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American Industrial Hygiene Association Journal Volume 57, 1996 - Issue 1
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Original Articles

Variability in Biological Exposure Indices Using Physiologically Based Pharmacokinetic Modeling and Monte Carlo Simulation

Russell S. Thomas Center for Environmental Toxicology & Technology, Department of Environmental Health, Colorado State University, Fort Collins, CO 80523
,
Phillip L. Bigelow Center for Environmental Toxicology & Technology, Department of Environmental Health, Colorado State University, Fort Collins, CO 80523
,
Thomas J. Keefe Center for Environmental Toxicology & Technology, Department of Environmental Health, Colorado State University, Fort Collins, CO 80523
&
Raymond S.H. Yang Center for Environmental Toxicology & Technology, Department of Environmental Health, Colorado State University, Fort Collins, CO 80523
Pages 23-32 | Published online: 04 Jun 2010

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Miyuki Breen, Caroline L Ring, Anna Kreutz, Michael-Rock Goldsmith & John F Wambaugh. (2021) High-throughput PBTK models for in vitro to in vivo extrapolation. Expert Opinion on Drug Metabolism & Toxicology 17:8, pages 903-921.
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Honesty Tohon, Andy Nong, Marjory Moreau, Mathieu Valcke & Sami Haddad. (2018) Reverse dosimetry modeling of toluene exposure concentrations based on biomonitoring levels from the Canadian health measures survey. Journal of Toxicology and Environmental Health, Part A 81:20, pages 1066-1082.
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Catherine Tomicic & David Vernez. (2014) Sex Differences in Urinary Levels of Several Biological Indicators of Exposure: A Simulation Study Using a Compartmental-Based Toxicokinetic Model. Journal of Occupational and Environmental Hygiene 11:6, pages 377-387.
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Sieto Bosgra, Jan van Eijkeren, Peter Bos, Marco Zeilmaker & Wout Slob. (2012) An improved model to predict physiologically based model parameters and their inter-individual variability from anthropometry. Critical Reviews in Toxicology 42:9, pages 751-767.
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David W. Pyatt, Sean M. Hays, Christine English & Colleen A. Cushing. (2012) United States voluntary children’s chemical evaluation program (VCCEP) risk assessment for children exposed to benzene. Toxicology Mechanisms and Methods 22:2, pages 81-104.
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M. Moiz Mumtaz, Meredith Ray, Susan R. Crowell, Deborah Keys, Jeffrey Fisher & Patricia Ruiz. (2012) Translational Research to Develop a Human PBPK Models Tool Kit—Volatile Organic Compounds (VOCs). Journal of Toxicology and Environmental Health, Part A 75:1, pages 6-24.
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Mathieu Valcke & Kannan Krishnan. (2011) Assessing the impact of the duration and intensity of inhalation exposure on the magnitude of the variability of internal dose metrics in children and adults. Inhalation Toxicology 23:14, pages 863-877.
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A. Berthet, A. de Batz, R. Tardif, G. Charest-Tardif, G. Truchon, D. Vernez & P.O. Droz. (2010) Impact of Biological and Environmental Variabilities on Biological Monitoring—An Approach Using Toxicokinetic Models. Journal of Occupational and Environmental Hygiene 7:3, pages 177-184.
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Sami Haddad, Ginette-Charest Tardif & Robert Tardif. (2006) Development of Physiologically Based Toxicokinetic Models for Improving the Human Indoor Exposure Assessment to Water Contaminants: Trichloroethylene and Trihalomethanes. Journal of Toxicology and Environmental Health, Part A 69:23, pages 2095-2136.
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Ginette Truchon, Robert Tardif, Pierre-Olivier Droz, Ginette Charest-Tardif & Guillaume Pierrehumbert. (2006) Biological Exposure Indicators: Quantification of Biological Variability Using Toxicokinetic Modeling. Journal of Occupational and Environmental Hygiene 3:3, pages 137-143.
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G. Hamelin, G. Charest-Tardif, G. Truchon & R. Tardif. (2005) Physiologically Based Modeling of n-Hexane Kinetics in Humans Following Inhalation Exposure at Rest and Under Physical Exertion: Impact on Free 2,5-Hexanedione in Urine and on n-Hexane in Alveolar Air. Journal of Occupational and Environmental Hygiene 2:2, pages 86-97.
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Allen Vinegar, Gary W. Jepson, Mark Cisneros, Reva Rubenstein, William J. Brock. (2000) SETTING SAFE ACUTE EXPOSURE LIMITS FOR HALON REPLACEMENT CHEMICALS USING PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING. Inhalation Toxicology 12:8, pages 751-763.
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