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Cell Cycle Volume 16, 2017 - Issue 1
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Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2

Eva AbsmeierFreie Universität Berlin, Laboratory of Structural Biochemistry, Berlin, Germany
,
Christian BeckeFreie Universität Berlin, Laboratory of Structural Biochemistry, Berlin, Germany
,
Jan WollenhauptFreie Universität Berlin, Laboratory of Structural Biochemistry, Berlin, Germany
,
Karine F. SantosFreie Universität Berlin, Laboratory of Structural Biochemistry, Berlin, GermanyCorrespondence[email protected] [email protected]
&
Markus C. WahlFreie Universität Berlin, Laboratory of Structural Biochemistry, Berlin, Germany;Helmholtz-Zentrum Berlin für Materialien und Energie, Macromolecular Crystallography, Berlin, GermanyCorrespondence[email protected] [email protected]
Pages 100-112 | Received 05 Oct 2016, Accepted 26 Oct 2016, Published online: 20 Dec 2016

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Eva Absmeier, Karine F. Santos & Markus C. Wahl. (2016) Functions and regulation of the Brr2 RNA helicase during splicing. Cell Cycle 15:24, pages 3362-3377.
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Articles from other publishers (20)

Pravin Kumar Ankush Jagtap, Marisa Müller, Anna E. Kiss, Andreas W. Thomae, Karine Lapouge, Martin Beck, Peter B. Becker & Janosch Hennig. (2023) Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless. Molecular Cell 83:23, pages 4318-4333.e10.
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Corbin S. Black, Thomas A. Whelan, Erin L. Garside, Andrew M. MacMillan, Naomi M. Fast & Stephen D. Rader. (2023) Spliceosome assembly and regulation: insights from analysis of highly reduced spliceosomes. RNA 29:5, pages 531-550.
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Junqiao Jia, Tarek Hilal, Katherine E. Bohnsack, Aleksandar Chernev, Ning Tsao, Juliane Bethmann, Aruna Arumugam, Lane Parmely, Nicole Holton, Bernhard Loll, Nima Mosammaparast, Markus T. Bohnsack, Henning Urlaub & Markus C. Wahl. (2023) Extended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex. Nature Communications 14:1.
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Catiana H Cartwright-Acar, Kenneth Osterhoudt, Jessie M N G L Suzuki, Destiny R Gomez, Sol Katzman & Alan M Zahler. (2022) A forward genetic screen in C. elegans identifies conserved residues of spliceosomal proteins PRP8 and SNRNP200/BRR2 with a role in maintaining 5′ splice site identity . Nucleic Acids Research 50:20, pages 11834-11857.
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Alexandra Bergfort, Tarek Hilal, Benno Kuropka, İbrahim Avşar Ilik, Gert Weber, Tuğçe Aktaş, Christian Freund & Markus C Wahl. (2022) The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling. Nucleic Acids Research 50:5, pages 2938-2958.
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Alexandra Bergfort, Marco Preußner, Benno Kuropka, İbrahim Avşar Ilik, Tarek Hilal, Gert Weber, Christian Freund, Tuğçe Aktaş, Florian Heyd & Markus C. Wahl. (2022) A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing. Nature Communications 13:1.
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Eva Absmeier, Karen Vester, Tahereh Ghane, Dmitry Burakovskiy, Pohl Milon, Petra Imhof, Marina V. Rodnina, Karine F. Santos & Markus C. Wahl. (2021) Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. Journal of Biological Chemistry 297:1, pages 100829.
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Pascal Donsbach & Dagmar Klostermeier. (2021) Regulation of RNA helicase activity: principles and examples. Biological Chemistry 402:5, pages 529-559.
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Tabitha Jenkins, Sarah J Northall, Denis Ptchelkine, Rebecca Lever, Andrew Cubbon, Hannah Betts, Vincenzo Taresco, Christopher D O Cooper, Peter J McHugh, Panos Soultanas & Edward L Bolt. (2021) The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core. NAR Cancer 3:1.
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Eva Absmeier & Markus C. Wahl. 2021. RNA Remodeling Proteins. RNA Remodeling Proteins 193 215 .
Junqiao Jia, Eva Absmeier, Nicole Holton, Agnieszka J. Pietrzyk-Brzezinska, Philipp Hackert, Katherine E. Bohnsack, Markus T. Bohnsack & Markus C. Wahl. (2020) The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations. Nature Communications 11:1.
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Florian HamannAndreas SchmittFilippo FavrettoRomina HofelePiotr NeumannShengQi XiangHenning Urlaub, Markus Zweckstetter & Ralf Ficner. (2020) Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proceedings of the National Academy of Sciences 117:6, pages 2948-2956.
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Karen Vester, Karine F. Santos, Benno Kuropka, Christoph Weise & Markus C. Wahl. (2020) The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit. Journal of Biological Chemistry 295:7, pages 2097-2112.
Crossref
Eva Absmeier, Karine F. Santos & Markus C. Wahl. (2020) Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase. Structure 28:2, pages 236-243.e3.
Crossref
David A Brow. (2019) An Allosteric Network for Spliceosome Activation Revealed by High-Throughput Suppressor Analysis in Saccharomyces cerevisiae . Genetics 212:1, pages 111-124.
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Wojciech P. Galej. (2018) Structural studies of the spliceosome: past, present and future perspectives. Biochemical Society Transactions 46:6, pages 1407-1422.
Crossref
Jan Wollenhaupt, Lisa M. Henning, Jana Sticht, Christian Becke, Christian Freund, Karine F. Santos & Markus C. Wahl. (2018) Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2. Biophysical Journal 114:4, pages 788-799.
Crossref
Ralf Ficner, Achim Dickmanns & Piotr Neumann. (2017) Studying structure and function of spliceosomal helicases. Methods 125, pages 63-69.
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Sara Espinosa, Lingdi Zhang, Xueni Li & Rui Zhao. (2017) Understanding pre-mRNA splicing through crystallography. Methods 125, pages 55-62.
Crossref
Kathleen B. Hall. (2017) RNA and Proteins: Mutual Respect. F1000Research 6, pages 345.
Crossref

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