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Separation & Purification Reviews Volume 44, 2015 - Issue 1
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Original Articles

Simulated Moving Bed Strategies and Designs: From Established Systems to the Latest Developments

José P. S. AnicetoCICECO and Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, Portugal
&
Carlos M. SilvaCICECO and Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, PortugalCorrespondence[email protected]
Pages 41-73 | Received 24 Jun 2013, Accepted 23 Sep 2013, Published online: 03 Sep 2014

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R. C. de Holanda, F. C. Cunha, A. R. Secchi & A. G. Barreto$suffix/text()$suffix/text(). (2023) Supervisory system for automated simulated moving bed (SMB) liquid chromatography (LC). Instrumentation Science & Technology 51:3, pages 319-334.
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Articles from other publishers (41)

Hechun Shi, Yuan Zong, Ling Zhao & Gance Dai. (2023) Flow and mass transfer for the adsorption separation of para-xylene in a packed bed by particle-resolved CFD simulations. Chemical Engineering Science, pages 119622.
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Xiaotong Zhang, Juming Liu, Ajay K. Ray & Yan Li. (2023) Research Progress on the Typical Variants of Simulated Moving Bed: From the Established Processes to the Advanced Technologies. Processes 11:2, pages 508.
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Reinaldo Calderón Supelano, Amaro Gomes Barreto Jr & Argimiro Resende Secchi. (2022) Evaluation of the optimal performance of ModiCon and ModiCon+VariCol simulated moving bed variants. Journal of Chromatography A 1675, pages 463182.
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Yun Luo, Hongliang Zhang, Muling Su, Qinghua Tang, Jin Xu & Weifang Yu. (2022) Effects of mobile phase composition on key parameters for the design of preparative chromatography separation of equol enantiomers. Separation and Purification Technology 288, pages 120645.
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Sirawee Maneewan, Preuk Tangpromphan & Attasak Jaree. (2021) Separation of Vitexin and Iso-vitexin from Mung Bean Seed Coats Using a Three-Zone Simulated Moving Bed (SMB). Waste and Biomass Valorization 12:12, pages 6601-6618.
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Reinaldo Calderón Supelano, Amaro Gomes BarretoJr.Jr. & Argimiro Resende Secchi. (2021) Optimal performance comparison of the simulated moving bed process variants based on the modulation of the length of zones and the feed concentration. Journal of Chromatography A 1651, pages 462280.
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Tae Hoon Oh, Jong Woo Kim, Sang Hwan Son, Hosoo Kim, Kyungmoo Lee & Jong Min Lee. (2021) Automatic control of simulated moving bed process with deep Q-network. Journal of Chromatography A 1647, pages 462073.
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Lukas Gerstweiler, Jingxiu Bi & Anton P.J. Middelberg. (2021) Continuous downstream bioprocessing for intensified manufacture of biopharmaceuticals and antibodies. Chemical Engineering Science 231, pages 116272.
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Mónica Moreno-González, Daphne Keulen, Joaquín Gomis-Fons, Gustavo Lopez Gomez, Bernt Nilsson & Marcel Ottens. (2021) Continuous adsorption in food industry: The recovery of sinapic acid from rapeseed meal extract. Separation and Purification Technology 254, pages 117403.
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Yoshiaki Kawajiri. (2020) Model-based optimization strategies for chromatographic processes: a review. Adsorption 27:1, pages 1-26.
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Reinaldo Calderón Supelano, Amaro Gomes Barreto Jr, Ataíde Souza Andrade Neto & Argimiro Resende Secchi. (2020) One-step optimization strategy in the simulated moving bed process with asynchronous movement of ports: A VariCol case study. Journal of Chromatography A 1634, pages 461672.
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Ivo S. Azenha, José P.S. Aniceto, Cristiana A. Santos, Adélio Mendes & Carlos M. Silva. (2020) Enhanced separation of bioactive triterpenic acids with a triacontylsilyl silica gel adsorbent: From impulse and breakthrough experiments to the design of a simulated moving bed unit. Separation and Purification Technology 248, pages 116991.
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Kyung-Min Kim, Kyeong-Woo Han, Seung-Ik Kim & Youn-Sang Bae. (2020) Simulated moving bed with a product column for improving the separation performance. Journal of Industrial and Engineering Chemistry 88, pages 328-338.
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I.S. Azenha, J.P.S. Aniceto, S.P. Sequeira, A. Mendes & C.M. Silva. (2020) Chromatographic separation of betulinic and oleanolic acids. Separation and Purification Technology 235, pages 116129.
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Mónica Moreno-González, Vasupradha Girish, Daphne Keulen, Hilde Wijngaard, Xavier Lauteslager, Guilherme Ferreira & Marcel Ottens. (2020) Recovery of sinapic acid from canola/rapeseed meal extracts by adsorption. Food and Bioproducts Processing 120, pages 69-79.
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Tae Hoon Oh, Se-Kyu Oh, Hosoo Kim, Kyungmoo Lee & Jong Min Lee. (2019) Transition Model for Simulated Moving Bed Under Nonideal Conditions. Industrial & Engineering Chemistry Research 58:47, pages 21625-21640.
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Hyeong-Seok Han, Kyung-Min Kim, Kyeong-Woo Han, Seung-Ik Kim & Youn-Sang Bae. (2019) Total-recycling partial-discard strategy for improved performance of simulated moving-bed chromatography. Journal of Industrial and Engineering Chemistry 79, pages 226-235.
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Idelfonso B.R. Nogueira, Márcio A.F. Martins, Reiner Requião, Amanda R. Oliveira, Vinícius Viena, Hannu Koivisto, Alírio E. Rodrigues, José M. Loureiro & Ana M. Ribeiro. (2019) Optimization of a True Moving Bed unit and determination of its feasible operating region using a novel Sliding Particle Swarm Optimization. Computers & Industrial Engineering 135, pages 368-381.
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Feng Wei, Licheng Shi, Qiang Wang & Yingxian Zhao. (2018) Fast and accurate separation of the paclitaxel from yew extracum by a pseudo simulated moving bed with solvent gradient. Journal of Chromatography A 1564, pages 120-127.
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Joana M. Pinheiro, Sérgio Salústio, Anabela A. Valente & Carlos M. Silva. (2018) Adsorption heat pump optimization by experimental design and response surface methodology. Applied Thermal Engineering 138, pages 849-860.
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Samuel Leweke & Eric von Lieres. (2018) Chromatography Analysis and Design Toolkit (CADET). Computers & Chemical Engineering 113, pages 274-294.
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Kevin R. Wood, Y. A Liu & Yueying Yu. 2018. Design, Simulation and Optimization of Adsorptive and Chromatographic Separations. Design, Simulation and Optimization of Adsorptive and Chromatographic Separations 395 398 .
J.P.S. Aniceto, I.S. Azenha, F.M.J. Domingues, A. Mendes & C.M. Silva. (2018) Design and optimization of a simulated moving bed unit for the separation of betulinic, oleanolic and ursolic acids mixtures: Experimental and modeling studies. Separation and Purification Technology 192, pages 401-411.
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Sa V. Ho & Kristi L. Budzinski. 2018. Green Techniques for Organic Synthesis and Medicinal Chemistry. Green Techniques for Organic Synthesis and Medicinal Chemistry 579 599 .
Kyung-Min Kim, Ju Weon Lee, Sunhee Kim, Francisco Vitor Santos da Silva, Andreas Seidel-Morgenstern & Chang-Ha Lee. (2017) Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography. Chemical Engineering & Technology 40:12, pages 2163-2178.
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Ganapathy SubramanianAnurag S. Rathore, Nikhil Kateja & Harshit Agarwal. 2017. Continuous Biomanufacturing ‐ Innovative Technologies and Methods. Continuous Biomanufacturing ‐ Innovative Technologies and Methods 259 288 .
Tae Hoon Oh, Se-Kyu Oh & Jong Min Lee. (2017) Modeling and optimization of simulated moving bed chromatography with side streams. Modeling and optimization of simulated moving bed chromatography with side streams.
Idelfonso B.R. Nogueira, Ana M. Ribeiro, Alírio E. Rodrigues & José M. Loureiro. (2017) Dynamic response to process disturbances—A comparison between TMB/SMB models in transient regime. Computers & Chemical Engineering 99, pages 230-244.
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Rohan Patil & Jason Walther. 2018. New Bioprocessing Strategies: Development and Manufacturing of Recombinant Antibodies and Proteins. New Bioprocessing Strategies: Development and Manufacturing of Recombinant Antibodies and Proteins 277 322 .
José P.S. Aniceto, Simão P. Cardoso & Carlos M. Silva. (2016) General optimization strategy of simulated moving bed units through design of experiments and response surface methodologies. Computers & Chemical Engineering 90, pages 161-170.
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Andrew L. Zydney. (2016) Continuous downstream processing for high value biological products: A Review. Biotechnology and Bioengineering 113:3, pages 465-475.
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Mehrdad Arshadi, Thomas M. Attard, Rafal M. Lukasik, Mladen Brncic, André M. da Costa Lopes, Michael Finell, Paul Geladi, Lia Noemi Gerschenson, Fahrettin Gogus, Miguel Herrero, Andrew J. Hunt, Elena Ibáñez, Birgit Kamm, Inmaculada Mateos-Aparicio, Ana Matias, Nikolaos E. Mavroudis, Enzo Montoneri, Ana Rita C. Morais, Calle Nilsson, Emmanouil H. Papaioannou, Aurore Richel, Pilar Rupérez, Biljana Škrbić, Marija Bodroža Solarov, Jaroslava Švarc-Gajić, Keith W. Waldron & F. J. Yuste-Córdoba. (2016) Pre-treatment and extraction techniques for recovery of added value compounds from wastes throughout the agri-food chain. Green Chemistry 18:23, pages 6160-6204.
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F. Janakievski, O. Glagovskaia & K. De Silva. 2016. Innovative Food Processing Technologies. Innovative Food Processing Technologies 133 149 .
Ricardo JS Silva, José PB Mota, Cristina Peixoto, Paula M Alves & Manuel JT Carrondo. (2015) Improving the downstream processing of vaccine and gene therapy vectors with continuous chromatography. Pharmaceutical Bioprocessing 3:8, pages 489-505.
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Rui P. Silva, Marcelo M.R. de Melo, Armando J.D. Silvestre & Carlos M. Silva. (2015) Polar and lipophilic extracts characterization of roots, stalks, leaves and flowers of water hyacinth (Eichhornia crassipes), and insights for its future valorization. Industrial Crops and Products 76, pages 1033-1038.
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José P.S. Aniceto & Carlos M. Silva. 2015. Analytical Separation Science. Analytical Separation Science 1207 1313 .
Andrew L Zydney. (2015) Perspectives on integrated continuous bioprocessing—opportunities and challenges. Current Opinion in Chemical Engineering 10, pages 8-13.
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Nicholas Soepriatna, N. H. Linda Wang & Phillip C. Wankat. (2015) Standing Wave Design and Optimization of Nonlinear Four-Zone Thermal Simulated Moving Bed Systems. Industrial & Engineering Chemistry Research 54:42, pages 10419-10433.
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Raquel V. Vaz, Ana L. Magalhães & Carlos M. Silva. (2013) Improved hydrodynamic equations for the accurate prediction of diffusivities in supercritical carbon dioxide. Fluid Phase Equilibria 360, pages 401-415.
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Ana L. Magalhães, Raquel V. Vaz, Ricardo M.G. Gonçalves, Francisco A. Da Silva & Carlos M. Silva. (2013) Accurate hydrodynamic models for the prediction of tracer diffusivities in supercritical carbon dioxide. The Journal of Supercritical Fluids 83, pages 15-27.
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Reinaldo Calderon Supelano, Amaro Gomes Barreto & Argimiro Resende Secchi. (2022) Evaluation of the Optimal Performance of Modicon and Modicon+Varicol Simulated Moving Bed Variants. SSRN Electronic Journal.
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