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RNA Biology Volume 19, 2022 - Issue 1
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Research Paper

Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells

Nadav Wallisa Department of Developmental Biology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelView further author information
,
Froma Obermana Department of Developmental Biology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelView further author information
,
Khriesto Shurrushb The Wohl Drug Discovery Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, IsraelView further author information
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Nicolas Germainb The Wohl Drug Discovery Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, IsraelView further author information
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Gila Greenwalda Department of Developmental Biology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelView further author information
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Tehila Gershona Department of Developmental Biology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelView further author information
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Talia Pearla Department of Developmental Biology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelView further author information
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Giancarlo Abisc Division of Biosciences, Institute of Structural and Molecular Biology, University College London, London, UKView further author information
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Vikash Singhd Department of Pediatrics, Division of Pediatric Hematology/Oncology, Pennsylvania State University, College of Medicine, Hershey, PA, USAView further author information
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Amandeep Singhe Department of Pharmacology, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USAView further author information
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Arun K. Sharmae Department of Pharmacology, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USAView further author information
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Haim M. Barrb The Wohl Drug Discovery Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, IsraelView further author information
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Andres Ramosc Division of Biosciences, Institute of Structural and Molecular Biology, University College London, London, UKORCID Iconhttps://orcid.org/0000-0002-9295-8042View further author information
ORCID Icon,
Vladimir S. Spiegelmand Department of Pediatrics, Division of Pediatric Hematology/Oncology, Pennsylvania State University, College of Medicine, Hershey, PA, USAView further author information
&
Joel K. Yisraelia Department of Developmental Biology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6538-6686View further author information
ORCID Icon show all
Pages 26-43 | Received 05 Aug 2021, Accepted 22 Nov 2021, Published online: 11 Dec 2021

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Shijie Zhao, Mengxue Zhang, Xiaolan Zhu, Jie Xing, Jiaming Zhou & Xinming Yin. (2023) The potential regulatory role of RNA methylation in ovarian cancer. RNA Biology 20:1, pages 207-218.
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Tony Gutschner. (2023) RNA therapeutics. RNA Biology 0:0, pages 1-2.
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Articles from other publishers (25)

Meiqi Duan, Haiyang Liu, Shasha Xu, Zhi Yang, Fusheng Zhang, Guang Wang, Yutian Wang, Shan Zhao & Xiaofeng Jiang. (2024) IGF2BPs as novel m6A readers: Diverse roles in regulating cancer cell biological functions, hypoxia adaptation, metabolism, and immunosuppressive tumor microenvironment. Genes & Diseases 11:2, pages 890-920.
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Amandeep Singh, Vikash Singh, Nadav Wallis, Giancarlo Abis, Froma Oberman, Tyler Wood, Mayura Dhamdhere, Tehila Gershon, Andres Ramos, Joel Yisraeli, Vladimir S. Spiegelman & Arun K. Sharma. (2024) Development of a specific and potent IGF2BP1 inhibitor: A promising therapeutic agent for IGF2BP1-expressing cancers. European Journal of Medicinal Chemistry 263, pages 115940.
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Aixiao Li, Ahmed Bouhss, Marie-Jeanne Clément, Cyril Bauvais, J. Paul Taylor, Guillaume Bollot & David Pastré. (2023) Using the structural diversity of RNA: protein interfaces to selectively target RNA with small molecules in cells: methods and perspectives. Frontiers in Molecular Biosciences 10.
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Xun Chen, Lejia Zhang, Yi He, Siyuan Huang, Shangwu Chen, Wei Zhao & Dongsheng Yu. (2023) Regulation of m6A modification on ferroptosis and its potential significance in radiosensitization. Cell Death Discovery 9:1.
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Nicholas J. Wallbillich & Hua Lu. (2023) Role of c-Myc in lung cancer: Progress, challenges, and prospects. Chinese Medical Journal Pulmonary and Critical Care Medicine 1:3, pages 129-138.
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Weichao Sun, Hanwei Cui, Tianhao Xu, Jiaji Yue, Jianhui Liang, Wei You, Wei Sun & Qian Yi. (2023) RNA binding proteins in extracellular vesicles and their potential value for cancer diagnosis and treatment (Review). International Journal of Oncology 63:4.
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Irina A. Elcheva, Chethana P. Gowda, Daniel Bogush, Svetlana Gornostaeva, Anna Fakhardo, Neil Sheth, Kathleen M. Kokolus, Arati Sharma, Sinisa Dovat, Yasin Uzun, Todd D. Schell & Vladimir S. Spiegelman. (2023) IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment. Frontiers in Immunology 14.
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Tian-Yu Zhu, Lian-Lian Hong & Zhi-Qiang Ling. (2023) Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential. Biomarker Research 11:1.
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Jean B. Bertoldo, Simon Müller & Stefan Hüttelmaier. (2023) RNA-binding proteins in cancer drug discovery. Drug Discovery Today 28:6, pages 103580.
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Xiaolan Deng, Ying Qing, David Horne, Huilin Huang & Jianjun Chen. (2023) The roles and implications of RNA m6A modification in cancer. Nature Reviews Clinical Oncology.
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Mayura R. Dhamdhere, Chethana P. Gowda, Vikash Singh, Zhenqiu Liu, Nicholas Carruthers, Christa N. Grant, Arati Sharma, Sinisa Dovat, Jeffrey M. Sundstrom, Hong-Gang Wang & Vladimir S. Spiegelman. (2023) IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis. Oncogene 42:19, pages 1558-1571.
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Li-Ting Shen, Lin-Rong Che, Zongsheng He, Qian Lu, Dong-Feng Chen, Zhong-yi Qin & Bin Wang. (2023) Aberrant RNA m6A modification in gastrointestinal malignancies: versatile regulators of cancer hallmarks and novel therapeutic opportunities. Cell Death & Disease 14:4.
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Sitong Feng, Haixia Cao, Ying Sui, Ziyang Shen, Jianzhong Wu, Rong Ma & Jifeng Feng. (2023) CDCA4 interacts with IGF2BP1 to regulate lung adenocarcinoma proliferation via the PI3K / AKT pathway . Thoracic Cancer 14:8, pages 724-735.
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Shaila A. Shetu, Nneoma James, Gildardo Rivera & Debasish Bandyopadhyay. (2023) Molecular Research in Pancreatic Cancer: Small Molecule Inhibitors, Their Mechanistic Pathways and Beyond. Current Issues in Molecular Biology 45:3, pages 1914-1949.
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Zhaotong Wang, Jiawang Zhou, Haisheng Zhang, Lichen Ge, Jiexin Li & Hongsheng Wang. (2022) RNA m 6 A methylation in cancer . Molecular Oncology 17:2, pages 195-229.
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Madeline Kuhn, Yang Zhang, John Favate, Mayu Morita, Aurora Blucher, Sukanya Das, Shun Liang, Ranjan Preet, Louis R. Parham, Kathy N. Williams, Sudheer Molugu, Randall J. Armstrong, Wei Zhang, Jiegang Yang, Kathryn E. Hamilton, Dan A. Dixon, Gordon Mills, Terry K. Morgan, Premal Shah & Sarah F. Andres. (2022) IMP1/IGF2BP1 in human colorectal cancer extracellular vesicles. American Journal of Physiology-Gastrointestinal and Liver Physiology 323:6, pages G571-G585.
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Nicole Betson, Mohammed Hajahmed, Tsige Gebretsadek, Kenneth Ndebele, H. Anwar Ahmad, Paul B. Tchounwou, Vladimir S. Spiegelman & Felicite K. Noubissi. (2022) Inhibition of insulin‐like growth factor 2 mRNA ‐binding protein 1 sensitizes colorectal cancer cells to chemotherapeutics . FASEB BioAdvances 4:12, pages 816-829.
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Anjugam Paramanantham, Rahmat Asfiya, Siddharth Das, Grace McCully & Akhil Srivastava. (2022) Extracellular Vesicle (EVs) Associated Non-Coding RNAs in Lung Cancer and Therapeutics. International Journal of Molecular Sciences 23:21, pages 13637.
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Deepthi Ramesh-Kumar & Sonia Guil. (2022) The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer. Seminars in Cancer Biology 86, pages 18-31.
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Shougeng Liu, Sihong Chen, Chengfang Tang, Yingxi Zhao, Wei Cui, Lina Jia & Lihui Wang. (2022) The emerging therapeutic target of dynamic and reversible N6-methyladenosine modification during cancer development. Frontiers in Oncology 12.
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Qian Yan, Xiaona Fang, Chenxi Li, Ping Lan & Xinyuan Guan. (2022) Oncofetal proteins and cancer stem cells. Essays in Biochemistry 66:4, pages 423-433.
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Yufeng Xi & Yujia Wang. (2022) IGF2BP1, a New Target to Overcome Drug Resistance in Melanoma?. Frontiers in Pharmacology 13.
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Jaeik Oh, Chanwoong Hwa, Dongjun Jang, Seungjae Shin, Soo-Jin Lee, Jiwon Kim, Sang Eun Lee, Hae Rim Jung, Yumi Oh, Giyong Jang, Obin Kwon, Joon-Yong An & Sung-Yup Cho. (2022) Augmentation of the RNA m6A reader signature is associated with poor survival by enhancing cell proliferation and EMT across cancer types. Experimental & Molecular Medicine 54:7, pages 906-921.
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Peng Li, Hope T. Richard, Kezhou Zhu, Linlin Li & Suyun Huang. (2022) The Roles and Regulation of m6A Modification in Glioblastoma Stem Cells and Tumorigenesis. Biomedicines 10:5, pages 969.
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Shaila A. Shetu & Debasish Bandyopadhyay. (2022) Small-Molecule RAS Inhibitors as Anticancer Agents: Discovery, Development, and Mechanistic Studies. International Journal of Molecular Sciences 23:7, pages 3706.
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