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Original Articles

Simulated Moving Bed Strategies and Designs: From Established Systems to the Latest Developments

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Pages 41-73 | Received 24 Jun 2013, Accepted 23 Sep 2013, Published online: 03 Sep 2014

REFERENCES

  • Ruthven, D.M. (1984) Principles of Adsorption and Adsorption Processes. Wiley: New York.
  • Wankat, P.C. (1994) Rate-controlled Separations. Blackie Academic & Professional: Great Yarmouth, United Kingdom.
  • Ruthven, D.M. and Ching, C.B. (1989) Counter-current and simulated counter-current adsorption separation processes. Chemical Engineering Science, 44: 1011–1038.
  • Broughton, D.B. and Gerhold, C.G. (1961) Continuous Sorption Process Employing Fixed Bed. U.S. Patent 2985589, May 23, 1961.
  • Broughton, D.B. and Carson, D.B. (1959) The Molex Process. The Petroleum Refiner, 38 130.
  • Broughton, D.B., Neuzil, R.W., Pharis, J.M., and Brearley, C.S. (1970) Parex process for recovering paraxylene. Chemical Engineering Progress, 66: 70.
  • Broughton, D.B. (1981) Production of pure m-xylene and pure ethyl benzene from a mixture of C8 aromatic isomers. U.S. Patent 4306107, December 15, 1981.
  • Broughton, D.B. (1983) Sucrose extraction from aqueous solutions featuring simulated moving bed. U.S. Patent 4404037, September 13, 1983.
  • Mai, N.L., Nguyen, N.T., Kim, J.I., Park, H.M., Lee, S.K., and Koo, Y.M. (2012) Recovery of ionic liquid and sugars from hydrolyzed biomass using ion exclusion simulated moving bed chromatography. Journal of Chromatography A, 1227: 67–72.
  • Fuereder, M., Panke, S., and Bechtold, M. (2012) Simulated moving bed enantioseparation of amino acids employing memory effect-constrained chromatography columns. Journal of Chromatography A, 1236: 123–131.
  • Grill, C.M., Abel, S., Juza, M., and Huthmann, E. (2012) Simulated moving bed starting conditions using an empirical model for S-shaped adsorption isotherms. Journal of Chromatography A, 1227: 73–81.
  • Kim, S.G., Nam, H.G., Kim, J.H., and Mun, S. (2011) Optimal design of a four-zone simulated moving bed process for separation of Homoharringtonine and Harringtonine. Canadian Journal of Chemical Engineering, 89: 304–313.
  • Ribeiro, A.E., Gomes, P.S., Pais, L.S., and Rodrigues, A.E. (2011) Chiral separation of flurbiprofen enantiomers by preparative and simulated moving bed chromatography. Chirality, 23: 602–611.
  • Ribeiro, A.E., Gomes, P.S., Pais, L.S., and Rodrigues, A.E. (2011) Chiral separation of ketoprofen enantiomers by preparative and simulated moving bed chromatography. Separation Science and Technology, 46: 1726–1739.
  • Lee, E., Park, M.B., Kim, J.M., Kim, W.S., and Kim, I.H. (2010) Simulated moving-bed for separation of mandelic acid racemic mixtures. Korean Journal of Chemical Engineering, 27: 231–234.
  • Freydell, E.J., Bulsink, Y., van Hateren, S., van der Wielen, L., Eppink, M., and Ottens, M. (2010) Size-exclusion simulated moving bed chromatographic protein refolding. Chemical Engineering Science, 65: 4701–4713.
  • Vankova, K. and Polakovic, M. (2012) Design of fructooligosaccharide separation using simulated moving-bed chromatography. Chemical Engineering Technology, 35: 161–168.
  • Yuan, L. (2012) Simulated moving bed chromatography device, has bypass channels provided for partition plates of outer fluid transfer segments, and flow channel formed by removal of partition plate between adjacent outer fluid transfer segments. U.S. Patent 8241492-B1, August 14, 2012.
  • Tenedorio Matos Da Silva, V., Marques Pereira, C.S., and Rodrigues, A.E. (2010) Simulated moving bed membrane reactor, new hybrid separation process and uses there of. U.S. Patent WO2010116335, October 14, 2010.
  • Koo, Y.M., Kim, J.I., and Kim, I. (2011) Method for asynchronously starting four zones-based simulated moving bed chromatography, involves moving raw material inlet from second zone to third zone to start chromatography when eluent solution is introduced into first zone. Korean Patent KR1036554-B1, May 24, 2011.
  • Decoodt, X., Hotier, G., Leflaive, P., Leinekugel Le Cocq, D., and Leinekugel, L.C.D. (2010) Simulated-moving-bed separation method and device with modulated tapped-off fluid flow. U.S. Patent WO2010020715, February 25, 2010.
  • Decoodt, X., Hotier, G., Leflaive, P., and Leinekugel, L.C.D. (2010) Process and device for separation in a simulated moving bed with a bypass fluid flow rate that is not regulated automatically. U.S. Patent 048973, November 1, 2011.
  • Woods, R.R., Krikorian, V., and Smithers, J. (2010) High efficiency separations method and apparatus. U.S. Patent 206812, August 19, 2010.
  • Kelliher, A., Morrison, A., Oroskar, A., Nair Rema, R.V., and Agarwal, A. (2011) Simulated moving bed chromatographic separation process for the purification of polyunsaturated fatty acids. U.S. Patent WO2011080503, August 25, 2011.
  • Zhang, D., Cai, Y., Zhang, W., Wang, Y., Ding, Y., Liao, X., Li, Z., and Luo, J. (2011) Method for continuously separating and purifying valine in fermentation liquor by using simulated moving bed chromatography. Chinese Patent CN101948399, January 19, 2011.
  • Zhang, L., Zhang, B., Tang, N., and Tang, L. (2010) Process for cleanly producing o (p) - aminoanisole (phenetidine) by coupling simulated moving bed. Chinese Patent CN101823972, September 8, 2010.
  • Tang, N., Tang, L., and Jiang, R. (2014) Simulated moving bed reactor coupled acetaminophen phenetidine cleaner production processes. Chinese Patent CN101823979, April 23, 2014.
  • Ma, L., Shang, H., Li, R., Xue, P., Wu, P., and He, Y. (2012) Separation and extraction of L-ribose, involves centrifuging and separating L-ribose liquid synthesized using L-arabinose, separating by simulated moving bed chromatography, and condensing and crystallizing obtained solution. Chinese Patent CN101781338, August 15, 2012.
  • Oroskar, A.R. (2013) Rotary valve apparatus for simulated moving bed separations U.S. Patent 8349175, January 8, 2013.
  • Cheng, C., Grabski, A.C., Mierendorf, R.C., and Wilke, A.P. (2010) Valve block assembly. U.S. Patent WO2010021815, February 25, 2010.
  • Juza, M., Mazzotti, M., and Morbidelli, M. (2000) Simulated moving-bed chromatography and its application to chirotechnology. Trends in Biotechnology, 18: 108–118.
  • Schulte, M. and Strube, J. (2001) Preparative enantioseparation by simulated moving bed chromatography. Journal of Chromatography A, 906: 399–416.
  • Rajendran, A., Paredes, G., and Mazzotti, M. (2009) Simulated moving bed chromatography for the separation of enantiomers. Journal of Chromatography A, 1216: 709–738.
  • Imamoglu, S. (2002) Simulated Moving Bed Chromatography (SMB) for Application in Bioseparation. In Modern Advances in Chromatography, Advances in Biochemical Enginnering Biotechnology; Freitag, R., ed.; Springer: Berlin/Heidelberg, 211–231.
  • Gomes, P.S., Minceva, M., and Rodrigues, A.E. (2006) Simulated moving bed technology: old and new. Adsorption-Journal of the International Adsorption Society, 12: 375–392.
  • Gomes, P.S. and Rodrigues, A.E. (2012) Simulated moving bed chromatography: from concept to proof-of-concept. Chemical Engineering Technology, 35: 17–34.
  • Chin, C.Y. and Wang, N.H.L. (2004) Simulated moving bed equipment designs. Separation and Purification Reviews, 33: 77–155.
  • Seidel-Morgenstern, A., Kessler, L.C., and Kaspereit, M. (2008) New developments in simulated moving bed chromatography. Chemical Engineering Technology, 31: 826–837.
  • Pynnonen, B. (1998) Simulated moving bed processing: escape from the high-cost box. Journal of Chromatography A, 827: 143–160.
  • Pais, L.S., Loureiro, J.M., and Rodrigues, A.E. (1998) Modeling strategies for enantiomers separation by SMB chromatography. AIChE Journal, 44: 561–569.
  • Pais, L.S. and Rodrigues, A.E. (2003) Design of simulated moving bed and Varicol processes for preparative separations with a low number of columns. Journal of Chromatography A, 1006: 33–44.
  • Storti, G., Mazzotti, M., Morbidelli, M., and Carra, S. (1993) Robust Design of Binary Countercurrent Adsorption Separation Processes. AIChE J., 39 471–492.
  • Mazzotti, M., Storti, G., and Morbidelli, M. (1997) Optimal operation of simulated moving bed units for nonlinear chromatographic separations. Journal of Chromatography A, 769: 3–24.
  • Kaspereit, M., Seidel-Morgenstem, A., and Kienle, A. (2007) Design of simulated moving bed processes under reduced purity requirements. Journal of Chromatography A, 1162: 2–13.
  • Migliorini, C., Gentilini, A., Mazzotti, M., and Morbidelli, M. (1999) Design of simulated moving bed units under nonideal conditions. Industrial Engineering Chemical Research, 38: 2400–2410.
  • Migliorini, C., Mazzotti, M., and Morbidelli, M. (1999) Simulated moving-bed units with extra-column dead volume. AIChE Journal, 45: 1411–1421.
  • Mazzotti, M. (2006) Equilibrium theory based design of simulated moving bed processes for a generalized Langmuir isotherm. Journal of Chromatography A, 1126: 311–322.
  • Abel, S., Mazzotti, M., and Morbidelli, M. (2002) Solvent gradient operation of simulated moving beds I. Linear isotherms. Journal of Chromatography A, 944: 23–39.
  • Ma, Z. and Wang, N.H.L. (1997) Standing wave analysis of SMB chromatography: Linear systems. AIChE Journal, 43: 2488–2508.
  • Mallmann, T., Burris, B.D., Ma, Z., and Wang, N.H.L. (1998) Standing wave design of nonlinear SMB systems for fructose purification. AIChE Journal, 44: 2628–2646.
  • Xie, Y., Wu, D.J., Ma, Z.D., and Wang, N.H.L. (2000) Extended standing wave design method for simulated moving bed chromatography: Linear systems. Industrial & Engineering Chemistry Research, 39: 1993–2005.
  • Hritzko, B.J., Xie, Y., Wooley, R.J., and Wang, N.H.L. (2002) Standing-wave design of tandem SMB for linear multicomponent systems. AIChE Journal, 48: 2769–2787.
  • Xie, Y., Farrenburg, C.A., Chin, C.Y., Mun, S., and Wang, N.H.L. (2003) Design of SMB for a nonlinear amino acid system with mass-transfer effects. AIChE Journal, 49: 2850–2863.
  • Xie, Y., Hritzko, B., Chin, C.Y., and Wang, N.H.L. (2003) Separation of FTC-ester enantiomers using a simulated moving bed. Industrial & Engineering Chemistry Research, 42: 4055–4067.
  • Lee, H.J., Xie, Y., Koo, Y.M., and Wang, N.H.L. (2004) Separation of lactic acid from acetic acid using a four-zone SMB. Biotechnology Program, 20: 179–192.
  • Dunnebier, G., Weirich, I., and Klatt, K.U. (1998) Computationally efficient dynamic modelling and simulation of simulated moving bed chromatographic processes with linear isotherms. Chemical Engineering Science, 53: 2537–2546.
  • Sudiro, M., Pellizzaro, M., Bezzo, F., and Bertucco, A. (2010) Simulated moving bed technology applied to coal gasification. Chemical and Engineering Research and Design, 88 465–475.
  • Minceva, M. and Rodrigues, A.E. (2005) Two-level optimization of an existing SMB for p-xylene separation. Computer Chemical Engineering, 29: 2215–2228.
  • Mota, J.P.B. and Araujo, J.M.M. (2005) Single-column simulated-moving-bed process with recycle lag. AIChE Journal, 51: 1641–1653.
  • Zabka, M., Minceva, M., Gornes, P.S., and Rodrigues, A.E. (2008) Chiral separation of R,S-alpha-tetralol by simulated moving bed. Separation Science and Technology, 43: 727–765.
  • Gomes, P.S., Zabkova, M., Zabka, M., Minceva, M., and Rodrigues, A.E. (2010) Separation of chiral mixtures in real SMB units: The FlexSMB-LSRE. AIChE Journal, 56: 125–142.
  • Wu, J.L., Peng, Q.J., Arlt, W., and Minceva, M. (2009) Model-based design of a pilot-scale simulated moving bed for purification of citric acid from fermentation broth. Journal of Chromatography A, 1216: 8793–8805.
  • Hur, J.S., Wankat, P.C., Kim, J.I., Kim, J.K., and Koo, Y.M. (2007) Purification of L-phenylalanine from a ternary amino acid mixture using a two-zone SMB/chromatography hybrid system. Separation Science Technology, 42: 911–930.
  • Long, N.V.D., Le, T.H., Kim, J.L., Lee, J.W., and Koo, Y.M. (2009) Separation of D-psicose and D-fructose using simulated moving bed chromatography. Journal of Separation Science, 32: 1987–1995.
  • Lee, J.W. and Wankat, P.C. (2010) Design of pseudo-simulated moving bed process with multi-objective optimization for the separation of a ternary mixture: Linear isotherms. Journal of Chromatography A, 1217: 3418–3426.
  • Mun, S. (2012) Development of a non-triangular separation region for improving the performance of a three-zone simulated moving bed chromatography for binary separation with linear isotherms. Journal of Chromatography A, 1256: 46–57.
  • Choi, Y.J., Han, S.K., Chung, S.T., and Row, K.H. (2007) Separation of racemic bupivacaine using simulated moving bed with mathematical model. Biotechnology and Bioprocessing Engineering, 12: 625–633.
  • Adam, P., Nicoud, R.N., Bailly, M., and Ludemann-Hombourger, O. (2000) Process and device for separation with variable-length. (US6136198).
  • Ludemann-Hombourger, O., Nicoud, R.M., and Bailly, M. (2000) The “VARICOL” process: A new multicolumn continuous chromatographic process. Separation Science and Technology, 35: 1829–1862.
  • Rodrigues, R.C.R., Araujo, J.M.M., Eusebio, M.F.J., and Mota, J.P.B. (2007) Experimental assessment of simulated moving bed and varicol processes using a single-column setup. Journal of Chromatography A, 1142: 69–80.
  • Toumi, A., Engell, S., Ludemann-Hombourger, O., Nicoud, R.M., and Bailly, M. (2003) Optimization of simulated moving bed and Varicol processes. Journal of Chromatography A, 1006: 15–31.
  • Zhang, Z.Y., Hidajat, K., Ray, A.K., and Morbidelli, M. (2002) Multiobjective optimization of SMB and Varicol process for chiral separation. AIChE Journal, 48: 2800–2816.
  • Zhang, Z., Mazzotti, M., and Morbidelli, M. (2003) Multiobjective optimization of simulated moving bed and Varicol processes using a genetic algorithm. Journal of Chromatography A, 989: 95–108.
  • Subramani, H.J., Hidajat, K., and Ray, A.K. (2003) Optimization of simulated moving bed and Varicol processes for glucose-fructose separation. Chemical Engineering Research and Development, 81 549–567.
  • Yu, W.F., Hidajat, K., and Ray, A.K. (2005) Optimization of reactive simulated moving bed and Varicol systems for hydrolysis of methyl acetate. Chemical Engineering Journal, 112: 57–72.
  • Zhang, Y., Hidajat, K., and Ray, A.K. (2009) Multi-objective optimization of simulated moving bed and Varicol processes for enantio-separation of racemic pindolol. Separation and Purification Technology, 65: 311–321.
  • da Silva, A.C., Salles, A.G., Perna, R.F., Correia, C.R.D., and Santana, C.C. (2012) Chromatographic separation and purification of mitotane racemate in a varicol multicolumn continuous process. Chemical Engineering Technology, 35: 83–90.
  • Kearney, M.M. and Hieb, K.L. (1992) Time variable simulated moving bed process. (US5102553).
  • Zhang, Z.Y., Mazzotti, M., and Morbidelli, M. (2003).PowerFeed operation of simulated moving bed units: changing flow-rates during the switching interval. Journal of Chromatography A, 1006: 87–99.
  • Zhang, Z.Y., Morbidelli, M., and Mazzotti, M. (2004) Experimental assessment of PowerFeed chromatography. AIChE Journal, 50: 625–632.
  • Kloppenburg, E. and Gilles, E.D. (1999) A new concept for operating simulated moving-bed processes. Chemical Engineering Technology, 22: 813–817.
  • Kawajiri, Y. and Biegler, L.T. (2006) Optimization strategies for simulated moving bed and PowerFeed processes. AIChE Journal, 52: 1343–1350.
  • Kawajiri, Y. and Biegler, L.T. (2006) Nonlinear programming superstructure for optimal dynamic operations of simulated moving bed processes. Industrial & Engineering Chemistry Research, 45: 8503–8513.
  • Schramm, H., Kaspereit, M., Kienle, A., and Seidel-Morgenstern, A. (2003) Simulated moving bed process with cyclic modulation of the feed concentration. Journal of Chromatography A, 1006: 77–86.
  • Schramm, H., Kaspereit, M., Kienle, A., and Seidel-Morgenstern, A. (2002) Improving simulated moving bed processes by cyclic modulation of the feed concentration. Chemical Engineering Technology, 25: 1151–1155.
  • Araujo, J.M.M., Rodrigues, R.C.R., and Mota, J.P.B. (2006) Optimal design and operation of a certain class of asynchronous simulated moving bed processes. Journal of Chromatography A, 1132: 76–89.
  • Zhang, Z.Y., Mazzotti, M., and Morbidelli, M. (2004) Continuous chromatographic processes with a small number of columns: Comparison of simulated moving bed with varicol, PowerFeed, and ModiCon. Korean Journal of Chemical Engineering, 21: 454–464.
  • Yoritomi, K., Kezuda, T., and Moriya, M. (1981) Method for the chromatographic separation of soluble components in feed solution. (US4267054).
  • Tanimura, M., Tamura, M., and Teshima, T. (1991) Method of chromatographic separation. (US5064539).
  • Katsuo, S. and Mazzotti, M. (2010) Intermittent simulated moving bed chromatography: 1. Design criteria and cyclic steady-state. Journal of Chromatography A, 1217: 1354–1361.
  • Katsuo, S. and Mazzotti, M. (2010) Intermittent simulated moving bed chromatography: 2. Separation of Troger’s base enantiomers. Journal of Chromatography A, 1217: 3067–3075.
  • Katsuo, S., Langel, C., Sandre, A.L., and Mazzotti, M. (2011) Intermittent simulated moving bed chromatography: 3. Separation of Troger’s base enantiomers under nonlinear conditions. Journal of Chromatography A, 1218: 9345–9352.
  • Acetti, D., Langel, C., Brenna, E., Fuganti, C., and Mazzotti, M. (2010) Intermittent simulated moving bed chromatographic separation of (RS,RS)-2-(2,4-difluorophenyl)butane-1,2,3-triol. Journal of Chromatography A, 1217: 2840–2846.
  • Jermann, S., Katsuo, S., and Mazzotti, M. (2012) Intermittent simulated moving bed processes for chromatographic three-fraction separation. Organic Process Research Development, 16: 311–322.
  • Nicoud, R., Perrut, M., and Hotier, G. (1995) Method and apparatus for fractionation of a mixture on a simulated fluidized bed in the presence of a compressed gas, a supercritical fluid or a subcritical liquid. U.S. Patent 5422007, June 6, 1995.
  • Mazzotti, M., Storti, G., and Morbidelli, M. (1997) Supercritical fluid simulated moving bed chromatography. Journal of Chromatography A, 786: 309–320.
  • Denet, F., Hauck, W., Nicoud, R.M., Di Giovanni, O., Mazzotti, M., Jaubert, J.N., and Morbidelli, M. (2001) Enantioseparation through supercritical fluid simulated moving bed (SF-SMB) chromatography. Industrial & Engineering Chemistry Research, 40: 4603–4609.
  • Peper, S., Johannsen, M., and Brunner, G. (2007) Preparative chromatography with supercritical. fluids Comparison of simulated moving bed and batch processes. Journal of Chromatography A, 1176: 246–253.
  • Rajendran, A., Peper, S., Johannsen, M., Mazzotti, M., Morbidelli, M., and Brunner, G. (2005) Enantioseparation of 1-phenyl-1-propanol by supercritical fluid-simulated moving bed chromatography. Journal of Chromatography A, 1092: 55–64.
  • Johannsen, M., Peper, S., and Depta, A. (2002) Simulated moving bed chromatography with supercritical fluids for the resolution of bi-naphthol enantiomers and phytol isomers. Journal of Biochemical and Biophysical Methods, 54: 85–102.
  • Cristancho, C.A.M., Peper, S., and Johannsen, M. (2012) Supercritical fluid simulated moving bed chromatography for the separation of ethyl linoleate and ethyl oleate. Journal of Supercritical Fluids, 66: 129–136.
  • Jensen, T.B., Reijns, T.G.P., Billiet, H.A.H., and van der Wielen, L.A.M. (2000) Novel simulated moving-bed method for reduced solvent consumption. Journal of Chromatography A, 873: 149–162.
  • Strohlein, G., Aumann, L., Mazzotti, M., and Morbidelli, M. (2006) A continuous, counter-current multi-column chromatographic process incorporating modifier gradients for ternary separations. Journal of Chromatography A, 1126: 338–346.
  • Wei, F., Li, M., Huang, F.M., Chen, M.J., Jiang, H.L., and Zhao, Y.X. (2011) A novel pseudo simulated moving bed with solvent gradient for ternary separations. Journal of Chromatography A, 1218: 2906–2911.
  • Wei, F., Shen, B., Chen, M.J., and Zhao, Y.X. (2012) Study on a pseudo-simulated moving bed with solvent gradient for ternary separations. Journal of Chromatography A, 1225: 99–106.
  • Gottschlich, N. and Kasche, V. (1997) Purification of monoclonal antibodies by simulated moving-bed chromatography. Journal of Chromatography A, 765: 201–206.
  • Mun, S. (2011) Optimal design of solvent gradient simulated moving bed chromatography for amino acid separation. Journal of Liquid Chromatography, 34: 1518–1535.
  • Nam, H.G., Jo, S.H., Park, C., and Mun, S. (2012) Experimental validation of the solvent-gradient simulated moving bed process for optimal separation of phenylalanine and tryptophan. Process Biochemistry, 47: 401–409.
  • Migliorini, C., Wendlinger, M., Mazzotti, M., and Morbidelli, M. (2001) Temperature gradient operation of a simulated moving bed unit. Industrial & Engineering Chemistry Research, 40: 2606–2617.
  • Jin, W.H. and Wankat, P.C. (2007) Thermal operation of four-zone simulated moving beds. Industrial & Engineering Chemistry Research, 46: 7208–7220.
  • Zang, Y.F. and Wankat, P.C. (2002) SMB operation strategy—Partial feed. Industrial & Engineering Chemistry Research, 41: 2504–2511.
  • Zang, Y.F. and Wankat, P.C. (2002) Three-zone simulated moving bed with partial feed and selective withdrawal. Industrial & Engineering Chemistry Research, 41: 5283–5289.
  • Bae, Y.S. and Lee, C.H. (2006) Partial-discard strategy for obtaining high purity products using simulated moving bed chromatography. Journal of Chromatography A, 1122: 161–173.
  • Kim, K.M., Lee, H.H., and Lee, C.H. (2012) Improved performance of a simulated moving bed process by a recycling method in the partial-discard strategy. Industrial & Engineering Chemistry Research, 51: 9835–9849.
  • Kessler, L.C. and Seidel-Morgenstern, A. (2008) Improving performance of simulated moving bed chromatography by fractionation and feed-back of outlet streams. Journal of Chromatography A, 1207: 55–71.
  • Li, S.Z., Kawajiri, Y., Raisch, J., and Seidel-Morgenstern, A. (2010) Optimization of simulated moving bed chromatography with fractionation and feedback: Part I. Fractionation of one outlet. Journal of Chromatography A, 1217: 5337–5348.
  • Li, S.Z., Kawajiri, Y., Raisch, J., and Seidel-Morgenstern, A. (2010) Optimization of simulated moving bed chromatography with fractionation and feedback: Part II. Fractionation of both outlets. Journal of Chromatography A, 1217: 5349–5357.
  • Mun, S. (2010) Partial port-closing strategy for obtaining high throughput or high purities in a four-zone simulated moving bed chromatography for binary separation. Journal of Chromatography A, 1217: 6522–6530.
  • Gomes, P.S. and Rodrigues, A.E. (2007) Outlet streams swing (OSS) and MultiFeed operation of simulated moving beds. Separation Science and Technology, 42: 223–252.
  • Gomes, P.S. and Rodrigues, A.E. (2010) Outlet Stream Swing Simulated Moving Bed: Separation and Regeneration Regions Analysis. Separation Science and Technology, 45: 2259–2272.
  • Abunasser, N., Wankat, P.C., Kim, Y.S., and Koo, Y.M. (2003) One-column chromatograph with recycle analogous to a four-zone simulated moving bed. Industrial & Engineering Chemistry Research, 42: 5268–5279.
  • Abunasser, N. and Wankat, P.C. (2004) One-column chromatograph with recycle analogous to simulated moving bed adsorbers: Analysis and applications. Industrial & Engineering Chemistry Research, 43: 5291–5299.
  • Hotier, G. (1996) Physically meaningful modeling of the 3-zone and 4-zone simulated moving bed processes. AIChE Journal, 42: 154–160.
  • Kessler, L.C., Gueorguieva, L., Rinas, U., and Seidel-Morgenstern, A. (2007) Step gradients in 3-zone simulated moving bed chromatography application to the purification of antibodies and bone morphogenetic protein-2. Journal of Chromatography A, 1176: 69–78.
  • Jeon, Y.J., Park, M.B., and Kim, I.H. (2010) l-Ribose from l-arabinose by epimerization and its purification by 3-zone simulated moving bed chromatography. Bioprocessing and Biosystems Engineering, 33: 87–95.
  • Song, S.M., Park, M.B., and Kim, I.H. (2012) Three-zone simulated moving-bed (SMB) for separation of cytosine and guanine. Korean Journal of Chemical Engineering, 29: 952–958.
  • Liang, M.T. and Liang, R.C. (2012) Fractionation of polyethylene glycol particles by simulated moving bed with size-exclusion chromatography. Journal of Chromatography A, 1229: 107–112.
  • Shen, B., Chen, M.J., Jiang, H.L., Zhao, Y.X., and Wei, F. (2011) Modeling study on a three-zone simulated moving bed without Zone I. Separation Science and Technology, 46: 695–701.
  • Hur, J.S. and Wankat, P.C. (2005) New design of simulated moving bed (SMB) for ternary separations. Industrial & Engineering Chemistry Research, 44: 1906–1913.
  • Hur, J.S. and Wankat, P.C. (2006) Two-zone SMB/chromatography for center-cut separation from ternary mixtures: Linear isotherm systems. Industrial & Engineering Chemistry Research, 45: 1426–1433.
  • Hur, J.S. and Wankat, P.C. (2006) Hybrid simulated moving bed and chromatography systems for center-cut separation from quaternary mixtures: Linear isotherm systems. Industrial & Engineering Chemistry Research, 45 8713–8722.
  • Mata, V.G. and Rodrigues, A.E. (2001) Separation of ternary mixtures by pseudo-simulated moving bed chromatography. Journal of Chromatography A, 939: 23–40.
  • Kurup, A.S., Hidajat, K., and Ray, A.K. (2006) Optimal operation of a pseudo-SMB process for ternary separation under non-ideal conditions. Separation and Purification Technology, 51: 387–403.
  • da Silva, E.A.B. and Rodrigues, A.E. (2006) Design of chromatographic multicomponent separation by a pseudo-simulated moving bed. AIChE Journal, 52: 3794–3812.
  • da Silva, E.A.B. and Rodrigues, A.E. (2008) Design methodology and performance analysis of a pseudo-simulated moving bed for ternary separation. Separ Sci Technol, 43: 533–566.
  • Wankat, P.C. (2001) Simulated moving bed cascades for ternary separations. Industrial & Engineering Chemistry Research, 40: 6185–6193.
  • Kim, J.K., Zang, Y.F., and Wankat, P.C. (2003) Single-cascade simulated moving bed systems for the separation of ternary mixtures. Industrial & Engineering Chemistry Research, 42: 4849–4860.
  • Kessler, L.C. and Seidel-Morgenstern, A. (2006) Theoretical study of multicomponent continuous countercurrent chromatography based on connected 4-zone units. Journal of Chromatography A, 1126: 323–337.
  • Kim, J.K. and Wankat, P.C. (2004) Designs of simulated-moving-bed cascades for quaternary separations. Industrial & Engineering Chemistry Research, 43: 1071–1080.
  • Wooley, R., Ma, Z., and Wang, N.H.L. (1998) A nine-zone simulating moving bed for the recovery of glucose and xylose from biomass hydrolyzate. Industrial & Engineering Chemistry Research, 37: 3699–3709.
  • Wang, X. and Ching, C.B. (2005) Chiral separation of beta-blocker drug (nadolol) by five-zone simulated moving bed chromatography. Chemical Engineering Science, 60: 1337–1347.
  • Xie, Y., Chin, C.Y., Phelps, D.S.C., Lee, C.H., Lee, K.B., Mun, S., and Wang, N.H.L. (2005) A five-zone simulated moving bed for the isolation of six sugars from biomass hydrolyzate. Industrial & Engineering Chemistry Research, 44: 9904–9920.
  • Wei, F., Shen, B., Chen, M.J., and Zhao, Y.X. (2012) Novel simulated moving-bed cascades with a total of five zones for ternary separations. Industrial & Engineering Chemistry Research, 51: 5805–5812.
  • Hashimoto, K., Shirai, Y., and Adachi, S. (1993) A simulated moving-bed adsorber for the separation of tricomponents. Journal of Chemical Engineering of Japan, 26: 52–56.
  • Nowak, J., Antos, D., and Seidel-Morgenstern, A. (2012) Theoretical study of using simulated moving bed chromatography to separate intermediately eluting target compounds. Journal of Chromatography A, 1253: 58–70.
  • Agrawal, G. and Kawajiri, Y. (2012) Comparison of various ternary simulated moving bed separation schemes by multi-objective optimization. Journal of Chromatography A, 1238: 105–113.
  • Hashimoto, K., Adachi, S., Noujima, H., and Ueda, Y. (1983) A new process combining adsorption and enzyme reaction for producing higher-fructose syrup. Biotechnology and Bioengineering, 25 2371–2393.
  • Kawase, M., Suzuki, T.B., Inoue, K., Yoshimoto, K., and Hashimoto, K. (1996) Increased esterification conversion by application of the simulated moving-bed reactor. Chemical Engineering Science, 51: 2971–2976.
  • Lode, F., Houmard, M., Migliorini, C., Mazzotti, M., and Morbidelli, M. (2001) Continuous reactive chromatography. Chemical Engineering Science, 56: 269–291.
  • Yu, W.F., Hidajat, K., and Ray, A.K. (2003) Modeling, simulation, and experimental study of a simulated moving bed reactor for the synthesis of methyl acetate ester. Industrial & Engineering Chemistry Research, 42: 6743–6754.
  • Mazzotti, M., Kruglov, A., Neri, B., Gelosa, D., and Morbidelli, M. (1996) A continuous chromatographic reactor: SMBR. Chemical Engineering Science, 51: 1827–1836.
  • Pereira, C.S.M., Zabka, M., Silva, V.M.T.M., and Rodrigues, A.E. (2009) A novel process for the ethyl lactate synthesis in a simulated moving bed reactor (SMBR). Chemical Engineering Science, 64: 3301–3310.
  • Minceva, M., Gomes, P.S., Meshko, V., and Rodrigues, A.E. (2008) Simulated moving bed reactor for isomerization and separation of p-xylene. Chemical Engineering Journal, 140: 305–323.
  • Bergeot, G., Leinekugel-Le-Cocq, D., Wolff, L., Muhr, L., and Bailly, M. (2010) Intensification of Paraxylene Production using a Simulated Moving Bed Reactor. Oil, Gas and Science Technology, 65: 721–733.
  • Baur, R., Krishna, R. (2005) A moving bed reactor concept for alkane isomerization. Chemical Engineering Journal, 109: 107–113.
  • Zhang, Z.Y., Hidajat, K., and Ray, A.K. (2001) Application of simulated countercurrent moving-bed chromatographic reactor for MTBE synthesis. Industrial & Engineering Chemistry Research, 40: 5305–5316.
  • Kruglov, A.V. (1994) Methanol synthesis in a simulated countercurrent moving-bed adsorptive catalytic reactor. Chemical Engineering Science, 49: 4699–4716.
  • Azevedo, D.C.S. and Rodrigues, A.E. (2001) Design methodology and operation of a simulated moving bed reactor for the inversion of sucrose and glucose-fructose separation. Chemical Engineering Journal, 82: 95–107.
  • Ching, C.B. and Lu, Z.P. (1997) Simulated moving-bed reactor: Application in bioreaction and separation. Industrial & Engineering Chemistry Research, 36: 152–159.
  • Meurer, M., Altenhoner, U., Strube, J., Untiedt, A., and SchmidtTraub, H. (1996) Dynamic simulation of a simulated-moving-bed chromatographic reactor for the inversion of sucrose. Starch-Starke, 48: 452–457.
  • Shieh, M.T. and Barker, P.E. (1996) Combined bioreaction and separation in a simulated counter-current chromatographic bioreactor–separator for the hydrolysis of lactose. Journal of Chemical Technology & Biotechnology, 66: 265–278.
  • Kawase, M., Pilgrim, A., Araki, T., and Hashimoto, K. (2001) Lactosucrose production using a simulated moving bed reactor. Chemical Engineering Science, 56: 453–458.
  • Palacios, J.G., Kramer, B., Kienle, A., and Kaspereit, M. (2011) Experimental validation of a new integrated simulated moving bed process for the production of single enantiomers. Journal of Chromatography A, 1218: 2232–2239.
  • Palacios, J.G., Kaspereit, M., and Kienle, A. (2009) Conceptual design of integrated chromatographic processes for the production of single (stereo-)isomers. Chemical Engineering Technology, 32: 1392–1402.
  • Palacios, J.G., Kaspereit, M., and Kienle, A. (2011) Integrated simulated moving bed processes for production of single enantiomers. Chemical Engineering Technology, 34: 688–698.
  • Wang, S.Y., Liang, Y., and Zheng, S.W. (2012) Separation of epigallocatechin gallate from tea polyphenol by simulated moving bed chromatography. Journal of Chromatography A, 1265: 46–51.
  • Wei, F., Shen, B., Chen, M.J., Zhou, X.B., and Zhao, Y.X. (2012) Separation of alpha-Tocopherol with a Two-Feed Simulated Moving Bed. Chinese Journal of Chemical Engineering, 20: 673–678.
  • Lee, H.H., Kim, K.M., and Lee, C.H. (2011) Improved performance of simulated moving bed process using column-modified feed. AIChE Journal, 57: 2036–2053.
  • Nam, H.G., Han, M.G., Yi, S.C., Chang, Y.K., Mun, S., and Kim, J.H. (2011) Optimization of productivity in a four-zone simulated moving bed process for separation of succinic acid and lactic acid. Chemical Engineering Journal, 171: 92–103.
  • Granato, M.A., Vlugt, T.J.H., and Rodrigues, A.E. (2010) Potential Desorbents for Propane/Propylene Separation by Gas Phase Simulated Moving Bed: A Molecular Simulation Study. Industrial & Engineering Chemistry Research, 49: 5826–5833.
  • Nguyen, V.D.L., Lee, J.W., Le, T.H., Kim, J.I., and Koo, Y.M. (2011) Solvent-gradient SMB to separate o-xylene and p-xylene. Korean Journal of Chemical Engineering, 28: 1110–1119.
  • Stewart, D.G., Chao, G., Smith, B.E., Sohn, S.W., and Noe, R.J.L. (2012) Method for minimizing cross-contamination of e.g. fluids in simulated moving bed, involves filling replacement volume on one side of valve corresponding to volume in line on another side of valve to receive remnant in line. U.S. Patent 8211312, July 3, 2012.
  • Wei, F. (2012) Method for separating a mixture comprising three components by simulated moving bed chromatography. U.S. Patent 2012071691, March 22, 2012.
  • Su, L.I., Mo, G.Y., Il, K.J., Sun, I.J., Il, J.W., and Jae, L.I. (2014) Control valve for a compressor. Chinese Patent CN201280051778, June 25, 2014.
  • Su, L.I., Sun, I.J., Il, J.W., Jae, L.I., and Yeol, R.J. (2012) Successive feedback flow controlling apparatus for processing simulated moving bed, is equipped with several components for measuring temperature, flow rate, and pressure around continuous simulated moving bed. Korean Patent KR2012008594, February 1, 2012.
  • Koo, Y.M., Kim, J.I., Park, H.M., Mo, G.Y., Il, K.J., and Min, P.H. (2012) Simulated moving bed processing method, involves producing switching time by area pump that is connected to extract outlet port line, and connecting raw material pump to supplying material inlet port line. Korean Patent KR2012011603, February 8, 2012.
  • Li, Q., Cong, J., Zhang, W., Wang, S., Lin, B., and Tang, X. (2010) Simulated moving bed chromatography separation method for preparing ginsenoside Rb1. Chinese Patent CN102336799, July 22, 2010.
  • Chen, S., Huang, J., Huang, K., Liao, F., Qin, J., Wei, X., and Xu, Y. (2011) Special molecular sieve for separating L-lactic acid and D-lactic acid with simulated moving bed and preparation method thereof. Chinese Patent CN102285664, May 27, 2011.
  • Liang, M. and Hong, Z. (2012) Method simulating moving bed to separate three-component compound. Chinese Patent CN102527086, July 4, 2012.
  • Hotier, G., Leinekugel, L.C.D., and Le Cocq, D.L. (2011) Process and apparatus for simulated moving bed separation comprising bypass lines in every other bed and with controlled flushing flow rates during injections and withdrawals. U.S. Patent 2011315634, December 29, 2011.
  • Bisschops, M.A.T. and Londo, T.R. (2011) Conversion of fixed-bed liquid chromatography processes to simulated moving bed processes. U.S. Patent WO2011046936, April, 21, 2011.
  • Lehoucq, S., Ludemann-Hombourger, O., Nicoud, R., Hamende, M., and Cavoy, E. (2011) Process and device for separating at least one component with a simulated moving bed in columns having an appropriate ratio of length to diameter. European Patent EP2301644, March 30, 2011.
  • Delaney, E. and Oroskar, A. (2011) Methods for purifying monosaccharide mixtures containing ionic impurities. U.S. Patent WO2011071890, June 16, 2011.
  • Tietz, W. and Schulze, J. (2011) Process for removing, isolating and purifying dicarboxylic acids. U.S. Patent WO2011160760, December 29, 2011.
  • Augier, F., Darmancier, D., and Hotier, G. (2013) System for stiffening the plates of a large-diameter multi-stage column. U.S. Patent 8388840, March 5, 2013.
  • Augier, F., Hotier, G., and Odier, G. (2011) Device for distributing fluids in a simulated moving bed column with a limited degree of immersion within the granular bed. U.S. Patent 20110303602, December 15, 2011.
  • Sohn, S.W., Rice, L.H., and Kulprathipanja, S. (2012) Ethylene production by steam cracking of normal paraffins. U.S. Patent 8283511, October 9, 2012.
  • Ichi, T. and Shimizu, R. (2011) Purifying rebaudioside A used as sweetener, involves separating rebaudioside A and stevioside in test sample using simulated moving bed chromatography and collecting simulation moving bed eluting solvents. Japanese Patent 2011051909, March 17, 2011.
  • Chen, M. and Wei, F. (2012) Five-zone simulated movable bed chromatographic separation system. Chinese Patent CN101961564, July 4, 2012.
  • Lu, F., Wang, C., Li, Y., and Meng, N. (2012) Method for separating and purifying oligo-xylose by using simulated moving bed. Chinese Patent CN101899486, October 3, 2012.
  • Zhang, L., Wang, L., Wang, X., Feng, X., and Jia, P. (2010) Method for purifying xylo-oligosaccharide by adsorption and separation by simulated moving bed. Chinese Patent CN101928305, December 29, 2010.
  • Yang, P., Li, X., Hu, J., Liang, K., Zhao, S., Cheng, D., Shang, L. (2012) Sequential simulated moving bed. Chinese Patent CN101940850, August 29, 2012.
  • Xu, P., Wang, Y., and Dong, D. (2011) Method for producing high-purity poly-glucose through simulated moving bed chromatography. Chinese Patent CN102199227, September 28, 2011.
  • Go, A., Pilliod, D.L., and Porter, J.R. (2011) Parex unit feed. U.S. Patent WO2010138284, February 24, 2011.
  • Augier, F., and Darmancier, D. (2009) Novel fluid distribution and collection system in a multistage column comprising a jet breaker. U.S. Patent 2009321359, December 31, 2009.
  • Decoodt, X., Hotier, G., Leflaive, P., and Le Cocq, D.L. (2011) Process and device for simulated moving bed separation with a modulated by-pass fluid flow. U.S. Patent 20110201865, August 18, 2011.
  • Lu, J. and Guo, X. (2012) Method for optimizing chromatograph operating parameters of simulated mobile bed. Chinese Patent CN101829438, May 30, 2012.
  • Gao, J., Zhang, C., Wei, Y., Gong, F., and Wang, Q. (2010) Rubbish leachate integrated treatment device. Chinese Patent CN201530771, July 21, 2010.
  • Cao, L. and Diao, J. (2010) Method for separating and purifying corn antioxidant peptide. Chinese Patent CN101781671, July 21, 2010.
  • Zhu, Q., Zhou, H., Cai, H., Wan, H., and Yuan, J. (2013) Method for separating and purifying L-ornithine by using simulated moving bed. Chinese Patent CN101774935, May 29, 2013.
  • Zhang, L., Zhang, B., Tang, N., and Tang, L. (2010) Pollution-free production process for ethoxy quinoline by coupling reactor and simulation moving bed. Chinese Patent CN101823998, September 8, 2010.
  • Wang, X. and Wang, Y. Multi-functional simulated moving bed chromatography separating device, has communicating channel whose ports are connected with port pipelines ats of chromatographic column. CN201441839, April 28, 2010.
  • Liu, D., Liu, Y., Sun, H., and Yu, H. (2013) Method for extracting high-content lutein by utilizing molecular distillation technology and simulated moving bed technology. Chinese Patent CN101712643, March 30, 2013.
  • Lee, C., Lee, H., Kim, G., Lee, C.H., Lee, H.H., and Kim, K.M. (2010) Sedimentation layer adsorbing apparatus, has preprocessing unit provided with simulated moving bed valve that controls movement of fluid inflow port, raffinate exhaust port, release agent inflow port, extract exhaust port and adjacent ports. Korean Patent KR2010098891, September 10, 2010.
  • Il Im, Y. (2010) Dead volumes simulation method for simulated moving bed chromatographic process, involves simulating fluid concentration change corresponding to time at dead volume. Korean Patent KR2010128970, December 8, 2010.
  • Gong, F., Wang, Q., and Wei, Y. (2011) Device and method for integrally processing garbage percolate. Chinese Patent CN101708917, November 23, 2011.
  • Cong, J., Lan, S., Lin, B., Tang, X., Wang, S., and Zhang, W. (2012) Three-section simulated moving bed chromatography device. Chinese Patent CN101732890, January 18, 2012.
  • Cao, L., Feng, X., Li, H., Wang, X., Zhang, G., and Zhang, L. (2011) Technology for separating stevioside in one step with simulated moving bed. Chinese Patent CN101717418, August 17, 2011.
  • Dai, D., Shao, M., Sun, Z., and Zhuang, P. (2011) Method for separating and preparing peony lactone glucoside by simulation moving bed chromatography method. Chinese Patent CN101607975, July 20, 2011.
  • Nagamatsu, S., Murazumi, K., and Makino, S. (1999) Chiral separation of a pharmaceutical intermediate by a simulated moving bed process. Journal of Chromatography A, 832 55–65.
  • Rosset, A.J. and Neuzil, R.W. (1972) Fluid-solid containing apparatus. U.S. Patent 3706812, December 19, 1972.
  • Rossiter, G.J. and Riley, R.J. (1997) Fluid-solid contacting apparatus. U.S. Patent 4676826, October 14, 1997.
  • Priegnitz, J.W. (1995) Small scale simulated moving bed separation process and apparatus. U.S. Patent 5470464, November 28, 1995.
  • Ruthven, D.M. and Ching, C.B. (1993) Preparative and Production Scale Chromatography; Marcel Dekker: New York.
  • Laroche, C., Leinekugel-le-Cocq, D., and Leflaive, P. (2011) Variable desorbent strength: influence on SMB operating conditions and performance. Adsorption-Journal of the International Adsorption Society, 17: 39–48.
  • Francotte, E.R. (2001) Enantioselective chromatography as a powerful alternative for the preparation of drug enantiomers. Journal of Chromatography A, 906: 379–397.
  • Natarajan, S. and Lee, J.H. (2000) Repetitive model predictive control applied to a simulated moving bed chromatography system. Computational Chemical Engineering, 24: 1127–1133.
  • Futterer, M. (2008) An adaptive control concept for simulated moving bed plants in case of complete separation. Chemical Engineering Technology, 31: 1438–1444.
  • Futterer, M. (2008) An Adaptive Control Concept for Simulated Moving Bed Plants under Reduced Purity Requirements. Chemical Engineering Technology, 31: 1816–1823.
  • Grossmann, C., Langel, C., Mazzotti, M., Morari, M., and Morbidelli, M. (2010) Experimental implementation of automatic ‘cycle to cycle’ control to a nonlinear chiral simulated moving bed separation. Journal of Chromatography A, 1217: 2013–2021.
  • Langel, C., Grossmann, C., Jermann, S., Mazzotti, M., Morari, M., and Morbidelli, M. (2010) Experimental optimizing control of the simulated moving bed separation of troger’s base enantiomers. Industrial & Engineering Chemistry Research, 49: 11996–12003.
  • Vilas, C. and Wouwer, A.V. (2011) Combination of multi-model predictive control and the wave theory for the control of simulated moving bed plants. Chemical Engineering Science, 66: 632–641.
  • Erdem, G., Abel, S., Morari, M., Mazzotti, M., Morbidelli, M., and Lee, J.H. (2004) Automatic control of simulated moving beds. Industrial & Engineering Chemistry Research, 43 405–421.

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