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RNA Biology Volume 18, 2021 - Issue sup2
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Research Paper

Inhibition of CDK9 activity compromises global splicing in prostate cancer cells

Qiang Hua Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USAView further author information
,
Ninu Pouloseb Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UKView further author information
,
Samuel Girmayc Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, FinlandView further author information
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Alma Heleväc Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, FinlandView further author information
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Dimitrios Doultsinosb Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UKView further author information
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Aishwarya Gondanec Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, FinlandView further author information
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Rebecca E Steeled PCUK/Movember Centre of Excellence for Prostate Cancer Research, Centre for Cancer Research and Cell Biology (CCRCB), Queen’s University Belfast, Belfast, UK;e Breast Cancer Now Toby Robins Research Centre, the Institute of Cancer Research, London, UKView further author information
,
Xiaozhuo Liuf Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USAView further author information
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Massimo Lodag Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA;h The Broad Institute of Harvard and Mit, Cambridge, Massachusetts;i The New York Genome Center, New York, New York, USAView further author information
,
Song Liua Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USAView further author information
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Dean G. Tangf Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USAView further author information
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Ian G Millsb Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK;d PCUK/Movember Centre of Excellence for Prostate Cancer Research, Centre for Cancer Research and Cell Biology (CCRCB), Queen’s University Belfast, Belfast, UKView further author information
&
Harri M Itkonenc Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, FinlandCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5194-7064View further author information
ORCID Icon show all
Pages 722-729 | Received 27 Mar 2021, Accepted 15 Sep 2021, Published online: 30 Sep 2021

Citations (8)

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Read on this site (1)

Edward C. Dominguez, Carly Roleder, Brian Ball & Alexey V. Danilov. (2023) Cyclin-dependent kinase-9 in B-cell malignancies: pathogenic role and therapeutic implications. Leukemia & Lymphoma 0:0, pages 1-12.
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Articles from other publishers (7)

Satu Pallasaho, Aishwarya Gondane, Anni Kuivalainen, Samuel Girmay, Siver Moestue, Massimo Loda & Harri M. Itkonen. (2022) Castration-resistant prostate cancer cells are dependent on the high activity of CDK7. Journal of Cancer Research and Clinical Oncology 149:8, pages 5255-5263.
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Aishwarya Gondane & Harri M. Itkonen. (2023) Revealing the History and Mystery of RNA-Seq. Current Issues in Molecular Biology 45:3, pages 1860-1874.
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Scott J. Barraza, Anuradha Bhattacharyya, Christopher R. Trotta & Matthew G. Woll. (2023) Targeting strategies for modulating pre-mRNA splicing with small molecules: Recent advances. Drug Discovery Today 28:1, pages 103431.
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Ana Paula Alarcón-Zendejas, Anna Scavuzzo, Miguel A. Jiménez-Ríos, Rosa M. Álvarez-Gómez, Rogelio Montiel-Manríquez, Clementina Castro-Hernández, Miguel A. Jiménez-Dávila, Delia Pérez-Montiel, Rodrigo González-Barrios, Francisco Jiménez-Trejo, Cristian Arriaga-Canon & Luis A. Herrera. (2022) The promising role of new molecular biomarkers in prostate cancer: from coding and non-coding genes to artificial intelligence approaches. Prostate Cancer and Prostatic Diseases 25:3, pages 431-443.
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Aishwarya Gondane, Ninu Poulose, Suzanne Walker, Ian G Mills & Harri M Itkonen. (2022) O-GlcNAc transferase maintains metabolic homeostasis in response to CDK9 inhibition. Glycobiology.
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Kai Funke, Robert Düster, Prince De-Graft Wilson, Lena Arévalo, Matthias Geyer & Hubert Schorle. (2022) Transcriptional CDK Inhibitors as Potential Treatment Option for Testicular Germ Cell Tumors. Cancers 14:7, pages 1690.
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Xiaoxi Ouyang, Longxian Lv, Yalei Zhao, Fen Zhang, Qingqing Hu, Zuhong Li, Danhua Zhu & Lanjuan Li. (2022) ASF1B Serves as a Potential Therapeutic Target by Influencing Cell Cycle and Proliferation in Hepatocellular Carcinoma. Frontiers in Oncology 11.
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