Dong, Yanping Zhang & Yin Li. (2019) Discovery of potential genes contributing to the biosynthesis of short-chain fatty acids and lactate in gut microbiota from systematic investigation in E. coli. npj Biofilms and Microbiomes 5:1.
Crossref
Xiaoyun Li, Mathias Wenes, Pedro Romero, Stanley Ching-Cheng Huang, Sarah-Maria Fendt & Ping-Chih Ho. (2019) Navigating metabolic pathways to enhance antitumour immunity and immunotherapy. Nature Reviews Clinical Oncology 16:7, pages 425-441.
Crossref
Aurélie StrickaertCyril CorbetSelim-Alex SpinetteLigia CraciunGeneviève DomGuy AndryDenis LarsimontRuddy WattiezJacques E. DumontOlivier FeronCarine Maenhaut. (2019) Reprogramming of Energy Metabolism: Increased Expression and Roles of Pyruvate Carboxylase in Papillary Thyroid Cancer. Thyroid 29:6, pages 845-857.
Crossref
Anthony Galenza & Edan Foley. (2019) Immunometabolism: Insights from the Drosophila model. Developmental & Comparative Immunology 94, pages 22-34.
Crossref
Huabo Wang, Jie Lu, Sucheta Kulkarni, Weiqi Zhang, Joanna E. Gorka, Jordan A. Mandel, Eric S. Goetzman & Edward V. Prochownik. (2019) Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts. Journal of Biological Chemistry 294:14, pages 5466-5486.
Crossref
Robert A. Harris & Aron W. Fenton. (2019) A critical review of the role of M2PYK in the Warburg effect. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1871:2, pages 225-239.
Crossref
Paul Castellano, Lisa Prevedel, Silvana Valdebenito & Eliseo A. Eugenin. (2019) HIV infection and latency induce a unique metabolic signature in human macrophages. Scientific Reports 9:1.
Crossref
Luigi Ippolito, Andrea Morandi, Elisa Giannoni & Paola Chiarugi. (2019) Lactate: A Metabolic Driver in the Tumour Landscape. Trends in Biochemical Sciences 44:2, pages 153-166.
Crossref
Carlos-Alberto Gonçalves, Letícia Rodrigues, Larissa D. Bobermin, Caroline Zanotto, Adriana Vizuete, André Quincozes-Santos, Diogo O. Souza & Marina C. Leite. (2019) Glycolysis-Derived Compounds From Astrocytes That Modulate Synaptic Communication. Frontiers in Neuroscience 12.
Crossref
Piumi Y. Liyanage, Regina M. Graham, Raja R. Pandey, Charles C. Chusuei, Keenan J. Mintz, Yiqun Zhou, James K. Harper, Wei Wu, Athula H. Wikramanayake, Steven Vanni & Roger M. Leblanc. (2018) Carbon Nitride Dots: A Selective Bioimaging Nanomaterial. Bioconjugate Chemistry 30:1, pages 111-123.
Crossref
Youcef Derbal. (2018) The Adaptive Complexity of Cancer. BioMed Research International 2018, pages 1-14.
Crossref
Mariafrancesca Scalise, Lorena Pochini, Lara Console, Maria A. Losso & Cesare Indiveri. (2018) The Human SLC1A5 (ASCT2) Amino Acid Transporter: From Function to Structure and Role in Cell Biology. Frontiers in Cell and Developmental Biology 6.
Crossref
Lidia de Bari & Anna Atlante. (2018) Including the mitochondrial metabolism of l-lactate in cancer metabolic reprogramming. Cellular and Molecular Life Sciences 75:15, pages 2763-2776.
Crossref
Jaroslav Zelenka, Martina Koncošová & Tomáš Ruml. (2018) Targeting of stress response pathways in the prevention and treatment of cancer. Biotechnology Advances 36:3, pages 583-602.
Crossref
Eric S. Goetzman & Edward V. Prochownik. (2018) The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues. Frontiers in Endocrinology 9.
Crossref
George A. Brooks. (2018) The Science and Translation of Lactate Shuttle Theory. Cell Metabolism 27:4, pages 757-785.
Crossref
Alejandro Fernandez-Martell, Yusuf B. Johari & David C. James. (2018) Metabolic phenotyping of CHO cells varying in cellular biomass accumulation and maintenance during fed-batch culture. Biotechnology and Bioengineering 115:3, pages 645-660.
Crossref
Guy Eelen, Pauline de Zeeuw, Lucas Treps, Ulrike Harjes, Brian W. Wong & Peter Carmeliet. (2018) Endothelial Cell Metabolism. Physiological Reviews 98:1, pages 3-58.
Crossref
Jing-chun Zhou, Jing-jing Zhang, Wei Ma, Wei Zhang, Zhao-yang Ke & Ling-guo Ma. (2018) Anti-tumor effect of HOTAIR–miR-613-SNAI2 axis through suppressing EMT and drug resistance in laryngeal squamous cell carcinoma. RSC Advances 8:52, pages 29879-29889.
Crossref
Sathish Sivaprakasam, Yangzom D. Bhutia, Shengping Yang & Vadivel Ganapathy. 2011. Comprehensive Physiology. Comprehensive Physiology 299 314 .
Youcef Derbal. (2017) Perspective on the dynamics of cancer. Theoretical Biology and Medical Modelling 14:1.
Crossref
Michel Bernier, Jonathan Catazaro, Nagendra S. Singh, Artur Wnorowski, Anna Boguszewska-Czubara, Krzysztof Jozwiak, Robert Powers & Irving W. Wainer. (2017) GPR55 receptor antagonist decreases glycolytic activity in PANC-1 pancreatic cancer cell line and tumor xenografts. International Journal of Cancer 141:10, pages 2131-2142.
Crossref
Shonagh Russell, Jonathan Wojtkowiak, Andy Neilson & Robert J. Gillies. (2017) Metabolic Profiling of healthy and cancerous tissues in 2D and 3D. Scientific Reports 7:1.
Crossref
Valéry L. Payen, Myriam Y. Hsu, Kristin S. Rädecke, Elisabeth Wyart, Thibaut Vazeille, Caroline Bouzin, Paolo E. Porporato & Pierre Sonveaux. (2017) Monocarboxylate Transporter MCT1 Promotes Tumor Metastasis Independently of Its Activity as a Lactate Transporter. Cancer Research 77:20, pages 5591-5601.
Crossref
Elena Panisova, Martin Kery, Olga Sedlakova, Lucie Brisson, Michaela Debreova, Martina Sboarina, Pierre Sonveaux, Silvia Pastorekova & Eliska Svastova. (2017) Lactate stimulates CA IX expression in normoxic cancer cells. Oncotarget 8:44, pages 77819-77835.
Crossref
Wei Shi, Xinyuan Xu, Fei Yan, Bao Wang, Hang Zhao, Aaron Chan, Zhen Ren, Yongzheng Ma, Fuli Wang & Jianlin Yuan. (2017) N‑Myc downstream‑regulated gene 2 restrains glycolysis and glutaminolysis in clear cell renal cell carcinoma. Oncology Letters.
Crossref
Yu Wu, Miaomiao Wang, Haihua Feng, Ying Peng, Jieyun Sun, Xiuxia Qu & Chunping Li. (2017) Lactate induces osteoblast differentiation by stabilization of HIF1α. Molecular and Cellular Endocrinology 452, pages 84-92.
Crossref
Nathalie Dehne, Javier Mora, Dmitry Namgaladze, Andreas Weigert & Bernhard Brüne. (2017) Cancer cell and macrophage cross-talk in the tumor microenvironment. Current Opinion in Pharmacology 35, pages 12-19.
Crossref
Andrea Morandi & Stefano Indraccolo. (2017) Linking metabolic reprogramming to therapy resistance in cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1868:1, pages 1-6.
Crossref
Lifeng Yang, Sriram VennetiDeepak Nagrath. (2017) Glutaminolysis: A Hallmark of Cancer Metabolism. Annual Review of Biomedical Engineering 19:1, pages 163-194.
Crossref
A Strickaert, M Saiselet, G Dom, X De Deken, J E Dumont, O Feron, P Sonveaux & C Maenhaut. (2016) Cancer heterogeneity is not compatible with one unique cancer cell metabolic map. Oncogene 36:19, pages 2637-2642.
Crossref
Michael D. Buck, Ryan T. Sowell, Susan M. Kaech & Erika L. Pearce. (2017) Metabolic Instruction of Immunity. Cell 169:4, pages 570-586.
Crossref
Seema Gupta, Amrita Roy & Bilikere S. Dwarakanath. (2017) Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy. Frontiers in Oncology 7.
Crossref
Vincent F. Van Hée, Daniel Labar, Gwenaël Dehon, Debora Grasso, Vincent Grégoire, Giulio G. Muccioli, Raphaël Frédérick & Pierre Sonveaux. (2017) Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors. Oncotarget 8:15, pages 24415-24428.
Crossref
Kuo-Liang Hou, Sze-Kwan Lin, Sang-Heng Kok, Han-Wei Wang, Eddie Hsiang-Hua Lai, Chi-Yuan Hong, Hsiang Yang, Juo-Song Wang, Li-Deh Lin & Jenny Zwei-Chieng Chang. (2017) Increased Expression of Glutaminase in Osteoblasts Promotes Macrophage Recruitment in Periapical Lesions. Journal of Endodontics 43:4, pages 602-608.
Crossref
Himalee S. Sabnis, Ranganatha R. Somasagara & Kevin D. Bunting. (2017) Targeting MYC Dependence by Metabolic Inhibitors in Cancer. Genes 8:4, pages 114.
Crossref
Vera Cappelletti, Egidio Iorio, Patrizia Miodini, Marco Silvestri, Matteo Dugo & Maria Grazia Daidone. (2017) Metabolic Footprints and Molecular Subtypes in Breast Cancer. Disease Markers 2017, pages 1-19.
Crossref
Maria Shoshan. (2017) On mitochondrial metabolism in tumor biology. Current Opinion in Oncology 29:1, pages 48-54.
Crossref
Hong-Wei Sun, Xing-Juan Yu, Wen-Chao Wu, Jing Chen, Ming Shi, Limin Zheng & Jing Xu. (2016) GLUT1 and ASCT2 as Predictors for Prognosis of Hepatocellular Carcinoma. PLOS ONE 11:12, pages e0168907.
Crossref
Iñigo San-Millán & George A. Brooks. (2016) Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect. Carcinogenesis, pages bgw127.
Crossref
Eric C. Woolf, Nelofer Syed & Adrienne C. Scheck. (2016) Tumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy. Frontiers in Molecular Neuroscience 9.
Crossref
Judith Penkert, Tim Ripperger, Maximilian Schieck, Brigitte Schlegelberger, Doris Steinemann & Thomas Illig. (2016) On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer. Oncotarget 7:41, pages 67626-67649.
Crossref
Ming Liu, Jiwei Wang, Qichao Qi, Bin Huang, Anjing Chen, Xingang Li & Jian Wang. (2016) Nitidine chloride inhibits the malignant behavior of human glioblastoma cells by targeting the PI3K/AKT/mTOR signaling pathway. Oncology Reports 36:4, pages 2160-2168.
Crossref
Brian J. Altman, Zachary E. Stine & Chi V. Dang. (2016) From Krebs to clinic: glutamine metabolism to cancer therapy. Nature Reviews Cancer 16:10, pages 619-634.
Crossref
Elizabeth Allen, Pascal Miéville, Carmen M. Warren, Sadegh Saghafinia, Leanne Li, Mei-Wen Peng & Douglas Hanahan. (2016) Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling. Cell Reports 15:6, pages 1144-1160.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.