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RNA Biology Volume 12, 2015 - Issue 3
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Research Papers

Two related trypanosomatid eIF4G homologues have functional differences compatible with distinct roles during translation initiation

Danielle MN MouraCentro de Pesquisas Aggeu Magalhães; Fundação Oswaldo Cruz; Campus UFPE; Recife, PE, Brazil;Departamento de Genética; Universidade Federal de Pernambuco; Cidade Universitária; Recife, PE, Brazil
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Christian RS ReisCentro de Pesquisas Aggeu Magalhães; Fundação Oswaldo Cruz; Campus UFPE; Recife, PE, Brazil
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Camila C XavierCentro de Pesquisas Aggeu Magalhães; Fundação Oswaldo Cruz; Campus UFPE; Recife, PE, Brazil
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Tamara D da Costa LimaCentro de Pesquisas Aggeu Magalhães; Fundação Oswaldo Cruz; Campus UFPE; Recife, PE, Brazil
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Rodrigo P LimaCentro de Pesquisas Aggeu Magalhães; Fundação Oswaldo Cruz; Campus UFPE; Recife, PE, Brazil
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Mark CarringtonDepartment of Biochemistry; University of Cambridge; Cambridge, UK
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Osvaldo P de Melo NetoCentro de Pesquisas Aggeu Magalhães; Fundação Oswaldo Cruz; Campus UFPE; Recife, PE, BrazilCorrespondence[email protected]
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Pages 305-319 | Received 30 Oct 2014, Accepted 09 Jan 2015, Published online: 31 Mar 2015

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Osvaldo P. de Melo Neto, Tamara D. C. da Costa Lima, Kleison C. Merlo, Tatiany P. Romão, Pollyanna O. Rocha, Ludmila A. Assis, Larissa M. Nascimento, Camila C. Xavier, Antonio M. Rezende, Christian R. S. Reis & Barbara Papadopoulou. (2018) Phosphorylation and interactions associated with the control of the Leishmania Poly-A Binding Protein 1 (PABP1) function during translation initiation. RNA Biology 15:6, pages 739-755.
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Osvaldo P de Melo Neto, Tamara D C da Costa Lima, Camila C Xavier, Larissa M Nascimento, Tatiany P Romão, Ludmila A Assis, Mariana M C Pereira, Christian R S Reis & Barbara Papadopoulou. (2015) The unique Leishmania EIF4E4 N-terminus is a target for multiple phosphorylation events and participates in critical interactions required for translation initiation. RNA Biology 12:11, pages 1209-1221.
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Articles from other publishers (23)

Anica Dadwal & Supratik Das. (2023) Architecture, domain organization, and functional signatures of trypanosomatid keIF4A1s and Plasmodium peIF4A1s suggest conserved functions. Journal of Biosciences 48:4.
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Maria J. R. Bezerra, Danielle M. N. Moura, Eden R. Freire, Fabiola B. Holetz, Christian R. S. Reis, Tallyta T. S. Monteiro, Adriana R. S. Pinto, Ning Zhang, Antonio M. Rezende, Antonio Pereira-Neves, Regina C. B. Q. Figueiredo, Christine Clayton, Mark C. Field, Mark Carrington & Osvaldo P. de Melo Neto. (2022) Distinct mRNA and protein interactomes highlight functional differentiation of major eIF4F-like complexes from Trypanosoma brucei. Frontiers in Molecular Biosciences 9.
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Franziska Falk, Rafael Melo Palhares, Albina Waithaka & Christine Clayton. (2022) Roles and interactions of the specialized initiation factors EIF4E2 , EIF4E5, and EIF4E6 in Trypanosoma brucei : EIF4E2 maintains the abundances of S‐phase mRNAs . Molecular Microbiology 118:4, pages 457-476.
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Supratik Das. (2022) Analysis of domain organization and functional signatures of trypanosomatid keIF4Gs. Molecular and Cellular Biochemistry 477:10, pages 2415-2431.
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Daniel Friedrich, Assen Marintchev & Haribabu Arthanari. (2022) The metaphorical swiss army knife: The multitude and diverse roles of HEAT domains in eukaryotic translation initiation. Nucleic Acids Research 50:10, pages 5424-5442.
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Nitin Tupperwar, Rohit Shrivastava, Nofar Baron, Orli Korchev, Irit Dahan & Michal Shapira. (2021) Characterization of an Atypical eIF4E Ortholog in Leishmania, LeishIF4E-6. International Journal of Molecular Sciences 22:23, pages 12720.
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Daniela Ross-Kaschitza & Michael Altmann. (2020) eIF4E and Interactors from Unicellular Eukaryotes. International Journal of Molecular Sciences 21:6, pages 2170.
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Nitin Tupperwar, Rohit Shrivastava & Michal Shapira. (2019) LeishIF4E1 Deletion Affects the Promastigote Proteome, Morphology, and Infectivity. mSphere 4:6.
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Lucca Pietro Camillo dos Santos, Bruno Moisés de Matos, Brenda Cecilia de Maman Ribeiro, Nilson Ivo Tonin Zanchin & Beatriz Gomes Guimarães. (2019) Crystal structure of the MIF4G domain of the Trypanosoma cruzi translation initiation factor EIF4G5 . Acta Crystallographica Section F Structural Biology Communications 75:12, pages 738-743.
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Christine Clayton. (2019) Regulation of gene expression in trypanosomatids: living with polycistronic transcription. Open Biology 9:6.
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Fabio Henrique dos Santos Rodrigues, Helena Firczuk, Alexander L Breeze, Alexander D Cameron, Martin Walko, Andrew J Wilson, Nilson I T Zanchin & John E G McCarthy. (2019) The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs . Nucleic Acids Research 47:3, pages 1493-1504.
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Tai An, Yi Liu, Stéphane Gourguechon, Ching C. Wang & Ziyin Li. (2018) CDK Phosphorylation of Translation Initiation Factors Couples Protein Translation with Cell-Cycle Transition. Cell Reports 25:11, pages 3204-3214.e5.
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Monica Terrao, Kevin K Marucha, Elisha Mugo, Dorothea Droll, Igor Minia, Franziska Egler, Johanna Braun & Christine Clayton. (2018) The suppressive cap-binding complex factor 4EIP is required for normal differentiation. Nucleic Acids Research 46:17, pages 8993-9010.
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Eden R. Freire, Danielle M. N. Moura, Maria J. R. Bezerra, Camila C. Xavier, Mariana C. Morais-Sobral, Ajay A. Vashisht, Antonio M. Rezende, James A. Wohlschlegel, Nancy R. Sturm, Osvaldo P. de Melo Neto & David A. Campbell. (2017) Trypanosoma brucei EIF4E2 cap-binding protein binds a homolog of the histone-mRNA stem-loop-binding protein. Current Genetics 64:4, pages 821-839.
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Martin Zoltner, Nina Krienitz, Mark C. Field & Susanne Kramer. (2018) Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNA. PLOS Neglected Tropical Diseases 12:7, pages e0006679.
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Naomi R. Genuth & Maria Barna. (2018) Heterogeneity and specialized functions of translation machinery: from genes to organisms. Nature Reviews Genetics 19:7, pages 431-452.
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Eden Freire, Nancy Sturm, David Campbell & Osvaldo de Melo Neto. (2017) The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids. Pathogens 6:4, pages 55.
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Luis Miguel De Pablos, Steve Kelly, Janaina de Freitas Nascimento, Jack Sunter & Mark Carrington. (2017) Characterization of RBP9 and RBP10, two developmentally regulated RNA-binding proteins in Trypanosoma brucei . Open Biology 7:4, pages 160159.
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Kunrao Li, Shuru Zhou, Qixuan Guo, Xin Chen, De-hua Lai, Zhao-rong Lun & Xuemin Guo. (2017) The eIF3 complex of Trypanosoma brucei : composition conservation does not imply the conservation of structural assembly and subunits function . RNA 23:3, pages 333-345.
Crossref
CE Clayton. (2016) Gene expression in Kinetoplastids. Current Opinion in Microbiology 32, pages 46-51.
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Smiths Lueong, Clementine Merce, Bernd Fischer, Jörg D. Hoheisel & Esteban D. Erben. (2016) Gene expression regulatory networks in T rypanosoma brucei : insights into the role of the mRNA-binding proteome . Molecular Microbiology 100:3, pages 457-471.
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Osvaldo P. de Melo Neto, Christian R. S. Reis, Danielle M. N. Moura, Eden R. Freire & Mark Carrington. 2016. Evolution of the Protein Synthesis Machinery and Its Regulation. Evolution of the Protein Synthesis Machinery and Its Regulation 435 475 .
Cornelia Klein, Monica Terrao, Diana Inchaustegui Gil & Christine Clayton. (2015) Polysomes of Trypanosoma brucei: Association with Initiation Factors and RNA-Binding Proteins. PLOS ONE 10:8, pages e0135973.
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