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Cell Cycle Volume 18, 2019 - Issue 18
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Research Paper

Circular RNA circ_0000950 promotes neuron apoptosis, suppresses neurite outgrowth and elevates inflammatory cytokines levels via directly sponging miR-103 in Alzheimer’s disease

Hui YangDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, ChinaView further author information
,
Huan WangDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, ChinaView further author information
,
Hong ShangDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, ChinaView further author information
,
Xiufen ChenDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, ChinaView further author information
,
Shiqi YangDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, ChinaView further author information
,
Yang QuDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, ChinaView further author information
,
Jing DingDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, ChinaView further author information
&
Xuling LiDepartment of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8664-0284View further author information
ORCID Icon show all
Pages 2197-2214 | Received 03 Oct 2018, Accepted 25 Mar 2019, Published online: 02 Aug 2019

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Junhua Wang & Ying Wang. (2021) Circular RNA cerebellar degeneration-related protein 1 antisense RNA (Circ-CDR1as) downregulation induced by dexmedetomidine treatment protects hippocampal neurons against hypoxia/reoxygenation injury through the microRNA-28-3p (miR-28-3p)/tumor necrosis factor receptor-associated factor-3 (TRAF3) axis. Bioengineered 12:2, pages 10512-10524.
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Articles from other publishers (52)

Ozal Beylerli, Aferin Beilerli, Tatiana Ilyasova, Alina Shumadalova, Huaizhang Shi & Albert Sufianov. (2024) CircRNAs in Alzheimer's disease: What are the prospects?. Non-coding RNA Research 9:1, pages 203-210.
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Jianjian Chu, Weicong Zhang, Yan Liu, Baofeng Gong, Wenbo Ji, Tong Yin, Chao Gao, Danqi Liangwen, Mengqi Hao, Cuimin Chen, Jianhua Zhuang, Jie Gao & You Yin. (2024) Biomaterials-based anti-inflammatory treatment strategies for Alzheimer’s disease. Neural Regeneration Research 19:1, pages 100-115.
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Omid Vakili, Pooria Asili, Zeinab Babaei, Maryam Mirahmad, Atoosa Keshavarzmotamed, Zatollah Asemi & Alireza Mafi. (2023) Circular RNAs in Alzheimer’s Disease: A New Perspective of Diagnostic and Therapeutic Targets. CNS & Neurological Disorders - Drug Targets 22:9, pages 1335-1354.
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Soudeh Ghafouri-Fard, Hamed Shoorei, Toofan Sabernia, Bashdar Mahmud Hussen, Mohammad Taheri & Hasan Pourmoshtagh. (2023) Circular RNAs and inflammation: Epigenetic regulators with diagnostic role. Pathology - Research and Practice 251, pages 154912.
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Ying Bai & Hong-hong Yao. (2023) Circular RNAs: Diagnostic and Therapeutic Perspectives in CNS Diseases. Current Medical Science 43:5, pages 879-889.
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Edward O. Olufunmilayo & R. M. Damian Holsinger. (2023) Roles of Non-Coding RNA in Alzheimer’s Disease Pathophysiology. International Journal of Molecular Sciences 24:15, pages 12498.
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Hailah M. Almohaimeed, Rasha Assiri, Eman Hillal Althubaiti, Waheeb S. Aggad, Sameerah Shaheen, Marwa Y. Shaheen, Munirah A. Batarfi, Nada Abdullah Alharbi, Areej Mohammed Alshehri & Basal sulaiman M. Alkhudhairy. (2023) Non-coding RNAs as key players in the neurodegenerative diseases: Multi-platform strategies and approaches for exploring the Genome’s dark matter. Journal of Chemical Neuroanatomy 129, pages 102236.
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Amaya Urdánoz-Casado, Javier Sánchez-Ruiz de Gordoa, Maitane Robles, Miren Roldan, Mónica Macías Conde, Blanca Acha, Idoia Blanco-Luquin & Maite Mendioroz. (2023) circRNA from APP Gene Changes in Alzheimer’s Disease Human Brain. International Journal of Molecular Sciences 24:5, pages 4308.
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Xiaotong Zhao, Murong Xu, Ying Tang, Dandan Xie, Youmin Wang & Mingwei Chen. (2022) Changes in miroRNA‐103 expression in wound margin tissue are related to wound healing of diabetes foot ulcers. International Wound Journal 20:2, pages 467-483.
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Rabea Basri, Faryal Mehwish Awan, Burton B. Yang, Usman Ayub Awan, Ayesha Obaid, Anam Naz, Aqsa Ikram, Suliman Khan, Ijaz ul Haq, Sadiq Noor Khan & Muslim Bin Aqeel. (2023) Brain-protective mechanisms of autophagy associated circRNAs: Kick starting self-cleaning mode in brain cells via circRNAs as a potential therapeutic approach for neurodegenerative diseases. Frontiers in Molecular Neuroscience 15.
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Nini Li, Dongdong Zhang, Hena Guo, Qian Yang, Peng Li & Yifan He. (2023) Inhibition of circ_0004381 improves cognitive function via miR-647/PSEN1 axis in an Alzheimer disease mouse model. Journal of Neuropathology & Experimental Neurology 82:1, pages 84-92.
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Katerina Pierouli, Eleni Papakonstantinou, Louis Papageorgiou, Io Diakou, Thanasis Mitsis, Konstantina Dragoumani, Demetrios Spandidos, Flora Bacopoulou, George Chrousos, George Goulielmos, Elias Eliopoulos & Dimitrios Vlachakis. (2022) Role of non‑coding RNAs as biomarkers and the application of omics technologies in Alzheimer's disease (Review). International Journal of Molecular Medicine 51:1.
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Liang He, Furong Zhang, Yuling Zhu & Meilin Lu. (2022) A crosstalk between circular RNA, microRNA, and messenger RNA in the development of various brain cognitive disorders. Frontiers in Molecular Neuroscience 15.
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Jen-Yang Tang, Ya-Ting Chuang, Jun-Ping Shiau, Kun-Han Yang, Fang-Rong Chang, Ming-Feng Hou, Ammad Ahmad Farooqi & Hsueh-Wei Chang. (2022) Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells. Cells 11:19, pages 2940.
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Chaosheng Zeng, Huaijie Xing, Min Chen, Lin Chen, Pengxiang Li, Xiaowen Wu & Li Li. (2022) Circ_0049472 regulates the damage of Aβ-induced SK-N-SH and CHP-212 cells by mediating the miR-107/KIF1B axis. Experimental Brain Research 240:9, pages 2299-2309.
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Huajun Wang, Guangying Zheng, Miaomiao Sun & Yingjie Chi. (2022) Circ‐POLR3A accelerates TGF‐β2‐induced promotion in cell viability, migration, and invasion of lens epithelial cells via miR‐31/TXNIP signaling cascade. Journal of Biochemical and Molecular Toxicology 36:9.
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Ximeng Yin, Wei Zheng, Ling He, Shengkai Mu, Yongle Shen & Jingxu Wang. (2022) CircHIPK3 alleviates inflammatory response and neuronal apoptosis via regulating miR-382-5p/DUSP1 axis in spinal cord injury. Transplant Immunology 73, pages 101612.
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Tao Meng, Yalan Chen, Pei Wang, Liu Yang & Chenggang Li. (2022) Circ-HUWE1 Knockdown Alleviates Amyloid-β-Induced Neuronal Injury in SK-N-SH Cells via miR-433-3p Release-Mediated FGF7 Downregulation. Neurotoxicity Research 40:4, pages 913-924.
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Qin Li, Zhaopeng Hu, Fang Yang & Yi Peng. (2022) Circ_0066881 targets miR-144-5p/RORA axis to alleviate LPS-induced apoptotic and inflammatory damages in human periodontal ligament cells. Innate Immunity 28:5, pages 164-173.
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Qianqian Dong, Ziqi Han & Limin Tian. (2022) Identification of Serum Exosome-Derived circRNA-miRNA-TF-mRNA Regulatory Network in Postmenopausal Osteoporosis Using Bioinformatics Analysis and Validation in Peripheral Blood-Derived Mononuclear Cells. Frontiers in Endocrinology 13.
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Yuanlong Li, Xiong Han, Hua Fan, Jun Sun, Ming Ni, Lulu Zhang, Fengqin Fang, Wei Zhang & Peizhi Ma. (2022) Circular RNA AXL increases neuron injury and inflammation through targeting microRNA-328 mediated BACE1 in Alzheimer’s disease. Neuroscience Letters 776, pages 136531.
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